ライフサイエンスコーパス: lateral line

1 in the developing ear and neuromasts of the lateral line.

2 linked to the mechanosensory function of the lateral line.

3 ls, and abnormal neuromasts on the posterior lateral line.

4 nsory hair cell function in the inner ear or lateral line.

5 as the migrating primordium of the posterior lateral line.

6 spikes) in hair-cell afferent neurons of the lateral line.

7 tion of germ cells and sensory organs of the lateral line.

8 ression and loss of Kremen1 in the zebrafish lateral line.

9 ation in vivo in the zebrafish inner ear and lateral line.

10 ion of supporting cells in the inner ear and lateral line.

11 regeneration of hair cells in the zebrafish lateral line.

12 m the mechanosensory organs of the posterior lateral line.

13 hair cell organs, including the cochlea and lateral line.

14 red for mechanotransduction in the zebrafish lateral line.

15 or GCaMP in mechanosensory hair cells of the lateral line.

16 ctional mechanotransduction in the zebrafish lateral line.

17 position, and variation in the neurosensory lateral line.

18 etent to respond to cues associated with the lateral lines.

19 Evolved over millions of years, fish use the lateral line, a distributed linear array of flow sensing

20 al symmetry in myelinated reticulospinal and lateral line afferent axons.

21 Many auditory, vestibular, and lateral-line afferent neurons display spontaneous action

22 These results indicate that lateral-line afferent neurons do not require synaptic ac

23 we recorded robust spontaneous spiking from lateral-line afferent neurons in the absence of external

24 emoving specific neuromasts of the posterior lateral line along the body, we show how the location an

25 Sema Z1a helps guide the growth cones of the lateral line along their normal pathway.

26 ory organ, adenohypophysis, lens, inner ear, lateral line and cranial ganglia.

27 terior portion, which is associated with the lateral line and eighth nerve senses, and the posterior

28 and an anterior caudal lobe associated with lateral line and eighth nerve senses.

29 onfiguration is reached only in the juvenile lateral line and in the inner ear from >2 months after h

30 and synaptic activity in hair cells from the lateral line and inner ear in vivo and using near-physio

31 The lateral line and its associated sensory nerves develop f

32 We also quantify differences in the lateral line and vision between cavefish and surface fis

33 h ganglionic placodes, including trigeminal, lateral line, and epibranchial placodes.

34 atrial siphon primordia and posterior (otic, lateral line, and epibranchial) placodes of vertebrates

35 t, skeletal muscle, otic vesicle, forebrain, lateral line, and ganglions, most of which have not been

36 line nerve for this head segment, the middle lateral line, appears to develop normally.

37 cells in the chick cochlea and the zebrafish lateral line are able to regenerate, prompting studies i

38 ing that in C. punctatum, glial cells in the lateral line are likely of neural crest origin.

39 ting experiments demonstrated that T. torosa lateral lines are competent to generate a melanophore-fr

40 teral current profile of hair cells from the lateral line becomes more segregated with age, and that

41 ccule in the inner ear and from the anterior lateral line both terminate in the medial vestibular nuc

42 olfactory neurons, and sensory cells of the lateral line, but not in the retina.

43 that hair cells and supporting cells of the lateral line can be directly patch-clamped, providing th

44 We show that the artificial lateral line can successfully perform dipole source loca

45 We found that the isolated lateral line cells are positioned by two antagonistic cu

46 tions between melanophores and xanthophores, lateral line-dependent alterations of the subepidermal b

47 ave been retained in T. torosa as redundant, lateral line-dependent mechanisms for stripe formation h

48 These results indicate that lateral line-dependent pattern-forming mechanisms are co

49 placodes (trigeminal, auditory, vestibular, lateral line) develop independently of the endoderm and

50 re, we attempt to highlight the diversity of lateral line development and the limits of the current r

51 ceptor and reveal its additional role in the lateral line development in zebrafish.

52 Moreover, prevention of lateral line development results in greater densities of

53 milar melanophore-free region forms prior to lateral line development, and ablation of the lateral li

54 ion and differentiation during inner ear and lateral line development.

55 ateral line development, and ablation of the lateral lines does not perturb the horizontal stripe pat

56 Lateral line effects on melanophores are inferred to be

57 We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefi

58 w that each afferent neuron of the posterior lateral line establishes specific contacts with hair cel

59 ent expression was observed in the posterior lateral line ganglia and developing trunk/tail.

60 Both lateral line ganglia and neuromasts develop on a stereot

61 also identify Tbx3 as a specific marker for lateral line ganglia in shark embryos.

62 st in trigeminal, Rohon-Beard, and posterior lateral line ganglia neurons, which are among the earlie

63 le, we analyzed (1) the pathways followed by lateral line growth cones in mutants in which the expres

64 tered in an interesting way, (2) response of lateral line growth cones to exogenous Sema Z1a in livin

65 ing embryos, and (3) the pathway followed by lateral line growth cones when Sema Z1a is misexpressed

66 l fate analyses of all dividing cells during lateral line hair cell regeneration revealed that suppor

67 cellular Ca(2+) underlies death in zebrafish lateral line hair cells after exposure to aminoglycoside

68 Channelrhodopsin (ChR2) expressed in ear and lateral line hair cells and acquired high-speed videos o

69 In lateral line hair cells from juvenile zebrafish, exocyto

70 mycin for 1 h results in death of almost all lateral line hair cells.

71 bundles and mechanosensitivity of individual lateral-line hair cells in vivo, we uncovered a central

72 e found that TRPN1 is prominently located in lateral-line hair cells, auditory hair cells, and ciliat

73 ocalizes to ribbon synapses in inner ear and lateral-line hair cells.

74 ted or inhibited D1-like receptors (D1Rs) in lateral-line hair cells.

75 chooling tendency in A. mexicanus, while the lateral line has a small effect on this behavior.

76 that develop supernumerary neuromasts in the lateral line has revealed an inhibitory mechanism, media

77 ic survey also revealed that ablation of the lateral lines has qualitatively similar effects on melan

78 tatoacoustic ganglion (SAG) development, and lateral line HC differentiation.

79 ot fully established, as isolated cells with lateral line identity are present caudal to the main pri

80 ent neurons that innervate the inner ear and lateral line in a sound-producing teleost fish while evo

81 in the migrating primordia of the posterior lateral line in dog embryos and as well as in regions of

82 siological properties from hair cells of the lateral line in juvenile zebrafish.

83 ere we show that neuromasts of the posterior lateral line in medaka are composed of two independent l

84 amenable model is provided by the posterior lateral line in zebrafish, which is formed by a cohesive

85 nsory neurons, the posterior ganglion of the lateral line, in zebrafish.

86 ine which receive auditory and which receive lateral line information.

87 bration stimuli peaking at 35 Hz, blocked by lateral line inhibitors, first detected after developmen

88 itory input via the medial pretoral nucleus, lateral line input via the ventrolateral toral nucleus,

89 free region, including steric effects of the lateral lines, interactions between melanophores and xan

90 and multiple pathways in vivo transforms the lateral line into a powerful paradigm to mechanistically

91 The lateral line is a placodally derived mechanosensory orga

92 The development of the artificial lateral line is aimed at fundamentally enhancing human a

93 The zebrafish lateral line is emerging as an excellent in vivo model f

94 We speculate that directional input from the lateral line is less important at an early age, whereas

95 The mechanosensory lateral line is located externally on the animal and the

96 athway; in the nucleus of the electrosensory lateral line lobe (ELL) and the big cells of the nucleus

97 hanisms was identified in the electrosensory lateral line lobe (ELL) in the hindbrain by field potent

98 Phase-locking neurons in the electrosensory lateral line lobe (ELL) of a weakly electric fish, Gymna

99 hase-sensitive neurons in the electrosensory lateral line lobe (ELL) of the African electric fish, Gy

100 formation transmission in the electrosensory lateral line lobe (ELL) of the hindbrain.

101 e describe correlations among electrosensory lateral line lobe (ELL) pyramidal cells' highly variable

102 I-type pyramidal cells in the electrosensory lateral line lobe (ELL) to random distortions of a mimic

103 ordered hindbrain maps of the electrosensory lateral line lobe (ELL), the dorsolateral zone (DLZ), an

104 n for central processing, the electrosensory lateral line lobe (ELL), were investigated by the in viv

105 olds of output neurons of the electrosensory lateral line lobe (ELL), where the representation of tim

106 nhibitory interneurons in the electrosensory lateral line lobe (ELL).

107 neurons in the nucleus of the electrosensory lateral line lobe (NELL) act as relays of peripheral res

108 Pyramidal cells in the electrosensory lateral line lobe burst in response to low-frequency, lo

109 nucleus in electric fish, the electrosensory lateral line lobe, resulted in markedly different behavi

110 s, the pyramidal cells in the electrosensory lateral-line lobe.

111 The external location of the zebrafish lateral line makes it a powerful model for studying mech

112 unk during embryonic development to form the lateral line mechanosensory system.

113 pathways mediating auditory, vestibular, and lateral line modalities as the animal transforms from an

114 ordium plays a crucial role in orchestrating lateral line morphogenesis.

115 sensory and electrosensory components of the lateral line must be dissociable.

116 medialis, the principal termination site of lateral line nerve afferents in the medulla, whereas ter

117 Interneuromast cells lie adjacent to the lateral line nerve and associated glia.

118 al tracer BDA into different branches of the lateral line nerve and into different parts of the dorsa

119 The proposed corresponding lateral line nerve for this head segment, the middle lat

120 Here, we show that the posterior lateral line nerve in zebrafish initially grows in the e

121 nd posterior to the otic vesicle: the middle lateral line nerve innervates the middle line, whereas t

122 recent study has addressed how the zebrafish lateral line nerve matches up with its glia.

123 The left, infraorbital, anterior lateral line nerve of brown ghosts (Apteronotus leptorhy

124 trunk canal and the ramules of the posterior lateral line nerve that innervate them seem to be organi

125 Otolithic, semicircular canal, and anterior lateral line nerves all project to the MgON, which may s

126 We describe the organization of lateral line nerves and ganglia in the embryonic zebrafi

127 Two lateral line nerves are found anterior to the otic vesic

128 An additional two lateral line nerves are found posterior to the otic vesi

129 Anterior and posterior lateral line nerves project to the CON and MON, with den

130 ne receptors are innervated by five pairs of lateral line nerves whose rami are secondarily associate

131 The regeneration of sensory hair cells in lateral line neuromasts of axolotls was investigated via

132 nd to possess significantly more superficial lateral line neuromasts than hatchery-reared juveniles,

133 umbers of hair cells in the otic vesicle and lateral line neuromasts with impaired sensory responses.

134 detailing the patterning and development of lateral line neuromasts, little is known about the organ

135 sensory hair cells in the developing ear and lateral line neuromasts.

136 ph9 in the kinocilia of the inner ear and/or lateral line neuromasts.

137 of the process of hair cell regeneration in lateral line neuromasts; numbers of macrophages were obs

138 cellular nuclei receive their input from the lateral line nucleus of the medulla.

139 rmation by each hair cell of the zebrafish's lateral line occurs during a particular interval after t

140 elopment, morphogenesis, and polarity in the lateral line of Danio rerio and the embryo of Caenorhabd

141 cal properties of mature hair cells from the lateral line of juvenile zebrafish.

142 In the posterior lateral line of larval zebrafish, each afferent neuron f

143 cell damage, we examined hair cells from the lateral line of the zebrafish, Danio rerio.

144 Investigating this issue in the lateral line of the zebrafish, we found that hair cells

145 mal number of neuromasts along the posterior lateral line of zebrafish larvae.

146 Hair cells in the posterior lateral lines of mutants contain numerous lysosomes and

147 nsory structures (e.g., auditory, gustatory, lateral line, olfactory, and visual nuclei) and motor nu

148 The lateral line organ is a mechanosensory organ of fish and

149 e patterns in an in vitro preparation of the lateral line organ of Xenopus laevis.

150 The lateral line organ of zebrafish has been used as a model

151 CGRP suppressed responses of the lateral line organ to displacement while increasing spon

152 ransduction, including cells of the ear, the lateral line organ, and the olfactory placodes.

153 ively expressed in hair cells of the ear and lateral line organ.

154 the overall development of the inner ear and lateral-line organ appeared normal, the sensory epitheli

155 ation, these results establish the posterior lateral-line organ as a vertebrate system for the in viv

156 ation of mechanosensory hair cells along the lateral-line organ of a fish or amphibian is essential f

157 The posterior lateral-line organ of larval zebrafish consists of polar

158 anosensory organs, such as the inner ear and lateral-line organ, is not clearly understood.

159 nically sensitive cells of the inner ear and lateral-line organ.

160 ranial ganglia, neural crest, and hindbrain, lateral line organization was analyzed in valentino muta

161 e axonal projections from the mechanosensory lateral line organize a somatotopic neural map.

162 y organ, retina, lens, cornea, otic vesicle, lateral line organs, and Rohon-Beard neurons.

163 hypersensitive mutants have additional trunk lateral line organs.

164 ant, progressive hair cell loss in zebrafish lateral-line organs.

165 cyte/xanthophore, iridophore, intraray glia, lateral line, osteoblast, dermal fibroblast, vascular en

166 The organization of the central lateral line pathways in the midshipman fish, Porichthys

167 he neuromasts, known mechanoreceptors of the lateral line peripheral nervous system.

168 mal derivatives including neurons, glia, the lateral line, peripheral sensory structures, and tissues

169 Intensive study of the migrating posterior lateral line placode in zebrafish has yielded a wealth o

170 mapping data that conclusively demonstrate a lateral line placode origin for ampullary organs and neu

171 nfirms that ampullary organs are ancestrally lateral line placode-derived in bony fishes.

172 at jawed vertebrates primitively possessed a lateral line placode-derived system of electrosensory am

173 of the lobe-finned clade of bony fishes) are lateral line placode-derived, non-placodal origins have

174 nt research focus on the zebrafish posterior lateral line placode.

175 ttle skate, Leucoraja erinacea, we show that lateral line placodes form both ampullary electrorecepto

176 Here, we test the hypothesis that lateral line placodes form electroreceptors in cartilagi

177 eral lines were ablated (by removing cranial lateral line placodes), the melanophore-free region did

178 and ampullary organ formation by elongating lateral line placodes, and even of other zebrafish later

179 function, suggesting that two derivatives of lateral line placodes, ganglia and migrating primordia,

180 l line placodes, and even of other zebrafish lateral line placodes, is sparse or non-existent.

181 tem throughout its development, expressed in lateral line placodes, sensory ridges and migrating prim

182 bony fish ampullary organs are derived from lateral line placodes, whereas a neural crest origin has

183 ntire system arises from a series of cranial lateral line placodes, which exhibit two modes of sensor

184 euromasts and ampullary organs, develop from lateral line placodes.

185 ogfish, with a focus on the epibranchial and lateral line placodes.

186 , Danio rerio, are expressed in the otic and lateral-line placodes at their earliest stages of develo

187 The zebrafish posterior lateral line (pLL) is a sensory system that comprises cl

188 Here we show that the posterior lateral line (PLL) of zebrafish is a suitable system to

189 regular intervals by the migrating posterior lateral line (pLL) primordium.

190 and the superficial horizontal myoseptum and lateral line primordia were not properly formed in the q

191 f proneuromast deposition from the posterior lateral line primordia.

192 In this study, we use the zebrafish lateral line primordium (LLP), a group of migrating epit

193 Here, we study the posterior lateral line primordium (PLLP) a group of about 100 cell

194 igration of cells in the zebrafish posterior lateral line primordium (PLLp) along a path defined by C

195 Migration of the posterior lateral line primordium (pLLP) generates the zebrafish s

196 The posterior lateral line primordium (PLLp) migrates caudally and per

197 The posterior lateral line primordium (pLLp) migrates caudally, deposi

198 modulation of Wnt signaling in the posterior lateral line primordium (pLLP), a cohort of ~100 cells t

199 rosette formation in the zebrafish posterior lateral line primordium (pLLp), a group of approximately

200 We captured dynamic changes in the zebrafish lateral line primordium and observed interactions betwee

201 ogenic cell migration, such as the zebrafish lateral line primordium and primordial germ cells, Droso

202 ecause melanophores retreat from the midbody lateral line primordium as it migrates caudally along th

203 g in which it enables the coalescence of the lateral line primordium from an initial fuzzy pattern in

204 The posterior lateral line primordium in zebrafish provides an amenabl

205 of this problem is afforded by the migrating lateral line primordium of the zebrafish.

206 The posterior lateral line primordium periodically deposits prosensory

207 R7 acts as a sink in the migrating zebrafish lateral line primordium to generate SDF1 gradients.

208 during migration of the zebrafish posterior lateral line primordium, a cohort of about 200 cells tha

209 ys in the initial formation of the posterior lateral line primordium, as well as during organ pattern

210 d vessel sprouting, and the migration of the lateral line primordium, neural crest cells, or head mes

211 lopmental contexts, such as in the zebrafish lateral line primordium, the vertebrate pancreas, the Dr

212 ErbB expressing Schwann cells inhibit lateral line progenitor proliferation and differentiatio

213 play a crucial role in negatively regulating lateral line progenitor proliferation.

214 e otolithic organs, semicircular canals, and lateral lines, project to seven hindbrain nuclei in dive

215 in stable across larval development, whereas lateral line projections degenerate during metamorphic c

216 The lateral line provides hydrodynamic information for intri

217 The lateral line receptors are innervated by five pairs of l

218 brain and hindbrain vocal circuitry, and the lateral line recipient nucleus medialis in the rostral h

219 into physiologically identified sites in the lateral line-recipient nucleus ventrolateralis in the mi

220 Detection of water motion by the lateral line relies on mechanotransduction complexes at

221 Single afferent neuron recordings from the lateral line revealed a similar intensity-dependent decr

222 In contrast, the eight mechanosensory lateral lines running over the head surface and the nume

223 re were no differences for all three traits, lateral-line scales, pectoral-fin rays and pelvic-fin ra

224 Lateral line sensory neuromasts develop independently of

225 (MON) is the principal first-order medullary lateral line sensory nucleus found in the majority of an

226 roreception is an ancient subdivision of the lateral line sensory system, found in all major vertebra

227 correlates with the development of the trunk lateral line sensory system.

228 defective in formation of the inner ear and lateral line sensory systems.

229 n; specific cells in the trigeminal (fifth), lateral line (seventh), and vestibular (eighth) cranial

230 chanosensory hair cells within the zebrafish lateral line spontaneously regenerate after aminoglycosi

231 es on several morphological traits including lateral line structure, otolith composition (a proxy for

232 s expressed in the migrating melanocytes and lateral line structures.

233 served DiI cells and Sox9 labeling along the lateral line, suggesting that in C. punctatum, glial cel

234 reased number of neuromasts in the posterior lateral line system and decreased body length, suggestin

235 imilarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibl

236 Using the zebrafish lateral line system as a platform for drug screen and su

237 The sensory lateral line system consists of only a few hundred cells

238 Our analysis of the posterior lateral line system defines a new process in which Schwa

239 morphological and molecular data describing lateral line system development in the basal ray-finned

240 ved S100-positive cells in neuromasts of the lateral line system in 2 dpf larvae, suggesting that the

241 siting neuromasts to establish the posterior lateral line system in zebrafish.

242 The lateral line system of anamniote vertebrates enables the

243 The lateral line system of larval zebrafish is emerging as a

244 to the inner ear of all vertebrates, and the lateral line system of some aquatic vertebrates, represe

245 The lateral line system of the channel catfish is formed by

246 We identify Eya4 as a novel marker for the lateral line system throughout its development, expresse

247 In this work, we used the zebrafish lateral line system to monitor the dynamic behavior of m

248 ior called rheotaxis, whereby they use their lateral line system to orient upstream in the presence o

249 (olfactory organs, inner ears and anamniote lateral line system), as well as the eye lenses, and mos

250 The anamniote lateral line system, comprising mechanosensory neuromast

251 s differs between the anterior and posterior lateral line system, suggesting potential differences in

252 quantifying morphological connections in the lateral line system, this study provides a detailed foun

253 tire postfacial body appear to function as a lateral line system.

254 monstrate here a proof-of-concept artificial lateral line system.

255 sensory cells of neuromasts belonging to the lateral line system.

256 sette-shaped sensory organs in the zebrafish lateral line system.

257 e expression in hair-cell progenitors of the lateral-line system.

258 The fibers of the gustatory and lateral line systems may use the neural crest, the devel

259 roreception or vibratory sensing through the lateral line systems plays a role in social signaling, a

260 The organs of the vestibular, auditory and lateral line systems rely on a common strategy for the s

261 ssing information from both the auditory and lateral line systems, including the eighth nerve-recipie

262 Hair cells in the auditory, vestibular, and lateral-line systems of vertebrates receive inputs throu

263 cal signals in the auditory, vestibular, and lateral-line systems of vertebrates.

264 stant and step stimuli in the vestibular and lateral-line systems.

265 In addition to the lateral line, these findings have important implications

266 We took advantage of the zebrafish sensory lateral line to define niche-progenitor interactions to

267 , we show that fish use their mechanosensory lateral line to first sense the curl (or vorticity) of t

268 -known mechanoreceptors of the inner ear and lateral line, typically exhibiting an apical hair bundle

269 We map mechanosensitivity along the lateral line using imaging and electrophysiology to dete

270 Using hair cells of the zebrafish lateral line, we found that chemical inhibition of mecha

271 he inner ear or by neomycin treatment in the lateral line, we observe rapid activation of several com

272 When the trunk lateral lines were ablated (by removing cranial lateral

273 other placodally derived sensory system, the lateral line, while hypersensitive mutants have addition