ライフサイエンスコーパス: leader

1 d another previously described leader, the i-leader.

2 uction of a RTC4 transcript with a longer 5' leader.

3 earch and Prevention to honor its pioneering leader.

4 eam at two independent sites in the long lrp leader.

5 e-initiation involving two uORFs in the mRNA leader.

6 n-sensitive degron within the IAP N-terminal leader.

7 lement (3'BE) located at the 3' untranslated leader.

8 de her an exceptional scientist, mentor, and leader.

9 regulatory upstream ORFs in its extended 5' leader.

10 as also detected and tentatively named the j-leader.

11 no effect on initial Rho binding to the corA leader.

12 ) people escalate their support for dominant leaders.

13 leader activity that underlie poxvirus polyA-leaders.

14 ulation, not just from the direct friends of leaders.

15 ttle evidence regarding direct persuasion by leaders.

16 rd, against each other, and against practice leaders.

17 t contain adenosine repeats, so-called polyA-leaders.

18 2013 that included (1) a quality improvement leader, (2) stroke content expert, (3) multidisciplinary

19 eading frames (uORFs), located in transcript leaders (5' UTRs), are potent cis-acting regulators of t

20 actions in the full-length, dimeric HIV-1 5'-leader (688 nucleotides; 230 kDa).

21 udy to establish whether educating religious leaders about male circumcision would increase uptake in

22 th care for the United States, and as health leaders across the country contemplate future directions

23 harged amino acids in plants, in which these leaders act as translational enhancers.

24 imicry and the mechanics of species-specific leader activity that underlie poxvirus polyA-leaders.

25 oncanonical initiation codons in the EPRS 5'-leader add complexity into the nature of uORF-mediated t

26 ng region and the resulting short transcript leader allows for efficient translation.

27 Index or peer leaders, along with two of their network members, were r

28 We now report that the corA leader also controls two subsequent steps of Rho-depende

29 ding 3D cancer cell packs to create purified leader and follower cell lines.

30 ted autonomous regenerative capacity in both leader and follower cells, with leaders displaying an en

31 Further truncates of PaaP leader and follower peptide sequences demonstrate the di

32 However, identification of leader and self-organizing communities is technically ch

33 the ratio of speeds of the downward negative leader and the corresponding positive UCL was about 3-4

34 g short 5' leaders and 3' trailers; however, leader and trailer lengths do not significantly alter th

35 The leader and trailer non-coding regions of the EBOV genome

36 ly binds precursor tRNAs containing short 5' leaders and 3' trailers; however, leader and trailer len

37 Moreover, the ratio of translation over 5' leaders and CDSes is conserved between human and mouse,

38 In humans, emergence of leaders and followers is key to group performance, but l

39 ing chimeric colonies that combine potential leaders and followers, we discover that leader-follower

40 Relationships between the partnership's leaders and influential individuals in the community, ho

41 liminate all ethical dilemmas and conflicts, leaders and organizations may wish to help improve nurse

42 commendations that may be helpful to nursing leaders and researchers who plan to use this instrument.

43 ted with parents of sick children, community leaders, and health workers to understand whether they a

44 contempt is used manipulatively by aspiring leaders, and how contempt can be cured or at least mitig

45 rnmental agencies, outcomes research thought leaders, and public and private healthcare partners.

46 ular Outcome Results-A Long Term Evaluation [LEADER] and Trial to Evaluate Cardiovascular and Other L

47 cient cells, RTC4 RNA with longer transcript leaders are expressed that are not efficiently translate

48 chological account for when and why dominant leaders are preferred over other respected and admired c

49 Effective leaders are thoughtful listeners, introspective, develop

50 (CPO) have been identified by global health leaders as an urgent threat.

51 hous molybdenum sulfide (Mo-S) catalysts are leaders as earth abundant materials for electrocatalytic

52 It will appeal to research team leaders as it allows for models to be created prior to a

53 rapped by the narrow neck that separates the leader bleb from the cell body.

54 ct antagonistically to organize actin within leader blebs, and Erk mediates this effect.

55 e scored and results broadcasted on a public leader board.

56 of the TRSs generated sg mRNAs with variant leader-body junction sequences.

57 For example, mRNA containing the 5'-leader (called Omega) of tobacco mosaic virus preferenti

58 Here we show that political leaders can persuade their constituents directly on thre

59 hat the process of working through religious leaders can serve as an innovative model to promote heal

60 udit feedback and targeting of local opinion leaders carried out between April 2009 and April 2010.

61 The leader cell cultures are phenotypically stable and highl

62 rmation as well as the mechanisms regulating leader cell density during the migration process remain

63 However, the factors driving the leader cell formation as well as the mechanisms regulati

64 es recruitment of follower cells but not for leader cell motility itself, which instead utilizes foca

65 device makes real-time tracking of invading leader cell phenotypes possible and has potential for us

66 ype cells have all the hallmarks of invasive leader cell populations and have been coisolated with N-

67 et of aggregation (as opposed to following a leader cell).

68 del can be used to investigate mechanisms of leader cell-directed invasion and understand how mechani

69 These results suggest that leader cell-facilitated access to the stromal ECM may tr

70 e microscopy reveals that Dll4 is induced in leader cells after the creation of the cell-free region

71 Gene profiling of invasive leader cells and detached cells suggest distinctive sign

72 rating monolayers results in dissociation of leader cells and impaired wound repair.

73 ing crucial to the physics of these systems: leader cells and jamming.

74 image velocimetry reveal that the density of leader cells and the speed of migrating clusters are tig

75 ter the creation of the cell-free region and leader cells are regulated via Notch1-Dll4 lateral inhib

76 The analysis of invading leader cells at the tumor invasion front is of significa

77 e the regulation and function of endothelial leader cells by plasma lithography geometric confinement

78 We recently showed that malignant leader cells can promote the invasion of otherwise non-i

79 Collectively, our data provide evidence that leader cells control endothelial collective migration by

80 peting patterns, we show that the density of leader cells correlates with the size and coherence of t

81 Endothelial leader cells display an aggressive phenotype, connect to

82 Leader cells display greater velocities and mechanical t

83 lling to dynamically regulate the density of leader cells during collective cell migration.

84 The characteristics of leader cells during endothelial collective migration und

85 When blood vessels are injured, leader cells emerge in the endothelium to heal the wound

86 imaging of cell-cycle dynamics, we show that leader cells form by spatiotemporally regulated endorepl

87 While leader cells provide an escape mechanism for followers,

88 nvasive function and whether they can act as leader cells to direct movement of a wounded epithelium

89 hese include a front of large, multinucleate leader cells, trailed by follower cells that divide to p

90 e rates depend on isolated cell speed and/or leader cells, we find that these correlations are not un

91 l and molecular characterization of invasive leader cells.

92 Leader communities and self-organizing communities have

93 tio of node degree variances, to distinguish leader communities from self-organizing communities, and

94 networks and citation networks contain more leader communities whereas technological networks such a

95 ganizing communities tend to be smaller than leader communities.

96 mdazoline receptors and (ii) to propose some leader compounds for the development of new sympatho-inh

97 Experts, government officials, and industry leaders concerned about the sustainability of shrimp aqu

98 The positive end of the bidirectional leader connected to another bidirectional leader to form

99 rger total impact on raid participation than leaders, despite leaders' greater connectivity.

100 or 2 events, speeds of positive and negative leaders developing toward each other inside the CSZ were

101 city in both leader and follower cells, with leaders displaying an enhanced capacity for surface cove

102 on host factor), that binds and bends CRISPR leader DNA.

103 ioning as a protein degron, the cellular IAP leader dramatically shortened the life span of a long-li

104 ies, the loss of important individuals (e.g. leaders, elites and queens) may have an especially detri

105 A potential new leader embedded within the E3 region was also detected a

106 pacers are inserted strictly at the A-T-rich leader end of CRISPR loci in vivo, the molecular mechani

107 ith knowledge and tools, and ultimately each leader established the most culturally-appropriate way t

108 Leaders evolve the system of care by reassessing and mod

109 We found that assigned leaders exerted significantly greater influence on other

110 roke process is actually associated with two leaders extending toward each other to collision inside

111 During the bidirectional leader extension, the negative end exhibited optical and

112 tial leaders and followers, we discover that leader-follower dynamics emerge from the site-specific s

113 reases colony survival in environments where leader-follower dynamics occur.

114 umicola shows regional variation in apparent leader-follower dynamics.

115 of bats flying over a water surface swapped leader-follower roles and performed chases or coordinate

116 We investigated plasticity in leader-follower roles in cooperation, where members choo

117 ts that humans are capable of adapting their leader-follower roles to their social environments, in b

118 rtner, we demonstrate adaptive plasticity in leader-follower roles.

119 to large, broad collectives with a distinct leader-follower structure.

120 of Ncad+ with Ecad+ cells did not promote a 'leader-follower' mode of collective cell invasion, demon

121 imentally manipulated which musician was the leader (followers were not informed who was leading) and

122 initiation factor (eIF)2-GTP scans the mRNA leader for an AUG codon in favorable "Kozak" context.

123 on complex bearing tRNAi(Met) scans the mRNA leader for an AUG start codon in favorable context.

124 tent in Patients With High Risk of Bleeding [LEADERS FREE]; NCT01623180).

125 its function: catalyzing cleavage of the 5'-leader from precursor tRNAs (pre-tRNAs).

126 ers from 111 villages and health workers and leaders from 54 villages in CLTS facilitation.

127 ent of this expert consensus document by key leaders from North America and Europe with expertise in

128 on raid participation than leaders, despite leaders' greater connectivity.

129 INTERPRETATION: Education of religious leaders had a substantial effect on uptake of male circu

130 ter a series of flock flights, we found that leaders had learned straighter homing routes than follow

131 At the same time, a growing number of policy leaders have called for going beyond the Patient Protect

132 Transplant leaders have focused attention on transplant center repo

133 Successful leaders have impeccable integrity, possess a service men

134 World leaders have pledged 350 Mha for restoration using a lan

135 nding of this crisis is now clear, and world leaders have pledged to avert it.

136 Key opinion leaders have recently made calls to the field to improve

137 sed approach provided reassurance to opinion leaders, health workers, and professional societies, thu

138 Academy leaders helped pave the way for the development of rigor

139 By interacting with the mutS leader, Hfq serves as a critical switch that modulates b

140 ll as give rise to the emergence of informal leaders, i.e. individuals with a disproportionately larg

141 a vital foreign aid service and the NIH is a leader in biomedical and health research, their surgical

142 The United States has been a leader in biomedical science for decades, in large part

143 2015 recipient Brian Charlesworth has been a leader in both theoretical and empirical evolutionary ge

144 As a recognized national leader in evidence-based guidelines, care systems, and q

145 The USA is the world leader in incarceration, which disproportionately affect

146 , FRS of Cambridge University became a world leader in respiratory physiology.

147 in planning and policy stand to make China a leader in sustainable, healthy transportation.

148 This award recognizes a leader in the field of computational biology for his or

149 man, MD, an exemplary scientist, mentor, and leader in the field of diabetes, obesity, hyperlipidemia

150 man, MD, an exemplary scientist, mentor, and leader in the field of diabetes, obesity, hyperlipidemia

151 diverse group of internationally recognized leaders in basic and clinical FBD research.

152 on caused an accumulation of ribosomes on 5' leaders in both cycloheximide-treated and untreated cell

153 olence increases when there is coercion from leaders in complex societies leading to group level bene

154 itiatives, and (iv) involvement of community leaders in decision-making.

155 c 10, 2015, we provided education for church leaders in eight intervention villages and compared the

156 We mapped transcription leaders in multiple Saccharomyces yeast species and appl

157 academic department chairs are accomplished leaders in ophthalmology and prolific authors with an es

158 ic neurology, and to suggest strategies that leaders in the field could consider in order to enhance

159 er multiple experimental approaches from key leaders in the field for obtaining Raman spectra using a

160 Ten years ago, leaders in the field of toxicology called for a transfor

161 They have done so by training leaders in the field, creating new methods and applicati

162 Other pseudopalindromic regions of the leader, including the transcription activation (TAR), po

163 We further show that the presence of leaders increases colony survival in environments where

164 ecting leaders (UCLs) and upward unconnected leaders, inferred to be mostly initiated from trees, exh

165 nd a panhandle domain involving a trailer-to-leader interaction.

166 intron-mediated enhancement (IME) of the 5' leader intron rather than by regulatory elements in the

167 We also found that leaders learn faster and become better navigators, even

168 the intervention, which consisted of opinion-leader-led training and coaching of front-line health wo

169 nists were identified: ELIXA (lixisenatide), LEADER (liraglutide), SUSTAIN 6 (semaglutide), and EXSCE

170 By contrast, leader males pose no threat to each other and congregate

171 "Leader" males with harems putatively use loud calls to d

172 Thus, we find that leaders matter more for raid initiation than participant

173 in which mixed cultures exhibit a follow-the-leader mechanism, we show coincident emergence of S- and

174 Peer-elected leaders moderated monthly meetings involving role-play,

175 igher rates of initiating group movements as leaders, more behavioural coordination by joining others

176 We previously demonstrated that the 5' leader mRNA of the Salmonella corA gene can adopt two mu

177 zed field trial to evaluate training natural leaders (NLs) as an addition to a community-led total sa

178 in part by upstream ORFs situated in the 5'-leader of CDKN1A mRNA.

179 mediate CGG repeat RAN translation in the 5' leader of fragile X mRNA, FMR1.

180 itory upstream ORF (uORF) situated in the 5'-leader of the CHOP mRNA.

181 The 5' leader of the mgtA mRNA contains a 17-codon, proline-ric

182 ort, upstream ORFs (uORFs) located in the 5'-leader of the mRNA can be selected for translation.

183 ponding author, assuming that he/she was the leader of the research group, the interaction between pr

184 nfected cells, is derived from Salmonella 5'-leader of the ribosomal RNA transcript and has a 'stem'

185 mediated by conserved elements within the 5'-leader of the RNA, including a palindromic dimer initiat

186 tes pausing at two sites in the untranslated leader of the trpEDCFBA operon.

187 d Institute for Health Policy Studies and Co-leader of the University of California, San Francisco Co

188 We report here that the N-terminal leader of two insect IAPs, Spodoptera frugiperda SfIAP a

189 Thus, the leaders of cellular IAPs from diverse insects carry uniq

190 Leaders of critical care services require knowledge and

191 sts from bioinformatics service providers to leaders of cutting-edge programs highlights the accompan

192 The 5'-leaders of GADD34 and CReP contain two upstream ORFs (uO

193 ach to science to improve human health, with leaders of national initiatives laying out their vision

194 Leaders of research infrastructures (RIs) in Europe who

195 e prognostic factors were requested from the leaders of the 6 trials.

196 Increased appreciation in faith leaders of the effect of their teachings on health care

197 er additional education for Christian church leaders on scientific, religious, and cultural aspects o

198 Church leaders or their congregations were not masked to random

199 inopathy (DR) were neutral with liraglutide (LEADER) or worse when compared with placebo in the case

200 ts that increase the preference for dominant leaders over their prestigious counterparts.

201 The presence of caring leaders, peer support, and an organizational commitment

202 (Phe) led to continued synthesis of the PheL leader peptide and attenuation of pheA transcription und

203 ine core from two dehydroalanines ejects the leader peptide as a C-terminal carboxamide.

204 In the spatial positioning model, leader peptide binding promotes certain reactions by est

205 es and the dependence of an eight-amino acid leader peptide for activity.

206 simulations support a mechanism in which the leader peptide guides posttranslational modification by

207 at the enzyme is functional when most of the leader peptide has been removed.

208 tational modeling to examine the role of the leader peptide in the biosynthesis of a homolog of strep

209 ptide recognition, we observe binding of the leader peptide in the catalytic barrel rather than the N

210 A 24-amino acid leader peptide of a new human recombinant manganese supe

211 rometry analysis, we show here that the LctA leader peptide plays critical roles in establishing the

212 Herein we investigate the leader peptide requirements for TclM from thiocillin bio

213 The proteolytic removal of the leader peptide was also performed in vitro.

214 rocyclization and cleavage of the N-terminal leader peptide, making them potentially useful biocataly

215 in an ordered, but nonlinear fashion that is leader-peptide-dependent.

216 C-to-N terminal directional process that is leader-peptide-independent.

217 tutively activated using covalently attached leader peptides and a GNAT-type N-acetyltransferase.

218 e show serves a purpose similar to canonical leader peptides in directing the biosynthetic enzymes to

219 that the McpM precursor peptide includes two leader peptides that undergo sequential cleavage at posi

220 ically locate to a wound edge are present in leader positions at the front of ZO-1-rich invading cord

221 domains of the foot-and-mouth disease virus leader protease and coronavirus PLPs, which act as deubi

222 y of the latency protein EBV nuclear antigen leader protein (EBNA-LP) resides predominantly within th

223 ional CLTS in which health workers and local leaders provided facilitation and an alternative approac

224 lex protospacers with free 3'-OH groups, and leader-proximal integration was stimulated by integratio

225 stepwise spacer integration process and the leader-proximal preference.

226 spacer is preferentially integrated into the leader-proximal region of the CRISPR array, guided by th

227 hilic attack that connects one strand of the leader-proximal repeat to the prespacer 3' overhang.

228 peptide modifications to human MIS [albumin leader Q425R MIS (LRMIS)] that increase production and p

229 ng policy issues, attributions regarding the leaders' qualities, and subsequent voting behavior.

230 te the different structural position of raid leaders, raid participants are recruited from the whole

231 translation of an open reading frame in the leader region of the Salmonella mgtCBR operon actually e

232 tural rearrangements in the 5' untranslated (leader) region of the mRNA in response to binding of a s

233 t it can also terminate transcription within leader regions to implement regulatory decisions.

234 eotides flanking the integration site at the leader-repeat 1 boundary of the CRISPR locus.

235 talyze the first integration reaction at the leader-repeat border.

236 untries, fostering legions of sustainability leaders rests upon a fundamental renewal of humans' conn

237 Analysis of the i-leader revealed a potential open reading frame within th

238 ribosomal footprints on coding sequences, 5' leader ribosomal densities, distribution of ribosomes al

239 ike ionic conditions in which the (Cap)1G 5'-leader RNA adopts a dimeric structure, the (Cap)2G and (

240 ansient transfection of DCs with synthesized leader RNA from either wt or attenuated RABV is capable

241 ematodes has been characterized as a spliced leader RNA-facilitated reaction; in contrast, its mechan

242 imeric structure, the (Cap)2G and (Cap)3G 5'-leader RNAs exist predominantly as monomers.

243 operties of (Cap)1G, (Cap)2G, and (Cap)3G 5'-leader RNAs in the NL4-3 strain of HIV-1.

244 Nursing leaders, scholars and policy makers need to recognise an

245 strative team members, service managers/team leaders, senior managers and software support staff.

246 al region of the CRISPR array, guided by the leader sequence and a pair of inverted repeats inside th

247 IHF binds to the leader sequence and induces a sharp DNA bend, allowing t

248 ed a potential open reading frame within the leader sequence and the termination of this potential pr

249 an exceptionally long (739-nucleotide [nt]) leader sequence in triticum mosaic virus (TriMV), a rece

250 initiates at the 13th start codon within the leader sequence independently of eIF4E but involves eIF4

251 eading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs.

252 CGG trinucleotide repeat expansion in the 5' leader sequence of the FMR1 gene.

253 Although the leader sequence of the precursor peptide is often requir

254 such as oxidation and deamidation, residual leader sequence, and proteolytic cleavage.

255 redominantly binds and presents MHC class Ia leader sequence-derived peptides for NK cell regulation.

256 e target site bears clear resemblance to the leader sequence-repeat junction which is the target for

257 tting AT-rich regions, similar to the CRISPR leader sequence.

258 insight into the regulatory code within mRNA leader sequences and their capacity to modulate translat

259 nding and explain the elusive role of CRISPR leader sequences during spacer acquisition.

260 Nase P is a universal enzyme that removes 5' leader sequences from tRNA precursors.

261 have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux

262 t of data, heterogeneous coverage and shared leader sequences of some CRISPRs pose challenges for ide

263 In the 5' leader sequences of transcripts with increased translati

264 g frames, and fewer occurred in untranslated leader sequences, antisense strands, and intergenic regi

265 tified sequences contain predicted secretion leader sequences, N-linked glycosylation sites, and a pu

266 nd UUG initiation codons in the EPRS mRNA 5'-leader serve to dampen levels of translation initiation

267 At project inception, tribal leaders should be consulted regarding the validity of pr

268 y, then it preferentially interacts with the leader-side CRISPR repeat, and finally, it catalyses a n

269 genic worms are generated in which a spliced leader (SL) RNA gene is fused with a sequence tag and dr

270 ptional mechanism whereby a specific Spliced Leader (SL) sequence is added to the 5'end of each mRNA

271 Here we report the detection of spliced leader (SL) trans-splicing in calanoid copepods.

272 Spliced leader (SL) trans-splicing is a critical element of gene

273 ellis, Bibaum(R), modified Bibaum(R), triple leader, slender spindle and Solaxe, were evaluated based

274 on to evaluate the relative contributions of leader social influence versus follower social susceptib

275 (ARLG) scientific agenda by engaging thought leaders; soliciting research proposals; and developing t

276 SPR loci in vivo, the molecular mechanism of leader-specific spacer integration remains poorly unders

277 by the participants as well as other thought leaders subsequently consulted, who together represent r

278 ve decisions through particular individuals, leaders, that have a disproportionate influence on group

279 he HAdV TPL and another previously described leader, the i-leader.

280 ntially other genes with uORFs in their mRNA leaders through delayed re-initiation, thereby enhancing

281 al leader connected to another bidirectional leader to form a larger bidirectional leader, whose nega

282 ting base-pairing of ArcZ sRNA with the mutS leader to inhibit translation.

283 nd study designs by investigators and tribal leaders to determine when aggregation or stratification

284 PLOS Medicine editors asked 7 global health leaders to discuss developments relevant to the equitabl

285 The HAdV tripartite leader (TPL), composed of three introns (TPL 1-3), is cr

286 NA structures in the Bacillus subtilis rplJL leader transcript that function as an anti-antiterminato

287 sses its translation by binding to the rplJL leader transcript.

288 event) with the GLP-1R agonists liraglutide (LEADER trial [Liraglutide Effect and Action in Diabetes:

289 A local leader, typically a well-trained pediatric oncologist wh

290 The majority of imaged upward connecting leaders (UCLs) and upward unconnected leaders, inferred

291 An interdisciplinary panel of 23 national leaders was convened for a 1-day conference at Harvard M

292 , until a bidirectionally extending channel (leader) was formed.

293 For 1 event, opposite polarity leaders were observed to accelerate inside the CSZ.

294 589 index or peer leaders were randomly assigned to the control group and

295 ties and initially lacked support from local leaders, which may have lessened their success.

296 e witness the rise of populist authoritarian leaders who are overbearing in their narrative, aggressi

297 of raids depends on the presence of specific leaders who tend to participate in many raids, to have m

298 tional leader to form a larger bidirectional leader, whose negative end attached to the ground and pr

299 or followers, follower cells in turn provide leaders with increased growth and survival.

300 We equipped church leaders with knowledge and tools, and ultimately each le