ライフサイエンスコーパス: leaflet

1 ar envelope and is assembled at the OM outer leaflet.

2 holipids from the exofacial to the cytosolic leaflet.

3 or a difference in the number of lipids per leaflet.

4 ue lipid bilayer containing LPS in its outer leaflet.

5 t and lipopolysaccharides (LPS) in the outer leaflet.

6 outer leaflet and phospholipids in the inner leaflet.

7 tracellular loop (EC2) at the outer membrane leaflet.

8 PE (duramycin) exposed in the extracellular leaflet.

9 to the ventricular surface of the prolapsed leaflet.

10 hordal attachment to base of anterior mitral leaflet.

11 n mimics the mammalian plasma membrane outer leaflet.

12 oligomerization on the plasma membrane inner leaflet.

13 ions of corresponding lipids at the opposite leaflet.

14 to the hydrocarbon chain region of the outer leaflet.

15 inner leaflet and a single site in the outer leaflet.

16 bilayer with lipopolysaccharide in the outer leaflet.

17 are restricted to the intracellular membrane leaflet.

18 generative mitral regurgitation with a flail leaflet.

19 the negatively charged plasma membrane inner leaflet.

20 outer leaflet and phospholipids in the inner leaflet.

21 lytic site are exposed to the inner membrane leaflet.

22 buted in both leaflets; and absent from both leaflets.

23 ing subunits that reside in opposite bilayer leaflets.

24 histopathology and flow cytometry of excised leaflets.

25 characterized by calcium deposition in valve leaflets.

26 es asymmetrically distributed across the two leaflets.

27 interactions in the outer and inner membrane leaflets.

28 n of 18F-fluoride uptake to individual valve leaflets.

29 onsistent with a direct coupling between the leaflets.

30 along the fibrosal layer in second trimester leaflets.

31 d remodel into highly organized thin fibrous leaflets.

32 rturbation moved through the inner and outer leaflets.

33 anslocation of phospholipid between membrane leaflets.

34 of floral organs, and laminar development of leaflets.

35 characterized by calcium deposition in valve leaflets.

36 n the posterior leaflet than in the anterior leaflet (0.13+/-0.03 versus 0.10+/-0.02; P<0.05).

37 and lipopolysaccharides comprising the outer leaflet (1-3) .

38 rent number of lipids in the outer and inner leaflet, a difference in transmembrane headgroup hydrati

39 GP's personal letter, with an evidence-based leaflet about overcoming barriers to accessing help for

40 cellular and molecular mechanisms underlying leaflet adaptation and fibrosis could yield new therapeu

41 The contribution of leaflet adaptation to the pathophysiology of TR has yet

42 closure area, reflecting the balance between leaflet adaptation versus annular dilation and tethering

43 MI altered leaflet adaptation, including a profibrotic increase in

44 Grasping the septal and anterior leaflets allowed for the best post-procedural outcome, e

45 ential molecular interactions with the inner leaflet along with Tec kinase-dependent tyrosine phospho

46 es were identified on UraA: two in the inner leaflet and a single site in the outer leaflet.

47 e phosphatidylserine on their outer membrane leaflet and activated clotting factors assemble into enz

48 ity to different regions of the aortic valve leaflet and commonly to areas of increased mechanical st

49 ressure in the headgroup region of the outer leaflet and increasing the positive pressure throughout

50 f is generally located in the outer membrane leaflet and its reverse sequence CRAC in the inner one.

51 ia is composed of phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leafl

52 try, with phospholipids comprising the inner leaflet and lipopolysaccharides comprising the outer lea

53 th lipopolysaccharide molecules in the outer leaflet and phospholipids in the inner leaflet.

54 sed of lipopolysaccharide (LPS) in the outer leaflet and phospholipids in the inner leaflet.

55 trafluoroethylene cords were anchored in the leaflet and then adjusted to the correct length to resto

56 rolapse (MVP) is characterized by myxomatous leaflets and left ventricular (LV) fibrosis of papillary

57 h features including crypts, abnormal mitral leaflets and trabeculae.

58 erine (restricted to the cell membrane inner leaflet) and cardiolipin (present in the inner and outer

59 es the bilayer, and enters the extracellular leaflet, and the reverse process happens twice as well.

60 enlargement, thickening of the mitral valve leaflets, and interatrial septum and mild pericardial ef

61 pposite leaflet; equally distributed in both leaflets; and absent from both leaflets.

62 d in VECs (4 weeks) and, later, cells in the leaflet/annulus junction mesenchyme expressing inactive

63 At this leaflet/annulus junction, CD44(+) cells clustered during

64 ng EndMT, which subsequently ascend from the leaflet/annulus junction.

65 prolapse are classically seen with abnormal leaflet apposition during contraction of the heart.

66 nanotube seed leads to domains of different leaflet architecture within single nanotubes.

67 ge distribution and lipid hydration, but the leaflets are not detectably asymmetric in terms of the n

68 Leaflet area also increased significantly.

69 hen alphaSyn is bound to the vesicle's outer leaflet at a 200:1 L/P.

70 e connecting the origins of the mitral valve leaflets at end systole and end diastole.

71 dentify which patients stand to benefit from leaflet augmentation during tricuspid valve repair.

72 d a new special diet form and an information leaflet based on the new allergy guidelines.

73 ns capable of interdigitating into the inner leaflet, both outer- and inner-leaflet Lo domains were d

74 inner membrane is flipped to the periplasmic leaflet by MsbA, an ATP-binding cassette transporter.

75 The excessive mobility of the leaflets caused by posterior systolic curling accounts f

76 Systolic anterior motion of mitral leaflets caused the MR in most patients.

77 unique as it achieves nearly universal inner leaflet cellular activity to enable the exit of parasite

78 patients who underwent transcatheter mitral leaflet clip in 2015 were similar to patients from 2013

79 adjusted to the correct length to restore MV leaflet coaptation and secured at the epicardium.

80 tethering angle (P<0.001) despite a similar leaflet coaptation status compared with patients with le

81 ent device implantation to improve tricuspid leaflet coaptation, thereby reducing TR.

82 Its occurrence in both membrane leaflets commonly gives rise to matching liquid or liqui

83 Either homogeneous or mixed leaflet composition is possible, and both create nanotub

84 ntion group), or a prolapse lifestyle advice leaflet (control group).

85 Strain analysis of leaflet deformation was derived from these models.

86 e this entity has annular dilatation without leaflet deformation.

87 ore persistent and can correlate between the leaflets depending on lipid mixture, Brain or Average, a

88 l 2 (March, 2012), a supplementary narrative leaflet describing people's stories; trial 3 (June, 2013

89 versely, grasping the anterior and posterior leaflets did not reduce FTR, and was detrimental in some

90 MVP and NDMs were distinguished by leaflet displacement >2 versus </=2 mm beyond the mitral

91 men, 57+/-11 years) had greater increases of leaflet displacement, thickness, and jet height than ref

92 ed longitudinal changes in annular diameter, leaflet displacement, thickness, anterior/posterior leaf

93 progress, the 17 who progressed had greater leaflet displacement, thickness, coaptation height, and

94 ly repacks the segment in the inner membrane leaflet due to a swivel movement.

95 obilization of long acyl-chain lipids at one leaflet effects transbilayer interactions of correspondi

96 For asymmetric vesicles with outer-leaflet egg SM or milk SM, a fluorescent lipid with unsa

97 facing the DCVs; exclusively in the opposite leaflet; equally distributed in both leaflets; and absen

98 inside MsbA at the height of the periplasmic leaflet, establishing extensive hydrophilic and hydropho

99 mmetric in terms of the number of lipids per leaflet, even though geometrical packing arguments would

100 ed from a semimicroscopic model in which the leaflets experience a "direct" area-dependent coupling,

101 With PE in the leaflet facing the DCVs, overall fusion was most efficie

102 a membrane were examined: exclusively in the leaflet facing the DCVs; exclusively in the opposite lea

103 raphy is the gold standard for evaluation of leaflet flail and prolapse due to high sensitivity and s

104 domain interacts with the periplasmic lipid leaflet, forming an interfacial entrance from the lipid

105 ressed by VEGF between human semilunar valve leaflets from first and second trimester hearts.

106 er increases the charge density of the inner leaflet, generating foci of enhanced charge and curvatur

107 is revealed that both anterior and posterior leaflets have the highest strain concentration in the co

108 Leaflet immobility and valve thrombosis have been report

109 he highest sensitivity in studies evaluating leaflet immobility and valve thrombosis.

110 they are often found co-localized across the leaflets, implying the presence of a thermodynamic inter

111 atrium; the tricuspid annulus; or between TV leaflets, improving coaptation.

112 generative mitral regurgitation with a flail leaflet in 6 tertiary European and US centers.

113 strain intensity was noted for the posterior leaflet in both normal and organic valves.

114 ickened leaflets or thrombotic apposition of leaflets in 20 (77%) and a thrombotic mass on the leafle

115 d for further investigation using porcine AV leaflets in an ex vivo shear system.

116 g to probe lipid distribution across bilayer leaflets in lipid vesicles.

117 te phase separation and communication across leaflets in ternary lipid bilayers, including saturated

118 ytetrafluoroethylene (ePTFE) cords on mitral leaflets in the beating heart.

119 ets in 20 (77%) and a thrombotic mass on the leaflets in the remaining 6 (23%) patients.

120 nesis and describe enlarged posterior mitral leaflets in Tns1(-/-) mice.

121 ic spines and shafts, and on some astrocytic leaflets, in both hippocampus and cerebellum.

122 ned charged lattices stabilizing the bilayer leaflet interface.

123 asymmetric lipid bilayer in which the outer leaflet is composed of lipopolysaccharide (LPS) and the

124 The OM outer leaflet is comprised of endotoxin containing lipid A, wh

125 ed of lipopolysaccharide (LPS) and the inner leaflet is formed by glycerophospholipid (GPL).

126 ngest phenotypes include severe reduction of leaflet laminae due to a decrease in cell size and numbe

127 Specifically, inner leaflet lateral mobility of globular actin-supported DMP

128 maximal LVOT gradient (rest/provocable), MV leaflet length (parasternal long, 4 and 3-chamber views)

129 hickness, bifid PM mobility, anterior mitral leaflet length, and abnormal chordal attachment to base

130 hology, left atrial volume, and mitral valve leaflet lengths (all P=non-significant).

131 defined for erythrocytes, as judged by outer leaflet lipid composition; and plasma membrane outer lea

132 Plasma membrane function requires distinct leaflet lipid compositions.

133 interaction between an amino acid and inner-leaflet lipid that governs the gating transformations of

134 This indicates that inner- and outer-leaflet Lo domains can have significantly different phys

135 Here, we characterize how outer-leaflet Lo domains induce inner-leaflet-ordered domains,

136 asymmetric vesicles containing egg SM, outer-leaflet Lo domains were also depleted in a saturated flu

137 nto the inner leaflet, both outer- and inner-leaflet Lo domains were depleted, to a similar extent, i

138 ed fluorescent lipid (NBD-DPPE), while inner-leaflet Lo domains were not.

139 Additionally, CD44(+) cells play a role in leaflet maturation toward the trilaminar structure, poss

140 ast, in asymmetric vesicles containing outer-leaflet milk SM, which has long acyl chains capable of i

141 nsequence of mechanical interference with TV leaflet mobility or coaptation and is amenable to lead e

142 Changes in mitral leaflet morphology are associated with both NDM and MVP

143 (1.92 strokes per 100 person-years) reduced leaflet motion (p=0.10), subclinical leaflet thrombosis

144 (12 [14%] of 88) than did those with normal leaflet motion (seven [1%] of 632; p<0.0001).

145 Mechanical artifacts from aortic valve leaflet motion may be observed during mapping, although

146 eevaluated with follow-up CT, restoration of leaflet motion was noted in all 11 patients who were rec

147 eaflet thrombosis as the presence of reduced leaflet motion, along with corresponding hypoattenuating

148 es the upper leaflet to slide over the lower leaflet, moving domains out of registry.

149 chain of L596 interacts with the inner lipid leaflet near the polar-nonpolar interface in our model-a

150 ging in the space between the native and THV leaflets (neosinus).

151 enrichment of both these lipids in the outer leaflet of cancer cells is highly significant for MP1's

152 opolysaccharide (LPS) constituting the outer leaflet of Gram-negative bacteria.

153 s from the cytoplasmic to the exocytoplasmic leaflet of membranes.

154 s a recruitment factor for FGF2 at the inner leaflet of plasma membranes that may control phosphatidy

155 tidic acid commonly present within the inner leaflet of plasma membranes, and potently disrupts lipos

156 monolayer on the PDMS surface and the upper leaflet of the bilayer on the glass substrate.

157 Substrate binding from the inner leaflet of the bilayer releases the protons and triggers

158 CADs are known to accumulate in the inner leaflet of the cell membrane where they bind to anionic

159 in a coiled-coil domain of Rz near the outer leaflet of the cytoplasmic membrane and were not allele

160 al protein NS5A, anchored at the cytoplasmic leaflet of the endoplasmic reticulum, plays a role in vi

161 rived exosomes and is localized on the outer leaflet of the exosomal membrane.

162 s an essential component of LPS in the outer leaflet of the Gram-negative bacterial outer membrane.

163 xtracts lipopolysaccharide from the external leaflet of the inner membrane and propels it along a fil

164 LPS synthesized in the cytoplasmic leaflet of the inner membrane is flipped to the periplas

165 ng hopanoid virulence factors from the outer leaflet of the inner membrane to the periplasm.

166 rst nucleotide binding domain near the inner leaflet of the lipid bilayer.

167 holipids across the bilayer to the cytosolic leaflet of the membrane, but how these enzymes distingui

168 igosaccharide (LOS) exclusively in the outer leaflet of the membrane, establishes an impermeable barr

169 acyl carrier protein synthetase on the inner leaflet of the membrane.

170 en the hypertrophied septum and the anterior leaflet of the mitral valve.

171 in that removes phospholipids from the outer leaflet of the OM of Escherichia coli, increases OM perm

172 rt of misplaced phospholipids from the outer leaflet of the OM to the cytoplasmic membrane (4) .

173 a 20-A-thick doughnut embedded in the inner leaflet of the OM with a central, amphipathic pore.

174 er membrane (IM) or transferred to the inner leaflet of the outer membrane (OM).

175 pid A species comprise the bulk of the outer leaflet of the outer membrane and are produced through a

176 anchor of a lipopolysaccharide in the outer leaflet of the outer membrane of Gram-negative bacteria.

177 deliver lipopolysaccharide into the external leaflet of the outer membrane.

178 al structural protein Gag binds to the inner leaflet of the plasma membrane (PM), and many cellular p

179 e signaling circuit forms on the cytoplasmic leaflet of the plasma membrane and directs both actin an

180 lipid, is predominantly located in the inner leaflet of the plasma membrane and has been proposed to

181 e show that coupling may extend to the outer leaflet of the plasma membrane by examining the flow of

182 , phosphatidylserine exposed on the external leaflet of the plasma membrane functions as a ligand for

183 th the GM1 ganglioside receptor in the outer leaflet of the plasma membrane in intestinal (HT-29) cel

184 Surface charges at the inner leaflet of the plasma membrane may contribute to regulat

185 sphingolipids and phospholipids in the outer leaflet of the plasma membrane of living mammalian cells

186 Lipids enriched in the outer leaflet of the plasma membrane oscillated in a highly co

187 hosphatidylserine (PS) exposure on the outer leaflet of the plasma membrane preceded loss of PM integ

188 K-Ras attaches to the inner leaflet of the plasma membrane via a farnesylated polyba

189 cells, an actin-based cortex lines the inner leaflet of the plasma membrane, endowing the cells with

190 he enzyme, peculiarly localized on the outer leaflet of the plasma membrane, has been shown to be abl

191 Several proteins expressed at the inner leaflet of the plasma membrane, including alpha-actinin-

192 a small GTPase found primarily on the inner leaflet of the plasma membrane, is an important signalin

193 anes and, most interestingly, with the outer leaflet of the plasma membrane, suggesting a role at the

194 to net transport from the outer to the inner leaflet of the plasma membrane.

195 ] is a minor phospholipid in the cytoplasmic leaflet of the plasma membrane.

196 idylethanolamine (PE) to the inner cytosolic leaflet of the plasma membrane.

197 2 redistribution from the inner to the outer leaflet of the plasma membrane.

198 ndogenous actin cortex attached to the inner leaflet of the plasma membrane.

199 rine from the outer leaflet to the cytosolic leaflet of the plasma membrane.

200 erophospholipids from the outer to the inner leaflet of the plasma membrane.

201 osylphosphatidylinositol anchor to the outer leaflet of the plasma membrane.

202 s restricted almost exclusively to the inner leaflet of the plasmalemma.

203 ing membrane segment, only the outer bilayer leaflet of the vesicle is depleted of negatively charged

204 rix protein VP40 (mVP40) underlies the inner leaflet of the virus and regulates budding from the host

205 uses display phosphatidylserine on the outer leaflet of their membranes, enabling TAM receptor activa

206 hatidylserine (PtdSer) exposure on the outer leaflet of transduced cells triggers their engulfment by

207 recombinant proteins exposed on the luminal leaflet of transport vesicles.

208 cardiolipin (present in the inner and outer leaflets of bacterial membranes).

209 Variations between the inner and outer leaflets of cell membranes are crucial for cell function

210 dothelial cells (LECs) specifically from the leaflets of intraluminal valves in collecting LVs.

211 ately 1:1 if only the PG lipids in the outer leaflets of membranes are accessible to daptomycin.

212 s a 3-nm compartment between two cytoplasmic leaflets of stacked myelin membranes, mostly occupied by

213 When both leaflets of the bilayer contain domains, they are often

214 vement (scrambling) of phospholipids between leaflets of the membrane bilayer.

215 ences in tension between the inner and outer leaflets of the membrane contribute to this process.

216 nteractions of PCB 52 molecules in different leaflets of the model bilayer.

217 s are segregated between the inner and outer leaflets of the plasma membrane by ATP-dependent lipid t

218 ally distributed between the outer and inner leaflets of the plasma membrane in eukaryotic cells.

219 w different PE distributions between the two leaflets of the supported bilayers affected SNARE-mediat

220 ilayer exchange of phospholipids between the leaflets of the vesicle membrane at a rate >10,000 per t

221 s glycoproteins and glycolipids on the outer leaflets of their plasma membranes and constitute a majo

222 sicles and plasma membranes to the cytosolic leaflets of these membranes.

223 n is mediated by fusion between the proximal leaflets of two bilayers (hemi-fusion) to produce a hemi

224 r from England's Chief Medical Officer and a leaflet on antibiotics for use with patients.

225 t (40.5+/-14.0 mm Hg), presence of thickened leaflets or thrombotic apposition of leaflets in 20 (77%

226 0.20, 0.70), or to have read the information leaflet (OR, 0.18; 95% CI: 0.08, 0.41).

227 This suggests the inner-leaflet-ordered domains were depleted in unsaturated lip

228 ze how outer-leaflet Lo domains induce inner-leaflet-ordered domains, i.e., interleaflet coupling.

229 E) was depleted in both the outer- and inner-leaflet-ordered domains.

230 considering all possible 15 combinations of leaflet pairs and medial/commissural grasping.

231 rt, single-clip treatments involved grasping leaflet pairs in the medial or commissural position (6 c

232 lipid composition; and plasma membrane outer leaflet phosphatidylcholine had a significantly lower le

233 phospholipids to the pore, but allows outer leaflet phospholipids to bind to a pronounced ridge surr

234 sport protein that selectively removes outer leaflet phospholipids to help maintain the essential bar

235 This architecture prevents access of inner leaflet phospholipids to the pore, but allows outer leaf

236 Each underwent percutaneous mitral valve leaflet plication to reduce systolic anterior motion (SA

237 ndent changes in leaf form, including faster leaflet production.

238 displacement, thickness, anterior/posterior leaflet projections onto the annulus, coaptation height,

239 Eleven patients with posterior leaflet prolapse and severe MR, with mean+/-SD age of 65

240 were more likely to present with a posterior leaflet prolapse than those undergoing MV replacement.

241 e, mild intraoperative residual MR, anterior leaflet prolapse, bileaflet prolapse, perfusion time >90

242 en domains embedded within opposing membrane leaflets provide a robust means to co-localize the domai

243 ally in PSDs, and in perisynaptic astrocytic leaflets, provides morphologic evidence that EphA7 plays

244 generative mitral regurgitation with a flail leaflet referred to mitral surgery, MV repair was associ

245 charged fluorescent lipids, while the inner leaflet remains unaffected.

246 tral valve repair, particularly edge-to-edge leaflet repair, is a well-established alternative for pa

247 With PE exclusively in the opposite leaflet, resolution of pore opening and content release

248 icant effect on MMP activation, aortic valve leaflet separation or flow velocity.

249 ticles was held at a distance from the outer leaflet-solution interface of bilayers containing smooth

250 nd location of binding relative to the outer leaflet-solution interface.

251 r may impact the outcome by comparing single leaflet-spanning DNA-lipid mediated vesicle fusion with

252 erophospholipids from the outer to the inner leaflet, stimulated via phosphorylation by cortically lo

253 complexes are required for sensing OM outer leaflet stress.

254 the TMD region spanning the vesicle's outer leaflet strongly impairs exocytosis and decelerates fusi

255 s: trial 1 (November, 2012), a supplementary leaflet summarising the gist of the key information; tri

256 n important determinant of mitral valve (MV) leaflet tethering before and after repair.

257 In patients with myocardial infarction (MI), leaflet tethering by displaced papillary muscles induces

258 nature and caused by annular dilatation and leaflet tethering from adverse right ventricular remodel

259 0.11+/-0.02 and was higher in the posterior leaflet than in the anterior leaflet (0.13+/-0.03 versus

260 nding, nitinol valve with bovine pericardial leaflets that is placed using a transapical delivery sys

261 yer: upon hemifusion and mixing of the outer leaflets, the DNA-lipid is free to diffuse into the targ

262 omyelin resided in the plasma membrane outer leaflet; the asymmetry of metabolically active cells was

263 MDCT scans were evaluated for hypoattenuated leaflet thickening that indicated THV thrombosis.

264 t R patients with and without hypoattenuated leaflet thickening were included to study differences be

265 if there was any evidence of hypoattenuated leaflet thickening.

266 al anticoagulants (NOACs) on the subclinical leaflet thrombosis and subsequent valve haemodynamics an

267 We defined subclinical leaflet thrombosis as the presence of reduced leaflet mo

268 ater proportion of patients with subclinical leaflet thrombosis had aortic valve gradients of more th

269 was to report the prevalence of subclinical leaflet thrombosis in surgical and transcatheter aortic

270 ves, prevention and treatment of subclinical leaflet thrombosis might offer a potential opportunity f

271 INTERPRETATION: Subclinical leaflet thrombosis occurred frequently in bioprosthetic

272 Subclinical leaflet thrombosis of bioprosthetic aortic valves after

273 Subclinical leaflet thrombosis resolved in 36 (100%) of 36 patients

274 reduced leaflet motion (p=0.10), subclinical leaflet thrombosis was associated with increased rates o

275 Subclinical leaflet thrombosis was associated with increased rates o

276 Prosthetic leaflet thrombosis was detected in 1 patient at follow-u

277 Subclinical leaflet thrombosis was less frequent among patients rece

278 SAPIEN 3 valves with leaflet thrombosis were on average 10% further expanded

279 106 (12%) of 890 patients had subclinical leaflet thrombosis, including five (4%) of 138 with thro

280 ve in prevention or treatment of subclinical leaflet thrombosis.

281 d at sites of maximal mechanical stress: the leaflet tips and the commissures.

282 e two pairs of helices converge at the inner leaflet to create an intramembrane pocket with additiona

283 trix layer beneath the plasma membrane inner leaflet to facilitate budding from the host cell.

284 This causes the upper leaflet to slide over the lower leaflet, moving domains

285 lamine and phosphatidylserine from the outer leaflet to the cytosolic leaflet of the plasma membrane.

286 way from MBP binding onto a single membrane leaflet to the organisation of a stable MDL.

287 in which the initial response of the apposed leaflets upon quenching is to increase local asymmetry (

288 They occur in the leaflets, usually elongating them, and also in the submi

289 Coronary artery disease and flail leaflet were seen in 10% and 28% of patients, respective

290 nt-specific models of the mitral annulus and leaflets were computed at mid- and end-systole.

291 ontact zones where the two proximal membrane leaflets were in most cases indistinguishable from each

292 Tethered plus MI leaflets were markedly thicker than tethered-alone valve

293 cture, followed by fusion between the distal leaflets, whereas fission is via hemi-fission, which als

294 ng are each required for growth of the valve leaflets, whereas Foxc2 is not required for VV maintenan

295 1(+/-) mice had prolapse of thickened mitral leaflets, which could be traced back to developmental er

296 gy for the phase behavior of coupled bilayer leaflets, which is implicated in cellular processes and

297 ncing of miR-214 by anti-miR-214 in whole AV leaflets with the fibrosa exposed to OS significantly in

298 drophobic boundary of the cytosolic membrane leaflet, with striking parallels to the glutathione bind

299 ormals, MV strain is higher in the posterior leaflet, with the highest strain at the commissures, ann

300 reduced strain concentration in the central leaflet zone.