ライフサイエンスコーパス: least

1 cutive prostate-specific antigen rises of at least 0.2 ng/mL.

2 farction (280/397, 71%) versus those with at least 1 additional criterion (10.4%; 95% CI, 6.7-15.7, v

3 ed with nonpsychotic MDD, unresponsive to at least 1 antidepressant course meeting minimal standards

4 56.0% of patients developed at least 1 complication, and 26.9% experienced major morbid

5 Hemodynamically significant stenosis in at least 1 coronary artery as indicated by a fractional flo

6 nths (11-37 mo), and 44% had delirium for at least 1 day (1-2 d).

7 children in 1583271 families (37507 with at least 1 diagnosis of ASD) enrolled in commercial health

8 lateral large drusen or noncentral GA and at least 1 eye without advanced disease (n = 317).

9 cient tumors, and 40 patients (83.3%) had at least 1 gene mutation: 37 had Lynch syndrome (13, MLH1 [

10 nderwent definitive surgical treatment in at least 1 kidney by 12 weeks and 39% retained parts of bot

11 erm, women with a preterm first birth and at least 1 later preterm birth had a HR of CVD of 1.65 (95%

12 We defined incident FI as a report of at least 1 liquid or solid FI episode per month during 4 ye

13 and among 401 adults with acute cough and at least 1 lower respiratory tract symptom not requiring im

14 ubjects, predictors of >/=70% stenosis in at least 1 major coronary vessel were identified from >200

15 with continuous insurance enrollment from at least 1 month prior to the month of diagnosis to 12 mont

16 sis (93%), no mental status change (91%), at least 1 ocular weakness finding (84%), and neuroimaging

17 t images, clusters or trophozoite images (at least 1 of the 3 features), the positive predictive valu

18 udy participants (59%) tested positive by at least 1 of the 3 methods.

19 ing sessions, 22% had an IOH in an eye on at least 1 of the e-ROP visits.

20 tory response syndrome and dysfunction of at least 1 organ system of the renal, respiratory, cardiova

21 eyes without deep stromal scarring, with at least 1 postoperative examination 1 month after complete

22 al varices, 21% were Child-B, and 29% had at least 1 previous episode of liver decompensation.

23 ays showed a reduction in PVR severity of at least 1 PVR class at 1 year.

24 Of the 49 authors evaluated, 40 received at least 1 reported industry payment, 31 accepted more than

25 e all women, aged 18 to 69 years, who had at least 1 reticular vein with a minimum length of 10 cm in

26 who were resident in these boroughs, had at least 1 sexual partner in the last 12 months, stated wil

27 reduced/absent T-cell proliferation, and at least 1 significant clinical event/year, demonstrating t

28 included the proportion of patients with at least 1 skeletal-related event by disease type, pain as

29 of poor academic performance (defined as at least 1 standard score greater than 2 SD below the mean

30 treated for HCV, 257 achieved SVR and had at least 1 subsequent RNA measurement.

31 5% CI, 77.9%-86.0%) of indoor tanners had at least 1 sunburn during the preceding year compared with

32 able in daily analyses being displaced by at least 1 y.

33 reported following a gluten-free diet for at least 1 year before the study began.

34 with a history of cerebrovascular events at least 1 year prior to randomization; the Breslow-Day tes

35 linary medical follow-up expected to last at least 1 year that included an eye examination as part of

36 and delays conversion to AD dementia for at least 1 year; however, this effect of IVIG appears to wa

37 Of these, 176 proteins were altered at least 1.5-fold (p-value < 0.05) in abundance during hypo

38 CS) enhance wet deposition by a factor of at least 1.6 relative to nonconvective morphologies.

39 of patients with alkaline phosphatase of at least 1.67 times the upper limit of normal (ULN) despite

40 ssociated hippocampal atrophy might occur at least 10 years before death.

41 e integrity of our DNA is challenged with at least 100,000 lesions per cell on a daily basis.

42 T-AQ provides excellent reversibility for at least 1000 cycles.

43 of all caspases, with phosphorylation of at least 11 distinct residues in all three caspase-9 domain

44 from the Sabrina Coast continental shelf at least 11 times during the Oligocene and Miocene epochs.

45 This lineage was introduced at least 11 times since 1970, into two main regions, West A

46 ing patients after 1 January 2000 and had at least 12 months of follow-up.

47 inuous trimethoprim-sulfamethoxazole plus at least 12 weeks of isoniazid-pyridoxine (coformulated wit

48 Overall, we found evidence for at least 13 independent mesopolyploidies followed by differ

49 n was defined as daytime ambulatory BP of at least 135/85 mm Hg and was further divided into masked a

50 ypertension as systolic blood pressure of at least 140 mm Hg, or diastolic blood pressure of at least

51 and tufted cells belonging to clusters of at least 15 glomerular modules, providing a potential mecha

52 urred at 200 mg (the patient did not take at least 16 of 21 prescribed total daily doses in cycle 1 b

53 nters and involving participants who were at least 16 years old, had undergone allogeneic HSCT for a

54 cal management of LVOTO were observed for at least 18 months after the procedure (mean [SD] follow-up

55 Participants who were aged at least 18 years with influenza and were at increased risk

56 wer than 30 x 10(9) platelets per L, aged at least 18 years, with refractoriness, ineligibility to re

57 ngdom) and was defined by the presence of at least 2 adjacent testing points located within the same

58 d treated with appropriate antibiotic for at least 2 days still progressed to VAP.

59 te, therapy with an active antibiotic for at least 2 days when blood cultures were taken, and subsequ

60 ween July 1, 2009, and June 30, 2010, and at least 2 HF hospitalizations between July 1, 2009, and De

61 At least 2 HMPV subtypes occurred each season.

62 California electronic medical records on at least 2 occasions any time from birth through June 2015.

63 DMA, and poly(styrenesulfonate), PSS, are at least 2 orders of magnitude faster than the diffusion of

64 In comparison with women with at least 2 pregnancies, all of which were delivered at term

65 15.1] years) had areas of DDAF present on at least 2 visits; these eyes were included in the estimati

66 nces the date of diagnosis of melanoma by at least 2 years.

67 stochemistry (>/= 25% of tumor cells with at least 2+ staining intensity).

68 884 patients (44.9%) had a DAPT score of at least 2, and 1086 (55.1%) had a score less than 2.

69 Step count was at least 2-fold greater on POD1 [mean difference 843.3 step

70 ort by 2.8% whereas bringing everybody to at least $2.97 PPP would increase the required mitigation r

71 microbiota), particularly in the gut, and at least 20% of the small molecules in human blood are prod

72 0 m from a fast-food outlet, those living at least 2000 m away had 0.26 cm smaller waist circumferenc

73 A cutoff of RAI-C of at least 21 classified 18.3% patients as "frail" with a sen

74 al as far in advance as possible, ideally at least 24 months.

75 ch more common than previously suspected: at least 25 have arisen across three Drosophila species ove

76 is and previous ruxolitinib treatment for at least 28 days who either required red blood cell transfu

77 Among a subset of 516 MSM who had at least 3 clinic visits, there was general stability acros

78 and patients expected to stay in ICU for at least 3 days in whom enteral nutrition was indicated.

79 h of birth through 15 months who received at least 3 doses of diphtheria-tetanus-acellular pertussis

80 celerometer-measured daily time expending at least 3 METs.

81 1; CI, 0.39-0.65), needing assistance for at least 3 months (OR = 0.79; CI, 0.62-1.00), and proxy nee

82 antibodies at 2 consecutive clinic visits at least 3 months apart.

83 n in eGFR less than 30 mL/min/1.73 m2 for at least 3 months during the year after discharge.

84 all 3 lamotrigine products and completed at least 3 pharmacokinetic assessments and 46 (92%) complet

85 tection of nanoencapsulated quercetin was at least 3 times better than that of free quercetin.

86 t increase in cortical activation lasting at least 3 years after GT was observed for all participants

87 ib or nilotinib who stopped therapy after at least 3 years of TKI treatment and in molecular response

88 Previously, an incidence of at least 3.5% has been proposed as a cutoff to justify prop

89 r even suppressed through the addition of at least 30% of water to the reaction mixture.

90 rthermore, evidence for translocations in at least 36 of the maps was found.

91 Escherichia coli contains at least 36 putative toxin-antitoxin gene pairs, and some p

92 tinuously engulf and kill bacteria during at least 4 hours of infection in vitro.

93 We show that at least 4 introductions, but potentially as many as 40, co

94 disorder, and psychotic symptoms scoring at least 4 on at least one of the following Positive and Ne

95 100% for infants infected in pregnancy or at least 4 weeks prior to testing, and a mother-to-child tr

96 olecular searching ability of Pol beta is at least 4-fold higher than that of Pol mu and approximatel

97 ite strong evolutionary conservation over at least 400 Myr.

98 Based on nine bacterial host genera with at least 45 infectious viruses, we show that random forest

99 grade 3 or worse, with palpable spleen of at least 5 cm and without grade 2 or greater peripheral neu

100 8-1.59) were more likely to be exposed to at least 5 sources of eye health information in the past 12

101 -term clinical trials in adolescents with at least 5 years of follow-up data that capture financial a

102 p therapy-related myeloid neoplasms after at least 5 years of follow-up.

103 tor for immediately adjacent regions, and at least 5-times sensitivity gain for regions separated by

104 Single gene mutations in at least 50 genes have been proposed to account for 25-50%

105 Prior to PCV introduction, at least 53% of pneumonia cases were due to pneumococci in

106 he first questionnaire response collected at least 6 months but not more than 4 years after diagnosis

107 HIV-1 RNA per mL) on a stable regimen for at least 6 months, CD4 count of more than 100 cells per muL

108 HPV elicits antibodies that persisted for at least 6 years, and induced immune memory, suggesting pos

109 n if samples are taken at a soil depth of at least 60 cm.

110 cohort were Medicare recipients who were at least 65 years of age.

111 nary atherosclerosis severity in patients at least 65 years old.

112 unctional genome annotation predicts that at least 66 potential PME genes are contained in Arabidopsi

113 nfrastructures have significantly altered at least 7% of streams, which influence habitats for over 6

114 in 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,33

115 and serum VEGF levels are suppressed for at least 8 to 12 weeks.

116 baseline of at least one SBM per week for at least 9 weeks of the 12-week treatment period including

117 rrent estimates of global forest cover by at least 9%.

118 In grafts surviving at least 90 days, early events (acute rejection [AR] and de

119 140 mm Hg, or diastolic blood pressure of at least 90 mm Hg, or self-reported antihypertensive medica

120 ly(dT), and Poly(I:C), respectively, with at least a 1-fold change relative to unexposed thrombocytes

121 wever, bacterial lysis typically requires at least a 10-fold higher electric field ( approximately 10

122 iated on meeting prespecified criteria of at least a 10-letter visual acuity loss at 2 consecutive vi

123 al acuity loss at 2 consecutive visits or at least a 15-letter visual acuity loss from the best previ

124 We identified 764 genes with at least a 2-fold difference in TL1A-mediated expression be

125 The percentage of patients who had at least a 50% reduction in convulsive-seizure frequency wa

126 or at least a small improvement, 0.69 for at least a moderate improvement, and 0.73 for predicting a

127 stics of 0.65 for not worsening, 0.68 for at least a small improvement, 0.69 for at least a moderate

128 s that the human auditory system employs (at least) a 2-timescale processing mode, in which lower and

129 loped using electronic health records) and a least absolute shrinkage and selection operator method.

130 tinct from bulk skin, most strikingly in the least abundant CD8+ T effector population.

131 ble stochastic system, we use the stochastic least-action principle to derive the entropy production

132 es C, respectively) were associated with the least amount of estimated useable space (18.6% and 24.6%

133 (M=0.019; CL95 -0.007-0.044), suggesting at least an additive effect.

134 ded simultaneously in a multilocus model and least angle regression was used to select the most poten

135 nded to live at their current address for at least another 4 years.

136 th TF2 and (213)Bi-IMP288 is feasible and at least as effective as (177)Lu-IMP288.

137 t of glucocorticoid antagonism, which was at least as effective as high-dose prednisolone with potent

138 Intra-arterial treatment may be at least as effective in patients with ECD as in those with

139 ransformation of Laplace-smoothed data is at least as good as state-of-the-art models, particularly a

140 context in which hyperkalemia develops is at least as important as the degree of hyperkalemia is in d

141 tion using the evening specimen produced the least bias overall, no single equation worked well acros

142 c diarrhea, human astroviruses are among the least characterized enteric RNA viruses.

143 Here we focused on prophages, the least characterized mobile elements of H. pylori.

144 or to members of native communities that are least-closely related to the colonizer.

145 %), intermediate in the claustrum (15%), and least common in the dLGN (12%).

146 d provides a robust performance, which is at least comparable to traditional feature-selection method

147 ratio of 94 is observed between the most and least conducting states.

148 of the cell, where molecules experience the least confinement, and hence turn three-dimensional trac

149 conservation goals from LCC partners for the least cost.

150 The least developed economies have been found to experience

151 No-induction was the least effective and most costly option in both risk grou

152 hat TMAO disrupts the water structure to the least extent, whereas glycine exerts the greatest influe

153 age range, 3-17 years) who were imaged in at least five consecutive 1.5-T MR examinations with the ex

154 oductive-aged women is largely made up of at least five different community state types.

155 In this study, if at least five of 25 response-evaluable patients had an obje

156 Purpose To determine the effect of at least five serial injections of the macrocyclic gadolini

157 These subjects were followed up at least for 12 months.

158 d yellow colors in the natural world and, at least for most animals, these molecules must be acquired

159 tion that are related to future goals, or at least free from the constraints of immediate environment

160 must therefore either plausibly exist or at least have existed at the primordial protein stage.

161 g from the first (healthiest) to the fourth (least healthy) quartiles of the ED, HF, and LFD pattern

162 und capacity to regenerate, heart muscle, at least in mammals, has poor regenerative potential.

163 production required STIM2, but not STIM1, at least in part as a result of redox regulation of cytokin

164 ulated by promoter methylation, resulting at least in part from increased expression of the DNA methy

165 enotype of atlazy1,2,4 mutants may be due at least in part to a reversal in the gravitropism mechanis

166 biting ERalpha-negative breast cancer due at least in part to epigenetic reactivation of ERalpha, whi

167 our studies strengthen models that posit, at least in part, a SecA dimer-driven translocation mechani

168 Morphine exerts its rewarding actions, at least in part, by inhibiting GABAergic input onto substa

169 at KLHL41 is poly-ubiquitinated and acts, at least in part, by preventing aggregation and degradation

170 and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability.

171 by UV-B in this zone, which is regulated, at least in part, by the expression of GRF1 and possibly ot

172 NAc levels is therefore likely to result, at least in part, from the epigenetic regulation of MYBL1 e

173 unction protein occludin (OCLN), explain, at least in part, HCV's limited ability to enter mouse hepa

174 ts also confirmed that bottomfish relied, at least in part, on a benthic food web and identified the

175 cell ICOS surface expression and rescues, at least in part, T follicular helper numbers and the abnor

176 We also show that TEX19.1 likely acts, at least in part, through promoting the activity of the E3

177 aicalein attenuated TNBS-induced colitis, at least in part, via inhibition of TLR4/MyD88 signaling ca

178 patients who were diagnosed with HIT, an at least intermediate clinical HIT-risk (4Ts score >/=4 poi

179 boundary and expanded their known range, at least, into western North America.

180 Patients covered by private insurance were least likely to have a readmission compared with Medicai

181 entify where coarse climate data is most and least likely to reduce the accuracy of impact assessment

182 ed until liver fibrosis has progressed to at least moderate fibrosis and, in some cases, cirrhosis.

183 g 1213 patients, 73% of the patients with at least moderate PVR at 30 days showed a reduction in PVR

184 ions of individuals and groups tend to be at least moderately, and often highly accurate.

185 CO in tetrahydrofuran at -0.48 V vs NHE, the least negative potential reported for a molecular cataly

186 etylated derivatives, Binocrit expressed the least Neu5Gc, and CIGB-EPO showed the greatest variety o

187 n is a composite of transitions involving at least nine unique species: three native or native-like s

188 yzed data from 7663 participants screened at least once and found to have a negative FIT result at ba

189 ischarged from inpatient psychiatric care at least once before their 15th birthday (n = 5882) were ex

190 363 (63%) underwent endoscopic ultrasound at least once.

191 s) comprised 57% of 406 organics detected at least once.

192 pectively included until March 2015, when at least one (18)F-FDG PET/CT scan was obtained.

193 ASD participants performed atypically in at least one aspect of gaze perception, the particular aspe

194 We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or m

195 classes available were more likely to use at least one blood pressure-lowering medicine (adjusted odd

196 esults Significantly more patients showed at least one BML on ADC maps (98%, 95 of 97 patients) than

197 malies in a cohort of children presenting at least one cerebral or spinal pial arteriovenous fistula

198 combination, which is regulated to ensure at least one CO per homolog pair.

199 one dose of everolimus and exemestane and at least one confirmed dose of dexamethasone mouthwash) ver

200 We found that 32% of brain tumors had at least one ctDNA alteration.

201 es included all participants who received at least one dose (partial or complete) of study drug.

202 full analysis set (patients who received at least one dose of everolimus and exemestane and at least

203 is included all participants who received at least one dose of investigational product, whereas the e

204 randomly assigned treatment, 207 received at least one dose of MABp1 and 102 at least one dose of pla

205 ere analysed in all patients who received at least one dose of pembrolizumab (all-patients-treated po

206 ceived at least one dose of MABp1 and 102 at least one dose of placebo.

207 is included all participants who received at least one dose of study drug and had at least one post-b

208 l randomly assigned patients who received at least one dose of study drug during the maintenance peri

209 All patients who received at least one dose of study drug were included in all analys

210 was assessed in all patients who received at least one dose of study treatment.

211 was assessed in all patients who received at least one dose of study treatment.

212 alysis included all patients who received at least one dose of the randomised treatment; the safety a

213 was assessed in all patients who received at least one dose of trial medication (analysed according t

214 ug and included all patients who received at least one dose of venetoclax.

215 At least one emergent adverse event (AE) was recorded for 7

216 rolled period were similar across groups (at least one event occurred for 182 patients assigned to pl

217 with early TOP2A-normal breast cancer and at least one high-risk factor were randomly assigned to rec

218 red with patients who were homozygous for at least one HLA locus.

219 icare fee-for-service beneficiaries, with at least one home health claim between July 1, 2009, and Ju

220 en who attended follow-up visits required at least one hospitalization by 2 years of age, and the mos

221 was assessed in all patients who received at least one injection of study medication.

222 ferent frequencies in 5,724 subjects with at least one invasive tumor and 1,943 subjects with in situ

223 exceeding the current rainfall record in at least one month in any given winter.

224 ction to less than 20 mg twice a day with at least one of grade 3 thrombocytopenia, anaemia, or bleed

225 of field isolates were also positive for at least one of the alleles tested.

226 coli) appears to favor crosstalk wherein at least one of the cross-linked FFLs remains modular.

227 psychotic symptoms scoring at least 4 on at least one of the following Positive and Negative Syndrom

228 Additionally, eligible patients had at least one of the following within the screening period o

229 BPH and eight of 14 patients with CPr had at least one oral pathogen in their prostatic secretions.

230 of the PRO questionnaires at baseline and at least one other assessment.

231 atients with biallelic MFN2 mutations and at least one p.Arg707Trp allele.

232 d at least one dose of study drug and had at least one post-baseline efficacy measurement.

233 Most individuals had at least one potentially actionable alteration (94.7%), wit

234 tients and Methods Eligible patients with at least one prior irinotecan-containing therapy received l

235 imulated during 2014 exist within 2 km of at least one recently constructed (2000-2014) domestic grou

236 er week with an increase from baseline of at least one SBM per week for at least 9 weeks of the 12-we

237 nce reproductive success among females of at least one species and (5) implicate larval cultivation o

238 ecorded, and 90 patients (2.1%) presented at least one SR.

239 t isolation of the intermediates, whereby at least one step is catalyzed by an enzyme.

240 er a thousand of human L1 loci containing at least one stop codon in their ORF1 sequence.

241 Severe burnout was seen on at least one subscale in 55.6%-10% showed evidence of sever

242 gated, confirm that the backbone amide of at least one Thr (Thr(304)), adjacent to conserved Ser, com

243 r (27.6%) of adults were current users of at least one type of tobacco product in 2013 and 2014, alth

244 At least part of the explanation may be found by turning to

245 s of age and amyloid on Abeta42 amplitude at least partially affect each other.

246 in nearly all aspects of immunity, which at least partially explain the increased susceptibility to

247 options are available which completely or at least partially reduce the number or duration of attacks

248 ydroxylation of U2AF65 could account for, at least partially, their co-regulated alternative splicing

249 tantially higher than previous estimates, at least partly due to an increase in nursing home episodes

250 de evidence that increased AD risk may be at least partly mediated by deficient microglia polarizatio

251 on offspring outcomes, which are mediated at least partly through changes in epigenetic processes, su

252 -protecting functions of neutrophils via, at least partly, the induction of lactoferrin to present a

253 beneficial effects of IVIG were mediated, at least partly, via SHIP1/PIP3 pathway.

254 and interest, with the most likely levels of least resistance being the interdigitation zone or betwe

255 h hybridisation rates appear to be stable at least since the 1990s.

256 nriched for regulatory variants, of which at least six (35%) alter transcription factor-DNA binding i

257 At least six miRNAs show cycling expression levels within t

258 that, although the replication modules of at least some classes of viruses might descend from primord

259 ere unique to one method, indicating that at least some of the variability in published palmitoyl pro

260 RESULT: We proposed an expectation least square (ELS) algorithm and binomial analysis of th

261 Partial least square (PLS) regression models confirmed reliabili

262 ion algorithms were combined using a partial least square classifier to determine the presence or abs

263 th different classification methods (Partial Least Square Discrimination Analysis "PLS-DA" and Suppor

264 was satisfactory predicted through a partial least square model based on DeltaK, hydroxytyrosol, pino

265 e Martens Uncertainty test, interval Partial Least Square Regression (iPLS) and Genetic Algorithm (GA

266 aterials (i-HRM) using two different Partial Least Square-Regression (PLS-R) multivariate quantificat

267 t week 24 from baseline in SGRQ total score (least squares mean [SE] change from baseline -15.6 (1.0)

268 Least squares mean change from baseline to week 6 in AIM

269 The least squares mean difference compared with placebo in a

270 isits up to and including the week 24 visit, least squares mean difference was -1.09 units (95% CI -1

271 tion was a significant slope of the ordinary least squares regression of a simulated patient's mean d

272 crete model and use the method of non-linear least squares to estimate the age-specific annual rate o

273 We used segmented ordinary least-squares (OLS) regression using Newey-West standard

274 gative matrix factorization with alternating least-squares algorithm (NMF-ALS) to solve spectral over

275 NMR) profiles were analyzed by using partial least-squares discriminant analysis, and the results wer

276 The least-squares mean difference versus placebo with respec

277 AC components were used to develop a partial least-squares regression-based model (r(2) = 0.53; Nash-

278 rental strains reveal that mcrA regulates at least ten SM gene clusters.

279 al genetic continuity in the Levant since at least the Bronze Age.

280 For surgeons or, at least, those men who performed surgical operations, the

281 The BF contains at least three different cell types (cholinergic, glutamate

282 Depending on the bubble velocity U, at least three different flow regimes are found.

283 ARL13B is a ciliary GTPase with at least three missense mutations identified in JS patients

284 of the 12-week treatment period including at least three of the last 4 weeks.

285 A responder had at least three spontaneous bowel movements (SBMs) per week

286 We show that at least three vesicles need to fuse to induce the phagopho

287 had associations with frost tolerance in at least two different environments with two different stat

288 ecies within the Caryophyllales suggested at least two distinct [Na]shoot phenotypes within this orde

289 have shown that motor learning results in at least two important neurophysiological changes: modulati

290 tion of beta-glucan by host cells through at least two mechanisms: concealment of beta-glucans beneat

291 Asia fat-tail and European sheep, reveal at least two phylogeographically distinct genepools of fat-

292 cascade is defined as the combination of at least two reaction steps in a single reaction vessel wit

293 can be cleaved by caspase or calpain into at least two receptor fragments.

294 though 88% of proteins in our network has at least two structures in Protein Data Bank (PDB), only 22

295 se inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: norma

296 abase for the United States, we show that at least two-thirds of the decline in organic aerosol can b

297 d the presence of PLTX, hydroxy-PLTX and, at least, two additional compounds with PLTX-like profile i

298 the responsiveness of piriform neurons is at least twofold less sparse than currently believed.

299 y used acceptor (about 50%) and A3 (tat) the least used (about 3%).

300 BL1 transcripts for the 2 preceding years at least were eligible for inclusion.