ライフサイエンスコーパス: led us to

1 The functional studies led us to a new structural model for the ErmC or ErmE-rRNA co

2 equential and partly nonsequential enzymatic modifications, led us to a verifiable concept termed "superchanneling." In s

3 n E. scolopes MIF (EsMIF) in the light-organ transcriptome, led us to ask whether EsMIF might be the gatekeeper controlli

4 k topology (SOFT) studies on the two polymorphic structures led us to conclude that the mechanochromic phase transformati

5 This led us to consider if satisfactory estimates of heat of forma

6 These experiments led us to construct a model of cortical pulling forces in whi

7 between the cationic indium(I) complex and primary anilines led us to develop an In(I)(+)-catalyzed hydroamination of alk

8 This led us to develop inhibitors of MEIS1 that could modulate HSC

9 Efforts to identify sources of the Ras/Mapk signaling led us to discover that GNPs respond to laminin, but not vitr

10 he prototypical intracellular bacterial pathogen Salmonella led us to discover that type I IFN (IFN-I) remodels lysosomes

11 stigating the biological implications of these interactions led us to discover that XRN2 depletion compromised cell survi

12 These findings led us to discuss whether modifying pores could be used as a

13 g the correlation between the temporal profiles of isoforms led us to distinguish two classes of genes: those with highly

14 ely adjacent to L420 and the polymerase primer grip region, led us to engineer additional polymerase mutations into polio

15 This more realistic approach led us to establish a correlation between changes in mammal a

16 The seemingly counterintuitive self-restriction of growth led us to explore if there were any benefits associated with

17 ve, we briefly discuss the underlying conceptual steps that led us to explore partial leptin reduction as a viable therap

18 This unexpected observation led us to find additional mutations that reduced or eliminate

19 Our dissection of the GMP hierarchy led us to further identify a previously unknown intermediate

20 decan-3 (SDC3) is selectively pro-inflammatory in the joint led us to hypothesise that SDC3 might play an important role

21 This led us to hypothesize that DNA methylation differences in the

22 These results led us to hypothesize that heterodimerization alters the intr

23 These findings led us to hypothesize that IL-15 stimulation could reveal a s

24 the evolution of the genus Phelsuma, and this early origin led us to hypothesize that island populations within the Anda

25 e association of citrin with glycolysis and NAD+/NADH ratio led us to hypothesize that it may play a role in carcinogenes

26 This observation led us to identify a pelX paralogue, PFL_5533, which we desig

27 ctroelectrochemistry together with spectroscopic techniques led us to identify elusive key electrocatalytic intermediates

28 High-throughput virtual screening led us to identify hit compound 5, endowed with promising ant

29 tin states and associated with misregulated gene expression led us to identify SCC25 enriched regulatory sequences and tr

30 cifically designed CD83-based NF-kappaB CRISPR screen which led us to identify TAK1 kinase as a major mediator for NF-kap

31 This anatomic proximity led us to investigate functional changes in mitochondria resu

32 This concerning report led us to investigate our library of 7,025 genome sequences o

33 gs of decreased Hla in vitro but increased necrosis in vivo led us to investigate the role of the proteases regulated by

34 These findings led us to investigate whether mGluR5 might act downstream of

35 Our work has led us to obtain different results when the correlation analy

36 These results led us to perform a fine molecular characterization of target

37 The weak cytotoxicity encountered led us to perform an in vivo experiment dealing with the trea

38 This led us to propose a simple mechanical model that shows that a

39 These relations led us to propose an integral-threshold model in which the ce

40 the progression towards obesity and metabolic comorbidities led us to propose that these developments might similarly cor

41 These observations led us to question the need for stoma creation in intestinal

42 discovery of non-native kelp washed up on Antarctic beaches led us to question the permeability of these barriers to spec

43 model and in 2 rare diseases (GSD-Ib and G6PC3 deficiency) led us to repurpose the widely used antidiabetic drug empagli

44 This led us to search for potential Zn(2+)-binding sites outside o

45 This link led us to search for targeted molecules that inhibit Fli-1.

46 These findings led us to separate the two chiral species and test their effe

47 Nonetheless, the weight of published evidence has led us to speculate that RAGE may be physically interacting w

48 l models of ulcerative colitis and lung allograft rejection led us to test the effect of the PHI dimethyl oxalyl glycine

49 's largest herbivorous crab (Maguimithrax spinosissimus)(9) led us to test the effectiveness of their grazing on seaweed

50 Our interest in fenestranes led us to wonder how large the change in strain energy with c