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1 unlabeled drug dose and plasma concentration leading to a 50% reduction of (11)C-BMT-136088 specific
2 mplicated may be caused by aberrant salience leading to a change in the nature of the information tha
3 and the nearby Src homology 3 (SH3) domain, leading to a closed conformation, whereas a non-phosphor
5 udied workplace interruptions in healthcare, leading to a complex and conflicting body of literature.
6 g, enzymatic maceration and microfiltration, leading to a concentration of these components in the la
7 context alters which inputs are suppressed, leading to a deep dynamic reshaping of neural receptive
10 y of the H7 HA in the humanized mouse model, leading to a greater than 4-fold increase in HA-binding
11 e penetration losses of microwaves in foams, leading to a greatly improved EMI shielding performance.
13 BPh3 prevents the dissociation of CN(-), leading to a less rigid kappa(2)-phosphoramidite-neutral
14 ZIPIII and KAN gene expression in the shoot, leading to a model in which dorsoventral genes coordinat
15 chain dysfunction, as observed in few cells leading to a mosaic in aged tissues, might be involved i
16 for a thymine nucleotide (C64T) at codon 22, leading to a premature stop codon (R22X) in the albino r
17 cular hemolysis, and activation of platelets leading to a procoagulative state, formation of microthr
18 yperplastic sympathoadrenal precursor cells, leading to a reduced latency and increased penetrance of
19 ks might become a novel anticancer strategy, leading to a selective depletion of cancer-relevant prot
20 a functional corneocyte-bound lipid envelope leading to a severe skin barrier defect and premature de
22 the latter is rarely used in curve-fitting, leading to a significant loss of information from experi
23 alleviating proteasomal degradation of TRF1, leading to a stable association of TRF1 with Tin2 to for
24 ls rise to the upper surface of a community, leading to a strong spatial structuring that can be crit
25 lises the native conformation of EF-hand IV, leading to a transient unfolding and dissociation of hel
27 attern-recognition receptors (TLR9 and TLR3) leading to a type-I IFN mediated innate immune response
28 higher affinity to their DNA binding sites, leading to a xylose catabolic activation independent of
29 upregulation but also misexpression of Ihh, leading to abnormal phalanges, fusion of sutures and syn
30 dies that attempted to uncover the mechanism leading to abnormal tooth development, little is known r
31 the most pronounced increase in processing, leading to accumulation of both secreted and intracellul
32 ce, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosom
33 HIF-1alpha activates INSIG-2 transcription, leading to accumulation of Insig-2 protein, which binds
35 l expression of the IL-6-like cytokine Upd3, leading to activation of JAK/STAT signaling, differentia
36 n amplifies systemic inflammatory processes, leading to activation of the hypothalamic-pituitary-adre
37 Toll-like receptors 2 and 4 on macrophages, leading to activation of the MyD88 pathway and TNF-alpha
38 or misguided concerns promoting radiophobia, leading to actual risks far greater than the hypothetica
39 al for chemotaxis, we uncovered a Ca(2+) NFL leading to adaptation that would be difficult to find by
40 ion of serotonin (5-HT) neuronal precursors, leading to altered global serotonergic neuroarchitecture
42 f the NUS ratio, up to 26 times at NUS 1/32, leading to an acquisition time reduced in the same ratio
43 can further suppress the background signals leading to an additional increase of more than five-fold
44 intraparenchymal spread of neoplastic cells, leading to an anatomically separate but genetically rela
45 hancement with a specific signal generation, leading to an enhanced and therefore easy to detect sign
47 mbranes, PmB forms clusters on the membranes leading to an indentation of the bilayers and increase i
48 ng early ontogeny in BRCA1-mutation carriers leading to an international breast cancer prevention tri
49 e of IL-4Ralpha limits thymocyte emigration, leading to an intrathymic accumulation of mature thymocy
59 isotype can undergo in vivo Fab arm exchange leading to bispecific antibody and off-target effects.
60 ith vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patient
62 large and personally connected, potentially leading to both a broad and deep engagement in science.
63 are reacting with HOBr by direct bromination leading to Br-Cl-DOM and by bromine substitution of chlo
65 human responses; evaluate biological events leading to carcinogenesis both spatially and temporally;
66 of the hallmarks of endothelial dysfunction leading to cardiovascular disorders, but the underlying
67 lic tails of the cargos by adaptor proteins, leading to cargo packaging into coated vesicles destined
68 on of pathogen-associated molecular patterns leading to caspase-1 activation and cytokine release, wh
71 s-talk between FcalphaRI and different TLRs, leading to cell type-specific amplification of proinflam
73 ippo pathway, which in turn inactivates YAP, leading to changes in the regulation of genes that contr
74 an unstable system after gastric conditions leading to coalesced oil droplets, while Tween80 emulsio
76 in spatio-temporal beta-diversity patterns, leading to consistent differences in relative partitioni
78 ic cells to utilize extracellular glutamine, leading to cytosolic accumulation of NADH and increased
79 eeding the hardness of the diamond indenter, leading to debate about methodology and the very definit
80 with the representation of the familiar one, leading to decreased field stability in both environment
82 results in an aberrant activation of STAT3, leading to deleterious downstream effects in pancreatic
84 nical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 methylatio
88 input molecules in water with high affinity leading to displacement of CB7 from included pharmacopho
89 ell, with deficiencies in individual enzymes leading to dissimilar disease states such as CHARGE synd
90 nd lacrimal glands as well as to the kidney, leading to dose-limiting toxicities and adverse events a
91 onal migration toward an SDF1alpha gradient, leading to ectopic platelet release within the bone marr
92 ese rules describe a network of interactions leading to either clearance of the virus or death of the
93 ve osteosarcomas, miR-874 is down-regulated, leading to elevated CCNE1 expression and appearance of c
94 perating in the SMM cycle of rosette leaves, leading to elevated transport of SMM toward the seeds, w
95 f therapy-induced cancer stem-like cells and leading to endocrine therapy resistance in OXPHOS-depend
97 rations in estrogen receptor-alpha (ERalpha) leading to enhanced anti-hormone therapeutic efficacy in
98 interactions with target sites within mRNAs, leading to enhanced degradation of the mRNA or inhibitio
99 bitor reduces Skp2 levels and stabilizes LT, leading to enhanced MCV replication and transmission.
100 more, evolution of these traits is variable, leading to enhanced variance in speed among replicate po
101 on inhibits the ameloblast secretory pathway leading to ER stress and an activated unfolded protein r
106 moderately large effective population sizes, leading to extensive incomplete lineage sorting (ILS).
107 bian Sea, driving surges of moisture supply, leading to extreme rainfall episodes across the entire c
110 und influence on working memory performance, leading to faster access times as well as more accurate
111 and also shows a very favorable ADME profile leading to favorable predicted human pharmacokinetic pro
112 SNARE complexes are shown to form aggregates leading to formation of lipid nanodomains, which are enr
113 hen given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by endoscopy.
114 stage malaria infection is often persistent, leading to generation of CD4 effector and effector memor
116 entially expressed in the polarized tissues, leading to genome-wide Irx3(+) caudal-polarization signa
119 diform moles) is a fundamental genetic event leading to global alteration of imprinting gene expressi
120 with STAT5-driven transcriptional activity, leading to global downregulation of STAT5-regulated gene
123 entially occurs at telomeric lagging strands leading to heterogeneous telomere lengths observed in mo
124 ving USP9X-ERAS formed by chromothripsis and leading to high expression of ERAS, a constitutively act
125 eaks continue to occur regularly in Nigeria, leading to high morbidity and mortality rates for childr
127 in an expansion of Gr-1(lo) cells in the BM, leading to high plasma suPAR and proteinuric kidney dise
129 Ccr7 results in a significant leukocytosis, leading to hypercellularity within the CNS, where monocy
134 ling inputs results in decreased glycolysis, leading to impaired endothelial cell proliferation and m
135 trafficking by trapping it in the endosomes, leading to impaired insulin signaling and insulin-stimul
136 ss of RNF146 stabilized its substrate AXIN1, leading to impairment of WNT3a-induced beta-catenin acti
138 ed their predictive value for major bleeding leading to improved clinical usefulness compared to the
140 hermore, the mechanisms of natural evolution leading to improved or novel substrate specificities are
142 lps to mitigate cytonuclear incompatibility, leading to increased fitness of F1 hybrids and recovery
143 olyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element
144 cycling of the TCR-CD3 complex was impaired, leading to increased lysosomal targeting and reduced sur
145 replication fork progression and stability, leading to increased mutation rates at highly transcribe
147 hibition enriches the FV(+) HG/CD42b(+) MKs, leading to increased platelet yield in vivo, but not in
148 LD breakdown and fatty acid (FA) oxidation, leading to increased ROS production and apoptosis in hyp
149 nd cellular location of uncoating of virions leading to infection has been confounded by defective, n
151 by fluorescence lifetime imaging microscopy, leading to integrin-mediated phosphorylation of Src and
152 s in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction
156 t-dependent phosphorylation of Sox2 at T118, leading to its stabilization and transcriptional activat
157 on of C5 by an elimination-addition sequence leading to l-ido disaccharide (GH unit) with a total yie
158 transmission of virus to adjacent skin, thus leading to larger skin lesions and satellite lesions in
162 tion of the monolayer/dielectric interfaces, leading to localized electronic states that serve as a b
164 e telomerase and its nucleic acid substrates leading to loss of telomerase activity and processivity.
166 front elevates Ca(2+) inside the SR locally, leading to luminal RyR sensitization and lowering of the
167 y airway epithelial cells may be a mechanism leading to lung function decline in a subset of children
170 rin-betaV amino acid sequence in the lineage leading to mammals, together with substantial difference
173 g stimuli appears to attenuate ERG currents, leading to membrane potential depolarization and increas
178 ase, is known to promote cell proliferation, leading to neovascularization as well as neuroprotection
180 shed Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction (NMJ) dysfunction and
181 ase, we have a lesser degree of interaction, leading to normal hydrogen bonds of type YH-X analogous
182 ction of a polymerization-defective laminin, leading to normalized muscle structure and strength in a
183 ly preferred over the loss of sulfur dioxide leading to o-quinodimethane, which is the key intermedia
185 eatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficie
187 ased rates of mitochondrial H2O2 production, leading to part of the SA-dependent transcriptional resp
188 l susceptibility, (2) identifying mechanisms leading to pathology, and (3) informing the development
189 egrates its viral genome into the host cell, leading to persistent infection wherein HIV-1 can remain
191 sponding sequence alignment is usually poor, leading to poor performance for the recognition of simil
192 ess to explore and investigate test stimuli, leading to poor test performance that was only slightly
195 poly(A) polymerase to the 3' terminus, thus leading to pre-mRNA stabilization, or decay depending on
196 dopaminergia and neurodegenerative phenotype leading to premature death in 36% of the population.
197 xecutive functioning and semantic knowledge, leading to preserved cognitive performance in patients w
198 automatic navigation of a chemical network, leading to previously unreported molecules while needing
200 se in both the peak and late sodium currents leading to prolongation of the action potential duration
202 ent of Pol II in transcriptional elongation, leading to promoter-proximal accumulation of Pol II.
203 pho-SRC1 to RORgammat displaced bound Foxp3, leading to prompt degradation of the dissociated Foxp3 v
204 United States suffer from dental infections, leading to pulp necrosis, arrested tooth-root developmen
205 ve stress as a common pathological mechanism leading to PVI impairment in schizophrenia and some form
208 d by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion.
209 terference with the lipid signaling pathway, leading to reduced expression of MDR transporters and th
210 in kinase C conventional subclass alpha/beta leading to reduced phosphorylation of NADPH oxidase comp
211 ta-catenin targets and some K-Ras effectors, leading to reduced tumor cell proliferation and viabilit
213 ryotic initiation factor-2alpha (eIF2alpha), leading to repression of general translation and latency
214 oup between the oxidized and reduced states, leading to reversible switching of the DNA conductance b
215 model fully captures the pulsation dynamics leading to rupture and reproduces empirical time scales
217 neration and impedes processing of miR-125b, leading to Rybp upregulation and suppression of lineage-
219 can attach to most immersed solid surfaces, leading to serious economic and ecological consequences
220 izing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to
222 ing RNA intermediates with 3' end extension, leading to severe reduction of mature piwi-interacting R
225 rightward shifts in inactivation parameters, leading to significant increases in the magnitude of win
229 may experience greater HPA and HPG activity, leading to steeper decreases in cortical thickness with
231 s and activates HER2 at p1248 in PDAC cells, leading to stimulation of HER2 signaling cascade, includ
234 experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treat
235 ing different mutations arose independently, leading to subclonal heterogeneity of resistant disease.
237 nic sites are subject to error-prone repair, leading to substitution and short frameshift mutations,
240 hat were modulated in the first domain type, leading to sum formula Ce4-0.5xLi3P18N35-1.5xO1.5x (x ap
241 ought to study the molecular pathophysiology leading to susceptibility to infection in 3 siblings wit
242 cion activates AMP-activated protein kinase, leading to synergistic inhibition of human leukemia cell
243 ot normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsi
244 al compartments, (c) TCR signal transduction leading to T cell activation, and (d) TCR degradation.
245 creases the mitochondrial membrane potential leading to the activation of Ca(2+)-independent phosphol
246 rongly activates human and mouse iNKT cells, leading to the assumption that iNKT cell physiology in h
249 tein has lost it tumour suppressive function leading to the clinical manifestations of BHD, whereas t
250 ied by variable temperature NMR spectroscopy leading to the conclusion that the rate-determining step
251 polar intramolecular cycloaddition reaction, leading to the corresponding isoxazolidines bearing a qu
252 scalability and integration are implemented, leading to the creation of a sensor unparalleled in sens
253 ion of key structure-activity relationships, leading to the development of a small molecule with arou
254 while support for translational research is leading to the development of some new neglected disease
255 o stimulate protective tolerogenic pathways, leading to the development of the type 2 immune response
257 uring the rolling circle process, ultimately leading to the direct immobilization of proteins into DN
258 ositionally engineered into single lattices, leading to the discovery of high-entropy alloys and high
260 rt the discovery of self-assembly strategies leading to the emergence of lipid bicontinuous single cr
266 ntity and hierarchy of the HDR (sub)pathways leading to the formation of PGE products remain elusive.
267 e light activation of o-methylbenzaldehydes, leading to the formation of reactive o-quinodimethanes (
268 tioxidant activity of polyphenolic compounds leading to the formation of stable diketones e.g. 1,2-qu
269 ound that the ring closure of the zwitterion leading to the formation of sultines was kinetically pre
270 contributions can vary between plant species leading to the generation of datasets which are difficul
271 hat disappointing body weight changes, often leading to the hormone/mediator in question being dismis
272 ure are at increased risk of cardiotoxicity, leading to the hypothesis that genetic susceptibility lo
273 anges in phenotype are observed, potentially leading to the identification of new growth regulators.
274 ion of ROS activates the Nrf2-Keap 1 pathway leading to the induction of genes through antioxidant re
275 en proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity a
276 complexes restrict AMPAR dendritic mobility, leading to the intracellular trapping of receptors and i
277 poproteins in HCV secretion and infectivity, leading to the notion that HCV coopts the secretion of v
278 a common set of recurring structural motifs, leading to the perspective that a generalizable model of
279 P-transposable element transcripts in vivo, leading to the production of the non-transposase-encodin
280 o the photothermal effect of gold nanocages, leading to the release and decomposition of the loaded i
281 product is formed by annealing each surface, leading to the removal of Ag atoms and the formation of
282 ne gene by another allelic exchange mutation leading to the restoration of transcription and protein
283 sion of the metallacyclobutane intermediate, leading to the spin-triplet 12-electron complex (SIMes)R
285 amics simulations to show that the oligomers leading to the type of oligomer distributions observed i
286 regulation of PTPRJ gene expression in MCs, leading to their activation in the context of T cell-med
288 ncer stem cells into cancer stem cells (CSC) leading to therapy resistance remains poorly investigate
291 duction of long-term plasticity (LTP) in M1, leading to transient occlusion of additional LTP-like pl
295 vascular endothelial cells (ECs) to VEGF-A, leading to upregulation of angiopoietin-2 (Ang2) in ECs
297 ribution to pathological and clinical stages leading to vision loss in diabetic retinopathy (DR) are
298 haracterized the temporal sequence of events leading to voltage sensor stabilization upon membrane de
300 iosynthesis is regulated at multiple levels, leading to wide variability in terpene content and chemi
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