ライフサイエンスコーパス: lauric acid

1 N(SiMe(3))(2)}(2)(thf)], hexadecylamine, and lauric acid.

2 crosomal capacity for omega-hydroxylation of lauric acid.

3 tans that had been mono- and diacylated with lauric acid.

4 ome unusual cooperativity with the substrate lauric acid.

5 tion of AKT induced by lipopolysaccharide or lauric acid.

6 er when compared with diets rich in myristic/lauric acid.

7 sgenic B. napus line that has high levels of lauric acid.

8 fold higher for the omega-1 hydroxylation of lauric acid.

9 oteins were each active in the metabolism of lauric acid.

10 L131F mutant only omega-1 hydroxylation, of lauric acid.

11 79+/-1.77 versus 0.97+/-0.57 nmol 12-hydroxy lauric acid/10(6) cells per h).

12 of saturated fatty acids with 4-10 carbons, lauric acid (12:0), and myristic acid (14:0) were associ

13 Lauric acid (12:0), myristic acid (14:0), and palmitic a

14 Lauric acid 1omega-hydroxylase activities of Pro30 and P

15 Together, these results demonstrate that lauric acid activates TLR2 dimers as well as TLR4 for wh

16 isotopically labeled palmitic, myristic, and lauric acids added to the medium were incorporated into

17 tudy evaluated the antimicrobial property of lauric acid against P. acnes both in vitro and in vivo.

18 icate that P. acnes is the most sensitive to lauric acid among these bacteria.

19 In this study, we examined the metabolism of lauric acid and 14C-acetate in developing seeds of oilse

20 A nitroxide-labeled derivative of lauric acid and a fluorescence-labeled derivative of pal

21 ith selected synthetic agonists but not with lauric acid and allowed for the characterization of bind

22 Together, these results demonstrate that lauric acid and DHA reciprocally modulate TLR4 activatio

23 thesis of glucose esters with palmitic acid, lauric acid and hexanoic acid using lipase enzyme was st

24 The binding of lauric acid and its analogues shows that fatty acids ass

25 The oxidations of lauric acid and methyl laurate displayed saturation kine

26 YkuN and YkuP supported monohydroxylation of lauric acid and myristic acid, but secondary oxygenation

27 ) anhydride derived from the condensation of lauric acid and oxaloacetic acid.

28 Lauric acid and pentadecanoic acid were associated with

29 le to catalyze ceramide synthesis using [14C]lauric acid and sphingosine as substrates.

30 enz-2-oxa-1,3-diazol-4-yl)) (NBD)-conjugated lauric acid and sphingosine were added to cultured lymph

31 f benzyl alcohol, ethylbenzene, Tris buffer, lauric acid, and methyl laurate and epoxidations of styr

32 B activation and COX-2 expression induced by lauric acid are at least partly mediated through the TLR

33 tained data highlight the potential of using lauric acid as an alternative treatment for antibiotic t

34 ates of up to approximately 100 min(-1) with lauric acid as substrate.

35 Using D-erythro-sphingosine and lauric acid as substrates, the reaction followed normal

36 ried out using (S)-warfarin, diclofenac, and lauric acid as substrates.

37 cells metabolized lauric acid to 12-hydroxy-lauric acid at a rate 5 times greater than that of cells

38 cept electrons from NADPH in the presence of lauric acid at a rate comparable to that of the unmodifi

39 tioning lauroyl acyl transferase that adds a lauric acid at position 2' in the lipid A backbone.

40 The presence of lauric acid at such a position appears to be crucial for

41 HeLa cells did not elongate lauric acid, but infected HeLa cell cultures elongated l

42 inooctanoic acid (Aoc) residue acylated with lauric acid (C12 fatty acid), which is linked to a pepti

43 Lauric acid (C12:0) dose dependently activated NF-kappaB

44 The strong bactericidal properties of lauric acid (C12:0), a middle chain-free fatty acid comm

45 owever, it has not been demonstrated whether lauric acid can be used for acne treatment as a natural

46 -I hydroxylates the unactivated C-H bonds of lauric acid [D(C-H) ~ 100 kilocalories per mole], with a

47 e presence of lysine and the major component lauric acid derivative, as indicated by electrospray ion

48 nstead a peptide-containing compound high in lauric acid derivative.

49 In addition, lauric acid did not induce cytotoxicity to human sebocyt

50 al injection and epicutaneous application of lauric acid effectively decreased the number of P. acnes

51 Similarly, LPS and lauric acid enhanced the association of TLR4 with MD-2 a

52 fflower oil, linolenic acid from canola oil, lauric acid from coconut oil, and palmitic and stearic a

53 revealed a higher concentration of about 70% lauric acid from total fatty acids.

54 hydrolyzed by bacteria, one of the products, lauric acid, has identical inhibitory activity and is me

55 from 22 to 28 with 7 alanines did not reduce lauric acid hydroxylase activity of the proteins express

56 orresponding CYP4B1(Ser) variants, supported lauric acid hydroxylation preferentially at the omega-po

57 P4A3 decrease the apparent k(cat) values for lauric acid hydroxylation.

58 netic deuterium isotope effects for all four lauric acid hydroxylations indicated that the rate of C-

59 Mass spectra of the products of lauric acid imply the 8-, 9-, 10-, and 11-hydroxy deriva

60 e is available, is shown here to hydroxylate lauric acid in a reaction supported by putidaredoxin and

61 residues that could potentially accommodate lauric acid in addition to the inhibitor itself.

62 se showed that the intracavitary position of lauric acid in TL is similar to that in beta-lactoglobul

63 The lower MIC values of lauric acid indicate stronger antimicrobial properties t

64 the first time that the saturated fatty acid lauric acid induced dimerization and recruitment of TLR4

65 Lauric acid induced the transient phosphorylation of AKT

66 Furthermore, lauric acid induced, but docosahexaenoic acid inhibited

67 Saturated fatty acid (lauric acid)-induced NFkappaB activation was inhibited b

68 A saturated fatty acid, lauric acid, induced NFkappaB activation when TLR2 was c

69 olyunsaturated fatty acid, inhibited LPS- or lauric acid-induced dimerization and recruitment of TLR4

70 its downstream signaling components inhibits lauric acid-induced expression of a CD86 promoter-report

71 ne lactone, suppress both ligand-induced and lauric acid-induced Nod2 signaling, leading to the suppr

72 , the previously observed cooperativity with lauric acid is explained by a surprisingly open substrat

73 In summary, lauric acid is highly oxidized, whereas the polyunsatura

74 How is oil content maintained if lauric acid is inefficiently converted to triacylglycero

75 way occurs, presumably to compensate for the lauric acid lost through beta-oxidation or for a shortag

76 14L mutation, whereas kinetic parameters for lauric acid metabolism, a substrate which cannot interac

77 protein with a significantly reduced AA and lauric acid metabolizing activity.

78 howed that for the dominant hexaacyl form, a lauric acid moiety was lost at one position on the lipid

79 Lauric acid molecules and poly(vinyl chloride) (PVC) lay

80 However, neither lauric acid nor DHA affected the heterodimerization of T

81 CYP4A measured as either arachidonic acid or lauric acid omega-hydroxylase activity (1.4-2.0-fold inc

82 in CYP4A protein levels and arachidonic and lauric acid omega-hydroxylase activity.

83 ses showed (a) the presence of an endogenous lauric acid omega-hydroxylase and arachidonic acid epoxy

84 maximal effective concentration (EC(50)) of lauric acid on P. acnes, S. aureus, and S. epidermidis g

85 clooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active (CA) TLR4.

86 of NF-kappaB and IL-8 expression induced by lauric acid or known Nods ligands in HCT116.

87 induced, but docosahexaenoic acid inhibited lauric acid- or Nod2 ligand MDP-induced, Nod2 oligomeriz

88 Incubation of lauric acid, palmitic acid, or oleic acid (OA) with huma

89 While lauric acid predominates in endosperm oil, the major fat

90 The unactivated C-H positions of lauric acid reacted with a rate constant of k(ox) = 0.8

91 Accumulation of lauric acid relied on the dramatic up-regulation of a sp

92 ity for omega-1 and omega-2 hydroxylation of lauric acid, respectively.

93 pha in vitro, N-lauroylethanolamine, but not lauric acid, selectively inhibited abscisic acid-induced

94 Similarly, DCs treated with lauric acid show increased T cell activation capacity, w

95 tic efficiency with those of arachidonic and lauric acids showed that EETs are one of the best endoge

96 ted side reaction which consumes part of the lauric acid, the main stabilizing ligand, transforming i

97 8.3 pmol/microg/h, respectively, whereas for lauric acid they were 73.76 microM and 232.5 pmol/microg

98 data-collection period ranged from 0.36 for lauric acid to 0.77 for alcohol (mean r = 0.53).

99 ells, (b) the CYP 4A3-dependent oxidation of lauric acid to 11- and 12-hydroxylaurate (24 and 76% of

100 d-SM22-4A1-transduced A7r5 cells metabolized lauric acid to 12-hydroxy-lauric acid at a rate 5 times

101 rase that is responsible for the addition of lauric acid to the lipid A moiety of LPS, as well as a D

102 y demonstrate that the saturated fatty acid, lauric acid, up-regulates the expression of costimulator

103 A2, that catalyzes in-chain hydroxylation of lauric acid was also shown to be involved in sporopollen

104 unmodified forms, although oxidation of the lauric acid was not observed with either modified enzyme

105 (ii) Lauric acid was rapidly transported across the bilayer b

106 for the less abundant heptaacyl species, the lauric acid was replaced with palmitoleic acid.

107 The effects of lauric acid were also attenuated by small RNA interferen

108 These effects of lauric acid were inhibited by dominant negative forms of

109 including a high amounts of mono-esterified lauric acid with beta-cryptoxanthin and with cryptocapsi

110 o catalyze the light-driven hydroxylation of lauric acid with total turnover numbers of 935 and initi

111 led in that it slowly (omega-1)-hydroxylates lauric acid yet consumes NADPH at approximately the same

112 hylococcus epidermidis (S. epidermidis) with lauric acid yielded minimal inhibitory concentration (MI