ライフサイエンスコーパス: led to

1 In rodents, URMC-099 activation of autophagy led to 50-fold increases in the plasma drug concentration of

2 tion of the crystal packing would improve solubility, which led to a change from N-methylpyridone to a tetrahydropyranyl

3 Overall, (68)Ga-PSMA PET/CT scanning led to a change in planned management in 51% of patients.

4 All images led to a clear final diagnosis.

5 After 3 years, surgery led to a gain of 0.199 QALYs compared with no surgery at an i

6 corticosteroids who required surgery, mepolizumab treatment led to a greater reduction in the need for surgery and a grea

7 in mice caused increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective gut c

8 CD11d deficiency led to a marked reduction in lipid deposition in aortas and i

9 17beta-estradiol led to a significant upregulation in pentose phosphate flux a

10 Loss of Sin3a in mouse early foregut endoderm led to a specific and profound defect in lung development wit

11 Surprisingly, dnGluN1 expression led to an enhancement in the motivation to self-administer co

12 lly, Asian-lineage ZIKV infection of pregnant women's blood led to an exacerbated M2-skewed immunosuppression of non-clas

13 e of the flavanol structural unit in the pyranoanthocyanins led to an increase in their interaction with aPRPs.

14 Protein design advancements have led to biotechnological strategies based on more stable and m

15 While ATP depletion led to cell death, over-acetylated tubulin led to inhibition

16 Structural optimization led to compound 28, which was 4-fold more potent than its par

17 Cell wall profiling techniques showed that the pretreatment led to depectination of the outer layers thereby exposing xyl

18 ntal and theoretical studies of electrosensory systems have led to detailed accounts of how negative images are formed at

19 ionization to diphenyl sulfide radical cation that in turn led to diphenyl sulfoxide.

20 pted the interaction of PU.1 with target gene promoters and led to downregulation of canonical PU.1 transcriptional targe

21 Msh3 overexpression led to high expansion activity and elevated levels of MutSbet

22 d by aryloxy-2-methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and selectiv

23 ght on the pathogenesis of different amyloid types and have led to identification of numerous new amyloid types, includin

24 -1 silencing in macrophages exposed to HIV-related proteins led to increased caspase 3 activation and reduced Bcl-2 expre

25 Active compared to sham tDCS led to increased performance in the orienting (mean differenc

26 le ATP depletion led to cell death, over-acetylated tubulin led to inhibition of motility and mitosis.

27 These substitutions led to inhibitors with increased PACE4 selectivity and potent

28 fission, red-shifted dispersive waves were generated which led to large broadening from 1.5 um-25 um.

29 of CD8(+) T cells prevented recovery from MRV infection and led to lethality in infected animals, whereas B cell-deficien

30 In this randomized trial, off-pump CABG led to lower rates of 5-year survival and event-free survival

31 ognosis compared with other non-CBF aberrant karyotypes and led to lower remission rates (complete remission + complete r

32 Severe Perkinsea infections (SPI) were systemic and led to multiorganic failure and death.

33 sion Faster navigation speed at endoluminal CT colonography led to progressive restriction of visual search patterns.

34 Infection with low-dose A/X31 H3N2 led to prolonged deterioration of lung function, aggravated m

35 Similar to in many women with PCOS, DHT exposure led to reduced adiponectin levels, larger adipocyte size, and

36 d with a reduction in the quality of evoked potentials that led to reduced performance on the BCI task.

37 particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery.

38 me-related gene sets, promoted excessive proliferation, and led to retinoblastoma with anaplastic changes.

39 ored scaffolding maintained hMSC stemness, engraftment, and led to robust motosensory improvement, neuropathic pain and t

40 increased surface UV radiation indicate that the eruptions led to stratospheric ozone depletion.

41 Prolonging the reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecular a

42 Short-term IL-33 treatment in mice led to sustained expansion of IL-33 receptor-positive kidney

43 al epithelial permeability and proliferation increase; this led to the concept that glia are required for maintenance of

44 departments among older patients with palliative needs has led to the development of several service-level interventions

45 This work led to the discovery of a highly selective PI3Kbeta/delta inh

46 een, isolate, and characterize HIV-specific antibodies have led to the identification of a new generation of potent broad

47 JB12 knockdown by siRNA led to the induction of caspase processing but not the unfold

48 ited from some selective advantage over Neanderthals, which led to the their extinction.

49 Recent evolutions in rectal cancer surgery led to transanal dissection of the rectum resulting in a bett

50 equiring immediate intervention and that led (or could have led) to major disability or death.