ライフサイエンスコーパス: lateral plate mesoderm

1 receded by abnormal Pitx2c expression in the lateral plate mesoderm.

2 ed with re-deployment of these mechanisms to lateral plate mesoderm.

3 derm, whereas paired appendages develop from lateral plate mesoderm.

4 establishment of southpaw expression in the lateral plate mesoderm.

5 ion within a subset of cells in the anterior lateral plate mesoderm.

6 expression to the appropriate region of the lateral plate mesoderm.

7 ene expression around the node and/or in the lateral plate mesoderm.

8 to specifically alter gene expression in the lateral plate mesoderm.

9 itive streak derivatives such as somites and lateral plate mesoderm.

10 s as well as altered Pitx2 expression in the lateral plate mesoderm.

11 mesoderm precursors and then within the left lateral plate mesoderm.

12 arkers gata1 and gata2 in the most posterior lateral plate mesoderm.

13 enes in the paraxial mesoderm but not in the lateral plate mesoderm.

14 fty/Pitx2 expression on the left side of the lateral plate mesoderm.

15 of the right-specific gene SnR in the right lateral plate mesoderm.

16 expansion at the expense of intermediate and lateral plate mesoderm.

17 ilateral primary heart fields located in the lateral plate mesoderm.

18 heart-specific gene expression in posterior lateral plate mesoderm.

19 nals derived from neural tube, notochord and lateral plate mesoderm.

20 diogenic and forelimb-forming regions of the lateral plate mesoderm.

21 asymmetrically in a large domain in the left lateral plate mesoderm.

22 e, ventral neural tube, and intermediate and lateral plate mesoderm.

23 sis of independent Hox codes in paraxial and lateral plate mesoderm.

24 naling pathway, is variably lost in the left lateral plate mesoderm.

25 dent induction of left-specific genes in the lateral plate mesoderm.

26 aintenance of high-level BMP-4 expression in lateral plate mesoderm.

27 sulting in asymmetric gene expression in the lateral plate mesoderm.

28 srupts asymmetric expression in the node and lateral plate mesoderm.

29 oderm, show expression in the right and left lateral plate mesoderm.

30 half of the Nkx2.5-expressing region in the lateral plate mesoderm.

31 ing to left-sided expression of nodal in the lateral plate mesoderm.

32 ons are derived from connective cells of the lateral plate mesoderm.

33 nd circumferentially in the intermediate and lateral plate mesoderm.

34 changes in expression of three Hox genes in lateral plate mesoderm.

35 ass of the trunk, a derivative of the dorsal lateral plate mesoderm.

36 res share an embryological origin within the lateral plate mesoderm.

37 Sonic hedgehog expression in the underlying lateral plate mesoderm.

38 ging mesoderm and, from E7.5 onwards, in the lateral plate mesoderm.

39 y a population of SMC precursor cells in the lateral plate mesoderm.

40 tes, while connective tissues originate from lateral plate mesoderm.

41 n the node and restrict southpaw to the left lateral plate mesoderm.

42 al precursors arise from distinct subsets of lateral plate mesoderm.

43 progenitor specification within the anterior lateral plate mesoderm.

44 oposed domain in the splanchnic layer of the lateral plate mesoderm.

45 e first to identify a repulsive role for the lateral plate mesoderm.

46 ignaling failed to be propagated to the left lateral plate mesoderm.

47 rmined by asymmetric Nodal signalling in the lateral plate mesoderm.

48 phological boundaries between somites and in lateral plate mesoderm a wing- or non-wing-forming bound

49 vascular zones are directly generated by the lateral plate mesoderm, a critical source of Sema3E.

50 ective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vas

51 rated and propagated from the KV to the left lateral plate mesoderm, activating a transcriptional res

52 age tracing in the living embryo, are in the lateral plate mesoderm adjacent to the notochord-prechor

53 Subsequently, Nodal signaling from the left lateral plate mesoderm alleviates this repression ipsila

54 are good candidates for encoding position in lateral plate mesoderm along the body axis and thus for

55 at additional cell types within the anterior lateral plate mesoderm (ALPM) also underwent subduction,

56 1 and Cyp26c1, are expressed in the anterior lateral plate mesoderm (ALPM) and predominantly overlap

57 ring primitive neutropoiesis in the anterior lateral plate mesoderm (ALPM) but has little effect on e

58 scripts are conspicuously absent in anterior lateral plate mesoderm (ALPM), where SHF progenitors are

59 ification in the nkx2.5(+) field of anterior lateral plate mesoderm (ALPM).

60 Ectopic expression of Pitx2 in the right lateral-plate mesoderm alters looping of the heart and g

61 ating the transcription of VegfA in both the lateral plate mesoderm and also in the somites.

62 ric midline domains and unilaterally in left lateral plate mesoderm and anterior dorsal endoderm.

63 localized to the presumptive presomitic and lateral plate mesoderm and CYP26 mRNA to the presumptive

64 eage perturbed asymmetric gene expression in lateral plate mesoderm and disrupted organ LR asymmetrie

65 to initiate molecular asymmetry in the left lateral plate mesoderm and exhibit multiple left-right p

66 regulates the developmental potential of the lateral plate mesoderm and is required cell autonomously

67 nitially specified in the dorsal part of the lateral plate mesoderm and later become incorporated int

68 riginate in distinct regions of the anterior lateral plate mesoderm and migrate to the midline where

69 three intermediate lineages: neuroectoderm, lateral plate mesoderm and paraxial mesoderm.

70 to disrupt asymmetric gene expression in the lateral plate mesoderm and randomize the placement of in

71 tissues, a strong expression of RARbeta2 in lateral plate mesoderm and somites, and an anterior expr

72 ription factor expressed throughout the left lateral plate mesoderm and subsequently on the left side

73 known to be expressed asymmetrically in the lateral plate mesoderm and the brain during embryogenesi

74 The dermis originates from the somites, the lateral plate mesoderm and the cranial neural crest.

75 proliferation of hindlimb progenitors in the lateral plate mesoderm and the expression of a common fa

76 anscripts were enriched in cardiac mesoderm, lateral plate mesoderm and the neural plate.

77 The gene Pitx2 is expressed in the left lateral plate mesoderm and, subsequently, in the left he

78 d shift of Nodal expression in the left LPM (lateral plate mesoderm), and speculate that the higher l

79 skeleton and sternum arise from the somatic lateral plate mesoderm, and all of the muscles for both

80 The second population resides in the dorsal lateral plate mesoderm, and contains precursors of adult

81 tion to the neural groove, primitive streak, lateral plate mesoderm, and Hensen's node, while distinc

82 he nodal-related gene southpaw (spaw) in the lateral plate mesoderm, and its downstream targets pitx2

83 e of the genes specifically expressed in the lateral plate mesoderm, and later in its derivative, the

84 In the absence of FoxF1 function, the lateral plate mesoderm, and later the visceral mesoderm,

85 e, midbrain, spinal cord, paraxial mesoderm, lateral plate mesoderm, and limb bud.

86 superfamily, which is expressed in the left lateral plate mesoderm, and loss of nodal function produ

87 entral neural tube, notochord, ectoderm, and lateral plate mesoderm, and none was detected in the neu

88 soderm, the primitive streak at the level of lateral plate mesoderm, and the base of the allantois.

89 These somites induced ectopic pronephroi in lateral plate mesoderm, and the IM that received signals

90 Expression reappears transiently in the left lateral-plate mesoderm, and in an unprecedented asymmetr

91 itx2 is asymmetrically expressed in the left lateral-plate mesoderm, and mutant mice with laterality

92 ess through the primitive streak and to form lateral plate mesoderm; and prospective mesoderm from on

93 Lateral plate mesoderm appears to pattern the endoderm i

94 symmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located

95 llinear domains of expression in the forming lateral plate mesoderm, as demonstrated by functional pe

96 r-1 is re-expressed unilaterally in the left lateral plate mesoderm at neurula/tailbud stages.

97 e of a differential growth of cells from the lateral plate mesoderm at specific axial levels.

98 by reciprocal transplantation of somites or lateral plate mesoderm at stages prior to muscle formati

99 rafish development, cbfb is expressed in the lateral plate mesoderm at tail bud stage and in the inte

100 Here we show that T is expressed in lateral plate mesoderm at the onset of limb bud formatio

101 xperiments show that bmp2a, expressed in the lateral plate mesoderm at these stages, is essential for

102 The grl gene is expressed in lateral plate mesoderm before vessel formation, and ther

103 ng activity) but negatively regulated by the lateral plate mesoderm (BMP4).

104 d with gata4 and nkx2.5 not only in anterior lateral plate mesoderm but also in noncardiac mesoderm a

105 ation, the cardiac progenitors reside in the lateral plate mesoderm but maintain close contact with t

106 Hox gene expression is reprogrammed in lateral plate mesoderm, but is unaffected in paraxial me

107 silon is an adapter protein expressed in the lateral plate mesoderm, but its in vivo cardiac function

108 of Xc-Myc, XSlug/Snail2 or XTwist within the lateral plate mesoderm, but not the neural crest, provok

109 ormed via repressing venous cell fate at the lateral plate mesoderm by Hh signaling during vasculogen

110 onveyed to the node, and subsequently to the lateral plate mesoderm, by a complex cascade of epigenet

111 eir highest cell-type specific expression in lateral plate mesoderm cells and at the developmental st

112 of transgenic zebrafish reporters documents lateral plate mesoderm cells that emerge lateral of the

113 mesenchyme with cranial mesenchyme, but not lateral plate mesoderm, could rescue expression of the R

114 Left-side expression of XNR1 in the lateral plate mesoderm depends on XCR2, whereas posterio

115 in which BMP signalling converts a subset of lateral plate mesoderm-derived cells to a myogenic fate

116 tissues from two different germ layers; the lateral plate mesoderm-derived mesenchyme and ectoderm-d

117 mutant, the position of the hindlimb bud, a lateral plate mesoderm-derived structure, is posteriorly

118 es containing cells of all five of the major lateral plate mesoderm-derived tissues (cartilage, peric

119 ls, are generally described to come from the lateral plate mesoderm despite experimental evidence for

120 ential expression timing of Hox genes in the lateral plate mesoderm determines limb placement as well

121 netic programs involved in neural induction, lateral plate mesoderm differentiation, yolk sac hematop

122 tive signals emanating from the neighbouring lateral plate mesoderm, directing the endoderm towards s

123 essed in restricted bilateral domains in the lateral plate mesoderm directly adjacent to the liver-fo

124 repression of Xnr-1 expression in the right lateral plate mesoderm during closure of the neural tube

125 mmetric and topological within the fin-field lateral plate mesoderm during early fin bud initiation.

126 maintain the expression of Pitx2 in the left lateral plate mesoderm during the patterning of left-rig

127 eriments ruled out the need for signals from lateral plate mesoderm, ectoderm, or endoderm.

128 In presumptive wing lateral plate mesoderm, ectopic Tbx18 expression leads t

129 Neural tube and lateral plate mesoderm enhancers can be separated, but i

130 ABD, or ACD; somite expression by ACDE; and lateral plate mesoderm expression by DE.

131 M) cells will adopt either a chondrogenic or lateral plate mesoderm fate.

132 oderm for hindbrain patterning, and rarab in lateral plate mesoderm for specification of the pectoral

133 lly in the perinodal region of the posterior lateral plate mesoderm for the establishment of laterali

134 In these fish, GFP-expressing cells in the lateral plate mesoderm form two tubes that migrate ventr

135 tein) signaling activity specifically during lateral plate mesoderm formation while reducing fibrobla

136 re, we find the pericardium forms within the lateral plate mesoderm from dedicated mesothelial progen

137 first heart field differentiates earlier in lateral plate mesoderm, generates the linear heart tube

138 of the fetal limb and axial skeleton, and in lateral plate mesoderm giving rise to visceral muscle.

139 developing node and at later stages in left lateral plate mesoderm has been implicated as a key regu

140 l is generated at the node and transduced to lateral plate mesoderm in a linear signal transduction c

141 oD, Myf-5, and myogenin in both paraxial and lateral plate mesoderm in the absence of inducing tissue

142 pressed in the intermediate mesoderm and the lateral plate mesoderm in the presumptive chick forelimb

143 Subsequent nodal and Pitx2 expression in the lateral plate mesoderm in these mice is randomized, indi

144 quivalent embryological origin: the anterior lateral plate mesoderm in vertebrates and the dorsal-mos

145 ranscriptomics and live imaging of the early lateral plate mesoderm in wild-type embryos indeed revea

146 s show the requirement for Prt/Wnt2bb in the lateral plate mesoderm, in agreement with the inductive

147 The drl reporters initially delineate the lateral plate mesoderm, including heart progenitors.

148 embryos, tmem88a is expressed broadly in the lateral plate mesoderm, including the bilateral heart fi

149 Left-sided expression of Nodal in the lateral plate mesoderm is a conserved feature necessary

150 sient asymmetric Nodal signaling in the left lateral plate mesoderm (L LPM) during tailbud/early somi

151 absent, nodal signaling is randomized in the lateral plate mesoderm, leading to aberrant LR orientati

152 with striking spatial organization including lateral plate mesoderm-like cells on the colony border a

153 The chicken Tbx gene, Tbx18, is expressed in lateral plate mesoderm, limb, and developing somites.

154 t stem cells (HPSCs) through an intermediate lateral plate mesoderm (LM) stage.

155 In chicken, lateral plate mesoderm (LPM) adjacent to occipital somit

156 alities in asymmetric gene expression in the lateral plate mesoderm (LPM) and dorsal diencephalon of

157 is joined by dynamic expression in the left lateral plate mesoderm (LPM) and left dorsal endoderm.

158 mally is expressed predominantly in the left lateral plate mesoderm (LPM) and left side of the straig

159 elial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) and myoblast migration into

160 ignaling also controls the remodeling of the lateral plate mesoderm (LPM) and of the embryonic endode

161 l somatopleure, a tissue composed of somatic lateral plate mesoderm (LPM) and overlying ectoderm.

162 demonstrated loss of normal LR asymmetry in lateral plate mesoderm (LPM) antivin/lefty-1 and Pitx2 e

163 fish, asymmetric migration of the epithelial lateral plate mesoderm (LPM) displaces the gut leftward,

164 The lateral plate mesoderm (LPM) forms the progenitor cells

165 g in mouse embryonic stem cell (ESC)-derived lateral plate mesoderm (LPM) generates tracheal mesoderm

166 the primary heart field within the anterior lateral plate mesoderm (LPM) into a tubular heart involv

167 ulatory pathway specifically within the left lateral plate mesoderm (LPM) is critical for these event

168 os, the expression of Pitx2 gene in the left lateral plate mesoderm (LPM) is directly regulated by Xn

169 rality-determining Nodal cascade in the left lateral plate mesoderm (LPM) is largely unknown.

170 Nodal activity in the left lateral plate mesoderm (LPM) is required to activate lef

171 In VAD embryos nodal expression in left lateral plate mesoderm (LPM) is severely downregulated a

172 Disruption of lateral plate mesoderm (LPM) migration through knockdown

173 sion in the foregut endoderm and surrounding lateral plate mesoderm (lpm) prior to respiratory specif

174 These signals are then transferred to the lateral plate mesoderm (LPM) through cellular and molecu

175 the transmission of asymmetric cues from the lateral plate mesoderm (LPM) to the cardiac field but no

176 Here, we track mesothelial origins in the lateral plate mesoderm (LPM) using zebrafish.

177 ide markers such as nodal bilaterally in the lateral plate mesoderm (LPM), indicating that loss of AC

178 restricted expression of Pitx2c in the left lateral plate mesoderm (LPM), left half of heart tube an

179 Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evo

180 vements of the hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric po

181 e from embryonic Hoxb6(+) progenitors of the lateral plate mesoderm (LPM), whereas lymphatic endothel

182 es is thought to be derived exclusively from lateral plate mesoderm (LPM), which gives rise to a card

183 e node and Shh downstream genes in the right lateral plate mesoderm (LPM), while overexpression of ch

184 (hiPSCs) that were differentiated either to lateral plate mesoderm (LPM)-like cells, the development

185 the asymmetric migration of the neighboring lateral plate mesoderm (LPM).

186 ch as Nodal and Lefty2 is absent in the left lateral plate mesoderm (LPM).

187 ling system are also present in the cavefish lateral plate mesoderm (LPM).

188 erse lineages including axial, paraxial, and lateral plate mesoderm (LPM).

189 esenchymal limb progenitors derived from the lateral plate mesoderm (LPM).

190 nal response of Nodal expression in the left lateral plate mesoderm (LPM).

191 limb connective tissue progenitors from the lateral plate mesoderm (LPM).

192 asymmetric left-right gene expression in the lateral plate mesoderm (LPM).

193 equently, Nodal expression is delayed in the lateral plate mesoderm (LPM).

194 quires asymmetric expression of nodal in the lateral plate mesoderm (LPM).

195 laterality and southpaw (spaw) expression in lateral plate mesoderm (LPM).

196 to Nodal expression specifically in the left lateral plate mesoderm (LPM).

197 pendent regulation of Hox gene expression in lateral plate mesoderm may have been a key step in the e

198 in rargb morphants, suggesting Rargb affects lateral plate mesoderm migration.

199 Posterior lateral plate mesoderm normally forms blood, but cocultu

200 verely downregulated or abolished within the lateral plate mesoderm of Southpaw-deficient embryos.

201 COUP-TFII is expressed in lateral plate mesoderm of the early embryo prior to limb

202 gion produces the paraxial, intermediate and lateral plate mesoderm of the trunk.

203 abel single or small patches of cells in the lateral plate mesoderm of the zebrafish and to track the

204 ecursors of several organs reside within the lateral plate mesoderm of vertebrate embryos.

205 ere initially induced to form neuroectoderm, lateral plate mesoderm or paraxial mesoderm.

206 ments, both composed primarily of cells with lateral plate mesoderm origin.

207 ntly in somites and unsegmented paraxial and lateral plate mesoderm overlapping atrial precursors in

208 n begins during the convergence of posterior lateral plate mesoderm (PLM), well before aorta formatio

209 le effect on erythropoiesis or the posterior lateral plate mesoderm (PLPM) expression of neutrophil m

210 nct sites, the anterior (ALPM) and posterior lateral plate mesoderm (PLPM).

211 Analysis of the cardiogenic potential of the lateral plate mesoderm posterior to nkx-2.5 and actR-IIa

212 is study, cux2, is expressed in the pre-limb lateral plate mesoderm, posterior limb bud and flank mes

213 n by altering the patterning of the anterior lateral plate mesoderm, potentially favoring formation o

214 ppropriate number of cardiomyocytes from the lateral plate mesoderm requires a careful balance of bot

215 r notochord in late neurulae, and finally in lateral plate mesoderm restricted to the left side of ta

216 1 disrupts asymmetric gene expression in the lateral plate mesoderm, resulting in aberrant looping of

217 s Islet1, a hindlimb-specific factor, in the lateral plate mesoderm results in a failure to induce hi

218 zyme in the gpi-biosynthetic pathway, in the lateral plate mesoderm results in normally patterned lim

219 steps of this cascade (before it reaches the lateral plate mesoderm) results in random left-right asy

220 ptomics and trajectories of hand2-expressing lateral plate mesoderm reveal distinct populations of me

221 ly identified, here we provide evidence that lateral plate mesoderm sends instructive signals to the

222 that are normally expressed only in the left lateral plate mesoderm, show expression in the right and

223 n analyses show that Bmp2b, expressed in the lateral plate mesoderm, signals through Alk8 to induce e

224 tion factor Hand2, which is expressed in the lateral plate mesoderm starting at the completion of gas

225 tion of zebrafish hrT expression in anterior lateral plate mesoderm suggest a very early role for hrT

226 tion as cardiac precursors converge from the lateral plate mesoderm territories toward the embryonic

227 me), head paraxial mesoderm or non-paraxial (lateral plate) mesoderm tested in this assay were each a

228 ail2 function in a regulatory circuit within lateral plate mesoderm that directs normal vessel format

229 on of the expression domain corresponding to lateral plate mesoderm that is part of the early heart f

230 velopment of two structures derived from the lateral plate mesoderm - the heart and the pectoral fin.

231 In addition, we find that, in the lateral plate mesoderm, the domains of Hoxb-8 expression

232 a7/lacZ reporter within neural, paraxial and lateral plate mesoderm tissues.

233 red during somitogenesis within the anterior lateral plate mesoderm to induce myocardial differentiat

234 ine the relative contribution of somitic and lateral plate mesoderm to the avian scapula from quail-c

235 nt development, angioblasts migrate from the lateral plate mesoderm to the midline where they form a

236 regulation of the cell fate transition from lateral plate mesoderm to the specification of cardiomyo

237 ogenitor cells (HPCs) move from the anterior lateral plate mesoderm to the ventral midline, undergoin

238 that these cells migrate from the posterior lateral plate mesoderm to their site of differentiation

239 tissues, as well as the surface ectoderm and lateral plate mesoderm, together act to pattern somitic

240 uilding on established methods, hPSC-derived lateral plate mesoderm treated with either retinoic acid

241 ne expression domains are established in the lateral plate mesoderm, ultimately determining the direc

242 odel with conditional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gat

243 , the RA-synthesizing enzyme, in the foregut lateral plate mesoderm via an evolutionarily conserved i

244 rmerly lefty-2), nodal and Pitx2 in the left lateral plate mesoderm was absent, suggesting that Gdf1

245 onephros induction, stage 7 or earlier chick lateral plate mesoderm was cocultured with caudal stage

246 ymmetric Nodal signaling cascade in the left lateral plate mesoderm was detected, and began to be unr

247 m, and for the absence of Flk-1, a marker of lateral plate mesoderm, we derive a cell population from

248 different rostral and caudal domains of the lateral plate mesoderm, where limb induction occurs, mig

249 get genes Pitx2c, Nodal and Ebaf in the left lateral plate mesoderm, where they are required for esta

250 extra-embryonic mesoderm and intra-embryonic lateral plate mesoderm, which do not express Pax3.

251 orms the vertebral bodies and ribs, and from lateral plate mesoderm, which forms the sternum.

252 de dehydrogenase-2 (Raldh2) expressed in the lateral plate mesoderm, which generates a proximodistal

253 ular matrix degradation by SMCs derived from lateral plate mesoderm, which was confirmed using rat ao

254 Zebrafish gastrulae express agtrl1b in the lateral plate mesoderm, while apelin expression is confi

255 ty2/antivin, and Pitx2 does not occur in the lateral plate mesoderm, while in Cryptic mutants Lefty1

256 , we show that differentiating hiPSC-derived lateral plate mesoderm with BMP4, RA and VEGF (BVR) can

257 Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstrea