ライフサイエンスコーパス: lead to

1 In rodents, URMC-099 activation of autophagy led to 50-fold increases in the plasma drug concentratio

2 c phospholipase, and that novel edits in MTL lead to a 6.7% haploid induction rate (the percentage of

3 Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations

4 fects in one or more of these mechanisms can lead to a breakdown of tolerance.

5 Advanced stages of liver cirrhosis lead to a dramatically increased mortality.

6 ardiac TF over the skeletal TF by Ca(2+) and lead to a mechanistic model for the regulation of the ca

7 ion and reducing the DPM mass emissions, but lead to a significant increase in the total particle cou

8 unlabeled drug dose and plasma concentration leading to a 50% reduction of (11)C-BMT-136088 specific

9 mplicated may be caused by aberrant salience leading to a change in the nature of the information tha

10 and the nearby Src homology 3 (SH3) domain, leading to a closed conformation, whereas a non-phosphor

11 The two ring-shaped hexamers are staggered, leading to a kinked axial channel.

12 for a thymine nucleotide (C64T) at codon 22, leading to a premature stop codon (R22X) in the albino r

13 cular hemolysis, and activation of platelets leading to a procoagulative state, formation of microthr

14 cellular matrix proteins and its dysfunction leads to a form of muscular dystrophy frequently associa

15 at is provided by other health professionals leads to a greater effect on HbA1c, weight, and LDL chol

16 ce to support the claim that supplementation leads to a large increase in the risk of advanced AMD in

17 This leads to a lattice thermal conductivity as low as 0.4 Wm

18 The 267 nm excitation of dCyd leads to a non-negligible population of the second brigh

19 ation-theoretic nature of the epigenome that leads to a powerful approach for studying its role in di

20 Loss of circular fibres led to a bifurcated anterior-posterior axis with fused h

21 stal packing would improve solubility, which led to a change from N-methylpyridone to a tetrahydropyr

22 Overall, (68)Ga-PSMA PET/CT scanning led to a change in planned management in 51% of patients

23 All images led to a clear final diagnosis.

24 gamma-Irradiation led to a decrease in the concentration of gamma- and del

25 After 3 years, surgery led to a gain of 0.199 QALYs compared with no surgery at

26 who required surgery, mepolizumab treatment led to a greater reduction in the need for surgery and a

27 increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective

28 CD11d deficiency led to a marked reduction in lipid deposition in aortas

29 17beta-estradiol led to a significant upregulation in pentose phosphate f

30 oss of Sin3a in mouse early foregut endoderm led to a specific and profound defect in lung developmen

31 cell transplant assures good engraftment and leads to acceptable toxicity and disease control in the

32 ce, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosom

33 ine nurse cells (GLKD) of Drosophila ovaries leads to activation of transposons.

34 or misguided concerns promoting radiophobia, leading to actual risks far greater than the hypothetica

35 This work has led to advancements in a number of crucial sensing domai

36 Our findings indicate prenatal WD exposure leads to age-specific changes in voluntary physical acti

37 ion of serotonin (5-HT) neuronal precursors, leading to altered global serotonergic neuroarchitecture

38 res, there are few therapeutic alternatives, leading to amputations and death.

39 r weight distributions and oxidation levels, lead to an increase in the expression of 158 genes in a

40 f the NUS ratio, up to 26 times at NUS 1/32, leading to an acquisition time reduced in the same ratio

41 can further suppress the background signals leading to an additional increase of more than five-fold

42 intraparenchymal spread of neoplastic cells, leading to an anatomically separate but genetically rela

43 mbranes, PmB forms clusters on the membranes leading to an indentation of the bilayers and increase i

44 e of IL-4Ralpha limits thymocyte emigration, leading to an intrathymic accumulation of mature thymocy

45 In amblyopia, abnormal visual experience leads to an extreme form of eye dominance, in which visi

46 Knocking down TTP in primary macrophages leads to an increased induction of NLRP3 by LPS, which i

47 Surprisingly, dnGluN1 expression led to an enhancement in the motivation to self-administ

48 Conversely, JMJD2B silencing led to an enhancement of the DNA-damage driven induction

49 age ZIKV infection of pregnant women's blood led to an exacerbated M2-skewed immunosuppression of non

50 ol structural unit in the pyranoanthocyanins led to an increase in their interaction with aPRPs.

51 t, not a fixed fraction of the peak maximum) leading to any number of calibration curves.

52 to hypercarbia and hypoxia, which ultimately leads to asphyxia.

53 ed confounding from observational studies to lead to associations that are not causal in nature.

54 e GC response to self-antigens, subsequently leading to autoimmunity.

55 r ketone moiety at the C3-position of indole leads to azidation at the C2-position, whereas a less ra

56 oceeds with high levels of diastereocontrol, leading to beta-amino ketones in high yields.

57 pect the diagnostic information yielded will lead to better patient care, enhanced patient safety, an

58 sential insight into allograft rejection and lead to better therapies for transplant patients.

59 on the particle formation mechanisms and may lead to better-controlled synthesis protocols.

60 Protein design advancements have led to biotechnological strategies based on more stable

61 e feedback loop involving RAS and SOS, which leads to bistability and allows for switch-like response

62 ith vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patient

63 ngs highlight unique immunological processes leading to BOS and RAS.

64 y dehydrosulfurization and guanylation could lead to both symmetric and unsymmetric N,N',N''-substitu

65 N Lewis pairs at the periphery of anthracene leads to buckling of the backbone while also dramaticall

66 onses to S Typhimurium infection, eventually leading to cell death.

67 Cessation of cerebral blood flow (CBF) leads to cell death in the infarct core, but tissue surr

68 cumulates genomic instability and ultimately leads to cell death.

69 While ATP depletion led to cell death, over-acetylated tubulin led to inhibi

70 sease, the autoimmune attack on the CNS that leads to chronic inflammation, neuroaxonal degeneration

71 an unstable system after gastric conditions leading to coalesced oil droplets, while Tween80 emulsio

72 ing domain that abrogates binding to DNA and leads to complete loss of canonical TH action.

73 Structural optimization led to compound 28, which was 4-fold more potent than it

74 quire several days of turnaround time, which leads to compromised clinical outcome and promotes the s

75 We find that current model limitations lead to considerable biases in the simulated biomass and

76 found to follow a diffusion-limited behavior leading to core-shell morphologies.

77 ic cells to utilize extracellular glutamine, leading to cytosolic accumulation of NADH and increased

78 with the representation of the familiar one, leading to decreased field stability in both environment

79 Loss of KRIT1 leads to decreased microvessel barrier function and to t

80 results in an aberrant activation of STAT3, leading to deleterious downstream effects in pancreatic

81 ling techniques showed that the pretreatment led to depectination of the outer layers thereby exposin

82 nical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 methylatio

83 ro-inflammatory cytokine production, in turn leading to depression and cognitive deficits.

84 ion of MC surface FcepsilonRI expression and leads to desensitization of mice to IgE-mediated reactio

85 tical studies of electrosensory systems have led to detailed accounts of how negative images are form

86 chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular compos

87 diphenyl sulfide radical cation that in turn led to diphenyl sulfoxide.

88 essential to skin health and can potentially lead to disease when their abundances and activities cha

89 AD exposure induces a signaling cascade that leads to disruption of axonal transport, a critical func

90 Perturbations in the environment lead to distinctive gene expression changes within a cel

91 ntrast, warm temperatures without FTCs could lead to divergent responses in soil bacteria and their m

92 show that cellular localization of Clusterin leads to divergent effects on epithelial cell regenerati

93 r) to position 509 of the KCC2 promoter that leads to downregulation of KCC2 transcription in prenata

94 t HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and supp

95 ction of PU.1 with target gene promoters and led to downregulation of canonical PU.1 transcriptional

96 phoblast-specific GATA2/GATA3 function could lead to early pregnancy failure.

97 ese systems undergo during pretreatment that leads to efficient catalyst function.

98 tractility and adherens junction disassembly leading to endothelial barrier breakdown.

99 interactions with target sites within mRNAs, leading to enhanced degradation of the mRNA or inhibitio

100 bitor reduces Skp2 levels and stabilizes LT, leading to enhanced MCV replication and transmission.

101 in regulating birth and mortality rates can lead to erroneous demographic analyses and conclusions.

102 al virus (RSV) infection, and its inhibition leads to exaggerated immunopathology.

103 egulating myofiber length, as a loss of Abl2 leads to excessively long myofibers in the diaphragm, in

104 Strong-field laser-matter interactions often lead to exotic chemical reactions.

105 ons between the apoptotic cascade and events leading to extrusion are not fully understood.

106 Further development of this approach could lead to fast and automated purification of DNA nanostruc

107 und influence on working memory performance, leading to faster access times as well as more accurate

108 mechanisms by which central serotonin action leads to fat loss remain unknown.

109 and also shows a very favorable ADME profile leading to favorable predicted human pharmacokinetic pro

110 ized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting.

111 is possible to identify network motifs that lead to functional outputs such as bistability or oscill

112 These findings suggest that training can lead to fundamental changes in the way attention alters

113 tronically excited BODIPY chromophores could lead to further advances in these areas.

114 hen given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by endoscopy.

115 Finally, the initiating events that lead to gene body methylation are discussed as a model i

116 inhibitory afferents to MNTB neurons should lead to greater inhibitory output to the projections fro

117 r equilibrium constants of several reactions leading to halamines in water.

118 these drugs residues in honey as they often lead to health concerns or potential antibiotic resistan

119 studies have suggested that this regimen may lead to high failure rates in coinfected patients.

120 ving USP9X-ERAS formed by chromothripsis and leading to high expression of ERAS, a constitutively act

121 n shuttles, and the consequent ion migration led to high anode salinities and conductivity that favor

122 Msh3 overexpression led to high expansion activity and elevated levels of Mu

123 Therefore, better treatment strategies leading to higher disease control are warranted in CRS c

124 ss expression of CXCR4, which, when blocked, led to HSC mobilization and prolonged islet allograft su

125 metabolism resulting from insulin resistance leads to hyperglycemia, the hallmark of type 2 diabetes

126 ern lifestyle with high salt consumption can lead to hypertension and cardiovascular disease.

127 use increased vascular permeability that may lead to hypovolemic shock.

128 methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and sel

129 ogenesis of different amyloid types and have led to identification of numerous new amyloid types, inc

130 The mechanisms leading to IL-10 expression by CD4(+) T cells are being

131 art to the virus's high sequence variability leading to immune escape.

132 se additional changes in lysosomal pH, which leads to impairment of lysosomal enzyme activity and dis

133 Incorrectly handling missing data can lead to imprecise and biased estimates.

134 cation and strategies to change practice can lead to improved nurses' knowledge, quality of care, and

135 ory monocyte-derived cells (MCs) in the CNS, leading to improved clinical outcome.

136 ed their predictive value for major bleeding leading to improved clinical usefulness compared to the

137 Influenza viral infections often lead to increased mortality in older people.

138 hat affect the immune system and, with time, lead to increased vulnerability to infectious diseases.

139 olyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element

140 and enhanced osteoclast-progenitor survival, leading to increased osteoclastogenesis.

141 Prenatal ethanol exposure (PE) leads to increased addiction risk which could be mediate

142 e further demonstrated that deletion of ami1 leads to increased cell wall permeability and enhanced s

143 macrophages exposed to HIV-related proteins led to increased caspase 3 activation and reduced Bcl-2

144 Further, inhibition of MARKs led to increased pathological alpha-synuclein burden.

145 Active compared to sham tDCS led to increased performance in the orienting (mean diff

146 n led to cell death, over-acetylated tubulin led to inhibition of motility and mitosis.

147 These substitutions led to inhibitors with increased PACE4 selectivity and p

148 This process has limited precision leading to inhomogeneous non-planar sampling of the axia

149 Prolonged activation of these synapses leads to initial depression, which is followed by steady

150 hair grooming is a common practice that can lead to injury and morbidity.

151 s in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction

152 Use of continuous flow leads to isolation of the desired compounds in enhanced

153 s or (hydr)oxides and Mn(III/IV) oxides-that lead to its production.

154 hifted dispersive waves were generated which led to large broadening from 1.5 um-25 um.

155 ls prevented recovery from MRV infection and led to lethality in infected animals, whereas B cell-def

156 synthesis in the epidermis of psoriatic skin leading to localized deficiency of cortisol.

157 tion of the monolayer/dielectric interfaces, leading to localized electronic states that serve as a b

158 combined, elevated CO2 and temperature will lead to long-term declines in the amount of carbon store

159 er the reaction conditions for homologation, leading to low stereospecificity.

160 This leads to low, pure technical noise that is atypical of r

161 These competing processes lead to lower variability in MeHg concentrations in zoop

162 In this randomized trial, off-pump CABG led to lower rates of 5-year survival and event-free sur

163 d with other non-CBF aberrant karyotypes and led to lower remission rates (complete remission + compl

164 reasing presynaptic activity, which actually led to LTP in PE animals, whereas LTD was still observed

165 front elevates Ca(2+) inside the SR locally, leading to luminal RyR sensitization and lowering of the

166 e that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6

167 ate intervention and that led (or could have led) to major disability or death.

168 The fact that defects in signaling can lead to malignancy illustrates the need to control Notch

169 eractions between the host and pathogen that lead to metal homeostasis provide several opportunities

170 Recently, we demonstrated that HCV infection leads to monocyte differentiation into polarized MPhis t

171 likelihood of biomarker discovery and could lead to more comprehensive understanding of disease etio

172 myocardial microenvironment are expected to lead to more physiologically relevant cardiac tissue-lik

173 ation, while changes in the coding sequences lead to mRNAs encoding distinct proteins.

174 Perkinsea infections (SPI) were systemic and led to multiorganic failure and death.

175 Dietary fat overconsumption leads to myocardial lipid accumulation through mechanism

176 of all Tln forms from the heart-muscle cell leads to myocyte instability and a dilated cardiomyopath

177 ase, is known to promote cell proliferation, leading to neovascularization as well as neuroprotection

178 Mechanisms of disease leading to neurodevelopmental deficits in infected infan

179 shed Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction (NMJ) dysfunction and

180 Validating these associations in vivo will lead to new diagnostic tools for Alzheimer disease and b

181 tween granulocytes and endothelial cells may lead to new therapeutic approaches to improve blood vess

182 s that underlie restless legs syndrome could lead to new treatment options.

183 ase, we have a lesser degree of interaction, leading to normal hydrogen bonds of type YH-X analogous

184 of monolayer two-dimensional materials could lead to novel multi-functionalities.

185 Dysregulation of this mechanism leads to numerous human neurodegenerative or neurodevelo

186 t featured an elongated O-O bond but did not lead to O-O cleavage or reactivity toward external subst

187 enses and disrupts the gut microbiota, which leads to overgrowth of indigenous E. coli and facilitate

188 Per a 10 leads to PAR-2 activation on BMDCs resulting in downstre

189 repeat kinase 2 (LRRK2) and alpha-synuclein lead to Parkinson's disease (PD).

190 sion, an active multistage process naturally leads to pattern transitions from actin vortices over st

191 se model of AUD showed that alcohol exposure leads to PCSK9 downregulation.

192 Conversely, in males, erasure leads to permanent X dosage decompensation.

193 In vitro, ISG15 deficiency also leads to persistently high levels of type I IFN-stimulat

194 e data support a model in which EAP deficits lead to poor functional outcome via impaired cognition a

195 dopaminergia and neurodegenerative phenotype leading to premature death in 36% of the population.

196 Ectopic expression of Cdh1 leads to premature differentiation of neuroprogenitors,

197 Heavy alcohol use can lead to progressive liver damage, especially in individu

198 igation speed at endoluminal CT colonography led to progressive restriction of visual search patterns

199 biquitin ligase to an E2-conjugating enzyme, leading to prolonged inflammatory signaling.

200 Infection with low-dose A/X31 H3N2 led to prolonged deterioration of lung function, aggrava

201 ith its specific and potent inhibitors could lead to promising host-directed therapeutic adjuvants fo

202 ent of Pol II in transcriptional elongation, leading to promoter-proximal accumulation of Pol II.

203 nce of self-epitope specific Treg cells that leads to protection or causation of autoimmunity.

204 United States suffer from dental infections, leading to pulp necrosis, arrested tooth-root developmen

205 erations decrease RcnR-DNA binding affinity, leading to rcnAB expression.

206 ng-term carbon isotope mass balance, and may lead to reassessment of the role that the delta(13)C rec

207 action is more susceptible to processes that lead to reduced light absorption, while larger-molecular

208 d by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion.

209 terference with the lipid signaling pathway, leading to reduced expression of MDR transporters and th

210 lar to in many women with PCOS, DHT exposure led to reduced adiponectin levels, larger adipocyte size

211 ion in the quality of evoked potentials that led to reduced performance on the BCI task.

212 opical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic der

213 Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery.

214 s study include measurement error that could lead to residual confounding; and the possibilities for

215 s, where the formation of chemical gradients leads to resource limitation for cells at depth.

216 sets, promoted excessive proliferation, and led to retinoblastoma with anaplastic changes.

217 oup between the oxidized and reduced states, leading to reversible switching of the DNA conductance b

218 g maintained hMSC stemness, engraftment, and led to robust motosensory improvement, neuropathic pain

219 CO1 variants may impair autophagic function, leading to RV formation in sIBM patient muscle.

220 or tissues has lifesaving potential, but can lead to serious complications.

221 promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restric

222 ing RNA intermediates with 3' end extension, leading to severe reduction of mature piwi-interacting R

223 inting such wavefunctions on electron pulses leads to shape-preserving multi-electrons ultrashort pul

224 served in the bulk at defects and interfaces lead to significant compositional segregation effects.

225 rightward shifts in inactivation parameters, leading to significant increases in the magnitude of win

226 We show that this dry air leads to significant low-level sublimation of snowfall.

227 findings demonstrate that the former loading leads to size-independent mechanical properties while th

228 ion of AnkG from established nodal complexes leads to slow but progressive nodal destabilization over

229 n siRNA-mediated knockdown of Mule or TRIM26 leads to stabilisation of NEIL1, demonstrating that thes

230 may experience greater HPA and HPG activity, leading to steeper decreases in cortical thickness with

231 lectrostatic fields emanating from the oxide lead to steering and reorientation of the molecules appr

232 omplex in the transition state as the factor leading to stereoselectivity.

233 s and activates HER2 at p1248 in PDAC cells, leading to stimulation of HER2 signaling cascade, includ

234 ace UV radiation indicate that the eruptions led to stratospheric ozone depletion.

235 In contrast, loss of Mll3/4 proteins leads to strong depletion of enhancer Pol II occupancy a

236 experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treat

237 examine whether repeated shocks of this kind lead to substantial increases in the prevalence of firea

238 Prolonging the reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecu

239 Short-term IL-33 treatment in mice led to sustained expansion of IL-33 receptor-positive ki

240 mal accumulation of Abeta at nerve terminals leads to synaptic pathology and ultimately to neurodegen

241 cion activates AMP-activated protein kinase, leading to synergistic inhibition of human leukemia cell

242 Activation of Nlrp3 leads to synthesis of proinflammatory cytokines and infl

243 un to elucidate how skin barrier defects can lead to systemic allergen sensitization.

244 s a key event of pAg sensing that ultimately leads to T cell activation.

245 rus (HIV) disease, chronic immune activation leads to T-cell exhaustion.

246 y, and eventually correct, the failures that lead to the deterioration of this important cell populat

247 ch are toxic and, if consumed regularly, can lead to the development of kidney stones.

248 te the complex mechanisms of the disease and lead to the development of more effective individualized

249 essarily mutually exclusive and together can lead to the emergence of complex patterns of control.

250 various enzyme activities that collectively lead to the formation of Ang-(1-7) from Ang II, in both

251 on results, because the different substrates lead to the formation of different ice polytypes.

252 als (e.g., breaded frozen fish products) can lead to the formation of fatty acid esters of 2-monochlo

253 How RASA1 mutations lead to the LV leakage defects that occur in CM-AVM is n

254 by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor supp

255 creases the mitochondrial membrane potential leading to the activation of Ca(2+)-independent phosphol

256 ied by variable temperature NMR spectroscopy leading to the conclusion that the rate-determining step

257 a number of brain regions are implicated in leading to the disorder.

258 rt the discovery of self-assembly strategies leading to the emergence of lipid bicontinuous single cr

259 Nonetheless, the dynamic mechanism leading to the establishment and maintenance of tissue-s

260 We observe extensive splicing diversity leading to the formation of altered open reading frames

261 se to FVIII, because of a lack of tolerance, leading to the formation of inhibitory antibodies.

262 ntity and hierarchy of the HDR (sub)pathways leading to the formation of PGE products remain elusive.

263 e light activation of o-methylbenzaldehydes, leading to the formation of reactive o-quinodimethanes (

264 en proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity a

265 poproteins in HCV secretion and infectivity, leading to the notion that HCV coopts the secretion of v

266 P-transposable element transcripts in vivo, leading to the production of the non-transposase-encodin

267 e asialoglycoprotein receptor with Astn2 TM2 leads to the appearance of a carboxyl-terminal fragment

268 hat patterned disorder at the cellular level leads to the emergence of organism-level order.

269 codons in the full-length human L1 sequence leads to the expression of truncated ORF1 proteins.

270 combination of dopamine and ketones in a PSR leads to the formation of 1,1'-disubstituted tetrahydroi

271 ion of target dsDNA (dsDNA-T), which in turn leads to the formation of a high density of PNA/DNA hete

272 assembling into hierarchical structures and leads to the formation of discrete nickel-seamed pyrogal

273 r differentiation event in mouse development leads to the formation of the blastocyst consisting of t

274 he application of 10 mmol/L ammonium formate led to the best findings, while the use of 0.02% acetic

275 rofiling and next-generation sequencing have led to the classification of HCCs based on molecular fea

276 ermeability and proliferation increase; this led to the concept that glia are required for maintenanc

277 Accordingly, these reactions led to the construction of new classes of pyrrolidone-ri

278 ong older patients with palliative needs has led to the development of several service-level interven

279 This work led to the discovery of a highly selective PI3Kbeta/delt

280 n of the center (S)-proline-based lead 7 has led to the discovery of noncovalent reversible and selec

281 cells in a TAS3 ta-siRNA-insensitive mutant led to the formation of supernumerary megaspore mother c

282 nd characterize HIV-specific antibodies have led to the identification of a new generation of potent

283 rug design, and parallel medicinal chemistry led to the identification of pyridine 12.

284 sing concentration of the dyes in a solution led to the increase in absorption band intensity in diff

285 JB12 knockdown by siRNA led to the induction of caspase processing but not the u

286 selective advantage over Neanderthals, which led to the their extinction.

287 ds biogeochemical hotspots, which ultimately leads to their critical, but poorly recognized role in r

288 r compounds that alter neuronal function can lead to therapeutic advances that ameliorate age-related

289 fection and inflammation that may eventually lead to tissue remodeling and respiratory disease.Cystic

290 Recent evolutions in rectal cancer surgery led to transanal dissection of the rectum resulting in a

291 tection of metastatic infectious foci, often leading to treatment modification.

292 e both tumor size and invasiveness and could lead to tumor eradication.

293 pidemia contribute to glucolipotoxicity that leads to type 2 diabetes.

294 the network operates close to an instability leading to unbounded cortical activation.

295 side, inaccurate forecasts and sole sourcing lead to under-procurement.

296 not allow detection of mild disease and may lead to underestimation of severity.

297 discuss how associated genetic variants can lead to understanding causal mechanisms, and to disentan

298 Hyperactive Hnf4 signaling leads to up-regulation of lipase 3 and enzymes for mitoc

299 r Leishmania species causing the disease can lead to variable performance.

300 These false assignments will eventually lead to wrong conclusions on the structural information