ライフサイエンスコーパス: leakiness

1 cells by decreasing intratumoral microvessel leakiness.

2 ably integrated TRE-reporter from exhibiting leakiness.

3 also characterized by an increase in mucosal leakiness.

4 ng EC proliferation associated with vascular leakiness.

5 nsporter and, perhaps, for minimizing cation leakiness.

6 ation, increased ANG2 expression, and vessel leakiness.

7 after irradiation while increasing vascular leakiness.

8 intrinsic property of VEGF to promote vessel leakiness.

9 d the opposite effect of increased Delta and leakiness.

10 rage of tumor vessels and decreased vascular leakiness.

11 lux does not correlate with increased vessel leakiness.

12 enhanced lumen formation, and reduced vessel leakiness.

13 pled synthase activity accompanied by proton leakiness.

14 ity but exhibited growth deficits and proton leakiness.

15 J, preventing persistent endothelial barrier leakiness.

16 , presumably because of angiogenic capillary leakiness.

17 ndothelial junctions and prevent microvessel leakiness.

18 any significant influence on the nanovalves' leakiness.

19 ical-mechanical coupling, but increased RyR2 leakiness, a paradoxical response further exacerbated by

20 tially inhibited and a reduced level of cell leakiness, a prominent feature of F+ cells abortively in

21 MR imaging-assayed acute change in vascular leakiness after a single dose of bevacizumab was an earl

22 gonists were effective at preventing barrier leakiness after LPS administration.

23 liar to mutT bacteria due to transcriptional leakiness, although there is no evidence that this is a

24 of immune cells, increased lymphatic vessel leakiness and changes in the gene expression patterns of

25 s well known, lipid vehicles exhibit maximum leakiness and contents release in the vicinity of phase

26 of immune cells, increased lymphatic vessel leakiness and decreased expression of lymphatic specific

27 terminant of the persistent vascular barrier leakiness and edema formation associated with inflammato

28 rombocytopenia would increase tumor vascular leakiness and facilitate the effective delivery of chemo

29 t-derived xenografts (PDX), such as vascular leakiness and increased hypoxia.

30 tween these cells contribute to tumor vessel leakiness and may permit access of macromolecular therap

31 A Glu(54) to Asp(54) change increased proton leakiness and reduced malate growth 79-90%.

32 ultivar differences in cold-induced membrane leakiness and seedling vigor.

33 has been developed that demonstrates minimal leakiness and significant induction with doxycycline.

34 a, which in turn induced pleural vasculature leakiness and triggered NF-kappaB activation in pleural

35 inase C activation leads to tight junctional leakiness and, consequently, to increased transepithelia

36 n the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels.

37 d pumping altogether, possibly due to UNC-68 leakiness and/or malfunctional SR Ca(2+) homeostasis.

38 ransient due to increased ryanodine receptor leakiness and/or sarco/endoplasmic reticulum Ca ATPase a

39 Detergent sensitivity, leakiness, and growth characteristics of the novel vesic

40 ng rate, lymphatic vessel density, lymphatic leakiness, and lymphatic macromolecule clearance (all P

41 ed tissue oxygenation, limited microvascular leakiness, and prevented airway ischemia, even in the ab

42 cal processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells

43 Sunitinib rapidly decreased vessel leakiness, and this effect was more pronounced in patien

44 ol ratio (L:M), which primarily assesses gut leakiness, and which also measures absorption.

45 2/20), but not PLD(57), induces POPC vesicle leakiness as measured by entrapped CF leakage.

46 anoma-derived exosomes also induced vascular leakiness at pre-metastatic sites and reprogrammed bone

47 and Verapamil increases tumor angiogenesis, leakiness, blood flow, and Gemcitabine delivery.

48 c, unclosed phagolysosomal compartment whose leakiness blunts the toxicity of lysosomal enzymes, ther

49 ation by secreting Angpt1, reducing vascular leakiness but slowing niche recovery.

50 tor (PAF) induces severe endothelial barrier leakiness, but the signaling mechanisms remain unclear.

51 -2495 recapitulates this arrhythmogenic RyR2 leakiness by unzipping N-terminal and central domains.

52 Only through progressively increasing the leakiness can the model qualitatively reproduce the expe

53 This partitioning of benefits, also called 'leakiness', can produce negative frequency dependence of

54 r vessel leakiness, mediators of endothelial leakiness, consequences of tumor vessel leakiness, genom

55 ing progressive vascular disorganization and leakiness culminating in massive ascites.

56 Obesity induces lymphatic leakiness, decreases initial lymphatic vessel density, i

57 d defective junctions, resulting in vascular leakiness, edema, and impaired heart function.

58 discussed the cellular basis of tumor vessel leakiness, endothelial barrier function of blood vessels

59 The ubiquity of leakiness favors a 'race to the bottom' as members of a

60 accine-derived protection, and (IV) vaccine "leakiness." For scenarios I-IV, successful booster strat

61 ement observed was associated with a reduced leakiness from tumor vessels, consistent with induction

62 lial leakiness, consequences of tumor vessel leakiness, genomic analysis of vascular targets, targeti

63 ng pathways that mediate endothelial barrier leakiness (hyperpermeability) that are important in the

64 Our data demonstrate that barrier leakiness in asthmatic patients is induced by TH2 cells,

65 fully appreciate the consequences of vessel leakiness in cancer.

66 The different leakiness in cell cycle regulation between two stage-spe

67 tant component of capillary walls, affecting leakiness in healthy or tumor vasculature.

68 We tested for subtle generalized BBB leakiness in patients with lacunar stroke and control pa

69 Also, leakiness in repairing DNA lesions and uncapped telomere

70 ts increases with age, partly as a result of leakiness in the aged thymus, allowing reentry of naive

71 due to a lack of microsatellite markers and leakiness in the Rfv3 phenotype, which prevented definit

72 Despite the leakiness in the system, B cell-specific MHCII deletion

73 pression studies suggest that tight junction leakiness in these two strains of MDCK cells is conferre

74 focused on the significance of blood vessel leakiness in tumors.

75 elium in vivo and correlates with epithelial leakiness in vitro.

76 y on a treadmill and reduced muscle membrane leakiness in vivo that is characteristic of mdx and Sgcd

77 ine-type structures, indicating significant "leakiness" in the pathway which converts oligomannose to

78 d IgA in lung secretions because of "mucosal leakiness" in these mice.

79 measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance ima

80 knockdown tumors have significantly reduced leakiness, increased oxygenation, and greater apoptosis.

81 awater oligotrophy by reducing its selective leakiness, increasing the acquisition of essential nutri

82 itric oxide production trigger marrow vessel leakiness, instigating pro-leukemic function.

83 Blood vessel leakiness is an early, transient event in acute inflamma

84 This leakiness is largely attributable to a tumor-secreted cy

85 This leakiness is shown here to result in as much as a 20-fol

86 cer therapy, but the structural basis of the leakiness is unclear.

87 Our finding that nuclear "leakiness" is dramatically accelerated during aging and

88 receptor-2 activation, promoting less vessel leakiness, less tissue inflammation, and better perfusio

89 gies (which enhance blood vessel numbers and leakiness) may be optimized for combination therapies as

90 on of blood vessels, monitoring tumor vessel leakiness, mediators of endothelial leakiness, consequen

91 dow chamber, indicating that although vessel leakiness might be acting as a source of acid, it is not

92 Leakiness of blood vessels in tumors may contribute to d

93 the complex virus-cell interactions and the leakiness of cellular promoters in the viral genome.

94 ed a lower Delta and thus a lower calculated leakiness of CO(2) (the ratio of CO(2) leak rate from th

95 Abnormal leakiness of connexin hemichannels is likely a mechanism

96 cells within the central corneal epithelium, leakiness of corneal neovessels, loss of axons in cornea

97 arly, concentration-dependent, and transient leakiness of EC.

98 a (0.5 ng/mL) induced an early, irreversible leakiness of EC.

99 nea and function as a pump to counteract the leakiness of its basement membrane.

100 The intrinsic leakiness of LTR often makes the measurement of low-leve

101 ate inflammatory conditions by promoting gut leakiness of microbial products, by sensitizing immune c

102 difficult to detect directly because of the leakiness of proteoliposomes, vesicle aggregation and ru

103 g4-deficient embryos correlate with relative leakiness of residual end joining in these mutant backgr

104 ing can reduce the vascularity of tumors and leakiness of surviving vessels, but little is known abou

105 We propose that the leakiness of the chaperonin system under physiological c

106 oxygen species (ROS), which are generated by leakiness of the electron transport chain (ETC).

107 n and its consequence in contributing to the leakiness of the endothelial barrier.

108 hereby causing a general destabilization and leakiness of the lipid bilayer membrane.

109 edance plots, regardless of the tightness or leakiness of the paracellular shunt pathways.

110 In two animals, the leakiness of the tumors before disruption was evaluated

111 response was a result of an increase in the leakiness of the vascular system to air seeding.

112 struct into LLC-PK1 renal epithelia produces leakiness of tight junctions to certain types of solutes

113 that low platelet count selectively induces leakiness of tumor vessels and favors the delivery of ch

114 The leakiness of tumor vessels is well documented in experim

115 y vessels in inflammation, could explain the leakiness of tumor vessels.

116 d tight junctions may contribute to enhanced leakiness of vasculature in Kindlin-2(+/-) mice.

117 ne energetic cost of the C(4) pathway is the leakiness () of bundle sheath tissues, whereby a variabl

118 e to drug absorption, and (iv) the relative "leakiness" of the human jejunum is not so different from

119 ricyte-endothelial crosstalk alters vascular leakiness or remodeling in the airways of mice under fou

120 urface of endothelial cells through vascular leakiness or whether the rapid accessibility results ins

121 on of the acute change in MR imaging-assayed leakiness, or Delta K(PS).

122 rreversibility, hypersensitivity to promoter leakiness, restriction to proliferating cells, slow indu

123 reduced vessel patency and increased vessel leakiness, resulting in large increases in tumor hypoxia

124 associated with persistent vascular barrier leakiness such as acute lung injury.

125 maging-assayed change in tumor microvascular leakiness, tested as a potential biomarker, correlated s

126 cell fiber, leading to membrane ruptures and leakiness that induces myofiber necrosis, a subsequent i

127 For intact PLD(57) to cause CF leakiness, the soluble activator diC(4)PA must be presen

128 Angiopoietin/Tie2 signaling can reduce the leakiness through changes in endothelial cells.

129 TO-2 hamsters corrected muscle cell membrane leakiness throughout the body and normalized serum creat

130 he protective effect of Ang1 on blood vessel leakiness to plasma proteins raises the possibility of a

131 We demonstrate that this strategy reduces 'leakiness' to improve overall expression dynamic range,

132 efficacy, vascular enlargement, endothelial leakiness, venular marker expression, pericyte changes,

133 Chronic BBB leakiness was associated with cognitive impairment, as a

134 ole of HDAC activation on epithelial barrier leakiness was confirmed by HDAC inhibition, which improv

135 ts grown at elevated CO(2) and bundle sheath leakiness was estimated to be 24% and 33%, respectively,

136 eltapsi(m)) was decreased and inner membrane leakiness was increased moderately.

137 essel patency was reduced by 25%, and vessel leakiness was increased threefold, resulting in a 10-fol

138 several endothelial cell lines, but without leakiness when uninduced.

139 ll, alcohol-dependent subjects developed gut leakiness, which was associated with higher scores of de