ライフサイエンスコーパス: lateral plate

1 en's node can promote formation of IM in the lateral plate.

2 soderm that lies between the somites and the lateral plate.

3 ompartment comprising cells from somites and lateral plate.

4 ication has occurred in the node but not the lateral plate.

5 the prospective limb-forming regions of the lateral plate.

6 the prospective limb-forming regions of the lateral plate.

7 the prospective limb-forming regions of the lateral plate.

8 Subsequently, competing signals from the lateral plate and axial tissues modulate the number of c

9 ced by GSK3-beta inhibition did not generate lateral plate and cardiac mesoderm and favored instead s

10 te nonmyogenic cells to the limb: stage 9-12 lateral plate and distal portions of stage 25/26 limbs.

11 r that Pbx1 and Pbx2 are co-expressed in the lateral plate and early limb field mesoderm.

12 metric gene expression at the node or in the lateral plate and exhibit right isomerism of the lungs.

13 a transcription factors are expressed in the lateral plate and in vasculogenic regions of the avian s

14 te mesoderm lies between the somites and the lateral plate and is the source of all kidney tissue in

15 eobox genes prx-1 and prx-2 are expressed in lateral plate and limb bud mesoderm, but targeted inacti

16 ed in conferring limb-forming ability to the lateral plate and may promote the initial outgrowth of l

17 Combining lateral plate and paraxial tissue in vivo or in vitro le

18 t apparently adopt the Hox expression of the lateral plate and participate in the morphology appropri

19 riginally specified as ventral type, such as lateral plate and primary blood islands.

20 riginate from several sources, including the lateral plate and somite mesoderm.

21 dermal protein expression was limited to the lateral plate and somitic mesoderm.

22 somite by inhibitory signals produced by the lateral plate and ventral neural tube.

23 ricted to the primitive streak and posterior lateral plate, and is absent from the anterior region wh

24 d the formation of all but the most anterior lateral plates, and another independently segregating fa

25 sis, ndr2 is expressed asymmetrically in the lateral plate as are nodal-related genes of other organi

26 esceinated dextran, confirms that, normally, lateral plate cells next to the notochord do not contrib

27 nt and explant experiments revealed that the lateral plate contains an activity that can repress IM f

28 Misexpression of Hoxd-12 in other lateral plate derivatives (sternum, pelvis) likewise phe

29 pression of mesoderm markers associated with lateral plate derivatives.

30 First, the majority of the avian scapula is lateral plate derived and the somitic contribution to th

31 We have identified a population of lateral plate-derived limb mesodermal cells in both chic

32 ns of somite-derived myogenic precursors and lateral plate-derived mesenchymal stroma to the establis

33 n the thoracic region, Hox genes pattern the lateral plate-derived sternum in a non-colinear manner,

34 e HSC lineage have been identified in dorsal lateral plate (DLP) mesoderm, and a transcriptional gene

35 putative adult haemangioblasts in the dorsal lateral plate (DLP) mesoderm.

36 ate embryo, the blood islands and the dorsal lateral plate (DLP), participate in early hematopoietic

37 The anterior lateral plate domain of GFP expression gives rise to pri

38 g. neural tube, axial and paraxial mesoderm, lateral plate, ectoderm, endoderm) to drive axis morphog

39 ey strongly support the hypothesis that left lateral plate expression of nodal-related genes is a cau

40 e absence of Shh, BMP administration induces lateral plate gene expression in cultured psm.

41 ediate mesoderm gene expression and activate lateral plate genes.

42 anism for information relay between node and lateral plate in a process that is critical for the esta

43 asymmetric information from the node to the lateral plate is mediated by Caronte (Car), a novel memb

44 erivatives, including pronephros, muscle and lateral plate is not disrupted.

45 MP signaling no longer induces expression of lateral plate markers but now induces robust chondrogene

46 at additional cell types within the anterior lateral plate mesoderm (ALPM) also underwent subduction,

47 1 and Cyp26c1, are expressed in the anterior lateral plate mesoderm (ALPM) and predominantly overlap

48 ring primitive neutropoiesis in the anterior lateral plate mesoderm (ALPM) but has little effect on e

49 scripts are conspicuously absent in anterior lateral plate mesoderm (ALPM), where SHF progenitors are

50 ification in the nkx2.5(+) field of anterior lateral plate mesoderm (ALPM).

51 ng activity) but negatively regulated by the lateral plate mesoderm (BMP4).

52 sient asymmetric Nodal signaling in the left lateral plate mesoderm (L LPM) during tailbud/early somi

53 t stem cells (HPSCs) through an intermediate lateral plate mesoderm (LM) stage.

54 In chicken, lateral plate mesoderm (LPM) adjacent to occipital somit

55 alities in asymmetric gene expression in the lateral plate mesoderm (LPM) and dorsal diencephalon of

56 is joined by dynamic expression in the left lateral plate mesoderm (LPM) and left dorsal endoderm.

57 mally is expressed predominantly in the left lateral plate mesoderm (LPM) and left side of the straig

58 l somatopleure, a tissue composed of somatic lateral plate mesoderm (LPM) and overlying ectoderm.

59 demonstrated loss of normal LR asymmetry in lateral plate mesoderm (LPM) antivin/lefty-1 and Pitx2 e

60 fish, asymmetric migration of the epithelial lateral plate mesoderm (LPM) displaces the gut leftward,

61 the primary heart field within the anterior lateral plate mesoderm (LPM) into a tubular heart involv

62 ulatory pathway specifically within the left lateral plate mesoderm (LPM) is critical for these event

63 os, the expression of Pitx2 gene in the left lateral plate mesoderm (LPM) is directly regulated by Xn

64 Nodal activity in the left lateral plate mesoderm (LPM) is required to activate lef

65 In VAD embryos nodal expression in left lateral plate mesoderm (LPM) is severely downregulated a

66 Disruption of lateral plate mesoderm (LPM) migration through knockdown

67 sion in the foregut endoderm and surrounding lateral plate mesoderm (lpm) prior to respiratory specif

68 These signals are then transferred to the lateral plate mesoderm (LPM) through cellular and molecu

69 the transmission of asymmetric cues from the lateral plate mesoderm (LPM) to the cardiac field but no

70 ide markers such as nodal bilaterally in the lateral plate mesoderm (LPM), indicating that loss of AC

71 restricted expression of Pitx2c in the left lateral plate mesoderm (LPM), left half of heart tube an

72 vements of the hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric po

73 es is thought to be derived exclusively from lateral plate mesoderm (LPM), which gives rise to a card

74 e node and Shh downstream genes in the right lateral plate mesoderm (LPM), while overexpression of ch

75 the asymmetric migration of the neighboring lateral plate mesoderm (LPM).

76 ch as Nodal and Lefty2 is absent in the left lateral plate mesoderm (LPM).

77 nal response of Nodal expression in the left lateral plate mesoderm (LPM).

78 asymmetric left-right gene expression in the lateral plate mesoderm (LPM).

79 equently, Nodal expression is delayed in the lateral plate mesoderm (LPM).

80 quires asymmetric expression of nodal in the lateral plate mesoderm (LPM).

81 laterality and southpaw (spaw) expression in lateral plate mesoderm (LPM).

82 to Nodal expression specifically in the left lateral plate mesoderm (LPM).

83 n begins during the convergence of posterior lateral plate mesoderm (PLM), well before aorta formatio

84 le effect on erythropoiesis or the posterior lateral plate mesoderm (PLPM) expression of neutrophil m

85 nct sites, the anterior (ALPM) and posterior lateral plate mesoderm (PLPM).

86 velopment of two structures derived from the lateral plate mesoderm - the heart and the pectoral fin.

87 phological boundaries between somites and in lateral plate mesoderm a wing- or non-wing-forming bound

88 age tracing in the living embryo, are in the lateral plate mesoderm adjacent to the notochord-prechor

89 Subsequently, Nodal signaling from the left lateral plate mesoderm alleviates this repression ipsila

90 are good candidates for encoding position in lateral plate mesoderm along the body axis and thus for

91 ating the transcription of VegfA in both the lateral plate mesoderm and also in the somites.

92 ric midline domains and unilaterally in left lateral plate mesoderm and anterior dorsal endoderm.

93 localized to the presumptive presomitic and lateral plate mesoderm and CYP26 mRNA to the presumptive

94 eage perturbed asymmetric gene expression in lateral plate mesoderm and disrupted organ LR asymmetrie

95 to initiate molecular asymmetry in the left lateral plate mesoderm and exhibit multiple left-right p

96 regulates the developmental potential of the lateral plate mesoderm and is required cell autonomously

97 nitially specified in the dorsal part of the lateral plate mesoderm and later become incorporated int

98 riginate in distinct regions of the anterior lateral plate mesoderm and migrate to the midline where

99 three intermediate lineages: neuroectoderm, lateral plate mesoderm and paraxial mesoderm.

100 to disrupt asymmetric gene expression in the lateral plate mesoderm and randomize the placement of in

101 tissues, a strong expression of RARbeta2 in lateral plate mesoderm and somites, and an anterior expr

102 ription factor expressed throughout the left lateral plate mesoderm and subsequently on the left side

103 known to be expressed asymmetrically in the lateral plate mesoderm and the brain during embryogenesi

104 The dermis originates from the somites, the lateral plate mesoderm and the cranial neural crest.

105 proliferation of hindlimb progenitors in the lateral plate mesoderm and the expression of a common fa

106 anscripts were enriched in cardiac mesoderm, lateral plate mesoderm and the neural plate.

107 The gene Pitx2 is expressed in the left lateral plate mesoderm and, subsequently, in the left he

108 Lateral plate mesoderm appears to pattern the endoderm i

109 symmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located

110 r-1 is re-expressed unilaterally in the left lateral plate mesoderm at neurula/tailbud stages.

111 e of a differential growth of cells from the lateral plate mesoderm at specific axial levels.

112 by reciprocal transplantation of somites or lateral plate mesoderm at stages prior to muscle formati

113 rafish development, cbfb is expressed in the lateral plate mesoderm at tail bud stage and in the inte

114 Here we show that T is expressed in lateral plate mesoderm at the onset of limb bud formatio

115 xperiments show that bmp2a, expressed in the lateral plate mesoderm at these stages, is essential for

116 The grl gene is expressed in lateral plate mesoderm before vessel formation, and ther

117 d with gata4 and nkx2.5 not only in anterior lateral plate mesoderm but also in noncardiac mesoderm a

118 ation, the cardiac progenitors reside in the lateral plate mesoderm but maintain close contact with t

119 ormed via repressing venous cell fate at the lateral plate mesoderm by Hh signaling during vasculogen

120 Left-side expression of XNR1 in the lateral plate mesoderm depends on XCR2, whereas posterio

121 essed in restricted bilateral domains in the lateral plate mesoderm directly adjacent to the liver-fo

122 repression of Xnr-1 expression in the right lateral plate mesoderm during closure of the neural tube

123 mmetric and topological within the fin-field lateral plate mesoderm during early fin bud initiation.

124 maintain the expression of Pitx2 in the left lateral plate mesoderm during the patterning of left-rig

125 Neural tube and lateral plate mesoderm enhancers can be separated, but i

126 ABD, or ACD; somite expression by ACDE; and lateral plate mesoderm expression by DE.

127 M) cells will adopt either a chondrogenic or lateral plate mesoderm fate.

128 oderm for hindbrain patterning, and rarab in lateral plate mesoderm for specification of the pectoral

129 lly in the perinodal region of the posterior lateral plate mesoderm for the establishment of laterali

130 In these fish, GFP-expressing cells in the lateral plate mesoderm form two tubes that migrate ventr

131 of the fetal limb and axial skeleton, and in lateral plate mesoderm giving rise to visceral muscle.

132 developing node and at later stages in left lateral plate mesoderm has been implicated as a key regu

133 l is generated at the node and transduced to lateral plate mesoderm in a linear signal transduction c

134 oD, Myf-5, and myogenin in both paraxial and lateral plate mesoderm in the absence of inducing tissue

135 pressed in the intermediate mesoderm and the lateral plate mesoderm in the presumptive chick forelimb

136 Subsequent nodal and Pitx2 expression in the lateral plate mesoderm in these mice is randomized, indi

137 quivalent embryological origin: the anterior lateral plate mesoderm in vertebrates and the dorsal-mos

138 Left-sided expression of Nodal in the lateral plate mesoderm is a conserved feature necessary

139 pendent regulation of Hox gene expression in lateral plate mesoderm may have been a key step in the e

140 in rargb morphants, suggesting Rargb affects lateral plate mesoderm migration.

141 Posterior lateral plate mesoderm normally forms blood, but cocultu

142 verely downregulated or abolished within the lateral plate mesoderm of Southpaw-deficient embryos.

143 COUP-TFII is expressed in lateral plate mesoderm of the early embryo prior to limb

144 gion produces the paraxial, intermediate and lateral plate mesoderm of the trunk.

145 abel single or small patches of cells in the lateral plate mesoderm of the zebrafish and to track the

146 ecursors of several organs reside within the lateral plate mesoderm of vertebrate embryos.

147 ere initially induced to form neuroectoderm, lateral plate mesoderm or paraxial mesoderm.

148 ntly in somites and unsegmented paraxial and lateral plate mesoderm overlapping atrial precursors in

149 Analysis of the cardiogenic potential of the lateral plate mesoderm posterior to nkx-2.5 and actR-IIa

150 ppropriate number of cardiomyocytes from the lateral plate mesoderm requires a careful balance of bot

151 r notochord in late neurulae, and finally in lateral plate mesoderm restricted to the left side of ta

152 s Islet1, a hindlimb-specific factor, in the lateral plate mesoderm results in a failure to induce hi

153 zyme in the gpi-biosynthetic pathway, in the lateral plate mesoderm results in normally patterned lim

154 ly identified, here we provide evidence that lateral plate mesoderm sends instructive signals to the

155 tion factor Hand2, which is expressed in the lateral plate mesoderm starting at the completion of gas

156 tion of zebrafish hrT expression in anterior lateral plate mesoderm suggest a very early role for hrT

157 tion as cardiac precursors converge from the lateral plate mesoderm territories toward the embryonic

158 ail2 function in a regulatory circuit within lateral plate mesoderm that directs normal vessel format

159 on of the expression domain corresponding to lateral plate mesoderm that is part of the early heart f

160 a7/lacZ reporter within neural, paraxial and lateral plate mesoderm tissues.

161 red during somitogenesis within the anterior lateral plate mesoderm to induce myocardial differentiat

162 ine the relative contribution of somitic and lateral plate mesoderm to the avian scapula from quail-c

163 nt development, angioblasts migrate from the lateral plate mesoderm to the midline where they form a

164 regulation of the cell fate transition from lateral plate mesoderm to the specification of cardiomyo

165 ogenitor cells (HPCs) move from the anterior lateral plate mesoderm to the ventral midline, undergoin

166 that these cells migrate from the posterior lateral plate mesoderm to their site of differentiation

167 rmerly lefty-2), nodal and Pitx2 in the left lateral plate mesoderm was absent, suggesting that Gdf1

168 onephros induction, stage 7 or earlier chick lateral plate mesoderm was cocultured with caudal stage

169 ymmetric Nodal signaling cascade in the left lateral plate mesoderm was detected, and began to be unr

170 Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstrea

171 steps of this cascade (before it reaches the lateral plate mesoderm) results in random left-right asy

172 d shift of Nodal expression in the left LPM (lateral plate mesoderm), and speculate that the higher l

173 vascular zones are directly generated by the lateral plate mesoderm, a critical source of Sema3E.

174 ective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vas

175 rated and propagated from the KV to the left lateral plate mesoderm, activating a transcriptional res

176 skeleton and sternum arise from the somatic lateral plate mesoderm, and all of the muscles for both

177 The second population resides in the dorsal lateral plate mesoderm, and contains precursors of adult

178 tion to the neural groove, primitive streak, lateral plate mesoderm, and Hensen's node, while distinc

179 he nodal-related gene southpaw (spaw) in the lateral plate mesoderm, and its downstream targets pitx2

180 e of the genes specifically expressed in the lateral plate mesoderm, and later in its derivative, the

181 In the absence of FoxF1 function, the lateral plate mesoderm, and later the visceral mesoderm,

182 e, midbrain, spinal cord, paraxial mesoderm, lateral plate mesoderm, and limb bud.

183 superfamily, which is expressed in the left lateral plate mesoderm, and loss of nodal function produ

184 entral neural tube, notochord, ectoderm, and lateral plate mesoderm, and none was detected in the neu

185 soderm, the primitive streak at the level of lateral plate mesoderm, and the base of the allantois.

186 These somites induced ectopic pronephroi in lateral plate mesoderm, and the IM that received signals

187 Hox gene expression is reprogrammed in lateral plate mesoderm, but is unaffected in paraxial me

188 silon is an adapter protein expressed in the lateral plate mesoderm, but its in vivo cardiac function

189 of Xc-Myc, XSlug/Snail2 or XTwist within the lateral plate mesoderm, but not the neural crest, provok

190 onveyed to the node, and subsequently to the lateral plate mesoderm, by a complex cascade of epigenet

191 mesenchyme with cranial mesenchyme, but not lateral plate mesoderm, could rescue expression of the R

192 tive signals emanating from the neighbouring lateral plate mesoderm, directing the endoderm towards s

193 eriments ruled out the need for signals from lateral plate mesoderm, ectoderm, or endoderm.

194 In presumptive wing lateral plate mesoderm, ectopic Tbx18 expression leads t

195 first heart field differentiates earlier in lateral plate mesoderm, generates the linear heart tube

196 s show the requirement for Prt/Wnt2bb in the lateral plate mesoderm, in agreement with the inductive

197 The drl reporters initially delineate the lateral plate mesoderm, including heart progenitors.

198 embryos, tmem88a is expressed broadly in the lateral plate mesoderm, including the bilateral heart fi

199 absent, nodal signaling is randomized in the lateral plate mesoderm, leading to aberrant LR orientati

200 The chicken Tbx gene, Tbx18, is expressed in lateral plate mesoderm, limb, and developing somites.

201 is study, cux2, is expressed in the pre-limb lateral plate mesoderm, posterior limb bud and flank mes

202 n by altering the patterning of the anterior lateral plate mesoderm, potentially favoring formation o

203 1 disrupts asymmetric gene expression in the lateral plate mesoderm, resulting in aberrant looping of

204 that are normally expressed only in the left lateral plate mesoderm, show expression in the right and

205 n analyses show that Bmp2b, expressed in the lateral plate mesoderm, signals through Alk8 to induce e

206 In addition, we find that, in the lateral plate mesoderm, the domains of Hoxb-8 expression

207 tissues, as well as the surface ectoderm and lateral plate mesoderm, together act to pattern somitic

208 ne expression domains are established in the lateral plate mesoderm, ultimately determining the direc

209 odel with conditional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gat

210 m, and for the absence of Flk-1, a marker of lateral plate mesoderm, we derive a cell population from

211 different rostral and caudal domains of the lateral plate mesoderm, where limb induction occurs, mig

212 get genes Pitx2c, Nodal and Ebaf in the left lateral plate mesoderm, where they are required for esta

213 orms the vertebral bodies and ribs, and from lateral plate mesoderm, which forms the sternum.

214 de dehydrogenase-2 (Raldh2) expressed in the lateral plate mesoderm, which generates a proximodistal

215 ular matrix degradation by SMCs derived from lateral plate mesoderm, which was confirmed using rat ao

216 Zebrafish gastrulae express agtrl1b in the lateral plate mesoderm, while apelin expression is confi

217 ty2/antivin, and Pitx2 does not occur in the lateral plate mesoderm, while in Cryptic mutants Lefty1

218 mutant, the position of the hindlimb bud, a lateral plate mesoderm-derived structure, is posteriorly

219 es containing cells of all five of the major lateral plate mesoderm-derived tissues (cartilage, peric

220 receded by abnormal Pitx2c expression in the lateral plate mesoderm.

221 ed with re-deployment of these mechanisms to lateral plate mesoderm.

222 derm, whereas paired appendages develop from lateral plate mesoderm.

223 ion within a subset of cells in the anterior lateral plate mesoderm.

224 expression to the appropriate region of the lateral plate mesoderm.

225 ene expression around the node and/or in the lateral plate mesoderm.

226 to specifically alter gene expression in the lateral plate mesoderm.

227 itive streak derivatives such as somites and lateral plate mesoderm.

228 s as well as altered Pitx2 expression in the lateral plate mesoderm.

229 mesoderm precursors and then within the left lateral plate mesoderm.

230 arkers gata1 and gata2 in the most posterior lateral plate mesoderm.

231 res share an embryological origin within the lateral plate mesoderm.

232 enes in the paraxial mesoderm but not in the lateral plate mesoderm.

233 of the right-specific gene SnR in the right lateral plate mesoderm.

234 expansion at the expense of intermediate and lateral plate mesoderm.

235 ilateral primary heart fields located in the lateral plate mesoderm.

236 heart-specific gene expression in posterior lateral plate mesoderm.

237 nals derived from neural tube, notochord and lateral plate mesoderm.

238 diogenic and forelimb-forming regions of the lateral plate mesoderm.

239 asymmetrically in a large domain in the left lateral plate mesoderm.

240 establishment of southpaw expression in the lateral plate mesoderm.

241 e, ventral neural tube, and intermediate and lateral plate mesoderm.

242 sis of independent Hox codes in paraxial and lateral plate mesoderm.

243 naling pathway, is variably lost in the left lateral plate mesoderm.

244 dent induction of left-specific genes in the lateral plate mesoderm.

245 aintenance of high-level BMP-4 expression in lateral plate mesoderm.

246 sulting in asymmetric gene expression in the lateral plate mesoderm.

247 srupts asymmetric expression in the node and lateral plate mesoderm.

248 oderm, show expression in the right and left lateral plate mesoderm.

249 half of the Nkx2.5-expressing region in the lateral plate mesoderm.

250 ing to left-sided expression of nodal in the lateral plate mesoderm.

251 ons are derived from connective cells of the lateral plate mesoderm.

252 nd circumferentially in the intermediate and lateral plate mesoderm.

253 changes in expression of three Hox genes in lateral plate mesoderm.

254 ass of the trunk, a derivative of the dorsal lateral plate mesoderm.

255 Sonic hedgehog expression in the underlying lateral plate mesoderm.

256 progenitor specification within the anterior lateral plate mesoderm.

257 oposed domain in the splanchnic layer of the lateral plate mesoderm.

258 e first to identify a repulsive role for the lateral plate mesoderm.

259 fty/Pitx2 expression on the left side of the lateral plate mesoderm.

260 ignaling failed to be propagated to the left lateral plate mesoderm.

261 rmined by asymmetric Nodal signalling in the lateral plate mesoderm.

262 ess through the primitive streak and to form lateral plate mesoderm; and prospective mesoderm from on

263 Ectopic expression of Pitx2 in the right lateral-plate mesoderm alters looping of the heart and g

264 Expression reappears transiently in the left lateral-plate mesoderm, and in an unprecedented asymmetr

265 itx2 is asymmetrically expressed in the left lateral-plate mesoderm, and mutant mice with laterality

266 me), head paraxial mesoderm or non-paraxial (lateral plate) mesoderm tested in this assay were each a

267 ad us to propose that Tbx5a confers anterior lateral plate mesodermal cells the competence to respond

268 with later deficits in axial, paraxial, and lateral plate mesodermal derivatives.

269 ly the early mesodermal marker Brachy-T, the lateral plate mesodermal marker FLK1, and the endothelia

270 involve the directed migration of individual lateral-plate mesodermal cells into the future limb-bud-

271 rom the non-limb-forming flank region of the lateral plate of stage 9-15 chick embryos.

272 b-forming ability by discrete regions of the lateral plate of the chick embryo is dependent on a medi

273 b-forming ability by discrete regions of the lateral plate of the chick embryo is thought to depend o

274 as a second region also associated with the lateral plate phenotype.

275 on of the cryptic border between somitic and lateral plate populations reveals the dynamics of muscul

276 mits from the node to the distantly situated lateral plate remains unclear.

277 metrically in the left diencephalon and left lateral plate respectively, suggesting an additional rol

278 lance between Nodal and BMP signaling in the lateral plate that is critical for L/R axis formation.

279 the somites followed by lower levels in the lateral plate; the posterior half of the limb bud genera

280 , the node, and involves signal relay to the lateral plate, where it results in asymmetric organ morp

281 h as stage 9-15 neural tubes and stage 9- 12 lateral plates, while these transcripts are found at ver