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1 erdependence of circuits and their host is a leading cause.
2                       Atherosclerosis is the leading cause for cardiovascular mortality.
3                               Cocaine is the leading cause for drug-abuse-related visits to emergency
4 e adverse effect from chemotherapy drug is a leading cause for the patients to fail in long term ther
5  of reduction in mortality and DALYs in many leading causes has largely levelled off since 2005.
6 251 patients), and hepatitis B virus was the leading cause in the other African countries (597 [55%]
7                                          The leading cause of acute illnesses, respiratory viruses, t
8      Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF) in the United
9                  Acetaminophen toxicity is a leading cause of acute liver failure (ALF).
10 tional misuse of acetaminophen (APAP) is the leading cause of acute liver failure in the Western worl
11 hology, namely infection and trauma, was the leading cause of admissions.
12       Ischemia-reperfusion injury (IRI) is a leading cause of AKI.
13 l fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure.
14                        Rejection remains the leading cause of allograft loss, and a major barrier to
15  caused by the loss of functional FMRP, is a leading cause of autism.
16 nfections caused by Staphylococcus aureus, a leading cause of bacterial endocarditis.
17 lla Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia
18  Campylobacter jejuni and C. coli, remains a leading cause of bacterial gastroenteritis in many count
19                      Campylobacter jejuni, a leading cause of bacterial gastroenteritis, is naturally
20                        Escherichia coli is a leading cause of bacterial mastitis in dairy cattle.
21 n meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular o
22       Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is
23  Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries.
24                              Cataract is the leading cause of blindness in developing countries and i
25                   Cataract still remains the leading cause of blindness in middle-income and low-inco
26      Age related macular degeneration is the leading cause of blindness in the developed world.
27                                Glaucoma is a leading cause of blindness that leads to characteristic
28                                Glaucoma is a leading cause of blindness worldwide, and is characteriz
29     Long-term treatment of glaucoma, a major leading cause of blindness, is challenging due to poor p
30                                Glaucoma is a leading cause of blindness, with an estimated world-wide
31 (IOP) is a major risk factor for glaucoma, a leading cause of blindness.
32                   Staphylococcus aureus is a leading cause of both nosocomial and community-acquired
33                      Tumor recurrence is the leading cause of breast cancer-related death.
34 cancer from a rare reportable disease to the leading cause of cancer death among men and women worldw
35 nt course, prostate cancer remains the third-leading cause of cancer death in men.
36                           Lung cancer is the leading cause of cancer death in the United States and m
37                           Lung cancer is the leading cause of cancer death in the United States in al
38                Prostate cancer is the second leading cause of cancer deaths in US men.
39 Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide largely due to
40                           Lung cancer is the leading cause of cancer deaths worldwide, with the major
41                           Lung cancer is the leading cause of cancer deaths.
42  for 85% of malignant lung tumors and is the leading cause of cancer deaths.
43         Colorectal cancer (CRC) is the third-leading cause of cancer mortality in the United States a
44                   Liver cancer is the second leading cause of cancer mortality worldwide, causing mor
45 hronic liver inflammation, is now the second leading cause of cancer mortality worldwide.
46 imary malignancy of the liver, is the second leading cause of cancer mortality worldwide.
47 Hepatocellular carcinoma (HCC) is the second leading cause of cancer related-death.
48                    As chemoresistance is the leading cause of cancer spread, progression, and mortali
49                Hepatocellular carcinoma is a leading cause of cancer-related death in Africa, but the
50                   Ovarian cancer is the most leading cause of cancer-related death in women .
51           Primary liver cancer is the second leading cause of cancer-related death worldwide and ther
52                        Lung carcinoma is the leading cause of cancer-related death worldwide, and amo
53 s for approximately 40% of lung cancers, the leading cause of cancer-related death worldwide, and cur
54          Gastric adenocarcinoma is the third leading cause of cancer-related death worldwide, but no
55          Colorectal cancer (CRC), the second leading cause of cancer-related deaths in the US, has be
56 Hepatocellular carcinoma (HCC) is the second-leading cause of cancer-related deaths worldwide with a
57  Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, mainly
58                           Lung cancer is the leading cause of cancer-related deaths, primarily due to
59                           Lung cancer is the leading cause of cancer-related mortality in the United
60            Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide.
61 Kaposi's sarcoma-associated herpesvirus is a leading cause of cancers in individuals with AIDS.
62            Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairm
63      Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti-V
64       Respiratory syncytial virus (RSV) is a leading cause of childhood bronchiolitis and pneumonia,
65                    Neonatal infections are a leading cause of childhood mortality in low-resource set
66 he kidneys and urinary tract (CAKUT) are the leading cause of CKD in children, featuring a broad vari
67                  Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients
68                             Norovirus is the leading cause of community-acquired and nosocomial acute
69 ococcus pneumoniae (the pneumococcus) is the leading cause of community-acquired pneumonia and is now
70 ticipation sport in US high schools and is a leading cause of concussion among adolescents.
71 over, chronic OM with effusion (COME) is the leading cause of conductive hearing loss.
72 diverse field strains.IMPORTANCE HCMV is the leading cause of congenital viral infection, and develop
73          Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and develop
74  NF-kappaB and STAT3 signalling could be the leading cause of DC dysfunction in cancer.
75                        Suicide is the second leading cause of death among adolescents between the age
76                        Ovarian cancer is the leading cause of death among all gynecological malignanc
77                         Cancer is the second leading cause of death among American Indians and Alaska
78            Cardiovascular disease (CVD) is a leading cause of death among chronic diseases worldwide.
79                  Cardiovascular disease is a leading cause of death among incarcerated individuals, a
80   Group B streptococcus (GBS) infection is a leading cause of death among newborns in developed count
81  & AIMS: Cardiovascular disease (CVD) is the leading cause of death among patients with nonalcoholic
82 TATEMENT Traumatic brain injury (TBI) is the leading cause of death and disability around the world a
83 oke is one of the most common diseases and a leading cause of death and disability.
84                                  Sepsis is a leading cause of death and is the most expensive conditi
85 scular disease exceeded breast cancer as the leading cause of death at 10 years after diagnosis, when
86 )-associated uterine cervical SCC, the third-leading cause of death by cancer in women, is unknown.
87 se life-threatening complications and is the leading cause of death by cardiovascular disease.
88                            Metastasis is the leading cause of death for cancer patients.
89                   Abusive head trauma is the leading cause of death from physical abuse.
90                    Infectious diseases are a leading cause of death globally.
91                    Heart disease remains the leading cause of death globally.
92 ed by reduced lung function and is the third leading cause of death globally.
93              Cardiovascular diseases are the leading cause of death globally; fortunately, 90% of car
94                     Skeletal metastases, the leading cause of death in advanced breast cancer patient
95                            Metastasis is the leading cause of death in cancer patients, and successfu
96 Cystic fibrosis (CF) liver disease (CFLD), a leading cause of death in CF, is mostly described in ped
97                  Tuberculosis (TB) remains a leading cause of death in children globally.
98       Despite mass vaccination, it remains a leading cause of death in children in developing regions
99               Dystrophic cardiomyopathy is a leading cause of death in Duchenne muscular dystrophy pa
100               Epithelial ovarian cancer is a leading cause of death in gynecological cancers.
101              Tuberculosis (TB) is the fourth leading cause of death in Indonesia.
102     Sudden infant death syndrome remains the leading cause of death in infants aged 1 month to 1 year
103 ATIONALE: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial
104        Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis.
105                            Metastasis is the leading cause of death in people with lung cancer, yet t
106                       Neurodegeneration is a leading cause of death in the developed world and a natu
107                 Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facil
108 80 to 2014, cardiovascular diseases were the leading cause of death in the United States, although th
109                                  Sepsis is a leading cause of death in the United States, but the mec
110 d contributes to cardiovascular disease, the leading cause of death in the United States.
111  Atherosclerotic cardiovascular disease is a leading cause of death in the western world.
112 ctive pulmonary disease (COPD) is the fourth leading cause of death today.
113 ying etiology of cardiovascular disease, the leading cause of death worldwide.
114 rn countries and liver cirrhosis is the 12th leading cause of death worldwide.
115 sability in the United States and the second leading cause of death worldwide.
116 ses the risk of coronary artery disease, the leading cause of death worldwide.
117                                 Suicide is a leading cause of deaths in the United States.
118                    Macular edema (ME) is the leading cause of decreased visual acuity (VA) associated
119    Vibrio cholerae causes cholera and is the leading cause of diarrhea in developing countries, highl
120 genicity in mice.IMPORTANCE Rotavirus is the leading cause of diarrhea in humans.
121                        Rotavirus (RV) is the leading cause of diarrhea-related death in children worl
122                    Shigella infections are a leading cause of diarrhoeal death among children in low-
123 order and major depressive disorder, are the leading cause of disability worldwide and pose a major c
124 ing mortality, skin diseases were the fourth leading cause of disability worldwide.
125                 Osteoporotic fractures are a leading cause of disability, costs, and mortality.
126         Major depressive disorder (MDD) is a leading cause of disease burden worldwide.
127                              Depression is a leading cause of disease burden, yet current therapies f
128   Drug-induced liver injury (DILI) remains a leading cause of drug withdrawal from human clinical tri
129 sease in many developed countries and is the leading cause of enteric disease in Australia.
130               Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis
131 IMPORTANCE Human noroviruses (HNoVs) are the leading cause of epidemic gastroenteritis worldwide.
132                              Diabetes is the leading cause of ESRD.
133              Cardiovascular diseases are the leading cause of fatalities in the United States.
134                  Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis wit
135                        Campylobacteriosis, a leading cause of foodborne illness in the United States,
136                      Candida albicans is the leading cause of fungal infections; yet, complex genetic
137            Agricultural intensification is a leading cause of global biodiversity loss, which can red
138                            Tuberculosis is a leading cause of global childhood mortality; however, in
139 Skin and subcutaneous diseases were the 18th leading cause of global DALYs in Global Burden of Diseas
140                   Bipolar disorder (BD) is a leading cause of global disability.
141 disorder (MDD) is predicted to be the second leading cause of global disease burden by 2030.
142 ucing cardiovascular disease and combating a leading cause of global morbidity and mortality.
143 s (BKV)-associated nephropathy is the second leading cause of graft loss in kidney transplant recipie
144 e protozoan parasite Trypanosoma cruzi, is a leading cause of heart disease ("chagasic cardiomyopathy
145              Myocardial infarction (MI) is a leading cause of heart failure and death worldwide.
146  left ventricular hypertrophy (HTN-LVH) is a leading cause of heart failure.
147                    Hepatitis C virus was the leading cause of hepatocellular carcinoma in Egypt (1054
148 rative diseases, which together constitute a leading cause of hereditary blindness worldwide, are lar
149       Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is media
150                     Enterococcus faecalis, a leading cause of hospital-acquired infections, exhibits
151  pneumoniae is an opportunistic pathogen and leading cause of hospital-associated infections.
152                   Acute bronchiolitis is the leading cause of hospitalization among infants.
153 plication of sickle cell disease (SCD) and a leading cause of hospitalization and death in both child
154 lished therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide
155                         Picornaviruses are a leading cause of human and veterinary infections that re
156 have transitioned from a rare curiosity to a leading cause of human mortality.
157 aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis.
158 espiratory syncytial virus (RSV) is a global leading cause of infant mortality and adult morbidity.
159               Spontaneous preterm birth is a leading cause of infant mortality.
160                 Staphylococcus aureus is the leading cause of infection in the setting of critical il
161                 Chlamydia trachomatis is the leading cause of infection-induced infertility in women.
162 ) is a neurodevelopmental disorder that is a leading cause of inherited intellectual disability, and
163 n genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies.
164                              Suicide was the leading cause of injury deaths in individuals aged 15-24
165 agalactiae (group B Streptococcus, GBS) is a leading cause of invasive bacterial infections in newbor
166                Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially
167  Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among the elderl
168 overy of genes contributing to glaucoma, the leading cause of irreversible blindness world-wide.
169                              Glaucoma is the leading cause of irreversible blindness worldwide.
170 ge-related macular degeneration (AMD) is the leading cause of irreversible vision impairment in older
171      Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, wit
172  Age-related macular degeneration (AMD) is a leading cause of irreversible, severe vision loss in Wes
173 Late antibody-mediated rejection (ABMR) is a leading cause of kidney allograft failure.
174 on may play a role in Alzheimer disease, the leading cause of late-life dementia.
175 quent inherited ocular disorder and the most leading cause of lifelong visual loss.
176 V vaccines.IMPORTANCE Hepatitis C virus is a leading cause of liver disease and liver cancer, with ap
177  infarcts.SIGNIFICANCE STATEMENT Stroke is a leading cause of long-term disability.
178            Traumatic brain injury (TBI) is a leading cause of long-term neurological disability, yet
179 man respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in t
180                Prostate cancer is the second leading cause of male cancer deaths due to disease progr
181 ffects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death.
182                             It is the second leading cause of maternal mortality worldwide and may le
183 ATIONALE: Hypertension during pregnancy is a leading cause of maternal mortality.
184        PPCM affects women worldwide and is a leading cause of maternal mortality.
185                        B12 deficiency is the leading cause of megaloblastic anemia, and although more
186 dition, increased unmeasured anions were the leading cause of metabolic acidosis.
187 on at day 30, while infection/ sepsis is the leading cause of mid-term mortality.
188                         Cryptosporidium is a leading cause of moderate to severe childhood diarrhea i
189            Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a consid
190 iac allograft vasculopathy (CAV) remains the leading cause of morbidity and mortality after orthotopi
191                           Liver disease is a leading cause of morbidity and mortality among people wi
192  (NAFLD); and alcoholic liver disease, are a leading cause of morbidity and mortality globally.
193                               Pneumonia is a leading cause of morbidity and mortality in children.
194 nic bacterial infections of the lung are the leading cause of morbidity and mortality in cystic fibro
195                Cardiovascular disease is the leading cause of morbidity and mortality in patients wit
196                 Bloodstream infections are a leading cause of morbidity and mortality in the United S
197                    Introduction: Cancer is a leading cause of morbidity and mortality in the United S
198  the central nervous system (CNS), and are a leading cause of morbidity and mortality in VHL disease.
199        Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide, desp
200 s chronic bronchitis and emphysema, and is a leading cause of morbidity and mortality.
201 d-borne infection in the United States and a leading cause of morbidity and mortality.
202 fects more than 10.4 million people, being a leading cause of morbidity by infection.
203 rdiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (
204 of ventricular arrhythmias (VAs), and is the leading cause of mortality among atrial fibrillation (AF
205 Within the cohort, 32 patients died with the leading cause of mortality cancer (25%), infectious comp
206        Congenital heart disease (CHD) is the leading cause of mortality from birth defects.
207            Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport.
208                                          The leading cause of mortality in HFpEF is sudden death, but
209 ctor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide.
210 ic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
211                     Preterm birth (PTB) is a leading cause of neonatal death worldwide.
212 ibiotic prophylaxis, this pathogen remains a leading cause of neonatal infection.
213                   Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality.
214  developed world, extreme prematurity is the leading cause of neonatal mortality and morbidity due to
215                   Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with
216                         Preterm birth is the leading cause of neonatal mortality, and is frequently a
217                   Preterm birth (PTB) is the leading cause of neonatal mortality, and surviving infan
218 ed prediction in infants born prematurely, a leading cause of neuro-cognitive impairment worldwide [7
219  matter injury (DWMI) caused by hypoxia is a leading cause of neurological deficits following prematu
220 atic brain injury (TBI) is set to become the leading cause of neurological disability across all age
221 eatic allograft thrombosis (PAT) remains the leading cause of nonimmunologic graft failure.
222 e GII.17 cluster IIIb strains emerged as the leading cause of norovirus infection in select global lo
223 -resistant Enterococcus faecium (VREfm) is a leading cause of nosocomial infection.
224              Noise-induced hearing loss is a leading cause of occupational and recreational injury an
225 ccus pneumoniae (the pneumococcus) remains a leading cause of otitis media, a significant public heal
226 e protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly
227                      Perianal fistulas are a leading cause of patient morbidity because closure often
228 man respiratory syncytial virus (RSV) is the leading cause of pediatric bronchiolitis and hospitaliza
229                                   Although a leading cause of pediatric diarrhea, human astroviruses
230      Community-acquired pneumonia (CAP) is a leading cause of pediatric hospitalization.
231 al circumcision complicated by gangrene is a leading cause of penile loss in young men in South Afric
232 toperative pulmonary complications (PPCs), a leading cause of poor surgical outcomes, are heterogeneo
233     Sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality, likely c
234           Rheumatic heart disease (RHD) is a leading cause of premature death and disability in low-i
235                               Smoking is the leading cause of preventable death in the United States
236                     Cigarette smoking is the leading cause of preventable death worldwide and has bee
237                       Cigarette smoking is a leading cause of preventable mortality worldwide.
238   Recurrent hepatic encephalopathy (HE) is a leading cause of readmission despite standard of care (S
239            Neurocognitive dysfunction is the leading cause of reduced quality of life in long-term su
240    Unresponsive neovascular glaucoma was the leading cause of secondary enucleation in 78 of the 2499
241                                 Rotavirus, a leading cause of severe gastroenteritis and diarrhoea in
242 nteropathogenic Escherichia coli (EPEC) is a leading cause of severe intestinal disease and infant mo
243                 Staphylococcus aureus is the leading cause of skin and skin structure infections (SSS
244                 Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs)
245      Exposure to the sun's UV radiation is a leading cause of skin cancer.
246 olymorphic ventricular tachycardia (CPVT), a leading cause of sudden death in apparently healthy indi
247 sequent loss of protein homeostasis may be a leading cause of synaptic dysfunction.
248                                          The leading cause of synthetic graft failure includes thromb
249 agents in humans worldwide and represent the leading cause of upper respiratory tract infections.
250 sive pneumococcal diseases (IPDs) remain the leading cause of vaccine-preventable childhood death, ev
251       Human astroviruses are recognized as a leading cause of viral diarrhea worldwide in children, i
252                         Human norovirus is a leading cause of viral gastroenteritis worldwide.
253 therapeutics, diabetic retinopathy remains a leading cause of vision impairment.
254                         Macular edema is the leading cause of vision loss in bilateral chronic noninf
255 permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as
256 ntial for photoreceptor survival, and is the leading cause of vision loss in the elderly.
257         Alkali burns to the eye constitute a leading cause of worldwide blindness.
258                         Atherosclerosis is a leading cause of worldwide morbidity and mortality whose
259 ance of excitation/inhibition are one of the leading causes of abnormal sensory processing in Fragile
260      Retinal vascular diseases are among the leading causes of acquired blindness.
261 atory, and related disorders (CVRDs) are the leading causes of adult death worldwide, and substantial
262 eningitidis serogroups A and X are among the leading causes of bacterial meningitis in the African me
263        Retinal degenerative diseases are the leading causes of blindness worldwide.
264 iabetic retinopathy (DR) which is one of the leading causes of blindness, especially in developing co
265 n males in the United States and amongst the leading causes of cancer related deaths.
266  and other congenital abnormalities were the leading causes of childhood vision impairment in childre
267 of the US population, and they are among the leading causes of death and disability.
268               Age-related conditions are the leading causes of death and health-care costs.
269  (severe sepsis and septic shock), which are leading causes of death in intensive care units, are sti
270                             Cancer is one of leading causes of death in the world and occurs in more
271                             Cancer remains a leading causes of death worldwide and an elevated system
272 ependence (AD) and major depression (MD) are leading causes of disability that often co-occur.
273                             It is one of the leading causes of enteric disease in many developed coun
274 tococcus and respiratory syncytial virus are leading causes of infant morbidity and mortality worldwi
275 oxazole preventive therapy (CPT) in reducing leading causes of infectious morbidity is unclear.
276 osttransplant malignancy (PTM) is one of the leading causes of late death in kidney recipients.
277    Group B streptococci (GBS) are one of the leading causes of life-threatening illness in neonates.
278        Hepatitis C virus (HCV) is one of the leading causes of liver diseases and transplantation wor
279  Respiratory tract infections are one of the leading causes of mortality worldwide urging better unde
280 RATIONALE: Atherosclerosis and aneurysms are leading causes of mortality worldwide.
281 monary diseases, which represent some of the leading causes of mortality worldwide.
282 CKGROUND DATA: Injuries represent one of the leading causes of mortality, disability, and health care
283               Candida species are one of the leading causes of nosocomial infections.
284      Diabetic retinopathy (DR) is one of the leading causes of preventable blindness globally.
285 art disease, stroke, and type 2 diabetes are leading causes of preventable death.
286                 Poor lifestyle behaviors are leading causes of preventable diseases globally.
287 stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often le
288          Pseudomonas aeruginosa is among the leading causes of severe nosocomial infections, particul
289 ) Motor vehicle crashes and falls were the 2 leading causes of TBI mortality between 2006 and 2013.
290 nt gap for alcohol use disorders, one of the leading causes of the global burden among men worldwide.
291                                          The leading causes of under-5 mortality in 2015 were congeni
292         Diabetic macular edema is one of the leading causes of vision loss among working-age adults i
293                                          The leading causes of vision loss were cataract (19.7%), cor
294               In Indigenous Australians, the leading causes of vision loss were uncorrected refractiv
295                                          The leading causes of vision loss were uncorrected refractiv
296           In non-Indigenous Australians, the leading causes of vision loss were uncorrected refractiv
297 tive environmental quality and all-cause and leading cause-specific (heart disease, cancer, and strok
298 million [12.9 million to 65.4 million]), the leading causes were cataract (12.6 million [3.4 million
299 nterval 98.5 million to 359.1 million]), the leading causes were uncorrected refractive error (116.3
300        Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis.

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