ライフサイエンスコーパス: leaky

1 ort in intestinal epithelia, rendering them "leaky".

2 when vessels are uncompressed, but not very leaky.

3 giogenesis, but the newly formed vessels are leaky.

4 ted to the propensity of a nanocarrier to be leaky.

5 , rendering the sarcolemma more permeable or leaky.

6 ences, barriers to exchange between them are leaky.

7 The final state (FP) was not leaky.

8 nt ats1 mutant alleles revealed that all are leaky.

9 e imaging and found that the tumors were not leaky.

10 es to alleviate resurgence when vaccines are leaky.

11 such that HR is chemically inducible and non-leaky.

12 g off ABA signal transduction, to counteract leaky ABA signal transduction caused by "monomeric" PYL/

13 eta-band (10-30 Hz) signals, resulting in a "leaky" accumulation process that conferred greater behav

14 g models that forms decisions by acting as a leaky accumulator with non-absorbing bounds.

15 rcina mazei, Methanobrevibacter smithii) are leaky and aggregate at high salt concentrations.

16 curring switch of the lac operon; it is less leaky and can be induced more efficiently.

17 te if tumors grown in Cav-1 KO mice would be leaky and grow faster.

18 The neovessels in alpha(M)(-/-) mice were leaky and immature because they lacked smooth muscle cel

19 : In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms that are incompletely u

20 The blood vessels of cancerous tumours are leaky and poorly organized.

21 However, we found that the phot2-1 mutant is leaky and produces a small level of full-length phot2 pr

22 beta2 makes lysosomal membranes unstable and leaky and this effect is exacerbated with the addition o

23 he circumstances under which the gut becomes leaky and to discover bacterial metabolites that promote

24 er of the target membrane so that it becomes leaky and unable to form a clean fusion pore.

25 Vessels in the kindlin-2(+/-) mice were leaky, and BM transplantation from kindlin-2(+/-) to WT

26 cular function by exacerbating nonproductive leaky angiogenesis.

27 The shorter the linkers, the less leaky are the nanovalves.

28 Genetic ablation of Mfsd2a results in a leaky BBB from embryonic stages through to adulthood, bu

29 , WBCs populated the perivascular space of a leaky BBB.

30 As the tumors were not leaky before BBB disruption and there were no responders

31 e blockade of B-cell differentiation, with a leaky block in T-cell differentiation resulting in an ol

32 non-tortuous blood vessel formation and non-leaky blood vessels by 10 days post-stroke.

33 Architecturally defective, leaky blood vessels typify pathologic angiogenesis induc

34 s release factors that promote the growth of leaky blood vessels which contribute to metastatic sprea

35 sequent stages there were fewer capillaries, leaky blood vessels, disrupted endothelium - perivascula

36 orm transient openings and closings at these leaky blood vessels.

37 eter in the developing brain, resulting in a leaky blood-brain barrier (BBB).

38 ampus, and is essential for development of a leaky blood-brain barrier after seizures.

39 A leaky blood-brain barrier has long been implicated in co

40 /serine domain-binding protein that prevents leaky BMP type I receptor activation in the absence of l

41 ns resulting in abnormal cell mixing across 'leaky' borders.

42 te promotes and sustains an up-regulated and leaky - but N-limited - internal N cycle.

43 m the channel domain, leaving an unregulated leaky Ca(2+) pore.

44 rization dynamics in myocytes by acting as a leaky cap at thin filament pointed ends.

45 A leaky-capacitor model related to the dielectric properti

46 M treatment, no ultrastructural evidence of leaky capillaries in the brain was observed in the septi

47 to the formation of abundant microaneurysms, leaky capillaries, and retinal hemorrhages.

48 mpaired lymphatic function, characterized by leaky capillary lymphatics and decreased collecting vess

49 vasculature including endothelial cell lined leaky capillary vessels along with 3D solid tumors.

50 converts the receptor into a constitutively leaky cation channel.

51 c paralysis (hypoPP; usually associated with leaky cation channels in muscle cells).

52 al surface with masked surface rodlet layer, leaky cell wall allowing the deposition of proteins on t

53 to result from malformed vascular walls with leaky cell-to-cell junctions.

54 er carbon and energy metabolism, but only in leaky cells with a proton permeability equivalent to fat

55 s that simulate exercise, consistent with a "leaky" channel.

56 utations introduced into RyR2 that result in leaky channels and cause exercise induced polymorphic ve

57 ls in the brain cause epilepsy, and the same leaky channels in the heart cause exercise-induced sudde

58 , and PKA hyperphosphorylated, resulting in "leaky" channels in failing hearts.

59 g subunit calstabin1 (FKBP12), resulting in "leaky" channels that cause decreased exercise tolerance

60 RyR2 mutations cause "leaky" channels, resulting in diastolic Ca(2+) leak from

61 stabilizing binding protein), resulting in 'leaky' channels.

62 a fractured containment regime behaves as a leaky chemical reactor regarding its effect on isotopic

63 ition, there is substantial depletion of the leaky claudin, claudin-2, but not other tight junction c

64 Furthermore, leaky claudins have been shown to be required for epithe

65 pathies has been revealed by the finding of 'leaky' closed sodium channels.

66 sensitive but nonspecific in identifying FA leaky CNV.

67 udin-3-/- mice revealed dedifferentiated and leaky colonic epithelium, and developed invasive adenoca

68 rarchical evidence integration, hierarchical leaky competing accumulation (HLCA), and probabilistic e

69 nt scattering effects, which we attribute to leaky eigenmodes of the photonic crystal.

70 e representing a novel target for preventing leaky endothelial barrier syndrome.

71 ss fibers, resulting thereby in formation of leaky endothelial barrier.

72 JC as an underlying factor contributing to a leaky epithelial barrier in Crohn's patients.

73 mmatory bowel disease, are associated with a leaky epithelial barrier, resulting in excessive exposur

74 elial barrier integrity in AR, maintaining a leaky epithelial barrier.

75 with watery diarrhoea, which was caused by a leaky epithelium and reduced bile re-absorption in the i

76 eins, as its expression is restricted to the leaky epithelium in vivo and correlates with epithelial

77 otic activities of these compounds against a leaky Escherichia coli strain and the wild-type strain r

78 tringent catabolite repression, resulting in leaky expression of genes that are not required for grow

79 oic acid receptor alpha, enabling a mild and leaky expression of proinflammatory mediators.

80 We found that this loop can reduce leaky expression of target genes in the presence of gluc

81 Leaky expression resulted in two levels of PH-Tau: low b

82 ) tCRISPRi shows significantly less than 10% leaky expression.

83 liquid filaments are central to dripping of leaky faucets, inkjet drop formation, and raindrop fragm

84 ature, such as "dripping ants" or drops from leaky faucets.

85 rstanding of charge conduction mechanisms in leaky ferroelectrics and advance the design of switchabl

86 ay damage the intestinal epithelial barrier (leaky-flux diarrhea) and/or alter chloride ion secretion

87 by rendering the sarcoplasmic reticulum (SR) leaky for Ca(2+).

88 We develop a model where organisms perform 'leaky' functions that provide both private and public be

89 that CPP escape into the cytosol is based on leaky fusion (i.e., fusion associated with the permeabil

90 We ruled out leaky fusion as a mechanism of release by including 2 mo

91 des cross BMP-enriched membranes by inducing leaky fusion between them.

92 the G13A fusion domain mutant produces a new leaky fusion phenotype.

93 acute angle is required to promote clean non-leaky fusion suitable for virus entry presumably by inte

94 The relation of 'leaky' fusion to the observed prefusion structures is di

95 Genetic autopsies have detected "leaky" gain-of-function mutations in the ryanodine recep

96 tellar absorption lines for identifying such leaky galaxies.

97 Accordingly, we propose a "leaky gate" model in which Grp(+) neurons transmit both

98 s to polar amino acids produce channels with leaky gates that conduct ions in the resting state.

99 entials, consistent with the proposal that a leaky gating pore in R669H channels triggers attacks, wh

100 LplA imparts DeltalipB strains with a 'leaky' growth phenotype on aerobic glucose minimal mediu

101 r is utilized to demonstrate a novel type of leaky-guided acoustic wave that couples simultaneously t

102 The data suggest that a leaky gut barrier is linked with liver steatosis and cou

103 resenting increased intestinal permeability (leaky gut) such as depression, showing a potential thera

104 Psychosocial stress, diet, obesity, a leaky gut, and an imbalance between regulatory and pro-i

105 cient (Nr1i2(-/-)) mice showed a distinctly "leaky" gut physiology coupled with upregulation of the T

106 Prolonged morphine treatment results in a "leaky" gut, predisposing to colonic inflammation that is

107 blood vessels in tumours by making them less leaky--have been shown to improve the delivery and effec

108 iated cell death may be related to abnormal 'leaky' hemichannels but we produced direct evidence agai

109 The drug cessation caused highly leaky hepatic vasculatures permit tumour cell intravasat

110 In laser-irradiated tumors, the use of leaky HPPH liposomes resulted in improved doxorubicin bi

111 becomes more stringent if vaccine action is leaky (ie, the susceptibility of each vaccine recipient

112 ods from percolation theory we consider both leaky immunity, where all previously infected individual

113 properties, angiogenic blood vessels become leaky in premalignant tissue and at peripheries of carci

114 e of inducing BTB remodeling, making the BTB leaky in studies in vivo Furthermore, NC1 domain peptide

115 onstrated that Cre recombinase expression is leaky in un-induced EL350 cells and that some BAC/PAC se

116 ight junction disruption, making the barrier leaky), in the testis in vivo We report our findings tha

117 arsupials is characterized by exclusive, but leaky inactivation of the paternally derived X chromosom

118 blood vessels of tumors are a mess-chaotic, leaky, inefficient, and barely making do.

119 ise rather than by non-linearities; and 5) a leaky integrate and fire model reproduces these results

120 nts are conducted in a multilayer network of leaky integrate-and-fire (LIF) spiking neuron models.

121 rall, the spiking activity of the fractional leaky integrate-and-fire model deviates from the spiking

122 Here we developed and analyzed a fractional leaky integrate-and-fire model in which the exponent of

123 Similarly, in exponential leaky integrate-and-fire models using a shallow voltage-

124 random crossing of the firing threshold by a leaky integrate-and-fire neuron model, and (iii) assumin

125 SOC behavior in networks of non-conservative leaky integrate-and-fire neurons with short-term synapti

126 , we use the master equation for generalized leaky integrate-and-fire neurons with shot-noise synapse

127 of weight dynamics in a simple system with a leaky-integrate-and-fire neuron with a random spike-trai

128 t a simplified, sparse inhibitory network of Leaky-Integrate-and-Fire neurons can reproduce some key

129 s that estimate reward rates by a process of leaky integration, and that link together the input and

130 assuming an internal state that behaves as a leaky integrator of stimulus exposure.

131 e-dependent behavior could be described by a leaky integrator process with a time constant of 0.6 s.

132 A computational model using coupled leaky integrator units with biophysically plausible assu

133 These leaky integrators encode the Laplace transform of their

134 These vectors are leaky integrators that could be constructed from a popul

135 ce unfolding in time is encoded via a set of leaky integrators.

136 we demonstrate that sea urchin larvae have a leaky integument.

137 decrease in transepithelial resistance and a leaky intestinal epithelium that was determined by in vi

138 Compressor vents, leaky isolation valves, reciprocating engine exhaust, an

139 found that when electrode damage makes cells leaky it could profoundly distort cellular excitability

140 owth of rare cells with a duplication of the leaky lac allele.

141 ly as immediate early (alpha), early (beta), leaky late (gamma1), and true late (gamma2), where viral

142 revealed that UL91 protein is expressed with leaky-late (gamma1) kinetics, localizes in the nucleus w

143 ges, swollen axons and terminals, as well as leaky-like DiI-labeled terminals, were observed in long-

144 g pathway is a critical factor in persistent leaky lung microvessels and edema formation in the disea

145 y with scale-free properties--is examined in leaky Markovian networks.

146 opting an approach suitable for electrically leaky materials as MAPbI3, we show here ferroelectric hy

147 ld-type fusion domain promotes efficient non-leaky membrane fusion, we asked whether different angles

148 cannot be explained by classic quasi-steady "leaky membrane" models, which always predict instability

149 Pumping protons across leaky membranes offers no advantage, even when permeabil

150 Dclre1c(leaky) mice also had inflammatory symptoms, including wa

151 Dclre1c(leaky) mice present with a complete blockade of B-cell d

152 vironments, which are characterized by dense leaky microvasculature and acidic extracellular pH (pHe

153 mas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high

154 ctions) with different polarizations - a 'bi-leaky' mode.

155 ographic video displays based on anisotropic leaky-mode couplers, which have the potential to address

156 not superior in performance to conventional leaky-mode fiber optic silica HWGs having similar optica

157 Here, we show that leaky-mode resonances, which can gently confine light wi

158 elies on imaging multimode interference from leaky modes along a multimode tapered optical fibre, res

159 at visible wavelengths and engineering their leaky modes so that they overlap with the absorption and

160 d, allowing for the simulation of radiative (leaky) modes.

161 In the leaky mterf6-1 mutant, a defect in photosynthesis is ass

162 affect this process - on the gut flora, the 'leaky' mucosal membrane and endotoxin coupled lipid abso

163 to our knowledge for the first time, that a leaky mutation in the Arabidopsis (Arabidopsis thaliana)

164 sfunction of RyR2 channels in the brain via 'leaky mutations' can result in mild developmental delay

165 ridity and vegetation interact to maintain a leaky N cycle during periods when plant N uptake is low,

166 it of tumor cell dissemination, due to their leaky nature and secretion of tumor-recruiting factors.

167 tially and quantitatively with the amount of leaky neovasculature seen on T1Gd.

168 in tight junction proteins associated with "leaky" nephron segments (e.g., claudin-2).

169 fer of two particular types of noise: basal (leaky) network activity and cell-to-cell variability in

170 Previous studies identified a role of leaky neuronal RyR2 in posttraumatic stress disorder (PT

171 The biophysical mechanisms by which these leaky neurons maintain their excitability are not unders

172 contact with p15/ARPC5 led to unregulated ("leaky") nucleation in the absence of WASp.

173 The growth defect and leaky outer membrane phenotypes are suppressed when the

174 cin-sensitive Escherichia coli strain with a leaky outer membrane, we identified a mutant with increa

175 otope ratio data have suffered slightly from leaky p-n junctions produced during the manufacture of t

176 ctivity, which might result from one or more leaky pal mutant genes or from other unknown PAL genes.

177 Thus, one cause of the leaky pipeline in biomedical research may be the exclusi

178 ology, and policy-making has focused on the "leaky pipeline" problem: the observation that fewer wome

179 omen to pursue research careers to stop the 'leaky' pipeline.

180 ducible promoters cause background HR due to leaky protein expression, preventing the generation of r

181 nm nanoparticles after they extravasate from leaky regions of the tumor vasculature and are exposed t

182 rapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enh

183 and exhibit enhanced accumulation around the leaky regions of the tumor vasculature, but their large

184 translation is regulated by a combination of leaky ribosomal scanning and reinitiation, and that the

185 se a model in which AUGs 1-4 are accessed by leaky ribosomal scanning, with sORF2 repressing synthesi

186 ir proteomes and coordinate their functions, leaky ribosome scanning behavior provides adaptive advan

187 1 isoforms, probably via a context-dependent leaky ribosome scanning mechanism.

188 rillation (AF) risk has been associated with leaky ryanodine receptor 2 (RyR2) Ca release channels.

189 cating that these phenotypes are caused by a leaky ryanodine receptor.

190 errant diastolic calcium (Ca) release due to leaky ryanodine receptors (RyR2s) has been recently asso

191 release from the sarcoplasmic reticulum via "leaky" ryanodine receptors (RyR2s) is hypothesized to co

192 Targeting AF caused by leaky RyR2 Ca channels with R-propafenone may be a more

193 is a combined neurocardiac disorder in which leaky RyR2 channels in the brain cause epilepsy, and the

194 cause or inhibit SR Ca2+ leak, we found that leaky RyR2 channels result in mitochondrial Ca2+ overloa

195 signaling, and altered Ca(2+) signaling via leaky RyR2 channels.

196 Leaky RyR2 could be a therapeutic target for treatment o

197 Here we find that a human leaky RyR2 mutation, R176Q (RQ), alters neurotransmitter

198 uting to premature death in individuals with leaky RYR2 mutations.

199 We discovered that CPVT patients with mutant leaky RyR2 present with glucose intolerance, which was h

200 mpaired SR Ca2+ reuptake that conspires with leaky RyR2 to deplete SR Ca2+.

201 Our data demonstrate that leaky RyR2, but not IP3R2, channels cause mitochondrial

202 Thus, CPVT-associated mutant leaky Ryr2-R2474S channels in the brain can cause seizur

203 2.6 (also known as calstabin2), resulting in leaky RyR2.

204 -dependent protein kinase (CaMKII)-dependent leaky RyR2.

205 he arrhythmias induced by a CaMKII-dependent leaky RyR2.

206 As these mutations result in a "leaky" RyR2 channel, we exploited them to assess RyR2 ch

207 CPVT-associated RyR2 mutations result in "leaky" RyR2 channels due to the decreased binding of the

208 These leaky RyR2s contribute to depletion of Ca2+ from the SR,

209 Pathogen contamination from leaky sanitary sewers poses a threat to groundwater qual

210 (MH) susceptibility has been attributed to a leaky sarcoplasmic reticulum (SR) caused by missense mut

211 o neuroendocrine stress, with sensitized and leaky sarcoplasmic reticulum Ca(2)(+) release as a compe

212 ranslation induction is governed by means of leaky scanning and not re-initiation.

213 UUG codons (Sui(-) phenotype) and decreases leaky scanning at AUG, while the NTT mutation 17-21 supp

214 els of 40S-bound eIF5 and eIF1 and increases leaky scanning at the GCN4 uORF1.

215 tion of the major ORF of IFRD1 involves both leaky scanning at the upstream AUG codon and re-initiati

216 is responsive to stress conditions and that leaky scanning can induce ORF translation by bypassing p

217 ffects 40S occupancy of eIF3, and produces a leaky scanning defect indicative of a deregulation of th

218 Our data indicate that leaky scanning like re-initiation is responsive to stres

219 ct as negative regulators through a ribosome leaky scanning mechanism.

220 upt their interactions with the RRM increase leaky scanning of an AUG codon.

221 Leaky scanning past the uORFs facilitates ORF35 expressi

222 ey tryptophan residues results in the severe leaky scanning phenotype partially suppressible by overe

223 Such leaky scanning resulted in the suppression of mouse MOR

224 translation of uORFs on uORF1 and attenuate leaky scanning that bypasses uORFs.

225 The loss of SUA5 causes increased leaky scanning through AUG codons, +1 frameshifting, and

226 translation initiation by re-initiation and leaky scanning using downstream AUG codons.

227 de of translational initiation regulation is leaky scanning, and this regulatory process has not been

228 he downstream P gene translated by ribosomal leaky scanning.

229 of eIF5 and eIF2beta mutations and increases leaky scanning.

230 A leaky-scanning model of translation based on Kozak trans

231 ps5 that reduced bulk initiation, conferred 'leaky-scanning' of AUGs; and lowered initiation fidelity

232 entified in patients with Omenn syndrome and leaky SCID as a result of hypomorphic RAG mutations.

233 16, 32 patients with NBS-identified SCID and leaky SCID from California and other states were treated

234 py; these infants had typical SCID (n = 11), leaky SCID or Omenn syndrome (n = 3), or complete DiGeor

235 Most of the patients with leaky SCID were compound heterozygous for 1 loss-of-func

236 We have studied a mut/mut mouse model of leaky SCID with a homozygous Rag1 S723C mutation that im

237 rphic mutations can cause milder phenotypes (leaky SCID).

238 Screening detected 52 cases of typical SCID, leaky SCID, and Omenn syndrome, affecting 1 in 58,000 in

239 ng 68 patients with typical SCID and 32 with leaky SCID, Omenn syndrome, or reticular dysgenesis.

240 typical SCID; 13% were classified as having leaky SCID, Omenn syndrome, or reticular dysgenesis; and

241 1S723C/S723C mice, which serve as a model of leaky SCID, with agonists of the virus-recognizing recep

242 ional proteins and are often associated with leaky SCID.

243 restricted repertoire, reminiscent of human leaky SCID.

244 ctors, including the diagnosis of typical vs leaky SCID/Omenn syndrome, diagnosis via family history

245 The infant had "leaky" SCID (i.e., a form of SCID in which a minimal deg

246 A leaky self-incompatibility system was found, with self p

247 tial loss of T cells in a spectrum including leaky severe combined immunodeficiency (LS) and Omenn sy

248 cells to the pathology of Omenn syndrome and leaky severe combined immunodeficiency (SCID) has not be

249 binding of the inhibitor FKBP12 and promote leaky signaling in the absence of ligand.

250 FKBP12-mediated kinase inhibition to produce leaky signaling.

251 y mechanism in STKR1 to prevent pathological leaky signaling.

252 nals and leakage, and was sometimes the only leaky state.

253 ted by long-lived (~100 seconds) inactive or leaky states.

254 We used a leaky stochastic accumulator to model the neural decisio

255 F at the C terminus by using a read-through, leaky stop codon that facilitated expression of CP and c

256 more efficient than nonsynaptic (stationary, leaky) supply of glutamate in controlling sustained NMDA

257 species than in yeast, possibly because of a leaky termination machinery resulting from stop codon re

258 hift sequences, as well as the Sindbis virus leaky termination signal.

259 Here we take advantage of the leaky tetracycline promoter system in the Tat-transgenic

260 on (brush) in Lotus japonicus resulting in a leaky tetrameric channel.

261 We generated a novel mutant mouse (Dclre1c(leaky)) that develops a LS phenotype.

262 ion, making the tight junction (TJ) barrier "leaky." This effect was mediated by changes in the prote

263 corporation of the permeability-associated, "leaky" tight junction protein claudin-2 at intercellular

264 rphological defects revealed swollen hyphae, leaky tips, intrahyphal growth, and double cell wall, su

265 ion, and the alveolar epithelial barrier was leaky to (125)I-albumin tracer compared to wild type.

266 by E17.5 and the urothelial barrier becomes leaky to luminal fluid.

267 in response to temperature, while preventing leaky transcription in the absence of an activation sign

268 ing any mislocalized Oskar that results from leaky translational repression.

269 tumor tissues by passing through abnormally leaky tumor blood vessels.

270 the ability of macromolecules to extravasate leaky tumor vessels and accumulate in the tumor tissue.

271 Normalisation of dilated and leaky tumour vasculature might also enable anti-angiogen

272 hich do not contain PGP-Me, are unstable and leaky under such conditions.

273 maximum levels in heart failure resulting in leaky, unregulated channels gating in subconductance sta

274 stering (early growth predicts the level of 'leaky' vaccine needed for control and peak time, while t

275 of a role for TNP-470 in selection for less leaky vascular segments within healing wounds.

276 fect 0.1-0.5% of the population resulting in leaky vasculature and severe neurological defects.

277 We find that leaky vasculature can cause a net acidification of the n

278 at nanocarriers rely principally on abnormal leaky vasculature for tumor access, a transcytosis trans

279 nto circumventricular organs in the brain or leaky vasculature of late-stage intracranial tumors.

280 However, the leaky vasculature of tumors combined with a poor lymphat

281 is associated with the poorly organized and leaky vasculature seen in tumors or other human diseases

282 mpaired in both models, even at sites with a leaky vasculature.

283 hments near hydrothermal vents, however, the leaky vent hypothesis argues that some hydrothermal Fe p

284 Formation of new immature and leaky vessels along with inflammatory remodeling of exis

285 as the potential to prevent the formation of leaky vessels and edema in inflammatory diseases such as

286 cross the endothelial barrier has to rely on leaky vessels arising from disease states such as pathol

287 atical modelling to examine the potential of leaky vessels as an additional source of stromal acidifi

288 ted endothelial sprout clumping in vitro and leaky vessels in vivo.

289 cd93 was observed in pancreatic islets, and leaky vessels were apparent in cd93-deficient pancreases

290 ascular permeability due to the presence of "leaky vessels".

291 idly growing tumors, transporting fluid from leaky vessels, and/or connecting with the constitutional

292 Targeted deletion of miR-126 in mice causes leaky vessels, hemorrhaging, and partial embryonic letha

293 hese activities require the readthrough of a leaky viral polyadenylation signal located at nucleotide

294 omising applications of these structures are leaky-wave antennas which utilize the low frequency depe

295 The leaky well was located 170 m away from a monitoring well

296 when acidic, CO(2)-rich fluids flow along a leaky wellbore.

297 RPE from apoptosis, but makes the monolayer leaky when it is presented to the apical side of the mon

298 e failure in arterial maturation, and become leaky with the onset of coronary perfusion.

299 ired either by making the ryanodine receptor leaky (with caffeine or ryanodine) or by decreasing sarc

300 Protocell membranes that were initially leaky would eventually become less permeable, forcing ce