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1 rsor may be accumulating in biota and metabolizing to PFBS, leading to a higher than expected TMFs for this compound.
2 o an accelerated proteasomal degradation of KIF1A proteins, leading to a near depletion of KIF1A protein late in infectio
3 nd trans isomers and (2) a direct nucleophilic substitution leading to a stereoselective synthesis of the compounds of in
4 microdomain as well as enhanced phospho-signalling within, leading to a submicron gradient of activated CtrA-P(19) that
5 Melanomas frequently harbor activating NRAS mutations leading to activation of MAPK kinase (MEK) and extracellular
7 n in high-quality, electrically insulating single crystals, leading to anomalous transport properties well above cryogeni
8 ndscapes to aquatic environments in the region, potentially leading to bioaccumulation in fish and exposure to communitie
9 are used to gain fundamental understanding of all processes leading to catalytic activity, i.e., light absorption, charge
10 igens, the conjugates also retain T-independent properties, leading to detrimental effects on immune responses.
11 , BKM120, was tested in our patient-derived xenograft model leading to disease attenuation and prolonged survival.
12 appears to be extensively rewired among the three species, leading to distinct anatomical and morphological outcomes.
13 shifts in interactions appear to reshape network structure, leading to dramatic community changes, including loss of spec
16 This indicates that anthropogenic modifications leading to habitat fragmentation and a higher genetic diversi
18 razole functionalized surfaces was found to proceed rapidly leading to high grafting densities, while o-methylbenzaldehyd
19 te that phosphine oxides are highly polar functional groups leading to high solubility and metabolic stability but occasi
20 iation cause DNA damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of mali
21 ave the potential to rebalance disordered lipid metabolism, leading to improvements in nonalcoholic steatohepatitis (NASH
22 salt-inducible kinase 1 (SIK1) stabilized the deacetylase, leading to increased expression of c-Myc, which in turn stimu
23 ransmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals.
24 he role of hapten-carrier adducts in re-challenge reactions leading to mast cell degranulation and anaphylaxis is unclear
26 reater variety of fragment ions and complementary ion pairs leading to more complete functional group characterization co
28 were significantly enhanced by up to 3 orders of magnitude, leading to much higher spatial resolution.
29 fer profoundly from binding of multiply charged ions, often leading to overall compaction of the protein depending on the
31 out changes in nociceptive output in pathologic conditions, leading to pain hypersensitivity.SIGNIFICANCE STATEMENT Noxio
32 ding cerebral malaria (CM), driven by a high parasite load, leading to parasite sequestration in organs and consequent ex
34 tinct features to ER-negative DCIS.com breast cancer cells, leading to populations enriched with highly plastic hybrid ep
36 Parenchymal hematoma triggers a series of reactions leading to primary and secondary brain injuries and permanent
37 However, the underlying intracellular mechanisms leading to product aggregate formation remain unknown.
38 ase in methane production rates and poor process stability, leading to reactor failure after 40 days.
39 usitis (CRS) is complicated by frequent acute exacerbations leading to significant health care burden and impaired qualit
40 asites can cause major pathology and mortality to livestock leading to significant welfare and socio-economic issues, pre
41 ed the increased decomposition in the adaptation scenarios, leading to similar SOC stocks under different climate change
43 minant discontinuous conduits for flow dictated by geology, leading to surface expression that can be greater or less tha
44 fely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.
46 enzyme cleaved the tripeptide aldehyde protease inhibitors, leading to the formation of "pro-pyrazinones" featuring a het
47 ubiculum subfields of the hippocampus, while simultaneously leading to the formation of integrated representations of rel
48 e injury in Speg-KO mice was compared with that of WT mice, leading to the identification of similar abnormalities includ
49 ting that the DAP1 risk allele mediates enhanced autophagy, leading to the survival of autoreactive lymphocytes and incre
50 ion results in dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodiesterase type 4 (PDE4), w