ライフサイエンスコーパス: leaving group

1 ons at the bromine center (polyfluorophenide leaving group).

2 oheterolytic cleavage of an Ar-LG bond (LG = leaving group).

3 AlkA (their conjugate bases should be better leaving groups).

4 methyl from boron to carbon with loss of the leaving group.

5 nding solvent to assist the departure of the leaving group.

6 f the alkyl group antiperiplanar to the N(2) leaving group.

7 tates the reaction conditions, including the leaving group.

8 ement of a substituted benzyl alcohol as the leaving group.

9 lsiloxyfuran is activated by the carboxylate leaving group.

10 te by sulfur (5'-PS), which is a much better leaving group.

11 being dependent mainly on the nature of the leaving group.

12 nitrogen to the bridging oxygen atom of the leaving group.

13 of the radical anion or the expulsion of the leaving group.

14 well as for neutral nucleophiles with HF as leaving group.

15 stabilization of the aci-carboxylate dianion leaving group.

16 to produce the fluorescent Oregon Green 488 leaving group.

17 e reaction that is derived from the leftover leaving group.

18 und phosphate and weaker interactions to the leaving group.

19 e, semicircular surface around the substrate leaving group.

20 hydroxyl group at the 1-position to act as a leaving group.

21 ase and formation of the inorganic phosphate leaving group.

22 hiles with saccharide donors equipped with a leaving group.

23 1) is a likely proton donor for the hydroxyl leaving group.

24 id that facilitates departure of the beta-OH leaving group.

25 free bisphosphonic acid corresponding to the leaving group.

26 the catalytic proton directly to the organic leaving group.

27 eing able to hydrolyze DFP with its fluoride leaving group.

28 racil are not: chloride is a slightly better leaving group.

29 ex PMo(N[(t)Bu]Ar)(3), 5, serves as a stable leaving group.

30 the Asn50 assisted departure of the thiolate leaving group.

31 rge away from the nucleophile and toward the leaving group.

32 m the solution and thus rendered a traceless leaving group.

33 ion state with partial neutralization of the leaving group.

34 on and stabilizing both transition state and leaving group.

35 sfer from the hydroxyl nucleophile to the N6 leaving group.

36 eotide and thereby dictate the choice of the leaving group.

37 ng monomer, displacing the 2-methylimidazole leaving group.

38 attack on a Michael acceptor with an allylic leaving group.

39 dazolyl nucleophile and the p-nitrophenolate leaving group.

40 which ATP, rather than pyrophosphate, is the leaving group.

41 N3 of A1 is the proton donor to the oxyanion leaving group.

42 mechanism is dependent on the nature of the leaving group.

43 eficient double bond along with an excellent leaving group.

44 duct in the degree of proton transfer to the leaving group.

45 e implicated as proton donors to the epoxide leaving group.

46 on the incoming nucleophile and an enhanced leaving group.

47 he bridging beta phosphate oxygen of the GDP leaving group.

48 diphosphate-X, where X is a large variety of leaving groups.

49 triazine were used--1,3,5-triazines that had leaving groups.

50 e boronate occurs with both halide and ester leaving groups.

51 ometry in precursor ion scan mode for select leaving groups.

52 es that hydrolyze compounds with challenging leaving groups.

53 gnificant bond order to both nucleophile and leaving groups.

54 building blocks equipped with six different leaving groups.

55 in radiofluorination yields over traditional leaving groups.

56 r reactions involving relatively poor alkoxy leaving groups.

57 a variety of fluorine, bromine, and hydride leaving groups.

58 ted pathway when phosphate is bonded to good leaving groups.

59 aromatic compounds using sulfonium salts as leaving groups.

60 has been modifying hydroxylamines with good leaving groups.

61 ester with organolithium reagents with alpha-leaving groups.

62 selectivity can be tuned by using different leaving groups.

63 d loss from the carbonyl carbon to the amide leaving group (1.52 A).

64 eau phase, while those for the hydroxylamine leaving group [(15)(V/K)(NH(2)OH)] were 1.0013 +/- 0.000

65 ved nitrogen isotope effects for the ammonia leaving group [(15)(V/K)(NH(3))] were 1.0016 +/- 0.0005

66 In contrast to hydrolysis, the large leaving group (18)O isotope effect indicates the C-O3' b

67 little phosphorus-oxygen bond fission to the leaving group ((18)k(lg) = 1.0064 +/- 0.0009 and (15)k =

68 vanced phosphorus-oxygen bond fission to the leaving group ((18)k(LG) = 1.034 +/- 0.004) and phosphor

69 transition state with low bond order to the leaving group, a transition state different from the nat

70 For good leaving groups, a strong preference is observed for a mo

71 d 3-methyluracil are similar in acidity, the leaving group abilities of chloride and N1-deprotonated

72 in order to examine the correlation between leaving group ability and acidity for moieties that allo

73 oward neutral or basic, thus diminishing the leaving group ability of the amino group.

74 ophilicity of NHCs and aNHCs, as well as the leaving group ability of the former, the carbon-carbon d

75 ates of these systems and suggested that the leaving group ability of the N-OR substituent plays an i

76 The leaving group ability of the N1-deprotonated 3-methylura

77 provides cationic polarization and enhanced leaving group ability to the susceptible adenine.

78 yields for total products are insensitive to leaving group ability, and Phi(tot)(para-CO2CH3) = 0.04-

79 contributions of conformational preferences, leaving group ability, enzyme-base hydrogen bonding, and

80 e been compared as probes for evaluating the leaving group ability.

81 equilibria such as pKa values as measures of leaving group ability.

82 he extent of triazole formation depends upon leaving group ability.

83 protonates the hydroxyl group, enhancing the leaving group ability.

84 gative electrostatic potential, a large open leaving group-accommodating groove, and a pivotal acidic

85 ibited by our carbonyl substrates, where the leaving group activates the anti proton, leading to the

86 Catalytic forces originate primarily from leaving group activation evident in both RTA and SAP in

87 bosome-inactivating proteins include adenine leaving group activation, a remarkable lack of ribocatio

88 supporting a reaction coordinate with strong leaving group activation.

89 methylene substitution in the pyrophosphate leaving group affects cognate and non-cognate nucleotide

90 is blocked by the continued presence of the leaving group after opening of the beta-lactam ring.

91 as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated re

92 s 17 and 24, containing the benzyl sulfonate leaving group and a neutral DNA minor groove-binding sid

93 by redistributing electron density into the leaving group and away from the catalytic proton.

94 We evaluated the effects of the benzylic leaving group and core structure of arylboronates on H2O

95 hich is thought to chelate the chlorosulfite leaving group and deliver the halogen nucleophile from t

96 activate the nucleotide base as an efficient leaving group and demonstrate that the higher binding af

97 reactions by binding the fluoride or nitrite leaving group and facilitating displacement.

98 zyme leading to loss of a substituted phenol leaving group and generation of a reactive iminium elect

99 has an important role in stabilizing the 3'O leaving group and is the prime candidate for the general

100 c dyad lacks a general acid to protonate the leaving group and positively charged residues to stabili

101 on (E2 and Ecb) depends on the nature of the leaving group and reaction conditions.

102 mer displaces an activated nucleotide as the leaving group and results in extension of the primer by

103 the advantage that molecular nitrogen is the leaving group and sole byproduct in this reaction.

104 However, the nature of the photo-leaving group and the counterion of the precursor phosph

105 enerate the ribosyl cation by binding to the leaving group and then couple the ribose derivative with

106 ing information as to the specificity of the leaving group and therefore the most kinetically compete

107 g one aroyl group to another depended on the leaving group and vice versa.

108 olysis reaction through stabilization of the leaving group and/or transition state.

109 thyl sulfonate prodrugs containing sulfonate leaving groups and 7-substituted electron-withdrawing gr

110 g group combination was found independent of leaving groups and activators.

111 re dependent on the nature of the pyrazolone leaving groups and significantly on the structural prope

112 oups to a fully concerted mechanism for good leaving groups and supported by a theoretical study.

113 to explain FAAH's interaction with substrate leaving groups and their role in modulating inhibitor po

114 ting arylethynyl moieties, substituents, and leaving groups) and protic vs aprotic solvation.

115 arbon, proton transfer to the amide nitrogen leaving group, and C-N bond cleavage.

116 of C-substitution, N-substitution, solvent, leaving group, and counteranions on formation of the iso

117 ith the glycosyl moiety loosely bound to the leaving group, and eventually solvent-separated ion pair

118 f the (18)O KIEs on the 2'O nucleophile, 5'O leaving group, and nonbridging phosphoryl oxygens for RN

119 ent on the exact combination of nucleophile, leaving group, and substrate framework.

120 a special Michael acceptor having an allylic leaving group, and the product was then modified in such

121 he influence of the electronic nature of the leaving group, and variations in the 1-alkyl substituent

122 ucts were manipulated to introduce phosphate leaving groups, and subsequent reductive lithiation foll

123 For 1b, the kinetic isotope effects in the leaving group are (18)k(lg) = 1.0228 and (15)k = 1.0014,

124 ide of the nicotinamide mononucleotide (NMN) leaving group are oriented solely via atomic interaction

125 ysine residue that activates the 5'-hydroxyl leaving group, are strictly required to achieve >5% of w

126 w that the rates of loss of the two possible leaving groups, aryloxide and hydroxamate, are essential

127 Formation of a sulfate leaving group as a biosynthetic strategy to facilitate a

128 ton donor coordinates with the oxygen of the leaving group as the 2-hydroxyl of ribose attacks the un

129 rboxylate anion has a crucial role both as a leaving group as well as an internal nucleophile.

130 y both for anionic nucleophiles with F(-) as leaving group, as well as for neutral nucleophiles with

131 c displacement with bond separation from the leaving group at (2.53 A) and bond making to the attacki

132 Es for the nucleophilic 2'-O and in the 5'-O leaving group at pH 14 are both large relative to reacti

133 d ion pairs with the glycosyl moiety and the leaving group being separated by solvent molecules.

134 +/- 0.0010) indicate a later TS with greater leaving group bond fission and greater nucleophilic bond

135 A better leaving group (Br) and stepwise bisquinone methide forma

136 adium-amine complex and/or expel the anionic leaving group (bromide).

137 ivated water molecule and protonation of the leaving group by a histidine residue.

138 erstanding the thermal heterolysis of carbon-leaving group (C-LG) bonds, no general models connect st

139 gue into a more dissociative type, where the leaving group carries a large amount of negative charge.

140 ids is especially challenging even when good leaving groups (Cl(-) ) are employed.

141 tack occurs before complete departure of the leaving group, consistent with a D(N)A(N) reaction mecha

142 he trichloroacetimidate as the optimum donor leaving group, core skeletons of glycosylphosphatidyl in

143 ation of the data that involves catalysis of leaving group departure by Lys 83 functioning as a gener

144 ically assist initial catalysis by "pushing" leaving-group departure.

145 Increasing the ribocation to leaving-group distance in the second- to fourth-generati

146 et of serine hydrolases without release of a leaving group, does not covalently modify active site ca

147 nucleophile and stabilization of the thymine leaving group during the isotopically sensitive step.

148 y be transferred from the nucleophile to the leaving group during the reaction.

149 sitioning divalent metals that stabilize the leaving groups during each reaction.

150 n of DNA with epoxides substituted with good leaving groups (e.g. vinyl chloride epoxide).

151 rutinosyl donors bearing different anomeric leaving groups (e.g., SPh, OC(NH)CCl(3), Br, OH groups)

152 and mechanism of DNA polymerases, by probing leaving group effects on nucleotidyl transfer using a se

153 , being both a strong nucleophile and a good leaving group, exhibits the highest HTP activity and als

154 e electron-withdrawing nature of the allylic leaving group facilitates the addition by negative hyper

155 ns where hydrogen embedded within an alcohol leaving group facilitates turnover.

156 ent bond between the glycosyl moiety and the leaving group, followed by formation of contact ion pair

157 metal complex and orients the pyrophosphate leaving group for in-line catalysis with stereochemical

158 d metal complex and orient the pyrophosphate leaving group for in-line catalysis.

159 termediate, the dissociated but unprotonated leaving group forms an alkoxide coordinated to magnesium

160 oate (PFB) and 2,4,6-trifluorobenzoate (TFB) leaving groups have been derived from the solvolysis rat

161 ings of alkyl electrophiles that bear oxygen leaving groups have been limited to reactions of allylic

162 substituted hydroxylamines with carbon-based leaving groups have been synthesized, and their structur

163 ition state with little bond cleavage to the leaving group, highlighting the care that needs to be ta

164 y enhanced by using the acetamide as a quasi-leaving group in a subsequent conventional Pd-catalyzed

165 the first report that acetate is a competent leaving group in COP-catalyzed enantioselective S(N)2' s

166 The enzyme holds the nucleophile and leaving group in relatively fixed positions to create a

167 enzyme might protonate and stabilize the 3'O leaving group in the strand cleavage reaction, we examin

168 The binding mode of the leaving group in the transition state highlights that va

169 s in TS1 are examined in detail: the two non-leaving groups in particular are found to play an import

170 gen-bonded substituents were investigated as leaving groups in photoinduced ArS(N)1 reactions.

171 nabling cyanides to be used as highly active leaving groups in S(N)Ar reactions provides additional f

172 pansive in character when the acidity of the leaving group increases.

173 ve to reactions of phosphodiesters with good leaving groups, indicating that the reaction catalyzed b

174 O4'...O5' vibrational motion, (ii) optimized leaving group interactions, and (iii) activation of the

175 hate (or its mimic) and inhibitor cation, 2) leaving-group interactions to N1, O6, and N7 of 9-deazah

176 The P-O bond to the leaving group is about 50-60% broken in the transition s

177 hat hydrolyze aromatic amides, for which the leaving group is an aniline moiety.

178 Preferential glycosidation of a certain leaving group is determined neither by the strength of t

179 We show that, in many cases, the cyanide leaving group is displaced preferentially in the presenc

180 Elimination of the leaving group is generally preferred, even for LG(-) = P

181 site of catalytic dehydration only when the leaving group is present.

182 etate, it was found that the cleavage of the leaving group is the rate-determining step.

183 ries of HNO donors utilizing pyrazolone (PY) leaving groups, is described.

184 not observed with expectedly better tosyloxy leaving groups, is elucidated computationally.

185 In the catalyzed reaction, larger leaving group isotope effects ((18)k(lg) = 1.0113 +/- 0.

186 tivating reagent nor by the stability of the leaving group itself; instead, the type of activation pl

187 ermediates followed by departure of benzylic leaving groups leading to QMs which directly cross-link

188 of a nucleophile at a carbon atom bearing a 'leaving group' leads to a negatively charged intermediat

189 mplished through systematic variation of the leaving group (LG) and core substituents as well as subs

190 Substrates with good leaving groups (LGs) have little cleavage of the phospho

191 at/UV-sensitive alkene, bearing an activated leaving group (N-succinimidyl undecylenate), without suf

192 eries of arylsulfonate nucleophile assisting leaving groups (NALGs) were prepared in which the metal

193 substituted hydroxamic acids with pyrazolone leaving groups (NHPY), has been synthesized.

194 ition state with very low bond orders to the leaving group nicotinamide and the nucleophile acetyllys

195 witterionic benzotriazolyl species makes the leaving group noncompetitive and generates the nucleofug

196 We used a combination of different leaving groups, nucleobases, and templating sequences to

197 re it forms a hydrogen bond to the substrate leaving group O and a His20-Lys76 pair of the cap domain

198 catalytic base, and the dissociation of the leaving group occur almost simultaneously.

199 allow association of (His159)-Im+H with the leaving group of a substrate to provide its general acid

200 Through modification of the leaving group of allylic electrophiles, we found that tr

201 cal role of the metal in orienting the PP(i) leaving group of ATP during step 1, and the protein conf

202 The pyrophosphate leaving group of GTPalphaS is oriented apically to His40

203 156, are used to stabilize the pyrophosphate-leaving group of lipid II, and E100 in the acceptor site

204 ies between aryl/alkyl carbonate and another leaving group of similar nucleofugality (Nf) may occur i

205 se' reaction by donating a proton to the O5' leaving group of the 5'-PO4 strand.

206 orientated amide N-H is able to activate the leaving group of the allylic ester by hydrogen bonding t

207 otide (DIAL) that replaces the pyrophosphate leaving group of the native substrate with adenosine tri

208 merase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction.

209 Bisphosphonates can mimic the pyrophosphate leaving group of the nucleotidyl transfer reaction and e

210 tion by stabilizing the transition state and leaving group of the scissile bond.

211 leophilic hydroxide relative to the phenolic leaving group of the substrate.

212 ogue, DEVX, which contains the same thiolate leaving group of VX coupled to a diethoxyphosphate core

213 degrees C) than expected for a diester with leaving groups of pK(a) 9.09.

214 ay lead to the emergence of novel functions, leaving groups of similar genes - termed paralogs - in t

215 rly adulthood to middle adulthood, typically leaving groups of subjects with wheezing that persists i

216 We suggest that the leaving group order in the gas phase will be dependent o

217 n reactions (S(N)Ar) is characterized by the leaving group order, F > NO(2) > Cl approximately Br > I

218 upling process for electrophiles that bear a leaving group other than a halide adds a significant new

219 2,3LacbetaSPh for the ring oxygen ((18)V/K), leaving group oxygen ((18)V/K), C3-S deuterium ((D)V/K(S

220 .026 +/- 0.006), C2-(13)C (0.999 +/- 0.005), leaving group oxygen 2-(18)O (1.040 +/- 0.012), and C2-(

221 The KIEs in the leaving group oxygens (the beta nonbridge and the beta-g

222 KIEs in the gamma nonbridge oxygens and the leaving group oxygens reveal that the GAP(334) or NF1(33

223 ))(2)CH(+) was only achieved using the photo-leaving group P(p-Cl-C(6)H(4))(3) and the counter-anion

224 e reactions with the solvent, with the photo-leaving group PAr(3), or with the counter-anion X(-) of

225 ee enzymes exhibit a similar dependence upon leaving group pK(a) as shown by the use of the acyclic p

226 , Bronsted analysis (log(V(max)/K(M)) versus leaving group pK(a) value) reveals beta(LG) = -0.86 +/-

227 Altering the leaving group pK(a), by replacing the departing nucleosi

228 en the two pathways gradually reduces as the leaving group pKa increases and creates mechanistic ambi

229 drolysis to explore the effect of modulating leaving group pKa on the competition between solvent- an

230 Boc=tert-butoxycarbonyl, LG=leaving group, PMB=para-methoxybenzyl.

231 t have been denoted as the small, large, and leaving group pockets based on high-resolution crystal s

232 h a number of substrate classes that possess leaving groups, polyunsaturation, and acid-sensitive moi

233 ith and without thio modifications at the 5' leaving group position, would provide valuable insight i

234 interaction between the nucleophile and the leaving group previously proposed in the literature.

235 creases with pyrimidine N1 acidity, that is, leaving group quality of the target base.

236 We find the hemiacetal leaving group rapidly breaks down, enabling quantitative

237 a phosphate monoester complex with the same leaving group, rather than the isoelectronic diester com

238 tes with the trimethylsilyl group cis to the leaving group react with assistance due to gamma-silyl p

239 to the nucleophilic atom and the bond to the leaving group reacted approximately 250 times more slowl

240 logs having distances between the cation and leaving groups resembling those of the known transition

241 ng photolysis did not occur, thus ruling out leaving group return prior to rearrangement.

242 of phenethylamine systems bearing different leaving groups revealed significant differences in the r

243 primary substrate containing one of the new leaving groups rivaled or surpassed the reactivity of tr

244 ctivities were influenced by the sulfonyloxy leaving group, ruling out the possibility of a common me

245 ite, chemistry becomes rate limiting and the leaving group sensitivity of the FEN-catalyzed reaction

246 imination mechanism in which the diphosphate-leaving group serves as a general base.

247 measured in the nucleophilic atom and in the leaving group show that the uncatalyzed cyclization has

248 intrinsic barriers for substituted benzoate leaving groups show that substrates producing more stabi

249 n amidine-NH donor group cis to the chloride leaving group showed considerably reduced reactivity wit

250 phosphate monoester dianions with different leaving groups showed that the TS character gradually ch

251 This new leaving group significantly accelerates monomer addition

252 the oxyanion hole; the other, occupying the leaving group site of acylation or the nucleophile site

253 ologue, beta-phosphoglucomutase, control the leaving group size (phosphate vs glucose phosphate) and

254 ng analyses, a catalytic mechanism involving leaving group stabilization by H155 in motif 2 and water

255 nism is proposed which combines Lys12/Lys128 leaving group stabilization with zinc ion activation of

256 substrate and to orient a water molecule for leaving group stabilization, respectively.

257 cts with the UDP product and may function in leaving group stabilization.

258 olyze bulkyorganophosphates with challenging leaving groups such as diisopropyl fluorophosphate (DFP)

259 n center can reduce substrates (i) with good leaving groups such as DTNB, (ii) that are highly electr

260 The proximity of G32 to the O5' leaving group suggests that G32 may putatively serve as

261 opies (fluorescence, IR: cyanophenyl ether), leaving groups (sulfonate, halide, NHS, bromoacetate), a

262 rby thiolate while correctly positioning the leaving group sulfur atom to accept a proton from the en

263 tor substrate attacks on the side of the UDP leaving group that acts as a catalytic base.

264 ed GABA analogues with a properly positioned leaving group that could facilitate a ring-opening mecha

265 r the sugar that is removed but also for the leaving group that is produced.

266 Substrates (BABS) bear a hemiacetal aglycon leaving group that tethers fluorochromes in close proxim

267 Trialkylstannanes are good leaving groups that have been used for the formation of

268 presence of nucleophiles that are also good leaving groups, the reaction takes place under thermodyn

269 For poor leaving groups, this intrinsic preference disappears.

270 s His707 as the acid that protonates the THF leaving group through a water molecule trapped in the cl

271 allylic electrophile bearing an appropriate leaving group to access the reactive Pd(pi-allyl) interm

272 wn to involve metabolic reduction, loss of a leaving group to generate a reactive electrophile result

273 and stereoselectivity and then as a suitable leaving group to generate the desired conjugated lactam.

274 bosyl anomeric carbon from the pyrophosphate leaving group to the nicotinamide-N1 while the 5-phospho

275 olving a pentavalent intermediate for poorer leaving groups to a fully concerted mechanism for good l

276 ogical environment without displacement of a leaving group (tracelessly) are rare and highly desirabl

277 nzyl)imidazol-2-ylidene ligand but different leaving groups trans to it were examined for cytotoxicit

278 Departure of the leaving group triphosphate of ATP is well advanced and f

279 rs concomitantly with the protonation of the leaving group tyrosine and explains the different kineti

280 todecarboxylation of the pentafluorobenzoate leaving group underpins reaction efficiency.

281 g N-nucleophile displaces the alkyl chloride leaving group via 5-exo-tet or 6-exo-tet cyclizations, f

282 due to mortality or emigration, potentially leaving groups vulnerable to ecological challenges in ti

283 The sigma-complex approach failed when the leaving group was Cl/HCl or Br/HBr, both for anionic and

284 S-benzoxazolyl (SBox), and S-ethyl anomeric leaving groups was achieved by fine-tuning activation co

285 Different promoter systems and leaving groups were investigated, and only activation wi

286 These and previously disclosed chelating leaving groups were used in (18)F-fluorination reactions

287 oted correlation equation when both types of leaving groups were used to determine the electrofugalit

288 to another, in either the acyl group or the leaving group, were not additive, i.e., that the effect

289 ly, even challenging phosphoesters with poor leaving groups, which were found to be very stable in th

290 it stabilizes the accumulated charge of the leaving group while interacting with the 2'OH of G8, the

291 sociative with the increasing acidity of the leaving group, while reproducing the experimental LFER.

292 ic acid residue (Asp261) that protonates the leaving group, while the cap domain contributes residues

293 2'-hydroxyl group onto a secondary mesylate leaving group with clean inversion of stereochemistry wa

294 y with regioretention at the position of the leaving group with perfect chirality transfer.

295 Kinetic isotope effects in the leaving group with the substrate 4NPP are (18)(V/K) brid

296 llowed by a simultaneous displacement of the leaving groups with tris(tetra-n-butylammonium) hydrogen

297 reaction is completed by protonation of the leaving group, with a neutral Asp132 as a likely proton

298 nhydrous conditions in which water becomes a leaving group, with heat providing activation energy.

299 results establish activation of the thymine leaving group without requirement for phosphate.

300 hrough nucleophilic displacement of suitable leaving groups X by tethered OH groups to give lactones