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1 HSP90alpha-AHA1-survivin complex toward the leading edge.
2 omotes reorientation of the Golgi toward the leading edge.
3 ation and Arp2/3 complex localization at the leading edge.
4 triphosphate (PIP3) from distributing to the leading edge.
5 regulates Arp2/3 complex localization at the leading edge.
6 gulate the Arp2/3 complex and Cofilin at the leading edge.
7 l morphology, including the loss of a single leading edge.
8 red for the dynamic remodeling of the cell's leading edge.
9 those that do, reorient to maintain the same leading edge.
10 n sheath enables membrane trafficking to the leading edge.
11 force transmission from the cell body to the leading edge.
12 hr-7 regulates Rab5a trafficking to the cell leading edge.
13 lipodial protrusions at each follicle cell's leading edge.
14 positioning of new rows of adhesions at the leading edge.
15 ymerization against the membrane at the cell leading edge.
16 and Rab6IP2 in microtubule tethering at the leading edge.
17 ntegrin-beta first accumulated at the cell's leading edge.
18 rally together with vinculin to the membrane leading edge.
19 reased filopodia formation and length at the leading edge.
20 e that MTs experience retrograde flow at the leading edge.
21 could alter the sex ratio at the expansion's leading edge.
22 the Golgi complex does not define the cell's leading edge.
23 s new proto-neuromasts to form closer to the leading edge.
24 ics and actin cytoskeleton remodeling at the leading edge.
25 he nucleus orients the centrosome toward the leading edge.
26 ors and regulation of capping protein at the leading edge.
27 FBXL19 diminished formation of the migratory leading edge.
28 hat polymerization occurs exclusively at the leading edge.
29 light-chain kinase and myosin II behind the leading edge.
30 ngth results in waving protrusion of a short leading edge.
31 alizes both to adhesion complexes and to the leading edge.
32 osomes (but not other organelles) toward the leading edge.
33 f Rac2 and then Cdc42 immediately behind the leading edge.
34 ctions, and lead migrating clusters near the leading edge.
35 ssembly predominates over disassembly at the leading edge.
36 5% and with >80% of the regulon genes in the leading edge.
37 igher pPLCgamma1, which was localized at the leading edge.
38 induced calcium mobilization in cells at the leading edge.
39 se string indents the dorsal surface at each leading edge.
40 en protrusion to adhesion and advance of the leading edge.
41 usions associated with invadopodia and other leading edges.
42 e small, suggesting weak force generation by leading edges.
43 d molecule talin from focal adhesions to the leading edges.
44 essary and sufficient for p190A targeting to leading edges.
45 entrosome and Golgi reorientation toward the leading edge, a hallmark of cell polarization to ensure
46 that a surprising intercellular coupling of leading edge actin networks forms the basis of mutual re
47 tion that culminated in the formation of the leading edge actomyosin cable, a structure that is essen
51 rylated and activated at the epithelial cell leading edge after treatment with IL-22, but this effect
52 ssociation times (between each binding event leading edge), allow for sensitive and quantitative meas
53 lopodia-based probing mechanism ahead of the leading edge allows cells to migrate efficiently, by sen
54 olocalization of PKCzeta and beta-catenin at leading edge along with PKCzeta-dependent stabilization
56 s a net inflow of water and ions at the cell leading edge and a net outflow of water and ions at the
57 elicit mechanosensitive signaling within the leading edge and align the ECM, creating microtracks con
59 By driving reorientation of the Golgi to the leading edge and driving forward trafficking, particular
61 formation of lamellipodial extrusions at the leading edge and increased activation of the focal adhes
62 ed by Arp2/3 complex delocalization from the leading edge and increased rates of retrograde actin net
63 brain-expressed protein (KIBRA) at the cell leading edge and overexpression of KIBRA was able to rev
64 icrometers from the cell body, extending the leading edge and promoting highly persistent directional
65 trate rigidity at a distance in front of the leading edge and regulated their responses based on the
66 ences protrusive activity from the epidermal leading edge and the protrusion area changes in accord w
68 H1L, localization of SSH1L to F-actin at the leading edge, and increased cofilin activity, resulting
69 the signalling networks present at the glial-leading edge, and novel proteins, including members of t
70 eading edge of T24 cells, where ExoS altered leading-edge architecture and actin anchoring in conjunc
72 uent inhibition of Myosin II activity at the leading edge are required for mesenchymal chemotaxis.
73 ns that "zipper" up proximally, but at their leading edges are free to make junctions containing the
74 mble a contractile actomyosin cable at their leading edge, as well as dynamic filopodia that finally
75 maging showed that, whereas most MIIA at the leading edge assembled into dorsal contractile arcs, a s
77 etalloproteinase 1 (MMP-1; collagenase-1) by leading-edge basal keratinocytes migrating across the de
78 ordinating cytoskeletal rearrangement at the leading edge, both of which processes are early signalin
79 (i) forward and reverse movement of the RNAP leading edge, but not trailing edge, relative to DNA, an
80 es in which local depletion of VASP from the leading edge by adhesions-along with lateral propagation
81 tion of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation of v
83 by promoting F-actin assembly at the myotube leading edge, by restoring the expression of additional
84 ted zipping dynamics and found that apposing leading edge cells come together at their apical ends an
85 ols the specification and differentiation of leading edge cells during Drosophila melanogaster dorsal
86 t traction stresses are limited primarily to leading edge cells in mesendoderm explants, and that the
90 with actomyosin-rich purse strings near each leading edge) close an eye-shaped opening that is filled
92 d active Rac1 and Cdc42 were targeted to the leading edge, consistent with lamellipodia-based migrati
93 d targets with actin-rich projections at the leading edge, creating an initially actin-enriched conta
94 that invokes net membrane deposition at the leading edge due to an imbalance between the endocytic a
96 formation of branched actin networks at the leading edge during cell motility and endo/exocytosis, w
99 he Canada Excellence Research Chairs (CERC), Leading Edge Endowment Fund (LEEF), Don Rix BC Leadershi
100 on at the leading edge oscillates, with VASP leading-edge enrichment greatest just prior to protrusio
101 forces), and zipping at the canthi shortens leading edges, ensuring a continuous epithelium at closu
103 ut not Raptor, impairs actin polymerization, leading-edge establishment, and directional migration in
104 functions as a molecular clutch, organizing leading edge F-actin, generating ECM traction, and promo
105 ctivation of Rac2 in regions distal from the leading edge, followed by the activation of Rac1, a seco
110 observed that interactions between OIMs and leading edge genes of differentially expressed pathways
111 of this pathway, neutrophils exhibit larger leading edges, higher membrane tension, and profoundly d
113 I is concentrated in arc-like regions of the leading edge in between FLPs, and its activity is requir
114 but are insufficient to produce a continuous leading edge in fibroblasts lacking Arp2/3 complex.
115 ized by the persistent protrusion of a broad leading edge, increasing cell-substrate adhesion strengt
116 th FAK and LKB1 accumulation at the cellular leading edge is mutually excluded from regions of activa
117 I matrix metalloproteinase (MT1-MMP) to the leading edge is thought to be a crucial step during canc
118 egion expands with a sharp transition at the leading edge; it is this sharp gradient in hydrophilicit
119 filopodia, associated tip complexes, and the leading edge just behind the anti-capping protein mammal
120 e show that mitochondria actively infiltrate leading edge lamellipodia, thereby increasing local mito
121 he cell polarizes, forms lamellipodia at the leading edge (LE), and triggers the concurrent retractio
122 driving Drosophila dorsal closure--migratory leading-edge (LE) and nonmigratory amnioserosal (AS) cel
124 further show that DN-ERM expression disrupts leading edge localization of active ADF/cofilin and free
125 motility by preventing spatially restricted, leading edge localization of epidermal growth factor rec
127 s for the rapid production and adaptation of leading-edge machinery in migrating cells, the invasion
128 ma is required for IQGAP1 recruitment to the leading edge membrane in response to integrin or growth
130 t assembly at multiple locations, including: leading edge membranes, focal adhesions, and the surface
131 pharmacological activation of AMPK increases leading edge mitochondrial flux, ATP content, and cytosk
132 A have aberrant lateral protrusions, altered leading-edge morphology, and decreased directional persi
133 rgy, we model the dynamics of F-actin at the leading edge, motivated by data from EGF-stimulated mamm
135 pecies ranges shifted northward at both the leading edge (northern boundary) and trailing edge (sout
136 olysis by the Arp2/3 complex in building the leading edge of a cell by studying the effects of hydrol
137 acilitate f-actin polymerization to push the leading edge of a cell forward during self-propelled mot
139 ion of cytosolic PLAC8, CDH3, and VIM at the leading edge of a human colorectal tumor, supporting a r
141 d for the first time, which emerged from the leading edge of a slowly drifting complex convective clo
145 in most new species introductions, or at the leading edge of an ongoing invasion, is likely to be sma
147 ts proper localization in invadopodia at the leading edge of breast cancer cells during three-dimensi
149 nization of the cortical cytoskeleton at the leading edge of cells and extracellular Ca(2+) entry is
152 showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM1 and O
155 regulated the localization of F-actin at the leading edge of chemokine-stimulated cells and was also
156 as signaling, C2GAP1, which localizes at the leading edge of chemotaxing cells and is activated by an
157 and observed a distinct protein belt at the leading edge of constriction furrows in dividing cells.
158 strate that P2X7 expression increases at the leading edge of corneal epithelium after injury in an or
161 n the actin machineries that assemble in the leading edge of front row cells and that resemble the co
162 pool of G-actin dynamically localizes to the leading edge of growth cones and neuroblastoma cells to
163 report that increased GLI1 expression in the leading edge of HNSCC tumors is further increased by irr
166 n and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of
167 of the formation of 'sticky fingers' at the leading edge of migrating cells and show that an MIT com
169 ient localization of PKL and beta-PIX to the leading edge of migrating cells, and knockdown of Vav2 r
170 ocal adhesions are dynamic constructs at the leading edge of migrating cells, linking them to the ext
178 mitochondria, in between the nucleus and the leading edge of migrating epithelial cancer cells, corre
180 n of sparsely labeled F-actin network at the leading edge of migrating human keratinocytes, revealing
182 s contractile force and Rac1 activity at the leading edge of migratory cells and the spine head of ne
185 apability of producing pushing forces at the leading edge of motile cells without the implication of
186 II in the cortex of vegetative amoebae, the leading edge of motile cells, and the cleavage furrow of
191 t, activated GTP-bound Rac1 localized to the leading edge of nascent branches and was required for br
192 tion of Rac1 and Cdc42, but not RhoA, to the leading edge of polarized and migrating human bronchial
193 calizes to the cell edge, importantly to the leading edge of polarized cells, where it regulates the
194 philin-1 was detected at the plasma membrane leading edge of primary podocytes, where it elicited rem
200 precise mechanisms governing invasion at the leading edge of squamous cell carcinoma (SCC) and its su
201 g wild-type ExoS preferentially bound to the leading edge of T24 cells, where ExoS altered leading-ed
202 F4G-eIF3-40S interactions place eIF4E at the leading edge of the 40S subunit, and mRNA is threaded in
205 ic cells and underwent redistribution to the leading edge of the cell in hypoxia with a corresponding
206 ng lamellipodia-actin-rich extensions at the leading edge of the cell that have been well characteriz
207 ostatic pressure between the nucleus and the leading edge of the cell to drive lamellipodia-independe
208 on other +TIPs, EB1 and CLIP-170, but in the leading edge of the cell, CLASPs display lattice-binding
209 pression of GOLPH3 drives trafficking to the leading edge of the cell, which is functionally importan
210 The optically activated region becomes the leading edge of the cell, with Cdc42 activating Rac and
213 opulation of migratory myofibroblasts at the leading edge of the closing VBW that express the actin-b
215 ion is driven by cell wall remodeling at the leading edge of the engulfing membrane, with peptidoglyc
216 tion and artificial irrigation; that is, the leading edge of the Eu colloids moved at a velocity of 3
217 woe mice exhibited a failure to develop the leading edge of the eyelid and consequently failure of t
219 int membrane poration can be produced at the leading edge of the HeLa cell in standoff distance Sd </
222 yonuclear translocation: Kinesin acts at the leading edge of the nucleus, whereas Dynein acts at the
225 ation is promoted by the leader cells at the leading edge of the pLLP, which express the G protein-co
226 asive species in nature, cancer cells at the leading edge of the tumor possess a different phenotype
231 sa cells and actomyosin purse strings in the leading edges of epidermal cells promote closure, wherea
233 rse strings are localized at each of the two leading edges of lateral epidermis ("lids" of the eye).
234 action of amnioserosa cells ingress near the leading edges of lateral epidermis, consistent with the
235 p2, Arp3, cofilin, and phosphocofilin at the leading edges of migrating cells, in wound-healing assay
236 quires proper regulation of the F-actin-rich leading edges of migrating neurons and neurite growth co
237 w that Fra accumulates at dorsal and ventral leading edges of paired CBs, and this localization is de
238 se junctions is accompanied by fusion of the leading edges of successive evaginations to form discret
241 s remodels the tissue interfaces between the leading edges of the lateral epidermis and the amniosero
242 tricted in their habitat associations at the leading edges of their range margins, but some species h
243 ion such as the focal adhesion contacts, the leading edge or filopodia, where it contributes to F-act
244 tions, we show that VASP localization at the leading edge oscillates, with VASP leading-edge enrichme
245 ing forward trafficking, particularly to the leading edge, overexpression of GOLPH3 drives traffickin
246 of the 5th (the trailing edge) and 95th (the leading edge) percentiles of the spatial distribution of
248 rd migration highlights the need to conserve leading-edge populations for spearheading future range s
249 tion, and that, as the TSS changes, the RNAP leading-edge position changes, but the RNAP trailing-edg
250 4(10) promoter sequences, the TSS, the RNAP leading-edge position, and the RNAP trailing-edge positi
252 Inhibiting actomyosin dynamics back from the leading edge prevents junction shrinkage and inhibits th
253 of Src-phosphorylated RhoGDI1 to the cell's leading edge promotes local activation of Rac1 and Cdc42
256 rbations and computer simulations shows that leading edge protrusion in crawling cells increases memb
259 tes a stationary actin treadmill that allows leading-edge protrusion when adhesion increases in respo
260 We find that membrane tension doubles during leading-edge protrusion, and increasing tension is suffi
261 locks recruitment of GFP-NM-IIA filaments to leading edge protrusions in 2D, and this in turn blocks
262 als from each cell's trailing edge to induce leading edge protrusions in the cell behind, in part by
263 o1-mediated mitochondrial positioning at the leading edge provides localized energy production that p
264 lation of filamentous actin (F-actin) at the leading edge provides the driving force for protrusion a
265 morphology characterized by the formation of leading-edge pseudopods and a highly contractile cell re
266 xemplifies the role of pathology in defining leading-edge questions for continued molecular and patho
270 demographic stochasticity could also affect leading-edge sex ratios, perhaps overwhelming sex-biased
272 y major roles in formation of new FAs at the leading edge, STIM1 may also be involved in Orai1- and P
274 r is correlated with an abnormal actin-based leading edge, the latter is consistent with blockage in
275 ls to promote delivery of alphavbeta3 to the leading edge, thereby driving persistent cell motility a
277 of SCAR is compensated by WASP moving to the leading edge to generate morphologically normal pseudopo
278 t restrict Par-Tiam1 complex activity to the leading edge to maintain cell polarity during migration
279 Conversely, Lar signals from each cell's leading edge to stimulate trailing edge retraction in th
280 ace contact, curvature waves travel from the leading edge to the back of a cell at -35 microm/min.
284 so coordinates the movements of cells in the leading edge vanguard rafts and is required for the asse
287 nd phosphorylated Cdc42 with plasma membrane leading edges was also observed in the presence of growt
288 eed dispersal ability, whereas shifts at the leading edge were associated only with photosynthetic ca
291 ing mechanism for CARMIL localization at the leading edge, where it regulates cytoskeletal effectors
292 biogenesis, F-actin is redistributed to the leading edge, where its polymerization-based forces push
293 tes at nascent focal adhesions at the cell's leading edge, where myosin X promotes actin convergence
294 rictional rollers congregates near the sharp leading edge whereas a denser rear comprises highly fric
296 579 and Y580 preferentially localizes to the leading edge, whereas Y881-phosphorylated Pyk2 is enrich
297 ive cancer cells were no longer able to form leading edges, which are required for adequate migration
298 a gradient of activated Rac1 evident at the leading edge, while small protrusions, rapid turnover of
299 the Arp2/3 complex, fibroblast cells adopt a leading edge with filopodia-like protrusions (FLPs) and
300 hoice was preceded by the elaboration of two leading edges with a faster extension rate along the low
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