ライフサイエンスコーパス: lead

1 dentified 8 (PF-06445974) as a promising PET lead.

2 n guide national health-based benchmarks for lead and related community public health decisions.

3 Screening led by either specialists or ICU teams was equally prefe

4 Prostate cancer (PCa) is one of the leading cancers in men in the USA.

5 Spin fluctuations are a leading candidate for the pairing mechanism in high temp

6 ium-dependent protein kinase 1 (CpCDPK1) are leading candidates for treatment of cryptosporidiosis-as

7 Escherichia coli is a leading cause of bacterial mastitis in dairy cattle.

8 ed by reduced lung function and is the third leading cause of death globally.

9 n genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies.

10 Glaucoma is the leading cause of irreversible blindness worldwide.

11 Bloodstream infections are a leading cause of morbidity and mortality in the United S

12 d-borne infection in the United States and a leading cause of morbidity and mortality.

13 The leading cause of mortality in HFpEF is sudden death, but

14 sive pneumococcal diseases (IPDs) remain the leading cause of vaccine-preventable childhood death, ev

15 Human astroviruses are recognized as a leading cause of viral diarrhea worldwide in children, i

16 ntial for photoreceptor survival, and is the leading cause of vision loss in the elderly.

17 ethnographic study of nurses' roles in nurse-led chemotherapy clinics, including semi-structured inte

18 s by presenting several modifications in the lead compounds 1 (HS665) and 2 (HS666).

19 The resultant lead compounds possess potent activity against a multidr

20 Lead CpGs at PTPN6/PHB2, ANKRD11, and TNRC18 map to acti

21 t is not fully understood how WRN deficiency leads directly to telomere dysfunction.

22 ded target identification and fragment-based lead discovery with efforts to develop new antimicrobial

23 pecies ranges shifted northward at both the leading edge (northern boundary) and trailing edge (sout

24 Gene set enrichment and leading edge analyses identified Sphingosine kinase 1 (S

25 Filopodia protrude from the leading edge of cells and play important roles in cell m

26 entrosome and Golgi reorientation toward the leading edge, a hallmark of cell polarization to ensure

27 ntegrin-beta first accumulated at the cell's leading edge.

28 Rotavirus remained the leading etiology (overall weighted AF, 40.3% [95% confid

29 This compound is a promising lead for further development of cathepsin G inhibitors t

30 phenylbenzamides, providing a new structural lead for ligand design.

31 ability or impediment to coronary sinus (CS) lead implantation.

32 Acute upper gastrointestinal bleeding is a leading indication for red blood cell (RBC) transfusion

33 Arctic sea-ice loss is a leading indicator of climate change and can be attribute

34 cells (PSCs); however, suffer the issue that lead is toxic to the environment and organisms for a lon

35 ated the small molecule crystal structure of lead molecule 7 and hypothesized that disruption of the

36 disability abolished the spacing effect and led neurons to decode distinct stimulation patterns as m

37 A focused screening and lead optimization effort identified 4b (GS-5734) with an

38 essful application of SBDD paves the way for lead optimization for VEEV antivirals, and is an excitin

39 No interactions were observed between lead or bone turnover and other prognostic indicators.

40 ns requiring immediate intervention and that led (or could have led) to major disability or death.

41 ModFOLD6 is the latest version of our leading resource for Estimates of Model Accuracy (EMA),

42 andomized controlled studies comparing nurse-led self-management interventions to usual care Seven el

43 ccessing probe compounds, and generating new leads that yield manufactured cells with improved proper

44 A shorter lead time would provide valuable flexibility for decisio

45 te, are substantially improved for predicted lead times up to 10 weeks.

46 c phospholipase, and that novel edits in MTL lead to a 6.7% haploid induction rate (the percentage of

47 Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations

48 fects in one or more of these mechanisms can lead to a breakdown of tolerance.

49 Advanced stages of liver cirrhosis lead to a dramatically increased mortality.

50 r weight distributions and oxidation levels, lead to an increase in the expression of 158 genes in a

51 ed confounding from observational studies to lead to associations that are not causal in nature.

52 pect the diagnostic information yielded will lead to better patient care, enhanced patient safety, an

53 on the particle formation mechanisms and may lead to better-controlled synthesis protocols.

54 y dehydrosulfurization and guanylation could lead to both symmetric and unsymmetric N,N',N''-substitu

55 We find that current model limitations lead to considerable biases in the simulated biomass and

56 essential to skin health and can potentially lead to disease when their abundances and activities cha

57 Perturbations in the environment lead to distinctive gene expression changes within a cel

58 phoblast-specific GATA2/GATA3 function could lead to early pregnancy failure.

59 in regulating birth and mortality rates can lead to erroneous demographic analyses and conclusions.

60 Strong-field laser-matter interactions often lead to exotic chemical reactions.

61 Further development of this approach could lead to fast and automated purification of DNA nanostruc

62 is possible to identify network motifs that lead to functional outputs such as bistability or oscill

63 These findings suggest that training can lead to fundamental changes in the way attention alters

64 tronically excited BODIPY chromophores could lead to further advances in these areas.

65 Finally, the initiating events that lead to gene body methylation are discussed as a model i

66 inhibitory afferents to MNTB neurons should lead to greater inhibitory output to the projections fro

67 these drugs residues in honey as they often lead to health concerns or potential antibiotic resistan

68 studies have suggested that this regimen may lead to high failure rates in coinfected patients.

69 ern lifestyle with high salt consumption can lead to hypertension and cardiovascular disease.

70 use increased vascular permeability that may lead to hypovolemic shock.

71 Incorrectly handling missing data can lead to imprecise and biased estimates.

72 Influenza viral infections often lead to increased mortality in older people.

73 hat affect the immune system and, with time, lead to increased vulnerability to infectious diseases.

74 hair grooming is a common practice that can lead to injury and morbidity.

75 s or (hydr)oxides and Mn(III/IV) oxides-that lead to its production.

76 combined, elevated CO2 and temperature will lead to long-term declines in the amount of carbon store

77 The fact that defects in signaling can lead to malignancy illustrates the need to control Notch

78 likelihood of biomarker discovery and could lead to more comprehensive understanding of disease etio

79 myocardial microenvironment are expected to lead to more physiologically relevant cardiac tissue-lik

80 ation, while changes in the coding sequences lead to mRNAs encoding distinct proteins.

81 Validating these associations in vivo will lead to new diagnostic tools for Alzheimer disease and b

82 tween granulocytes and endothelial cells may lead to new therapeutic approaches to improve blood vess

83 s that underlie restless legs syndrome could lead to new treatment options.

84 t featured an elongated O-O bond but did not lead to O-O cleavage or reactivity toward external subst

85 repeat kinase 2 (LRRK2) and alpha-synuclein lead to Parkinson's disease (PD).

86 e data support a model in which EAP deficits lead to poor functional outcome via impaired cognition a

87 Heavy alcohol use can lead to progressive liver damage, especially in individu

88 ith its specific and potent inhibitors could lead to promising host-directed therapeutic adjuvants fo

89 ng-term carbon isotope mass balance, and may lead to reassessment of the role that the delta(13)C rec

90 opical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic der

91 s study include measurement error that could lead to residual confounding; and the possibilities for

92 promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restric

93 served in the bulk at defects and interfaces lead to significant compositional segregation effects.

94 lectrostatic fields emanating from the oxide lead to steering and reorientation of the molecules appr

95 examine whether repeated shocks of this kind lead to substantial increases in the prevalence of firea

96 un to elucidate how skin barrier defects can lead to systemic allergen sensitization.

97 y, and eventually correct, the failures that lead to the deterioration of this important cell populat

98 ch are toxic and, if consumed regularly, can lead to the development of kidney stones.

99 te the complex mechanisms of the disease and lead to the development of more effective individualized

100 essarily mutually exclusive and together can lead to the emergence of complex patterns of control.

101 various enzyme activities that collectively lead to the formation of Ang-(1-7) from Ang II, in both

102 on results, because the different substrates lead to the formation of different ice polytypes.

103 als (e.g., breaded frozen fish products) can lead to the formation of fatty acid esters of 2-monochlo

104 by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor supp

105 r compounds that alter neuronal function can lead to therapeutic advances that ameliorate age-related

106 fection and inflammation that may eventually lead to tissue remodeling and respiratory disease.Cystic

107 e both tumor size and invasiveness and could lead to tumor eradication.

108 side, inaccurate forecasts and sole sourcing lead to under-procurement.

109 not allow detection of mild disease and may lead to underestimation of severity.

110 discuss how associated genetic variants can lead to understanding causal mechanisms, and to disentan

111 r Leishmania species causing the disease can lead to variable performance.

112 unlabeled drug dose and plasma concentration leading to a 50% reduction of (11)C-BMT-136088 specific

113 mplicated may be caused by aberrant salience leading to a change in the nature of the information tha

114 and the nearby Src homology 3 (SH3) domain, leading to a closed conformation, whereas a non-phosphor

115 for a thymine nucleotide (C64T) at codon 22, leading to a premature stop codon (R22X) in the albino r

116 ce, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosom

117 or misguided concerns promoting radiophobia, leading to actual risks far greater than the hypothetica

118 res, there are few therapeutic alternatives, leading to amputations and death.

119 f the NUS ratio, up to 26 times at NUS 1/32, leading to an acquisition time reduced in the same ratio

120 intraparenchymal spread of neoplastic cells, leading to an anatomically separate but genetically rela

121 mbranes, PmB forms clusters on the membranes leading to an indentation of the bilayers and increase i

122 e of IL-4Ralpha limits thymocyte emigration, leading to an intrathymic accumulation of mature thymocy

123 t, not a fixed fraction of the peak maximum) leading to any number of calibration curves.

124 e GC response to self-antigens, subsequently leading to autoimmunity.

125 oceeds with high levels of diastereocontrol, leading to beta-amino ketones in high yields.

126 ith vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patient

127 onses to S Typhimurium infection, eventually leading to cell death.

128 an unstable system after gastric conditions leading to coalesced oil droplets, while Tween80 emulsio

129 found to follow a diffusion-limited behavior leading to core-shell morphologies.

130 with the representation of the familiar one, leading to decreased field stability in both environment

131 nical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 methylatio

132 ro-inflammatory cytokine production, in turn leading to depression and cognitive deficits.

133 tractility and adherens junction disassembly leading to endothelial barrier breakdown.

134 bitor reduces Skp2 levels and stabilizes LT, leading to enhanced MCV replication and transmission.

135 ons between the apoptotic cascade and events leading to extrusion are not fully understood.

136 und influence on working memory performance, leading to faster access times as well as more accurate

137 hen given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by endoscopy.

138 r equilibrium constants of several reactions leading to halamines in water.

139 ving USP9X-ERAS formed by chromothripsis and leading to high expression of ERAS, a constitutively act

140 Therefore, better treatment strategies leading to higher disease control are warranted in CRS c

141 The mechanisms leading to IL-10 expression by CD4(+) T cells are being

142 art to the virus's high sequence variability leading to immune escape.

143 ory monocyte-derived cells (MCs) in the CNS, leading to improved clinical outcome.

144 ed their predictive value for major bleeding leading to improved clinical usefulness compared to the

145 and enhanced osteoclast-progenitor survival, leading to increased osteoclastogenesis.

146 s in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction

147 synthesis in the epidermis of psoriatic skin leading to localized deficiency of cortisol.

148 er the reaction conditions for homologation, leading to low stereospecificity.

149 front elevates Ca(2+) inside the SR locally, leading to luminal RyR sensitization and lowering of the

150 ase, is known to promote cell proliferation, leading to neovascularization as well as neuroprotection

151 Mechanisms of disease leading to neurodevelopmental deficits in infected infan

152 ase, we have a lesser degree of interaction, leading to normal hydrogen bonds of type YH-X analogous

153 dopaminergia and neurodegenerative phenotype leading to premature death in 36% of the population.

154 biquitin ligase to an E2-conjugating enzyme, leading to prolonged inflammatory signaling.

155 United States suffer from dental infections, leading to pulp necrosis, arrested tooth-root developmen

156 erations decrease RcnR-DNA binding affinity, leading to rcnAB expression.

157 d by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion.

158 terference with the lipid signaling pathway, leading to reduced expression of MDR transporters and th

159 oup between the oxidized and reduced states, leading to reversible switching of the DNA conductance b

160 CO1 variants may impair autophagic function, leading to RV formation in sIBM patient muscle.

161 ing RNA intermediates with 3' end extension, leading to severe reduction of mature piwi-interacting R

162 rightward shifts in inactivation parameters, leading to significant increases in the magnitude of win

163 may experience greater HPA and HPG activity, leading to steeper decreases in cortical thickness with

164 omplex in the transition state as the factor leading to stereoselectivity.

165 s and activates HER2 at p1248 in PDAC cells, leading to stimulation of HER2 signaling cascade, includ

166 experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treat

167 cion activates AMP-activated protein kinase, leading to synergistic inhibition of human leukemia cell

168 creases the mitochondrial membrane potential leading to the activation of Ca(2+)-independent phosphol

169 ied by variable temperature NMR spectroscopy leading to the conclusion that the rate-determining step

170 a number of brain regions are implicated in leading to the disorder.

171 rt the discovery of self-assembly strategies leading to the emergence of lipid bicontinuous single cr

172 Nonetheless, the dynamic mechanism leading to the establishment and maintenance of tissue-s

173 We observe extensive splicing diversity leading to the formation of altered open reading frames

174 se to FVIII, because of a lack of tolerance, leading to the formation of inhibitory antibodies.

175 ntity and hierarchy of the HDR (sub)pathways leading to the formation of PGE products remain elusive.

176 e light activation of o-methylbenzaldehydes, leading to the formation of reactive o-quinodimethanes (

177 en proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity a

178 P-transposable element transcripts in vivo, leading to the production of the non-transposase-encodin

179 tection of metastatic infectious foci, often leading to treatment modification.

180 the network operates close to an instability leading to unbounded cortical activation.

181 cellular matrix proteins and its dysfunction leads to a form of muscular dystrophy frequently associa

182 at is provided by other health professionals leads to a greater effect on HbA1c, weight, and LDL chol

183 ce to support the claim that supplementation leads to a large increase in the risk of advanced AMD in

184 This leads to a lattice thermal conductivity as low as 0.4 Wm

185 The 267 nm excitation of dCyd leads to a non-negligible population of the second brigh

186 ation-theoretic nature of the epigenome that leads to a powerful approach for studying its role in di

187 cell transplant assures good engraftment and leads to acceptable toxicity and disease control in the

188 ine nurse cells (GLKD) of Drosophila ovaries leads to activation of transposons.

189 Our findings indicate prenatal WD exposure leads to age-specific changes in voluntary physical acti

190 In amblyopia, abnormal visual experience leads to an extreme form of eye dominance, in which visi

191 Knocking down TTP in primary macrophages leads to an increased induction of NLRP3 by LPS, which i

192 r ketone moiety at the C3-position of indole leads to azidation at the C2-position, whereas a less ra

193 cumulates genomic instability and ultimately leads to cell death.

194 sease, the autoimmune attack on the CNS that leads to chronic inflammation, neuroaxonal degeneration

195 ing domain that abrogates binding to DNA and leads to complete loss of canonical TH action.

196 quire several days of turnaround time, which leads to compromised clinical outcome and promotes the s

197 Loss of KRIT1 leads to decreased microvessel barrier function and to t

198 ion of MC surface FcepsilonRI expression and leads to desensitization of mice to IgE-mediated reactio

199 AD exposure induces a signaling cascade that leads to disruption of axonal transport, a critical func

200 r) to position 509 of the KCC2 promoter that leads to downregulation of KCC2 transcription in prenata

201 t HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and supp

202 ese systems undergo during pretreatment that leads to efficient catalyst function.

203 al virus (RSV) infection, and its inhibition leads to exaggerated immunopathology.

204 egulating myofiber length, as a loss of Abl2 leads to excessively long myofibers in the diaphragm, in

205 mechanisms by which central serotonin action leads to fat loss remain unknown.

206 ized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting.

207 metabolism resulting from insulin resistance leads to hyperglycemia, the hallmark of type 2 diabetes

208 Prenatal ethanol exposure (PE) leads to increased addiction risk which could be mediate

209 Prolonged activation of these synapses leads to initial depression, which is followed by steady

210 Use of continuous flow leads to isolation of the desired compounds in enhanced

211 This leads to low, pure technical noise that is atypical of r

212 e that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6

213 Dietary fat overconsumption leads to myocardial lipid accumulation through mechanism

214 of all Tln forms from the heart-muscle cell leads to myocyte instability and a dilated cardiomyopath

215 Dysregulation of this mechanism leads to numerous human neurodegenerative or neurodevelo

216 enses and disrupts the gut microbiota, which leads to overgrowth of indigenous E. coli and facilitate

217 sion, an active multistage process naturally leads to pattern transitions from actin vortices over st

218 se model of AUD showed that alcohol exposure leads to PCSK9 downregulation.

219 Conversely, in males, erasure leads to permanent X dosage decompensation.

220 In vitro, ISG15 deficiency also leads to persistently high levels of type I IFN-stimulat

221 Ectopic expression of Cdh1 leads to premature differentiation of neuroprogenitors,

222 nce of self-epitope specific Treg cells that leads to protection or causation of autoimmunity.

223 s, where the formation of chemical gradients leads to resource limitation for cells at depth.

224 inting such wavefunctions on electron pulses leads to shape-preserving multi-electrons ultrashort pul

225 We show that this dry air leads to significant low-level sublimation of snowfall.

226 findings demonstrate that the former loading leads to size-independent mechanical properties while th

227 n siRNA-mediated knockdown of Mule or TRIM26 leads to stabilisation of NEIL1, demonstrating that thes

228 In contrast, loss of Mll3/4 proteins leads to strong depletion of enhancer Pol II occupancy a

229 Activation of Nlrp3 leads to synthesis of proinflammatory cytokines and infl

230 s a key event of pAg sensing that ultimately leads to T cell activation.

231 rus (HIV) disease, chronic immune activation leads to T-cell exhaustion.

232 e asialoglycoprotein receptor with Astn2 TM2 leads to the appearance of a carboxyl-terminal fragment

233 hat patterned disorder at the cellular level leads to the emergence of organism-level order.

234 combination of dopamine and ketones in a PSR leads to the formation of 1,1'-disubstituted tetrahydroi

235 ion of target dsDNA (dsDNA-T), which in turn leads to the formation of a high density of PNA/DNA hete

236 assembling into hierarchical structures and leads to the formation of discrete nickel-seamed pyrogal

237 r differentiation event in mouse development leads to the formation of the blastocyst consisting of t

238 ds biogeochemical hotspots, which ultimately leads to their critical, but poorly recognized role in r

239 pidemia contribute to glucolipotoxicity that leads to type 2 diabetes.

240 Hyperactive Hnf4 signaling leads to up-regulation of lipase 3 and enzymes for mitoc

241 In rodents, URMC-099 activation of autophagy led to 50-fold increases in the plasma drug concentratio

242 stal packing would improve solubility, which led to a change from N-methylpyridone to a tetrahydropyr

243 Overall, (68)Ga-PSMA PET/CT scanning led to a change in planned management in 51% of patients

244 All images led to a clear final diagnosis.

245 After 3 years, surgery led to a gain of 0.199 QALYs compared with no surgery at

246 who required surgery, mepolizumab treatment led to a greater reduction in the need for surgery and a

247 increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective

248 CD11d deficiency led to a marked reduction in lipid deposition in aortas

249 17beta-estradiol led to a significant upregulation in pentose phosphate f

250 oss of Sin3a in mouse early foregut endoderm led to a specific and profound defect in lung developmen

251 Surprisingly, dnGluN1 expression led to an enhancement in the motivation to self-administ

252 Conversely, JMJD2B silencing led to an enhancement of the DNA-damage driven induction

253 age ZIKV infection of pregnant women's blood led to an exacerbated M2-skewed immunosuppression of non

254 ol structural unit in the pyranoanthocyanins led to an increase in their interaction with aPRPs.

255 Protein design advancements have led to biotechnological strategies based on more stable

256 While ATP depletion led to cell death, over-acetylated tubulin led to inhibi

257 Structural optimization led to compound 28, which was 4-fold more potent than it

258 ling techniques showed that the pretreatment led to depectination of the outer layers thereby exposin

259 tical studies of electrosensory systems have led to detailed accounts of how negative images are form

260 diphenyl sulfide radical cation that in turn led to diphenyl sulfoxide.

261 ction of PU.1 with target gene promoters and led to downregulation of canonical PU.1 transcriptional

262 n shuttles, and the consequent ion migration led to high anode salinities and conductivity that favor

263 Msh3 overexpression led to high expansion activity and elevated levels of Mu

264 ss expression of CXCR4, which, when blocked, led to HSC mobilization and prolonged islet allograft su

265 methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and sel

266 ogenesis of different amyloid types and have led to identification of numerous new amyloid types, inc

267 macrophages exposed to HIV-related proteins led to increased caspase 3 activation and reduced Bcl-2

268 Active compared to sham tDCS led to increased performance in the orienting (mean diff

269 n led to cell death, over-acetylated tubulin led to inhibition of motility and mitosis.

270 These substitutions led to inhibitors with increased PACE4 selectivity and p

271 hifted dispersive waves were generated which led to large broadening from 1.5 um-25 um.

272 ls prevented recovery from MRV infection and led to lethality in infected animals, whereas B cell-def

273 In this randomized trial, off-pump CABG led to lower rates of 5-year survival and event-free sur

274 d with other non-CBF aberrant karyotypes and led to lower remission rates (complete remission + compl

275 reasing presynaptic activity, which actually led to LTP in PE animals, whereas LTD was still observed

276 Perkinsea infections (SPI) were systemic and led to multiorganic failure and death.

277 igation speed at endoluminal CT colonography led to progressive restriction of visual search patterns

278 Infection with low-dose A/X31 H3N2 led to prolonged deterioration of lung function, aggrava

279 lar to in many women with PCOS, DHT exposure led to reduced adiponectin levels, larger adipocyte size

280 ion in the quality of evoked potentials that led to reduced performance on the BCI task.

281 Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery.

282 sets, promoted excessive proliferation, and led to retinoblastoma with anaplastic changes.

283 g maintained hMSC stemness, engraftment, and led to robust motosensory improvement, neuropathic pain

284 ace UV radiation indicate that the eruptions led to stratospheric ozone depletion.

285 Prolonging the reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecu

286 Short-term IL-33 treatment in mice led to sustained expansion of IL-33 receptor-positive ki

287 he application of 10 mmol/L ammonium formate led to the best findings, while the use of 0.02% acetic

288 ermeability and proliferation increase; this led to the concept that glia are required for maintenanc

289 ong older patients with palliative needs has led to the development of several service-level interven

290 This work led to the discovery of a highly selective PI3Kbeta/delt

291 nd characterize HIV-specific antibodies have led to the identification of a new generation of potent

292 JB12 knockdown by siRNA led to the induction of caspase processing but not the u

293 selective advantage over Neanderthals, which led to the their extinction.

294 Recent evolutions in rectal cancer surgery led to transanal dissection of the rectum resulting in a

295 ate intervention and that led (or could have led) to major disability or death.

296 the vicinity of the Hornsund Fracture Zone, leading us to postulate that the gas ascends along this

297 oned active site residue as a catalytic base leads us to propose an atypical water-mediated fucosylat

298 This observation led us to explore the possibility that resident macropha

299 This observation led us to speculate as to whether our data may form the

300 The role of hydrogen bonding led us to the rotation of NH4(+) within its solvent cage