ライフサイエンスコーパス: lead to

1 Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations in su

2 help to elucidate the complex mechanisms of the disease and lead to the development of more effective individualized trea

3 A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease.

4 Incorrectly handling missing data can lead to imprecise and biased estimates.

5 models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization.

6 ctivity, and defects in one or more of these mechanisms can lead to a breakdown of tolerance.

7 ning raw materials (e.g., breaded frozen fish products) can lead to the formation of fatty acid esters of 2-monochloropro

8 nmental factors in regulating birth and mortality rates can lead to erroneous demographic analyses and conclusions.

9 f oxalates, which are toxic and, if consumed regularly, can lead to the development of kidney stones.

10 Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (

11 The fact that defects in signaling can lead to malignancy illustrates the need to control Notch acti

12 Pubic hair grooming is a common practice that can lead to injury and morbidity.

13 ces are not necessarily mutually exclusive and together can lead to the emergence of complex patterns of control.

14 These findings suggest that training can lead to fundamental changes in the way attention alters the e

15 Heavy alcohol use can lead to progressive liver damage, especially in individuals w

16 We discuss how associated genetic variants can lead to understanding causal mechanisms, and to disentangling

17 Advanced stages of liver cirrhosis lead to a dramatically increased mortality.

18 contribution of various enzyme activities that collectively lead to the formation of Ang-(1-7) from Ang II, in both norma

19 FDA, can reduce both tumor size and invasiveness and could lead to tumor eradication.

20 Further development of this approach could lead to fast and automated purification of DNA nanostructures

21 ynamics of electronically excited BODIPY chromophores could lead to further advances in these areas.

22 pairment of trophoblast-specific GATA2/GATA3 function could lead to early pregnancy failure.

23 ines followed by dehydrosulfurization and guanylation could lead to both symmetric and unsymmetric N,N',N''-substituted d

24 O1/TRXR1 axis with its specific and potent inhibitors could lead to promising host-directed therapeutic adjuvants for tub

25 Perturbations in the environment lead to distinctive gene expression changes within a cell.

26 hus favoring infection and inflammation that may eventually lead to tissue remodeling and respiratory disease.Cystic fibr

27 er from that observed in the bulk at defects and interfaces lead to significant compositional segregation effects.

28 esearch should examine whether repeated shocks of this kind lead to substantial increases in the prevalence of firearm ow

29 We find that current model limitations lead to considerable biases in the simulated biomass and in k

30 d give insight on the particle formation mechanisms and may lead to better-controlled synthesis protocols.

31 normalities may not allow detection of mild disease and may lead to underestimation of severity.

32 e cross-talk between granulocytes and endothelial cells may lead to new therapeutic approaches to improve blood vessel re

33 pollen-specific phospholipase, and that novel edits in MTL lead to a 6.7% haploid induction rate (the percentage of hapl

34 Influenza viral infections often lead to increased mortality in older people.

35 Strong-field laser-matter interactions often lead to exotic chemical reactions.

36 the presence of these drugs residues in honey as they often lead to health concerns or potential antibiotic resistance.

37 at long-range electrostatic fields emanating from the oxide lead to steering and reorientation of the molecules approachi

38 commensals are essential to skin health and can potentially lead to disease when their abundances and activities change d

39 y and/or translation, while changes in the coding sequences lead to mRNAs encoding distinct proteins.

40 , a decrease in inhibitory afferents to MNTB neurons should lead to greater inhibitory output to the projections from thi

41 be our simulation results, because the different substrates lead to the formation of different ice polytypes.

42 in leucine-rich repeat kinase 2 (LRRK2) and alpha-synuclein lead to Parkinson's disease (PD).

43 Finally, the initiating events that lead to gene body methylation are discussed as a model illust

44 s are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppresso

45 ll help identify, and eventually correct, the failures that lead to the deterioration of this important cell population.S

46 al networks, it is possible to identify network motifs that lead to functional outputs such as bistability or oscillation

47 lated changes that affect the immune system and, with time, lead to increased vulnerability to infectious diseases.

48 ts suggest that combined, elevated CO2 and temperature will lead to long-term declines in the amount of carbon stored in

49 Validating these associations in vivo will lead to new diagnostic tools for Alzheimer disease and better

50 ly when they expect the diagnostic information yielded will lead to better patient care, enhanced patient safety, and ult