ライフサイエンスコーパス: leak

1 (17.2%) developed BCs (83 strictures and 44 leaks).

2 dysferlin prevents injury-induced SR Ca(2+) leak.

3 -induced inflammatory responses and vascular leak.

4 ased membrane excitability, and induced RyR2 leak.

5 receptor, which in turn suppresses vascular leak.

6 ulting in prolonged or uncontrolled vascular leak.

7 ed with an unusual HCO3(-) independent anion-leak.

8 sternography was considered positive for CSF leak.

9 ion may contribute by exacerbating capillary leak.

10 w at high pressure without significant water leak.

11 There was no severe paravalvular leak.

12 iectasia, chylolymphatic reflux, and chylous leak.

13 cy) eliminates the temperature dependence of leak.

14 XCL1, CCL2, and CCL7 and attenuated alveolar leak.

15 tabolism, as shown by the increase in proton leak.

16 ation and sarcoplasmic reticulum (SR) Ca(2+) leak.

17 role for alphavbeta5 in modulating vascular leak.

18 target for limiting SOCE-associated vascular leak.

19 ng (OGI) technologies to identify and repair leaks.

20 is realized by selectively targeting larger leaks.

21 ng and regulating stations and from pipeline leaks.

22 and concerns about strokes and paravalvular leaks.

23 se might affect the incidence of anastomotic leaks.

24 We registered 28 (5.6%) anastomotic leaks.

25 role in the development of BCs, particularly leaks.

26 rate at which each would identify and repair leaks.

27 the MLR reduction achievable by remediating leaks.

28 tomoses were more frequently associated with leaks.

29 way that allows for rapid detection of large leaks.

30 ng (OGI) technologies to identify and repair leaks.

31 en cohorts in the frequency of bile or chyle leaks.

32 ompression, fuel delivery, storage, and from leaks.

33 l, and decrease the incidence of anastomotic leaks.

34 Oral contrast swallow detected 7 anastomotic leaks.

35 risk difference, -9.8 to 13.5; P = .73), air leaks (1.9% vs 2.5%; 95% CI of risk difference, -3.3 to

36 Anastomotic leak (15.5% vs 21.2%, P = 0.028) and reintervention rate

37 Moderate paravalvular leak (2.7%) was associated with an increase in mortality

38 events for all patients included anastomotic leaks (30 events in chemotherapy alone group vs 69 in th

39 % reduction in pancreatic fistula/pancreatic leak/abscess (PF/PL/A) (21.9% to 9.2%).

40 Anastomotic leak after colon resection for cancer is a frequent, rel

41 Anastomotic leak after colorectal surgery is a severe complication a

42 an early and reliable marker of anastomotic leak (AL) after colorectal surgery.

43 te failure-to-rescue (FTR) after anastomotic leak (AL) in colectomy patients.

44 and no association between mild paravalvular leak and 1-year mortality was observed, although a small

45 was 61% in patients who had </=mild residual leak and 47% in patients with higher grade of residual P

46 naling increases sarcoplasmic reticulum Ca2+ leak and contributes to global oxidative stress, thereby

47 in remodeller Mxi1, our gates showed minimal leak and digital responses.

48 f(B6) mouse model through increased membrane leak and inflammation.

49 CaMKII phosphorylation of RyR2, SR Ca(2+) leak and mitochondrial membrane depolarization are criti

50 on was successful in patients with traumatic leak and PLPS and, thus, should be considered first-line

51 Patients with traumatic leak and PLPS were combined into 1 group of 16 patients

52 ning complications such as diffuse capillary leak and pulmonary oedema.

53 ally accompanies an increase in paracellular leak and rearrangement of alveolar tight junctions.

54 ty in the steady state and rate of SR Ca(2+) leak and that these actions are independent of store-ope

55 y of microbial functions that are inevitably leaked and the ease of mutational inactivation, our find

56 ect measurements at 230 underground pipeline leaks and 229 metering and regulating facilities using s

57 ent system was developed to quantify methane leaks and losses.

58 Anastomotic leaks and reinterventions were more frequently observed

59 erized by hemodynamic instability, capillary leak, and consumptive coagulopathy.

60 vates RhoB in ECs coincident with developing leak, and inactivation of RhoB correlates with barrier r

61 ing the role of Ca buffers, mitochondria, Ca leak, and regulation of diastolic [Ca(2+)]i.

62 ocessing facilities, storage tanks, pipeline leaks, and well pads, as well as a coal mine venting sha

63 icantly increase sarcoplasmic reticulum Ca2+ leak; and 4) when the chemical reducing capacity of the

64 n, MA, Staten Island, NY, and Syracuse, NY), leaked approximately 25-fold more methane than cities wi

65 Leaks are created stochastically, drawing from the curre

66 are statistically heavy-tailed, and that gas leaks are more extremely distributed than other natural

67 The mutant was also 'leaking' as revealed by a beta-galactosidase-based assay

68 be important in acquired systemic capillary leak associated with critical illness in humans.

69 n declined rapidly in wide-ranging models of leak-associated infections, including anthrax, influenza

70 effect on NOS1(-/-) cardiomyocytes; reducing leak at 37 degrees C but increasing it at subphysiologic

71 iated with MACE was the degree of persisting leak at follow-up (HR, 3.01; P=0.002).

72 Severity of persisting leak at follow-up is independently associated with both

73 or headspace analysis challenging due to gas leaks at the interface of the cell body and the rotator.

74 sted cross-validation to prevent information leaking between patients used for training and validatin

75 tigate whether the blood-brain barrier (BBB) leaks blood-circulating substances in patients with earl

76 significantly higher volume fraction of the leaking brain tissue in the gray matter (P = .004), norm

77 used to determine the volume fraction of the leaking brain tissue.

78 l insulin secretion via its effect on proton leak but instead via modulation of glucose-fueled respir

79 wn to lead to increased vascular endothelial leak, but the underlying molecular mechanisms remain inc

80 characterised the effects of two forms of Ca leak (Ca-sensitising and non-sensitising) on calcium cyc

81 Ca leak can also induce Ca waves.

82 Only Ca-sensitising leak can be reversed by traditional RyR inhibitors such

83 n the presence of adrenergic stimulation, Ca leak can produce biphasic decay; the slow phase results

84 wo pore-domain K(+) channel isoform 1 (K2P1) leak cation currents, reconstituting two levels of resti

85 rly counterbalance hypokalaemia-induced K2P1 leak cation currents, reconstituting two levels of resti

86 rly counterbalance hypokalaemia-induced K2P1 leak cation currents, yielding the N-shaped current-volt

87 te in the Qinghai-Tibet Plateau to analog a "leaking CCS site".

88 C80 is a large component of the NALCN sodium-leak channel complex that regulates the basal excitabili

89 nse, gain-of-function mutation in the sodium leak channel NALCN reduces the total amount and episode

90 scovered that SNr neurons express the sodium leak channel, NALCN, and that SNr neurons lacking NALCN

91 Because deficiency of sodium leak channel, non-selective (Nalcn) causes lethal apnea

92 identified missense mutations in the sodium leak channel, non-selective (NALCN) in four families aff

93 contrast, the roles of voltage-independent "leak" channels, important for the establishment and main

94 a fatal case of pediatric systemic capillary leak (Clarkson's disease) associated with a point mutati

95 LRiMM quantifies financial responsibility if leaked CO2 or brine interferes with subsurface resources

96 l signs evaluated were rectal contrast agent leak, collections of extruded fecal material, mural defe

97 ing dynamic clamp replacement of IKLT with a leak conductance and in the model when voltage-gating of

98 In addition, leak conductance density along the distal axon is estima

99 FHF-free Navs together with very low axonal leak conductance serves to minimize ionic fluxes and ene

100 Stress or injury may exacerbate this leak conductance, putting cells, and particularly neuron

101 x gating mode to convert K2P channels into a leak conductance.

102 lls with an outwardly rectifying background "leak" conductance.

103 further note that the Q913R-associated anion-leak could itself be pathogenic if expressed in the plas

104 Reliable methods to detect and remediate leaks could further minimize MLR.

105 ces conservative estimates of leak rates and leak counts, it can still help prioritize both leak repa

106 urrent) that effectively acted as a negative leak current and counterbalanced the temperature-induced

107 tudy demonstrated that ENaC mediates a Na(+) leak current that affects the steady state membrane pote

108 A depolarizing 'leak' current supports this firing pattern, but its mole

109 The Na(+) leak-current channel (NALCN) regulates locomotion, respi

110 and the upregulation of voltage-independent leak currents through a two-pore-domain potassium channe

111 and are thus dependent on persistent sodium leak currents.

112 2P) channels of the TREK subfamily generate 'leak' currents that regulate neuronal excitability, resp

113 ms leading to RyR2 dysfunction and SR Ca(2+) leak depend on the clinical stage of AF or specific anim

114 Focal-leaks detected in HT-29/B6 colonic monolayers were verif

115 Various leak detection and repair programs can be simulated to d

116 tool for modeling the performance of methane leak detection and repair programs that can be used to e

117 At these flow rates, trouble shooting and leak detection of LC systems has become increasingly cha

118 Our results show that low-cost leak detection programs can rely on high-cost technology

119 ata can be used for more effective design of leak detection technologies.

120 io level range such as workplace monitoring, leak detection, and process studies.

121 ers" greatly enhance the effectiveness of IR leak detection.

122 The degree of leak determines whether decay of Ca waves, biphasic or m

123 Understanding the nature of leak distributions can improve emission estimates, bette

124 se results suggest that neuronal RyR2 Ca(2+) leak due to Calstabin2 deletion contributes to learning

125 the arrhythmic events triggered by SR Ca(2+) leak due to CaMKII-dependent phosphorylation of the RyR2

126 -treat analysis, the primary endpoint of air leak duration was not different between the 2 groups: 1

127 -treat analysis, the primary endpoint of air leak duration was not different between the 2 groups: 1

128 hatase activity, thereby preventing vascular leak during alveolar hypoxia.

129 o detected, confirmed, and repaired pipeline leaks during the campaign.

130 hat differ markedly in capacity are known to leak electrons to oxygen to produce O2() and/or H2O2 We

131 Mice with intracellular Ca(2+) leak exhibited increased atrial RyR2 oxidation, mitochon

132 gates have effectively zero transcriptional leak explaining the limited signal degradation in the ci

133 temporal resolution, and minimal dark-state leak, FLARE should be useful for the study of activity-d

134 om former cell culture studies and suggest a leak flux mechanism of diarrhea.

135 ed to easily predict the risk of anastomotic leak for a given patient.

136 us, K201-induced the inhibition of SR Ca(2+) leak found in cell-system studies may relate to potentia

137 ative outcome domains (including anastomotic leak), four quality of life outcome domains (including f

138 d an assay automation system that provides a leak-free fluid interface during introduction of a seque

139 Azu-A was rendered leak-free in the electrode setup and also responded well

140 the long-term storage and implications of a leak from a carbon capture storage (CCS) site.

141 chylothorax: 2 patients (8%) with traumatic leak from a thoracic duct (TD) branch, 14 patients (56%)

142 ence of ESI-MS on FFE, but creates a current leak from the ESI interface, which adversely affects the

143 During ATP generation, electrons leak from the mitochondrial electron transport chain, wh

144 K201 (JTV-519) may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemi

145 that damage is mediated by increased Ca(2+) leak from the sarcoplasmic reticulum (SR) through the Ry

146 Ca leak from the sarcoplasmic reticulum through the ryanodi

147 n of the ryanodine receptor would lead to Ca leak from the sarcoplasmic reticulum, reducing sarcoplas

148 ce OSI causes increased RyR1-mediated Ca(2+) leak from the SR into the cytoplasm.

149 ia, and North Carolina) to evaluate possible leaking from coal ash ponds.

150 The leaks from digesters are found to significantly increase

151 location and magnitudes of natural gas (NG) leaks from urban distribution pipelines is important for

152 rtality at 1 year, whereas mild paravalvular leak had no significant association with mortality.

153 Anastomotic leak has a large overall effect on 30-day clinical and e

154 The level of leak has major effects on the shape of the Ca transient.

155 the molecular mechanisms governing vascular leak have been studied over the last few decades, recent

156 Two forms of Ca leak have been studied, Ca-sensitising (induced by caffe

157 ally results from ruptured aneurysm, but how leaked hemoglobin regulates the microcirculation in the

158 bowel obstruction, urinary stricture, urine leak, hernia formation, and delayed graft function.

159 Clogging of 150 mum diameter leak holes represented by glass capillary tubes, in reci

160 ted with death were the degree of persisting leak (HR, 2.87; P=0.037), New York Heart Association cla

161 ces such as natural hydrocarbon migration or leaking hydrocarbon wells.

162 New perspectives regarding how vascular leak impacts the progression of various diseases are hig

163 this mechanism, we use it to reduce network leak in an RNA-only cascade.

164 healing and increase the risk of anastomotic leak in colon surgery.

165 2, higher sarcoplasmic reticulum (SR) Ca(2+) leak in diastole and increased propensity to arrhythmias

166 ncing of Drp1 increases mitochondrial proton leak in MIN6 cells.

167 ltered, resulting in a mitochondrial calcium leak in Schwann cell cytoplasm, thereby priming the cell

168 nds in permanent stoma rates and anastomotic leaks in favor of LC but with an increased perineal woun

169 Inadequate surface casing and leaks in production casing and wellhead seals in older,

170 ter reduction (e.g., reduced meter error and leaks in the potable distribution system; 29%), and pota

171 In WT cardiomyocytes, SR Ca(2+) leak increased because temperature decreased from 37 deg

172 on, vascular complications, and paravalvular leak increased.

173 increased generation of superoxide; vascular leak; increased thrombin protein abundance and activity;

174 permeabilization, allowing dsDNA and IgG to leak into the cytosol and activate AIM2 and TRIM21.

175 urces that are important for cell growth yet leak into the environment.

176 a small amount of moisture from HMPA or air leaking into the solution, a minor complex was identifie

177 es have suggested that during AP cathepsin B leaks into the cytosol from co-localized organelles, thr

178 The galaxy is leaking ionizing radiation with an escape fraction of ab

179 As leak is increased, first biphasic decay and then slowed

180 nt understanding of the role played by TRPs, leak K(+) and voltage-gated Na(+) and K(+) channels in t

181 imerization may provide greater diversity of leak K(+) conductances also in native tissues.

182 ajor molecular correlates of the background (leak) K(+) current in a wide variety of cell types.

183 firing reflects a reduction in the standing (leak) K(+) current mediated by Ether-a-go-go-Related Gen

184 leak survey system can document patterns in leak location and magnitude within and among cities, eve

185 le K2P site that stabilizes the C-type gate 'leak mode' and provide direct evidence for K2P selectivi

186 vival to challenge in a lethal DENV vascular leak model in mice immunized with NS1 combined with alum

187 The "load and leak" models were used to screen two large molecular dat

188 6.8%), endophthalmitis (n = 1; 2.3%), wound leak (n = 1; 2.3%), and choroidal detachment (n = 2; 4.5

189 Here, we show that a leak Na(+) channel, Nalcn, is expressed in the CO2/H(+)-

190 alcn hyperpolarized RTN neurons, and reduced leak Na(+) current and firing rate.

191 l excitability, but physiological roles for "leak" Na(+) channels in specific mammalian neurons have

192 riate logistic model showed that the type of leak, namely a high-grade biliary leak, was the only ind

193 However, leaking natural gas causes climate damage because methan

194 gnificant difference in rates of anastomotic leak, nonroutine discharges or readmission among all fou

195 gnificant difference in rates of anastomotic leak, nonroutine discharges or readmission among all fou

196 complex I/NADH oxidase activity and electron leak occurring at complex III of the electron transport

197 During hyperammonaemia, leak of electrons from complex III results in oxidative

198 lishes the UQ-dependent activity, produces a leak of electrons to oxygen, and completely blocks the b

199 ain at the cytochrome bc1 complex, causing a leak of reducing equivalents to O2 whereby electrons tha

200 e United States, the systematic evidence for leaking of coal ash ponds shown in this study highlights

201 CCR tracers, provide strong evidence for the leaking of coal ash ponds to adjacent surface water and

202 myocytes, but enhances SR Ca(2+) sparks and leak on confocal microscopy.

203 hasic decay; the slow phase results from the leak opposing Ca uptake by SERCA.

204 DP had no impact on leaks or bleeds but showed an increase in weight loss wi

205 endently associated with reduced anastomotic leak (OR = 0.57, 95% CI: 0.35-0.94), SSI (OR = 0.40, 95%

206 binding protein coupling that reduces Ca(2+) leak) or local expression of Venus-dysferlin prevented O

207 e heterotroph to remineralize the inevitably leaked organic matter, making nutrients circulate in a m

208 ns into cilia and keeps ARL-13 (Arl13b) from leaking out of cilia via the TZ.

209 of mesoporous silica platforms prevents the leak-out and improves the stability of ICG by protecting

210 pendent risk factors for deep SSIs were bile leak (P < 0.001) and operative time (P < 0.001).

211 5.2% vs 1.9% in patients without anastomotic leak, P < 0.0001) and length of hospitalization (median

212 By functioning as a leak pathway for protons, the Na(+)/H(+) exchanger NHE9

213 An increased passive (leak) permeability to protons, together with reduced vac

214 ignificant difference in risk of anastomotic leak, pneumonia, nasogastric tube reinsertion, reoperati

215 a reduction in wound dehiscence, anastomotic leak, pneumonia, prolonged requirement of mechanical ven

216 formed to synthesize outcomes of anastomotic leaks, pneumonia, nasogastric tube reinsertion, reoperat

217 w punctate hypercyanescent spots on ICGA and leaking points on FA (P < .001 and P = .016, respectivel

218 in modulating injury-induced renal vascular leak, possibly through effects on pericyte adhesion and

219 p SSI, organ space SSI, any SSI, anastomotic leak, postoperative ileus, sepsis, readmission, and reop

220 cating that about one-third of the wells may leak, potentially releasing a total of 3-17 kt of methan

221 d low cuff leak volume or high preextubation leak pressure, poor sedation, and preexisting UAO (P < 0

222 Using this technique, preextubation leak pressures or cuff leak volumes predict subglottic U

223 However, in the presence of isoproterenol, leak produced a biphasic decay of the Ca transient in th

224 beta-adrenergic stimulation, RyR-mediated Ca leak produces a biphasic decay of the Ca transient with

225 oritize both leak repairs and replacement of leak-prone sections of distribution lines, thus minimizi

226 n of larger synthetic regulatory networks as leak propagation can interfere with desired network func

227 entially sutured surgical valve paravalvular leak (PVL) closure.

228 sure of prosthetic mitral valve paravalvular leak (PVL) has emerged as an alternative to surgical tre

229 Paravalvular leak (PVL) occurs in 5% to 17% of patients following sur

230 Staple line leak rate decreased from 6.5% to 1.4%.

231 , thereby providing a method for approximate leak-rate quantification.

232 SLR cases were associated with higher leak rates (0.96% vs 0.65%, odds ratio [OR] 1.20 95% con

233 Pasireotide was recently shown to decrease leak rates after pancreatic resection, though the signif

234 ng method produces conservative estimates of leak rates and leak counts, it can still help prioritize

235 /=38 was associated with significantly lower leak rates compared to BS <38 at patient and surgeon lev

236 Using methane leak rates measured from the Picarro mobile flux plane (

237 2015 and 13 February 2016, shows atmospheric leak rates of up to 60 metric tons of methane and 4.5 me

238 At the surgeon level, leak rates remained significant, but bleeding events bec

239 phagogastrectomy, post-operative anastomotic leak rates were higher in the chemotherapy plus bevacizu

240 SLR is associated with increased leak rates.

241 the TIE2 locus as a determinant of vascular leak-related clinical outcomes from common infections, s

242 capacity (E CI+II ; P = 0.01) increased, and LEAK-related flux control factor (FCFL; P = 0.02) decrea

243 centrations of phosphates that could inhibit leak repair over the short-term in one water tested were

244 ing the likelihood of scaling and in-service leak repair via clogging with calcium carbonate solids i

245 u and in-service water distribution pipeline leak repair via clogging.

246 ak counts, it can still help prioritize both leak repairs and replacement of leak-prone sections of d

247 dipocytes displayed higher ISO-induced basal leak respiration and overall oxygen consumption rate, al

248 b LCLs exhibited significantly higher proton leak respiration.

249 e model that such abnormal resting SR Ca(2+) leak resulted in reduced contractile function and muscle

250 h as hemorrhage, subhepatic collection, bile leak, retained stones, postoperative endoscopic retrogra

251 ed houses, major structural problems such as leaking roofs were repaired, windows screened, open eave

252 permeability was quantified by the Confocal Leak Score (CLS; range: 0=no impaired permeability to 10

253 ed urban groundwater intercepted NO3(-) from leaking sewers.

254 Anastomotic leak significantly increased mortality (15.2% vs 1.9% in

255 his study utilizes a naturally occurring CO2 leaking site in the Qinghai-Tibet Plateau to analog a "l

256 y to explore the distribution of natural gas leak sizes.

257 membranes formed from pure tetraether lipids leaked small ions at a rate that was about two orders of

258 that Nalcn, a unique channel that generates "leak" sodium currents, regulates excitability and neurom

259 The probability of entering the leak state is increased at higher DeltapH.

260 3 degrees C, whereas in NOS1(-/-) cells, the leak suddenly increased when the temperature surpassed 3

261 ee medium and S107, which inhibits SR Ca(2+) leak, suggest the SR as the primary source of Ca(2+) res

262 -prep) on outcomes, particularly anastomotic leak, surgical site infection (SSI), and ileus, were eva

263 Our data indicate that this automated leak survey system can document patterns in leak locatio

264 dexamethasone prophylaxis against capillary leak syndrome (CLS).

265 The enigmatic systemic capillary leak syndrome (SCLS) named for Dr Clarkson is characteri

266 cular permeability (e.g., systemic capillary leak syndrome and sepsis), we sought to analyze plasma c

267 ICU management of severe systemic capillary-leak syndrome episodes.

268 largest cohort of severe systemic capillary-leak syndrome flares requiring ICU admission.

269 (ANDV) is associated with a lethal vascular leak syndrome in humans termed hantavirus pulmonary synd

270 Systemic capillary-leak syndrome is a very rare cause of recurrent hypovole

271 brain microcirculation, underlying vascular leak syndrome that complicates cancer immunotherapy with

272 liberation protocol, be assessed with a cuff leak test if they meet extubation criteria but are deeme

273 ours before extubation if they fail the cuff leak test.

274 s, ventilator liberation protocols, and cuff leak tests.

275 in transporting methane without substantial leaks, the conversion of methane directly into electrici

276 contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel

277 ervious sedimentary layers trap CO2 that has leaked through the primary seal of the storage formation

278 the contribution of ATP turnover and proton leak to basal mitochondrial oxygen consumption rate (OCR

279 and counterbalanced the temperature-induced leak to rescue neuronal oscillations.

280 atory signal of one gene can stochastically 'leak' to the other, causing increased gene expression no

281 t, however, because commonly used components leak transcriptionally, do not arbitrarily interconnect

282 These channels produce background leak type potassium currents that act to regulate restin

283 A unifying result is that the largest 5% of leaks typically contribute over 50% of the total leakage

284 The integrated membranes display no leaking upon placement into the base.

285 ciated with subglottic UAO included low cuff leak volume or high preextubation leak pressure, poor se

286 hnique, preextubation leak pressures or cuff leak volumes predict subglottic UAO in children, but onl

287 Anastomotic leak was associated with the incidence of end-organ dysf

288 Contrast agent leak was highly specific (96%-98%), but insensitive (42%

289 Proton leak was lower in aged subjects when determined at the s

290 Ts, the presence or absence of preextubation leak was not associated with subglottic UAO.

291 Preprocedural leak was severe (61%), moderate (34%), or mild (5.7%) an

292 The mortality rate after leak was similar to mortality after other major complica

293 ent sensitivity, while rectal contrast agent leak was specific but insensitive.

294 he type of leak, namely a high-grade biliary leak, was the only independent prognostic factor associa

295 At low levels of leak, waves occur.

296 New endo-leaks were associated with increased aneurysm size measu

297 Besides, during the mobile surveys, many gas leaks were identified that are not included in the inven

298 nique is necessary to locate the site of CSF leak which is required for surgical/endoscopic repair of

299 This incomplete repression causes expression leak, which impedes the construction of larger synthetic

300 t-ischemic kidneys revealed reduced vascular leak with alphavbeta5 antibody treatment.

301 Increasing SR leak with either caffeine (to sensitise the RyR to Ca ac