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1 ance of excitation/inhibition are one of the leading causes of abnormal sensory processing in Fragile
2      Retinal vascular diseases are among the leading causes of acquired blindness.
3                                          The leading cause of acute illnesses, respiratory viruses, t
4      Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF) in the United
5                  Acetaminophen toxicity is a leading cause of acute liver failure (ALF).
6 tional misuse of acetaminophen (APAP) is the leading cause of acute liver failure in the Western worl
7 hology, namely infection and trauma, was the leading cause of admissions.
8 atory, and related disorders (CVRDs) are the leading causes of adult death worldwide, and substantial
9       Ischemia-reperfusion injury (IRI) is a leading cause of AKI.
10 l fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure.
11                        Rejection remains the leading cause of allograft loss, and a major barrier to
12  caused by the loss of functional FMRP, is a leading cause of autism.
13 nfections caused by Staphylococcus aureus, a leading cause of bacterial endocarditis.
14 lla Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia
15  Campylobacter jejuni and C. coli, remains a leading cause of bacterial gastroenteritis in many count
16                      Campylobacter jejuni, a leading cause of bacterial gastroenteritis, is naturally
17                        Escherichia coli is a leading cause of bacterial mastitis in dairy cattle.
18              Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infectio
19 eningitidis serogroups A and X are among the leading causes of bacterial meningitis in the African me
20 n meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular o
21       Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is
22  Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries.
23                              Cataract is the leading cause of blindness in developing countries and i
24                   Cataract still remains the leading cause of blindness in middle-income and low-inco
25      Age related macular degeneration is the leading cause of blindness in the developed world.
26                                Glaucoma is a leading cause of blindness that leads to characteristic
27                                Glaucoma is a leading cause of blindness worldwide, and is characteriz
28     Long-term treatment of glaucoma, a major leading cause of blindness, is challenging due to poor p
29                                Glaucoma is a leading cause of blindness, with an estimated world-wide
30 (IOP) is a major risk factor for glaucoma, a leading cause of blindness.
31 uses cold sores and neonatal herpes and is a leading cause of blindness.
32        Retinal degenerative diseases are the leading causes of blindness worldwide.
33 iabetic retinopathy (DR) which is one of the leading causes of blindness, especially in developing co
34                   Staphylococcus aureus is a leading cause of both nosocomial and community-acquired
35                      Tumor recurrence is the leading cause of breast cancer-related death.
36 cancer from a rare reportable disease to the leading cause of cancer death among men and women worldw
37 nt course, prostate cancer remains the third-leading cause of cancer death in men.
38                           Lung cancer is the leading cause of cancer death in the United States and m
39                           Lung cancer is the leading cause of cancer death in the United States in al
40                Prostate cancer is the second leading cause of cancer deaths in US men.
41 Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide largely due to
42                           Lung cancer is the leading cause of cancer deaths worldwide, with the major
43                           Lung cancer is the leading cause of cancer deaths.
44  for 85% of malignant lung tumors and is the leading cause of cancer deaths.
45         Colorectal cancer (CRC) is the third-leading cause of cancer mortality in the United States a
46                   Liver cancer is the second leading cause of cancer mortality worldwide, causing mor
47 hronic liver inflammation, is now the second leading cause of cancer mortality worldwide.
48 imary malignancy of the liver, is the second leading cause of cancer mortality worldwide.
49 Hepatocellular carcinoma (HCC) is the second leading cause of cancer related-death.
50                    As chemoresistance is the leading cause of cancer spread, progression, and mortali
51                Hepatocellular carcinoma is a leading cause of cancer-related death in Africa, but the
52                   Ovarian cancer is the most leading cause of cancer-related death in women .
53           Primary liver cancer is the second leading cause of cancer-related death worldwide and ther
54                        Lung carcinoma is the leading cause of cancer-related death worldwide, and amo
55 s for approximately 40% of lung cancers, the leading cause of cancer-related death worldwide, and cur
56          Gastric adenocarcinoma is the third leading cause of cancer-related death worldwide, but no
57          Colorectal cancer (CRC), the second leading cause of cancer-related deaths in the US, has be
58 Hepatocellular carcinoma (HCC) is the second-leading cause of cancer-related deaths worldwide with a
59  Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, mainly
60                           Lung cancer is the leading cause of cancer-related deaths, primarily due to
61                           Lung cancer is the leading cause of cancer-related mortality in the United
62            Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide.
63 n males in the United States and amongst the leading causes of cancer related deaths.
64 Kaposi's sarcoma-associated herpesvirus is a leading cause of cancers in individuals with AIDS.
65 ed basis for venous thromboembolism (VTE), a leading cause of cardiovascular mortality.
66            Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairm
67      Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti-V
68       Respiratory syncytial virus (RSV) is a leading cause of childhood bronchiolitis and pneumonia,
69                    Neonatal infections are a leading cause of childhood mortality in low-resource set
70  and other congenital abnormalities were the leading causes of childhood vision impairment in childre
71 he kidneys and urinary tract (CAKUT) are the leading cause of CKD in children, featuring a broad vari
72                  Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients
73                             Norovirus is the leading cause of community-acquired and nosocomial acute
74 ococcus pneumoniae (the pneumococcus) is the leading cause of community-acquired pneumonia and is now
75 ticipation sport in US high schools and is a leading cause of concussion among adolescents.
76 over, chronic OM with effusion (COME) is the leading cause of conductive hearing loss.
77 diverse field strains.IMPORTANCE HCMV is the leading cause of congenital viral infection, and develop
78          Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and develop
79  NF-kappaB and STAT3 signalling could be the leading cause of DC dysfunction in cancer.
80                        Suicide is the second leading cause of death among adolescents between the age
81                        Ovarian cancer is the leading cause of death among all gynecological malignanc
82                         Cancer is the second leading cause of death among American Indians and Alaska
83            Cardiovascular disease (CVD) is a leading cause of death among chronic diseases worldwide.
84        Opportunistic fungal infections are a leading cause of death among immune-compromised patients
85                  Cardiovascular disease is a leading cause of death among incarcerated individuals, a
86   Group B streptococcus (GBS) infection is a leading cause of death among newborns in developed count
87  & AIMS: Cardiovascular disease (CVD) is the leading cause of death among patients with nonalcoholic
88 TATEMENT Traumatic brain injury (TBI) is the leading cause of death and disability around the world a
89 oke is one of the most common diseases and a leading cause of death and disability.
90                                  Sepsis is a leading cause of death and is the most expensive conditi
91 scular disease exceeded breast cancer as the leading cause of death at 10 years after diagnosis, when
92 )-associated uterine cervical SCC, the third-leading cause of death by cancer in women, is unknown.
93 se life-threatening complications and is the leading cause of death by cardiovascular disease.
94                            Metastasis is the leading cause of death for cancer patients.
95                   Abusive head trauma is the leading cause of death from physical abuse.
96                    Infectious diseases are a leading cause of death globally.
97                    Heart disease remains the leading cause of death globally.
98 ed by reduced lung function and is the third leading cause of death globally.
99              Cardiovascular diseases are the leading cause of death globally; fortunately, 90% of car
100                     Skeletal metastases, the leading cause of death in advanced breast cancer patient
101                            Metastasis is the leading cause of death in cancer patients, and successfu
102 Cystic fibrosis (CF) liver disease (CFLD), a leading cause of death in CF, is mostly described in ped
103                  Tuberculosis (TB) remains a leading cause of death in children globally.
104       Despite mass vaccination, it remains a leading cause of death in children in developing regions
105               Dystrophic cardiomyopathy is a leading cause of death in Duchenne muscular dystrophy pa
106               Epithelial ovarian cancer is a leading cause of death in gynecological cancers.
107              Tuberculosis (TB) is the fourth leading cause of death in Indonesia.
108     Sudden infant death syndrome remains the leading cause of death in infants aged 1 month to 1 year
109 ATIONALE: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial
110        Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis.
111                            Metastasis is the leading cause of death in people with lung cancer, yet t
112                       Neurodegeneration is a leading cause of death in the developed world and a natu
113                 Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facil
114 a.SIGNIFICANCE STATEMENT Stroke is the fifth leading cause of death in the United States and is a lea
115 80 to 2014, cardiovascular diseases were the leading cause of death in the United States, although th
116                                  Sepsis is a leading cause of death in the United States, but the mec
117 d contributes to cardiovascular disease, the leading cause of death in the United States.
118  Atherosclerotic cardiovascular disease is a leading cause of death in the western world.
119        Maternal complications were the third leading cause of death in women of reproductive age in K
120 ctive pulmonary disease (COPD) is the fourth leading cause of death today.
121 ying etiology of cardiovascular disease, the leading cause of death worldwide.
122 rn countries and liver cirrhosis is the 12th leading cause of death worldwide.
123 sability in the United States and the second leading cause of death worldwide.
124 ses the risk of coronary artery disease, the leading cause of death worldwide.
125 of the US population, and they are among the leading causes of death and disability.
126               Age-related conditions are the leading causes of death and health-care costs.
127  (severe sepsis and septic shock), which are leading causes of death in intensive care units, are sti
128                             Cancer is one of leading causes of death in the world and occurs in more
129                             Cancer remains a leading causes of death worldwide and an elevated system
130                                 Suicide is a leading cause of deaths in the United States.
131                    Macular edema (ME) is the leading cause of decreased visual acuity (VA) associated
132    Vibrio cholerae causes cholera and is the leading cause of diarrhea in developing countries, highl
133 genicity in mice.IMPORTANCE Rotavirus is the leading cause of diarrhea in humans.
134                        Rotavirus (RV) is the leading cause of diarrhea-related death in children worl
135                    Shigella infections are a leading cause of diarrhoeal death among children in low-
136 order and major depressive disorder, are the leading cause of disability worldwide and pose a major c
137 ing mortality, skin diseases were the fourth leading cause of disability worldwide.
138                 Osteoporotic fractures are a leading cause of disability, costs, and mortality.
139 ependence (AD) and major depression (MD) are leading causes of disability that often co-occur.
140         Major depressive disorder (MDD) is a leading cause of disease burden worldwide.
141                              Depression is a leading cause of disease burden, yet current therapies f
142   Drug-induced liver injury (DILI) remains a leading cause of drug withdrawal from human clinical tri
143 sease in many developed countries and is the leading cause of enteric disease in Australia.
144                             It is one of the leading causes of enteric disease in many developed coun
145               Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis
146 IMPORTANCE Human noroviruses (HNoVs) are the leading cause of epidemic gastroenteritis worldwide.
147                              Diabetes is the leading cause of ESRD.
148              Cardiovascular diseases are the leading cause of fatalities in the United States.
149                  Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis wit
150                        Campylobacteriosis, a leading cause of foodborne illness in the United States,
151                      Candida albicans is the leading cause of fungal infections; yet, complex genetic
152            Agricultural intensification is a leading cause of global biodiversity loss, which can red
153                            Tuberculosis is a leading cause of global childhood mortality; however, in
154 Skin and subcutaneous diseases were the 18th leading cause of global DALYs in Global Burden of Diseas
155                   Bipolar disorder (BD) is a leading cause of global disability.
156 disorder (MDD) is predicted to be the second leading cause of global disease burden by 2030.
157 ucing cardiovascular disease and combating a leading cause of global morbidity and mortality.
158 s (BKV)-associated nephropathy is the second leading cause of graft loss in kidney transplant recipie
159 e protozoan parasite Trypanosoma cruzi, is a leading cause of heart disease ("chagasic cardiomyopathy
160              Myocardial infarction (MI) is a leading cause of heart failure and death worldwide.
161  left ventricular hypertrophy (HTN-LVH) is a leading cause of heart failure.
162                    Hepatitis C virus was the leading cause of hepatocellular carcinoma in Egypt (1054
163 rative diseases, which together constitute a leading cause of hereditary blindness worldwide, are lar
164       Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is media
165                     Enterococcus faecalis, a leading cause of hospital-acquired infections, exhibits
166  pneumoniae is an opportunistic pathogen and leading cause of hospital-associated infections.
167                   Acute bronchiolitis is the leading cause of hospitalization among infants.
168 plication of sickle cell disease (SCD) and a leading cause of hospitalization and death in both child
169 lished therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide
170                         Picornaviruses are a leading cause of human and veterinary infections that re
171 have transitioned from a rare curiosity to a leading cause of human mortality.
172 aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis.
173          Cardiovascular disease (CVD) is the leading cause of increased mortality in patients with CK
174 espiratory syncytial virus (RSV) is a global leading cause of infant mortality and adult morbidity.
175               Spontaneous preterm birth is a leading cause of infant mortality.
176 tococcus and respiratory syncytial virus are leading causes of infant morbidity and mortality worldwi
177                 Staphylococcus aureus is the leading cause of infection in the setting of critical il
178                 Chlamydia trachomatis is the leading cause of infection-induced infertility in women.
179                    Tuberculosis disease is a leading cause of infectious disease morbidity and mortal
180 oxazole preventive therapy (CPT) in reducing leading causes of infectious morbidity is unclear.
181 ) is a neurodevelopmental disorder that is a leading cause of inherited intellectual disability, and
182 n genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies.
183                              Suicide was the leading cause of injury deaths in individuals aged 15-24
184 agalactiae (group B Streptococcus, GBS) is a leading cause of invasive bacterial infections in newbor
185                Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially
186  Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among the elderl
187 overy of genes contributing to glaucoma, the leading cause of irreversible blindness world-wide.
188                              Glaucoma is the leading cause of irreversible blindness worldwide.
189 ge-related macular degeneration (AMD) is the leading cause of irreversible vision impairment in older
190      Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, wit
191  Age-related macular degeneration (AMD) is a leading cause of irreversible, severe vision loss in Wes
192 Late antibody-mediated rejection (ABMR) is a leading cause of kidney allograft failure.
193 on may play a role in Alzheimer disease, the leading cause of late-life dementia.
194 osttransplant malignancy (PTM) is one of the leading causes of late death in kidney recipients.
195    Group B streptococci (GBS) are one of the leading causes of life-threatening illness in neonates.
196 quent inherited ocular disorder and the most leading cause of lifelong visual loss.
197 V vaccines.IMPORTANCE Hepatitis C virus is a leading cause of liver disease and liver cancer, with ap
198        Hepatitis C virus (HCV) is one of the leading causes of liver diseases and transplantation wor
199  infarcts.SIGNIFICANCE STATEMENT Stroke is a leading cause of long-term disability.
200            Traumatic brain injury (TBI) is a leading cause of long-term neurological disability, yet
201 man respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in t
202                Prostate cancer is the second leading cause of male cancer deaths due to disease progr
203 ffects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death.
204                             It is the second leading cause of maternal mortality worldwide and may le
205 ATIONALE: Hypertension during pregnancy is a leading cause of maternal mortality.
206        PPCM affects women worldwide and is a leading cause of maternal mortality.
207                        B12 deficiency is the leading cause of megaloblastic anemia, and although more
208 dition, increased unmeasured anions were the leading cause of metabolic acidosis.
209 on at day 30, while infection/ sepsis is the leading cause of mid-term mortality.
210                         Cryptosporidium is a leading cause of moderate to severe childhood diarrhea i
211            Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a consid
212 iac allograft vasculopathy (CAV) remains the leading cause of morbidity and mortality after orthotopi
213                           Liver disease is a leading cause of morbidity and mortality among people wi
214  (NAFLD); and alcoholic liver disease, are a leading cause of morbidity and mortality globally.
215                               Pneumonia is a leading cause of morbidity and mortality in children.
216 nic bacterial infections of the lung are the leading cause of morbidity and mortality in cystic fibro
217                Cardiovascular disease is the leading cause of morbidity and mortality in patients wit
218                 Bloodstream infections are a leading cause of morbidity and mortality in the United S
219                    Introduction: Cancer is a leading cause of morbidity and mortality in the United S
220  the central nervous system (CNS), and are a leading cause of morbidity and mortality in VHL disease.
221        Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide, desp
222 s chronic bronchitis and emphysema, and is a leading cause of morbidity and mortality.
223 d-borne infection in the United States and a leading cause of morbidity and mortality.
224 fects more than 10.4 million people, being a leading cause of morbidity by infection.
225 rdiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (
226 of ventricular arrhythmias (VAs), and is the leading cause of mortality among atrial fibrillation (AF
227 Within the cohort, 32 patients died with the leading cause of mortality cancer (25%), infectious comp
228        Congenital heart disease (CHD) is the leading cause of mortality from birth defects.
229            Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport.
230                                          The leading cause of mortality in HFpEF is sudden death, but
231 ctor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide.
232 ic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
233  Respiratory tract infections are one of the leading causes of mortality worldwide urging better unde
234 RATIONALE: Atherosclerosis and aneurysms are leading causes of mortality worldwide.
235 monary diseases, which represent some of the leading causes of mortality worldwide.
236 CKGROUND DATA: Injuries represent one of the leading causes of mortality, disability, and health care
237                     Preterm birth (PTB) is a leading cause of neonatal death worldwide.
238 ibiotic prophylaxis, this pathogen remains a leading cause of neonatal infection.
239                   Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality.
240  developed world, extreme prematurity is the leading cause of neonatal mortality and morbidity due to
241                   Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with
242                         Preterm birth is the leading cause of neonatal mortality, and is frequently a
243                   Preterm birth (PTB) is the leading cause of neonatal mortality, and surviving infan
244 ed prediction in infants born prematurely, a leading cause of neuro-cognitive impairment worldwide [7
245  matter injury (DWMI) caused by hypoxia is a leading cause of neurological deficits following prematu
246 atic brain injury (TBI) is set to become the leading cause of neurological disability across all age
247 eatic allograft thrombosis (PAT) remains the leading cause of nonimmunologic graft failure.
248 e GII.17 cluster IIIb strains emerged as the leading cause of norovirus infection in select global lo
249 -resistant Enterococcus faecium (VREfm) is a leading cause of nosocomial infection.
250               Candida species are one of the leading causes of nosocomial infections.
251              Noise-induced hearing loss is a leading cause of occupational and recreational injury an
252 ccus pneumoniae (the pneumococcus) remains a leading cause of otitis media, a significant public heal
253 e protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly
254                      Perianal fistulas are a leading cause of patient morbidity because closure often
255 man respiratory syncytial virus (RSV) is the leading cause of pediatric bronchiolitis and hospitaliza
256                                   Although a leading cause of pediatric diarrhea, human astroviruses
257      Community-acquired pneumonia (CAP) is a leading cause of pediatric hospitalization.
258 al circumcision complicated by gangrene is a leading cause of penile loss in young men in South Afric
259 toperative pulmonary complications (PPCs), a leading cause of poor surgical outcomes, are heterogeneo
260     Sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality, likely c
261           Rheumatic heart disease (RHD) is a leading cause of premature death and disability in low-i
262                               Smoking is the leading cause of preventable death in the United States
263                     Cigarette smoking is the leading cause of preventable death worldwide and has bee
264                       Cigarette smoking is a leading cause of preventable mortality worldwide.
265      Diabetic retinopathy (DR) is one of the leading causes of preventable blindness globally.
266 art disease, stroke, and type 2 diabetes are leading causes of preventable death.
267                 Poor lifestyle behaviors are leading causes of preventable diseases globally.
268   Recurrent hepatic encephalopathy (HE) is a leading cause of readmission despite standard of care (S
269            Neurocognitive dysfunction is the leading cause of reduced quality of life in long-term su
270    Unresponsive neovascular glaucoma was the leading cause of secondary enucleation in 78 of the 2499
271 cause of death in the United States and is a leading cause of serious long-term disability worldwide.
272 stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often le
273                                 Rotavirus, a leading cause of severe gastroenteritis and diarrhoea in
274 nteropathogenic Escherichia coli (EPEC) is a leading cause of severe intestinal disease and infant mo
275          Pseudomonas aeruginosa is among the leading causes of severe nosocomial infections, particul
276                 Staphylococcus aureus is the leading cause of skin and skin structure infections (SSS
277                 Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs)
278      Exposure to the sun's UV radiation is a leading cause of skin cancer.
279 olymorphic ventricular tachycardia (CPVT), a leading cause of sudden death in apparently healthy indi
280 sequent loss of protein homeostasis may be a leading cause of synaptic dysfunction.
281                                          The leading cause of synthetic graft failure includes thromb
282 ) Motor vehicle crashes and falls were the 2 leading causes of TBI mortality between 2006 and 2013.
283 nt gap for alcohol use disorders, one of the leading causes of the global burden among men worldwide.
284                                          The leading causes of under-5 mortality in 2015 were congeni
285 agents in humans worldwide and represent the leading cause of upper respiratory tract infections.
286 sive pneumococcal diseases (IPDs) remain the leading cause of vaccine-preventable childhood death, ev
287       Human astroviruses are recognized as a leading cause of viral diarrhea worldwide in children, i
288                         Human norovirus is a leading cause of viral gastroenteritis worldwide.
289 therapeutics, diabetic retinopathy remains a leading cause of vision impairment.
290                         Macular edema is the leading cause of vision loss in bilateral chronic noninf
291 permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as
292 ntial for photoreceptor survival, and is the leading cause of vision loss in the elderly.
293         Diabetic macular edema is one of the leading causes of vision loss among working-age adults i
294                                          The leading causes of vision loss were cataract (19.7%), cor
295               In Indigenous Australians, the leading causes of vision loss were uncorrected refractiv
296                                          The leading causes of vision loss were uncorrected refractiv
297           In non-Indigenous Australians, the leading causes of vision loss were uncorrected refractiv
298       Uncorrected refractive error (RE) is a leading cause of visual impairment, and variations in oc
299         Alkali burns to the eye constitute a leading cause of worldwide blindness.
300                         Atherosclerosis is a leading cause of worldwide morbidity and mortality whose

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