ライフサイエンスコーパス: leader sequence

1 as cofactor and in the periplasm (29-residue leader sequence).

2 and (iv) secondary structure within the mRNA leader sequence.

3 at a Rho-independent termination site in the leader sequence.

4 ator located within the 5' untranslated pyrG leader sequence.

5 tting AT-rich regions, similar to the CRISPR leader sequence.

6 or without the tissue plasminogen activator leader sequence.

7 ein (224-235 amino acids) with a hydrophobic leader sequence.

8 e-tRNA binding by directly contacting the 5'-leader sequence.

9 asmic space upon cleavage of a 23-amino-acid leader sequence.

10 ns and encodes a 231-aa protein with a 21-aa leader sequence.

11 ic negative-strand RNAs to add a copy of the leader sequence.

12 xon, and it begins with the SL1 trans-splice leader sequence.

13 these proteins do not contain a hydrophobic leader sequence.

14 hat contains a 33-aa classical mitochondrial leader sequence.

15 n the presence or absence of an untranslated leader sequence.

16 mRNA than from mRNA that was deleted for its leader sequence.

17 s PLP and DM20 proteins with a 12 amino acid leader sequence.

18 ept for several insertions in the N-terminal leader sequence.

19 sive element in the transcribed noncoding 5' leader sequence.

20 high affinity AP2 sites in the untranslated leader sequence.

21 otein containing a 48-amino-acid hydrophobic leader sequence.

22 fic mRNAs, most of which do not possess a 5' leader sequence.

23 t they can be located in the 5' untranslated leader sequence.

24 otein coding region into the 5' untranslated leader sequence.

25 tion termination near the 3' end of a 371-bp leader sequence.

26 ally presents peptides derived from class Ia leader sequences.

27 am-positive bacteria containing similar pyrG leader sequences.

28 on of hydrophobic residues in NH(2)-terminal leader sequences.

29 sent in HLA-E-binding peptides from class Ia leader sequences.

30 er, and TcpB, all of which contain type IV-A leader sequences.

31 acteria is by riboswitches found within mRNA leader sequences.

32 of proteins that lack N-terminal hydrophobic leader sequences.

33 YopM consists of a 71-residue leader sequence, 15 LRRs, and a 32-residue tail.

34 P12 and J11/12) that were crosslinked to the leader sequence 5' immediately to the cleavage site in t

35 ated by four upstream AUGs present in the 5' leader sequence (5'-LS).

36 ter was fused with DNA segments encoding the leader sequence (5'-untranslated region [UTR]) of plasti

37 e they differ only in the length of their 5' leader sequence (5'LS).

38 were demonstrated in 79% of cases (74% with leader sequences, 64% with FR1, and 45% with FR3 primers

39 etion based on the presence of a hydrophobic leader sequence, a leader-sequence cleavage site, and th

40 dCat) and catalase cDNA with a mitochondrial leader sequence (AdmCat).

41 To examine how 5[prime] leader sequences affect 3' processing efficiency, we per

42 However, amino acid variations in class I leader sequences affected the stability of HLA-E.

43 a 70.9-kDa, soluble, periplasmic (37-residue leader sequence) alcohol dehydrogenase containing PQQ an

44 reas addition of either a TMG-cap or spliced leader sequence alone decreased reporter activity.

45 ns, like their human counterpart, contains a leader sequence, an amino-terminal globular domain, 10 l

46 ressed in all tissues tested, and contains a leader sequence, an LDLa domain, two EF-hand domains, an

47 ents that are synthesized with an N-terminal leader sequence and a C-terminal propeptide.

48 al region of the CRISPR array, guided by the leader sequence and a pair of inverted repeats inside th

49 The VDJ segment has a split leader sequence and a single open reading consistent wit

50 g this isotype are composed of a typical IgH leader sequence and a VDJ rearranged segment followed by

51 NA consisting of two domains, a catalytic 5'-leader sequence and an aminoacyl-acceptor tRNA.

52 function does not require the mitochondrial leader sequence and appears to affect transcription of n

53 essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity

54 ng a pelB leader sequence with a gene 3 (g3) leader sequence and by using a single lacZ promoter sequ

55 lized to the mitochondria by a mitochondrial leader sequence and encoded by a nuclear gene (Trx-2).

56 The deduced protein contains a leader sequence and four predicted proline-rich peptides

57 IHF binds to the leader sequence and induces a sharp DNA bend, allowing t

58 An alfalfa mosaic virus untranslated leader sequence and Lys-Asp-Glu-Leu (KDEL) endoplasmic r

59 n conserved residues of the alpha-neurexin 1 leader sequence and of an epidermal growth factor (EGF)-

60 has other unique features with regard to its leader sequence and posttranslational modification.

61 as an 8-kDa protein without its hydrophobic leader sequence and purified to homogeneity.

62 artificially at specific positions along the leader sequence and tested for the ability to recognize

63 ted into a vector downstream of a 5' Igkappa leader sequence and the hemagglutinin A (HA) sequence.

64 uorescent protein was introduced between the leader sequence and the rest of the putative mitochondri

65 ed a potential open reading frame within the leader sequence and the termination of this potential pr

66 orescent protein was fused to the galectin-3 leader sequence and transiently transfected into BT-549

67 s found in the middle of the 5'-untranslated leader sequence and was shown to robustly enhance the pr

68 retained when approximately one-third of the leader sequence and/or the length of the leader is signi

69 quence similarity, and both proteins contain leader sequences and putative C-terminal transmembrane r

70 in bacterial genomes can contain regulatory leader sequences and small RNAs (sRNAs), which both serv

71 sembled with peptides derived from different leader sequences and soluble CD94/NKG2-A and CD94/NKG2-C

72 insight into the regulatory code within mRNA leader sequences and their capacity to modulate translat

73 Interactions between signal (leader) sequences and membranes are critical to protein

74 such as oxidation and deamidation, residual leader sequence, and proteolytic cleavage.

75 1 and B-2 motifs, a hydrophobic NH2-terminal leader sequence, and the COOH-terminal residues HIEL tha

76 licing, cis-acting elements in the late mRNA leader sequence, and the production of viral microRNA.

77 We systematically define mRNA 5' leader sequences, and 3' UTRs, as well as antisense tran

78 s, including splice junctions, trans-spliced leader sequences, and polyadenylation tracts.

79 highly homologous family and have identical leader sequences, and the swine VH locus contains a sing

80 mes differ in their kinetic properties and N-leader sequences, and their regulation may vary with tis

81 g frames, and fewer occurred in untranslated leader sequences, antisense strands, and intergenic regi

82 This leader sequence appears to target these proteins to a di

83 ide precursors that trim away the N-terminal leader sequences (approximately 40 residues) while the C

84 f the start codon to the 5' terminus and the leader sequence are strong determinants of both ribosome

85 ence of a leader and find that mRNAs lacking leader sequences are dependent upon an AUG initiation co

86 This suggests that mRNAs lacking leader sequences are either more dependent on perfect co

87 and other examples support the idea that 5' leader sequences are sometimes structured deliberately i

88 thesis was confirmed by the finding that the leader sequences are transcribed as parts of small RNAs

89 The lipase contained a putative leader sequence, as well as the conserved Ser, His, and

90 pecifically, the MAGE-3 gene was linked to a leader sequence at its NH2 terminus for secretion and to

91 containing unique uridine residues in the 5' leader sequence at positions -1, -3, -5, -7, or -10.

92 ntimicrobial activity after removal of their leader sequences at an engineered Factor Xa cleavage sit

93 probing of mutant ribosomes with additional leader sequences at the 5(') end of 16S rRNA compared to

94 is identical with the previously identified leader sequence binding site in RNaseP holoenzyme.

95 MD-2 contains a leader sequence but lacks a transmembrane domain, and we

96 tAR (N-62 StAR) that lacks the mitochondrial leader sequence but retains full activity and appears to

97 the possibility that mRNAs in Hydra receive leader sequences by trans-splicing.

98 ights identified the presence of heavy chain leader sequence, C-terminal lysine, and C-terminal amida

99 The 5'-leader sequence (called Omega) of tobacco mosaic virus (

100 Our findings show that mRNA leader sequences can consist of complex regulatory eleme

101 Mutations to the N-terminal mitochondrial leader sequence causes a complete loss of mitochondrial

102 the fact that the translated desR gene has a leader sequence characteristic of secretory proteins, al

103 presence of a hydrophobic leader sequence, a leader-sequence cleavage site, and three possible N-glyc

104 ype I glycoproteins with a short hydrophobic leader sequence closely following the translation initia

105 ercistronic region, we demonstrate that this leader sequence confers functional internal ribosome ent

106 consisting of three domains: a 12-amino acid leader sequence containing a casein kinase I serine phos

107 ed that Isa2p harbors a bipartite N-terminal leader sequence containing a mitochondrial import signal

108 f aldehyde dehydrogenase so that an internal leader sequence could exist.

109 embrane domains with an immunoglobulin kappa leader sequence coupled to either an S-peptide tag (sG(S

110 sisting of murine immunoglobulin kappa-chain leader sequence coupled to sequence coding for murine en

111 n BCO2 isoforms possess cleavable N-terminal leader sequences critical for mitochondrial import.

112 ed variants that were missing the N-terminal leader sequence (Delta296nNOS) or missing the leader seq

113 nalysis of translational fusions with mutant leader sequences demonstrated that the principal reason

114 l position, and were nearly identical to the leader sequence-derived peptide previously shown to be a

115 lly recognize Qa-1 bound to the MHC class Ia leader sequence-derived peptide Qdm.

116 redominantly binds and presents MHC class Ia leader sequence-derived peptides for NK cell regulation.

117 he mitochondrial matrix (targeted using COX8 leader sequence) diffused freely (nearly 100% mobility)

118 The presence of a mitochondrial leader sequence does not prevent a portion of Rpm2p from

119 The 5'-leader sequence domain selectively self-charges phenylal

120 he mature bicistronic mRNAs have variable 5' leader sequences due to alternative splicing or promoter

121 me primarily responsible for cleaving the 5' leader sequence during maturation of tRNAs in all three

122 nding and explain the elusive role of CRISPR leader sequences during spacer acquisition.

123 n 11 within a novel 18 amino acid N-terminal leader sequence encoded through differential splicing.

124 egions of monocistronic reporter genes, both leader sequences enhanced translation efficiency in vege

125 ssociated protein 2, and alpha-CaM Kinase II leader sequences enhanced translation, whereas the dendr

126 a helical loop pattern suggestive of an srp leader sequence for a secreted protein.

127 s were determined by 5'-RACE revealing large leader sequences for each transcript.

128 isoleucyl-tRNA synthetase gene (ileS) T box leader sequences found in organisms of the phylum Actino

129 taxa, consisting in the transfer of a short leader sequence from a small SL RNA to the 5' end of a s

130 e P (RNaseP) catalyses the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5' t

131 sis are proteolytic removal of an N-terminal leader sequence from the prepeptide LctA and export of t

132 A DNA sequence encoding the amino-terminal leader sequence from the tobacco pathogen related protei

133 The VP5 promoter and leader sequences from positions -36 to +20, containing t

134 ase P (RNase P) catalyzes the cleavage of 5' leader sequences from precursor tRNAs (pre-tRNAs).

135 RNase P is the enzyme that removes 5' leader sequences from precursor tRNAs.

136 ptidases cleave, among other substrates, the leader sequences from prepilin-like proteins that are re

137 The rrn leader sequences from Pseudomonas aeruginosa, Bacillus s

138 Nase P is a universal enzyme that removes 5' leader sequences from tRNA precursors.

139 thers has shown that insertion of psi (i.e., leader) sequences from the Moloney murine leukemia virus

140 were performed with modified non-functioning leader sequences fused to either the native or a non-fun

141 Eliminating the leader sequence had no impact on nNOS structure or catal

142 Structure probing indicated that the 5' leader sequences had little effect on pre-tRNA folding.

143 characterize in vivo requirements of the SL1 leader sequence have been severely constrained by the es

144 Mitochondrial leader sequences have been found to be statistically enr

145 ouse hepatitis virus (MHV) are composed of a leader sequence, identical to the 5' 70 nucleotides of t

146 The predicted leader sequence, immunoglobulin-like IgV (variable)/IgC

147 stream open reading frame (uORF) in their 5' leader sequences, implying a common mode of post-transcr

148 A 5' leader sequence in dnaA mRNA represses gene expression b

149 the orientation and register of the pre-tRNA leader sequence in the central cleft places the protein

150 SD), focused on the base pairing of a unique leader sequence in the initiation site--the SD sequence-

151 dicistronic mRNA, the presence of the TEV 5' leader sequence in the intercistronic region increased e

152 The replacement of the native cyt b(562) leader sequence in this protein with that of a c-type cy

153 an exceptionally long (739-nucleotide [nt]) leader sequence in triticum mosaic virus (TriMV), a rece

154 the FR3 primer and subsequent analysis using leader sequences in negative cases.

155 ntified 10 new sRNAs and nine new regulatory leader sequences in the intergenic regions of E. coli.

156 initiates at the 13th start codon within the leader sequence independently of eIF4E but involves eIF4

157 The gene for NC contains a leader sequence indicating a periplasmic location.

158 e precursor deduced from the cDNA exhibits a leader sequence, indicating that it is synthesized throu

159 the acid-chain hypothesis to explain how the leader sequences interact with negatively charged recept

160 displays the most variability among class I leader sequences, interacts entirely with CD94, the inva

161 ent was further analyzed by inserting the 5' leader sequences into the intercistronic region of dicis

162 The T box leader sequence is an RNA element that controls gene exp

163 the MLS truncated form, indicating that the leader sequence is cleaved during or after mitochondrial

164 on messages, demonstrating that part of the leader sequence is essential for trans splicing in vivo.

165 The coding region of the leader sequence is interrupted in codon 17 by a second i

166 This UCS leader sequence is necessary for initiation of translati

167 wo-hybrid system, it was determined that the leader sequence is the site of PSI-N that associates wit

168 The SL1 leader sequence is trans-spliced to many mRNAs in C. ele

169 pled to a human tissue plasminogen activator leader sequence led to pronounced in vitro cytotoxic T-l

170 The p8 protein is synthesized without a leader sequence, like that of bacteriophage Pf3 but unli

171 ns), suggests that a 4 kilodalton N-terminal leader sequence, like that responsible for mitochondrial

172 ding a polypeptide of 264 amino acids with a leader sequence likely targeting the protein to the chlo

173 We therefore conclude that the tripartite leader sequence, long known to facilitate the translatio

174 Therefore, trans-splicing of the SL1 leader sequence may serve at least two functions in nema

175 All five leader sequences mediated internal initiation via intern

176 spot" within the region that encodes the HLA leader sequence mimic.

177 tified sequences contain predicted secretion leader sequences, N-linked glycosylation sites, and a pu

178 e conserved in the mycoplasmal gene, but the leader sequence necessary for its secretion by C. perfri

179 features of the Moloney murine sarcoma virus leader sequence necessary for RNA packaging function by

180 s an 81.4-kDa protein (pI 6.98) containing a leader sequence of 2.6 kDa; the deduced molecular mass a

181 unusually long, intronless, 5'-untranslated leader sequence of 715 bp.

182 d structural properties of the mitochondrial leader sequence of aldehyde dehydrogenase have been exte

183 Most often found in the 5'-leader sequence of bacterial mRNAs, they are generally c

184 tyltransferase reporter fused to the 5'-mRNA leader sequence of betaAPP without altering expression o

185 homologous set of peptides derived from the leader sequence of class Ia molecules, but its capacity

186 mino acids may therefore be conserved in the leader sequence of class II lantibiotics to direct other

187 Replacement of the N-terminal leader sequence of DmCSAS with the human CSAS N-terminal

188 The leader sequence of flaB transcript contains two conserve

189 eading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs.

190 To study the functional role of the unusual leader sequence of galectin-3, a mutant cDNA that causes

191 The upstream autoregulatory mRNA leader sequence of gene 32 of 17 T-even and related bact

192 indicated a nucleotide change, T-->C, in the leader sequence of GH, which suggested a polymorphism.

193 determinant modifier (Qdm), derived from the leader sequence of H-2D and L molecules.

194 le 9-aa peptide (AMAPRTLLL) derived from the leader sequence of many MHC class Ia proteins.

195 that binds nonamer peptides derived from the leader sequence of MHC class 1a molecules and is the maj

196 ific binding to a region in the untranslated leader sequence of Oskn2 was confirmed by yeast and in v

197 tation of a nonamer peptide derived from the leader sequence of other HLA molecules to CD94-NKG2 rece

198 rectly interacts with the single-stranded 5' leader sequence of pre-tRNA, and (ii) the orientation an

199 ponsible for cleaving the single-stranded 5' leader sequence of precursor tRNA molecules (pre-tRNA),

200 responsible for endonucleolytic removal of a leader sequence of precursor tRNA to generate the mature

201 This enzyme catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generati

202 etalloenzyme responsible for cleaving the 5'-leader sequence of precursor tRNAs during their maturati

203 nusual self-peptide epitope derived from the leader sequence of preproinsulin (PPI) and show that 50%

204 The leader sequence of rat liver aldehyde dehydrogenase has

205 The results indicate that the full upstream leader sequence of rpoS mRNA influences Hfq-facilitated

206 The SYNCRIP-binding site was mapped to the leader sequence of the 5'-UTR, requiring the UCUAA repea

207 report, we found that CsrA(Bb) binds to the leader sequence of the bb0589 transcript and that the in

208 t lacked these sequences or contained the 5' leader sequence of the CLN3 mRNA in the intercistronic r

209 CGG trinucleotide repeat expansion in the 5' leader sequence of the FMR1 gene.

210 ne have shown that peptides derived from the leader sequence of the HLA-G binds and up-regulates the

211 The same peptide is present in the leader sequence of the human cytomegalovirus (HCMV) glyc

212 e 175-kDa HARE cDNA, fused to the N-terminal leader sequence of the Ig kappa-chain, was transfected t

213 viously showed that a 9-nt segment in the 5' leader sequence of the mRNA encoding Gtx homeodomain pro

214 ve the potential to form base pairs with the leader sequence of the mRNA encoding the outer membrane

215 V12)-responsive element was mapped to the 5' leader sequence of the murine Dmp1 promoter, where endog

216 tive secondary-structural elements in the 5' leader sequence of the nascent mRNA is influenced by try

217 tudy, mutations of conserved residues in the leader sequence of the precursor peptide for lacticin 48

218 Although the leader sequence of the precursor peptide is often requir

219 bove data revealed FleQ binding to be in the leader sequence of these promoters, whereas FleQ binding

220 no acid biosynthetic genes is limited to the leader sequences of attenuator-regulated operons.

221 d regulatory elements found primarily in the leader sequences of bacterial mRNAs.

222 First, >32 N-terminal leader sequences of fungal type II membrane proteins wer

223 have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux

224 The 5' leader sequences of mRNAs encoding the activity-regulate

225 1(b) is to present peptides derived from the leader sequences of other MHC class I molecules for reco

226 contacts between the protein subunit and the leader sequences of pre-tRNAs may be common in bacterial

227 ribosome entry sites (IRESes) within the 5' leader sequences of Saccharomyces cerevisiae YAP1 and p1

228 We investigated the role of 5' untranslated leader sequences of simian immunodeficiency virus (SIV(m

229 t of data, heterogeneous coverage and shared leader sequences of some CRISPRs pose challenges for ide

230 Upstream ORFs are elements found in the 5'-leader sequences of specific mRNAs that modulate the tra

231 or extensive secondary structure of the long leader sequences of the dnaK transcripts, which could in

232 In the 5' leader sequences of transcripts with increased translati

233 The trans-spliced leader sequence on mRNAs reduces Dcp2 activity approxima

234 rences between JPV-BH and JPV-LW, one in the leader sequence, one in the GX gene, and three in the L

235 ogenetic conservation to identify regulatory leader sequences, only five of the newly discovered E. c

236 Deletion analysis revealed that the leader sequence or tail is alone insufficient to direct

237 on of a stable stem-loop upstream of the TEV leader sequence or upstream of either CIRE in dicistroni

238 iption terminator, trpt, located in the lacZ leader sequence, or a deletion derivative that functiona

239 rmined the structure of Qa-1(b) bound to the leader sequence peptide, Qdm (AMAPRTLLL), to a resolutio

240 eta2-microglobulin were refolded with an MHC leader-sequence peptide, biotinylated, and conjugated to

241 MHC class I molecules which provide suitable leader sequence peptides capable of binding to HLA-E.

242 All class I leader sequence peptides tested bound to HLA-E and were

243 eader sequence (Delta296nNOS) or missing the leader sequence plus the three core motifs (Delta349nNOS

244 tein-protein interactions or are missing the leader sequence plus three core structural motifs that i

245 vely charged residues, with only a few known leader sequences possessing negatively charged residues.

246 ng only in the length of the 5' untranslated leader sequences preceding a common ORF.

247 Untranslated leader sequences predicted from 42 different Salmonella

248 erase chain reaction amplification using the leader sequence primers is the most sensitive method for

249 inal sequencing of secreted protein revealed leader sequence processing at two sites, a primary site

250 e target site bears clear resemblance to the leader sequence-repeat junction which is the target for

251 forms that are missing either an N-terminal leader sequence required for protein-protein interaction

252 brid rJPV-BH strains with sequences from the leader sequence (rJPV-BH-Le-LW), the GX gene (rJPV-BH-GX

253 ssess an evolutionarily conserved regulatory leader sequence (S-box) that positively controls these g

254 , a short region of the AAV5 capsid gene RNA leader sequence surrounding the AUG of VP1 could induce

255 TR was replaced with an irrelevant synthetic leader sequence (syn 5'-UTR), translation of syn 5'-UTR

256 ystem, we found that the TMG-cap and spliced leader sequence synergistically collaborate to promote e

257 ulatory element called TAR, a 59-residue RNA leader sequence that folds into a specific stem-loop str

258 ent infection nuclear proteins have a common leader sequence that is spliced from the major internal

259 airpin structure located within the 130-base leader sequence that lies between the promoter of tetQ a

260 4 positioned downstream of its 20-amino-acid leader sequence that permitted cotranslational protein s

261 highly hydrophobic, suggesting that it is a leader sequence that targets ACC2 for insertion into mem

262 ined for the mitochondrial matrix space have leader sequences that are typically present at the most

263 Bacterial mRNAs often contain leader sequences that respond to specific metabolites or

264 erestingly, insertion of H5N1 HA between the leader sequence, the de facto promoter of PIV5, and the

265 ein does not contain a typical mitochondrial leader sequence, the enzyme is shown to colocalize with

266 eterminant camG encodes a lipoprotein with a leader sequence, the last 7 residues of which represent

267 The leader sequences, the fibronectin-binding domains, and t

268 ccurrence and length distribution of spliced leader sequences, the functional landscape of encoded pr

269 at when using the Caulobacter crescentus rrn leader sequence, there was little effect on terminator r

270 ly present peptides derived from MHC class I leader sequences, thereby monitoring MHC class I express

271 nce was replaced with more typical bacterial leader sequences (those from the P. laminosum plastocyan

272 ne provides an m(7)G cap and a 39-nucleotide leader sequence to all cellular mRNAs via a trans-splici

273 cDNA and catalase cDNA with a mitochondrial leader sequence to allow comparison of the effectiveness

274 activity of DeltaCD79b depended on an intact leader sequence to ensure endoplasmic reticulum (ER) tra

275 y the ability of their N-terminal 80-residue leader sequence to guide a chimeric GFP protein to this

276 nucleic acid molecules as a model for the 5'-leader sequence to probe the propensity for generic sing

277 dance of transcripts encoding the tripartite leader sequence (TPL) of the major late promoter.

278 globulin gamma 1 heavy chain with its native leader sequence, transmembrane and intracellular domains

279 egulatory sequences (TRSs) located in the 5' leader sequence (TRS-L) and upstream of each structural

280 In the K-12 leader sequence, two in-frame translation initiation cod

281 RNA fragments corresponding to leader sequence upstream of 12S rRNA accumulate upon TbD

282 The mitochondrial leader sequence was also present in mouse and rat Grx2 s

283 Recombinant NDM-1 bearing its native leader sequence was expressed in Escherichia coli BL21 c

284 The leader sequence was removed from the N terminus of a 30-

285 When the region encoding the cytochrome f leader sequence was replaced with more typical bacterial

286 e translation efficiency of specific 5' mRNA leader sequences was compromised in an eif3h mutant, inc

287 covarying residues in two B. subtilis S box leader sequences was employed to test the hypothesis tha

288 n the other hand, M-L1, lacking the putative leader sequence, was localized in the cytoplasm of E. co

289 FL-L1, containing the putative leader sequence, was localized in the periplasm of Esche

290 els of GM-CSF and retained the native GM-CSF leader sequence, was selected for further analysis.

291 esults from mutations made within the native leader sequence were consistent between the in vitro and

292 s, only five of the newly discovered E. coli leader sequences were present in the genomes of other en

293 terioopsin precursors with partially cleaved leader sequences were seen in all mass spectra.

294 s based upon their possession of hydrophobic leader sequences which presumably target these proteins

295 is the template for the synthesis of the 5' leader sequence, which is found on both full-length and

296 nthetic oligonucleotides by replacing a pelB leader sequence with a gene 3 (g3) leader sequence and b

297 rcA and prtP genes contains a 5' hydrophobic leader sequence with a treponeme lipobox.

298 Soaks with a pre-tRNA 5' leader sequence with and without metal help to identify

299 he fepB transcript includes a 217-nucleotide leader sequence with several features suggestive of post

300 r magnitude but required, in addition to the leader, sequences within the first 100 nt of the coding