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1 of the nitroso oxide isomers derived from 1b led to a set of stable products: the cis/anti isomer was
6 he structural and mineralization abnormality led to slight reduction in apparent modulus, which could
7 enantiomeric impurity with agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-6
8 n cells into sanroqueRag1(-/-) mice actually led to enhanced protection with reduced bacterial load,
9 reasing presynaptic activity, which actually led to LTP in PE animals, whereas LTD was still observed
11 th Cy2BH followed by addition of an aldehyde led to quaternary protected 2-amino-2-vinyl-1,3-diols in
13 escued the cytotoxicity of NK cells but also led to the emergence of an immature NK cell population t
14 ntion and each independent intervention also led to significant decreases in F2-isoprostane and IL-6
18 d the formation of omega-O-acylceramides and led to an accumulation of nonesterified omega-hydroxy-ce
19 gene resulted in a premature stop codon and led to small seeds and loss of seed shattering during Af
20 upted craniofacial cartilage development and led to decreased levels of the chondrogenic master trans
21 APC was maintained during cell division and led to an unequal inheritance of LFA-1 in divided T cell
22 disability abolished the spacing effect and led neurons to decode distinct stimulation patterns as m
23 g maintained hMSC stemness, engraftment, and led to robust motosensory improvement, neuropathic pain
24 ls prevented recovery from MRV infection and led to lethality in infected animals, whereas B cell-def
25 d with other non-CBF aberrant karyotypes and led to lower remission rates (complete remission + compl
27 ction of PU.1 with target gene promoters and led to downregulation of canonical PU.1 transcriptional
28 y the presence of etched enamel surfaces and led to the formation of large, randomly distributed plat
30 dentification and drug-screening testing and led to the identification of the ERK inhibitor SCH772984
31 t tracer uptake in PCa lesions over time and led to steadily increasing lesion-to-background ratios u
32 hibition, halted the adaptive transition and led to prolonged growth inhibition in multiple patient-d
34 onoclonal antibody to the controller animals led to a specific decline in levels of CD8(+) T cells an
35 ered DCs, when pulsed with a myelin antigen, led to myelin-specific suppression of ongoing experiment
36 ers of RCC cells to TRAIL-mediated apoptosis led to identification of the 17beta-hydroxywithanolide (
38 h-band gap absorbers for tandem applications led us to reconsider this attractive 1.95 eV material.
40 early imbalance in TE events in the PAG arm led to a clinical hold; thereafter, patients with TE eve
43 In rodents, URMC-099 activation of autophagy led to 50-fold increases in the plasma drug concentratio
45 enantiopure analogues of viridicatumtoxin B led to the discovery of highly potent, yet simpler analo
49 rahepatic T cells isolated from liver biopsy led to the targeted treatment with anti-tumor necrosis f
50 ss expression of CXCR4, which, when blocked, led to HSC mobilization and prolonged islet allograft su
51 age ZIKV infection of pregnant women's blood led to an exacerbated M2-skewed immunosuppression of non
54 licited no subjective emotional response but led to reliably improved memory compared with control im
57 mogeneous catalysis and enzymatic catalysis, led to a resurgence of interest in ArMs starting in the
58 ally, vigilin downregulation in target cells led to a significant increase in NK cell activation agai
60 years, addition of rituximab to chlorambucil led to significantly better EFS (hazard ratio, 0.54; 95%
62 igation speed at endoluminal CT colonography led to progressive restriction of visual search patterns
63 nd THO6, components of the THO/TREX complex, led to the formation of multiple megaspore mother cells,
65 ulation of these critical pathway components led to varying degrees of disruption to the normal diffe
67 ation of occurrences in these eight contexts led to the characterization of three different Mg(2+) bi
69 transmitted helminths compared with controls led to little to no improvement in weight over a period
70 proteinases mmp-9 and mmp-13, while cortisol led to stronger upregulation of the gluconeogenesis gene
71 standard-sensitivity cTnI (but not hs-cTnI) led to an increase in AUC to 0.931 (P<0.0001) and 0.926
77 duced viral burdens, whereas their depletion led to higher tissue burdens, and CD8(-/-) mice displaye
78 Alemtuzumab induction with desensitization led to nearly equivalent graft survival and functional o
79 tistical model based on ecological diffusion led to important ecological insights, obviated a commonl
81 for assessment of osseous metastatic disease led to changes in intended management in a substantial f
82 f Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation,
87 oss of Sin3a in mouse early foregut endoderm led to a specific and profound defect in lung developmen
91 ultural extensification, and also eventually led to the development of a mounted warrior elite able t
92 lar to in many women with PCOS, DHT exposure led to reduced adiponectin levels, larger adipocyte size
94 identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also i
95 ient mouse model and found that loss of Fdxr led to embryonic lethality potentially due to iron overl
97 he application of 10 mmol/L ammonium formate led to the best findings, while the use of 0.02% acetic
98 ipotriol plus 5-FU versus Vaseline plus 5-FU led to an 87.8% versus 26.3% mean reduction in the numbe
99 nt cells with the GLI1/GLI2 inhibitor Gant61 led to decreased invasion of the melanoma cells in a thr
100 ith other organizations and advocacy groups, led the development of the first clinical guidelines for
101 Prolonging the reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecu
103 n of the center (S)-proline-based lead 7 has led to the discovery of noncovalent reversible and selec
105 pping of WGDs within a major plant clade has led to uncertainty regarding the potential association o
106 about its associated morbidity and cost has led to a large body of research that has been summarised
108 of nanoparticles (NPs) to drug delivery has led to the development of novel nanotherapeutics for the
109 ce microscopy and calcium sensitive dyes has led to the routine quantification of calcium responses i
110 ion mechanism using single-molecule FRET has led to the hypothesis that substrate movements relative
111 ely singly scattered light-to reveal GCs has led to a focus on multiply-scattered, fluorescence, two-
112 al stigmata or suspicious family history has led to increased reliance on genetic testing, which, in
113 success of immune checkpoint inhibition has led to a resurgence of enthusiasm for immunotherapy in t
114 ng and trapping of atoms and atomic ions has led to advances including the observation of exotic phas
115 erest in the evolution of human language has led several fields of research to focus on primate vocal
116 on of mechanically interlocked molecules has led to the design and synthesis of shuttles, switches, a
117 f neoplasia caused by germline mutations has led to paradigm-changing precision prevention efforts, i
118 ice toward transradial access nationally has led to worse outcomes in percutaneous coronary intervent
119 ong older patients with palliative needs has led to the development of several service-level interven
120 The limited availability of donor organs has led to a search for alternatives to liver transplantatio
121 rate in critically ill elderly patients has led to questioning of the beneficial effect of intensive
122 deeper understanding of Abeta physiology has led to the recognition of distinct neuronal signaling pa
123 Recent progress in atmospheric plasmas has led to cold atmospheric plasma (CAP) devices with ion te
124 tatin analogs with various radionuclides has led to a revolution in patient management and establishe
125 e rise in emerging pathogens and strains has led to increased calls for more effective surveillance i
126 ith different phenotypes of tauopathies, has led to controversial assumptions about fibril constituti
127 nce of highly specific alloreactive TCRs has led to their use as immunotherapeutics that can circumve
129 ward continuous flow synthesis, and this has led to a number of innovations in flow cell design that
131 interaction non-invasively in real time has led to the emergence of its applications in areas that a
132 ir implementation in organic transistors has led to enhanced biosensing, neuromorphic function, and s
134 ent human papillomavirus (4vHPV) vaccine has led to reductions in the prevalence of human papillomavi
135 ay occur in one-third of patients, which has led to a search for alternative techniques such as multi
136 Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery.
139 ogenesis of different amyloid types and have led to identification of numerous new amyloid types, inc
140 an unusual component of the genome, and have led to its genetic variation becoming a key part of stud
141 nd characterize HIV-specific antibodies have led to the identification of a new generation of potent
142 in the development and spread of cancer have led to the realization of novel single cell analysis pla
143 Os, studies of bovine mitochondrial CcO have led to suggestions that its H channel instead provides t
146 increasing vaccination and development have led to dramatic declines in the global burden of measles
148 ropathology, epidemiology, and genetics have led to a deeper understanding of how vascular disease af
150 and that natural genetic variation may have led to a SLO3 variant that differs from wild type in bot
151 logical-level studies suggest that MMLs have led to substitution of cannabis for opioids, and also po
152 red design principles and nanomaterials have led to tremendous progress in autonomously moving synthe
153 gical characters, including nodulation, have led to major changes in our understanding of legume taxo
154 eusocial insect species, in particular, have led to several hypotheses for the processes underlying t
155 activated protein kinase (MAPK) pathway have led to clinical responses in lung and other cancers, but
156 These apparently conflicting results have led us to reexamine the effect of PGE2 on IL-1beta produ
157 rofiling and next-generation sequencing have led to the classification of HCCs based on molecular fea
159 0% of GISTs; subsequent genetic studies have led to the identification of mutation/epimutation of add
160 oth in-vitro and in-vivo animal studies have led to their steady progression through clinical trials.
161 tical studies of electrosensory systems have led to detailed accounts of how negative images are form
162 next generation sequencing technologies have led to the expenential growh of the sequence databases.
164 Improvements in care and treatment have led to more young adults with life-limiting conditions l
165 d land use associated with urbanization have led to higher levels of BTs in urban areas and provide a
166 er storms associated with polar warming have led to later winter floods around the North Sea and some
167 on the key advances in knowledge which have led to the definition and exemplification of protein deg
168 rtant areas of maternal and child healthcare led to a reduction in neonatal mortality of almost the h
169 olecular combination of these screening hits led to compound 22a (PF-543) with 2 orders of magnitude
170 the combination of compound 28 and ibrutinib led to tumor regression in an ABC-DLBCL mouse model.
174 cal folk medicines for wounds and infections led us to study Schinus terebinthifolia (Brazilian Peppe
175 RNA interference or small molecule inhibitor led to cell accumulation in G1 phase of the cell cycle a
176 Early access to low-intensity interventions led to significant reductions in uptake of high-intensit
181 sing cells to JAG1(Ndr), compared with JAG1, led to hypomorphic Notch signaling, based on transcripto
182 nt with the small-molecule CD11b agonist LA1 led to partial integrin activation, reduced IFN-I respon
185 ver, employing high concentrations of ligand led to the identification of a second transmembrane site
187 Expression of MAN2A1-FER in 4 cell lines led to epidermal growth factor receptor activation of BR
188 e transcriptional control of the Cspg4 locus led to ventricular arrhythmias, atrial fibrillation, atr
189 imary porcine pulmonary alveolar macrophages led to significant reduction of STAT3 protein level.
191 nic amphiphilic drugs (CADs), this mechanism led to the endolysosomal calcium as a critical target fo
193 dothelium-specific ablation of Hdac3 in mice led to blood-filled lymphatic vessels, edema, defective
194 a-cell-selective deletion of StarD10 in mice led to impaired glucose-stimulated Ca(2+) dynamics and i
196 n shuttles, and the consequent ion migration led to high anode salinities and conductivity that favor
200 ional depletion of Foxp1 in bone marrow MSCs led to premature aging characteristics, including increa
201 cells in a TAS3 ta-siRNA-insensitive mutant led to the formation of supernumerary megaspore mother c
203 mbining PvACR3 expression with HAC1 mutation led to As hyperaccumulation in the shoots, whereas combi
204 daily group (one of which was serious; none led to treatment discontinuation) and 68 (26%) of 266 pa
205 onditions, whereas liver RBP4 mRNA does not, led to a widely held hypothesis that elevated circulatin
207 andomized controlled studies comparing nurse-led self-management interventions to usual care Seven el
208 ethnographic study of nurses' roles in nurse-led chemotherapy clinics, including semi-structured inte
214 rus disease during the 2014-to-2016 outbreak led to an explosion in the development of diagnostics th
216 n in growth medium supplemented with phytate led to marked increases in growth and total P content of
217 alizing antibody or STAT5 inhibitor Pimozide led to reverse CD8+ T cell-enhanced BECs proliferation.
219 methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and sel
220 ased transcription factor binding prediction led to the identification of Hnf4a as the potential tran
221 ling techniques showed that the pretreatment led to depectination of the outer layers thereby exposin
222 small estimates of effect size have probably led to much of the current controversy about PPI safety.
224 macrophages exposed to HIV-related proteins led to increased caspase 3 activation and reduced Bcl-2
226 ol structural unit in the pyranoanthocyanins led to an increase in their interaction with aPRPs.
229 he transient activation of viral replication led to HIV-1 reservoir reduction after viremia resuppres
233 fluctuations, the energy-normalized signals led to larger values of MR and higher intelligibility th
237 h in vitro-reconstituted and cellular snRNPs led to similar changes in SHAPE reactivities, confirming
238 sing concentration of the dyes in a solution led to the increase in absorption band intensity in diff
239 al management practices initiated under STEP led to a decade-long decline in the incidence levels.
242 Recent evolutions in rectal cancer surgery led to transanal dissection of the rectum resulting in a
247 stry program starting from amicarbalide that led to two compounds with optimized pharmacological and
248 ns requiring immediate intervention and that led (or could have led) to major disability or death.
253 ccessibility of regions of each protein that led to predictions about each's role in tubulin folding.
254 scribe the different experimental works that led to the fabrication of active particles based on this
255 , and atmosphere over the last 30,000 y that led to extensive changes in subseafloor carbon storage t
256 ermeability and proliferation increase; this led to the concept that glia are required for maintenanc
260 Increasing the pH before heat treatment led to increases in casein dissociation and the concentr
261 who required surgery, mepolizumab treatment led to a greater reduction in the need for surgery and a
262 celeration of puberty by oestrogen treatment led to increased or decreased survival from endotoxemia,
263 our microCT data showed that I-PTH treatment led to an increased bone volume fraction, tissue density
264 ur histology showed that the I-PTH treatment led to an increased number of cells expressing Col1a1, C
265 s after stroke, post-ischaemic tPA treatment led to sustained suppression of regulatory T cells in th
266 osome, spurious poly(A) additions to mt-tRNA led to reduced levels of aminoacylated pool of certain m
267 aled new insights in the biology of tRNASec, led to the discovery of a novel bacterial selenoprotein
269 isiting less-productive waters; this in turn led to differences in flight activity and energy expendi
271 The increased cytosolic calcium, in turn, led to the phosphorylation of calcium/calmodulin-depende
273 adverse effects on consumers, but ultimately led to population extinction and loss of ecosystem proce
277 k of GABARAPs reduced Arf1 activation, which led to formation of interferon-inducible GTPase-containi
278 formation of charged grain boundaries, which led to the enhanced TE properties via the energy filteri
279 ence was overexpressed in SW480 cells, which led to the detection of two mature TrkC-miR2 isomiRs, an
283 s mediated mainly by immunomodulation, which led to lower macrophage infiltration and higher presence
284 increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective
285 opressin peptide-receptor interaction, which led to the identification of key residues of the recepto
286 d by the treatment with an isonitrile, which led to the formation of a base-stabilized B,N-containing
287 d nanoporous materials have been made, which led to major progress in the physisorption characterizat
289 from Li-non-responsive (NR) patients, which led us to partition our BD neurons into two sub-populati
290 gic stimulation rapidly activated PKA, which led to the phosphorylation of ATGL and HSL and their rec
291 reak (DSB) sites, blocking DSB repair, which led to DSB accumulation, DNA damage responses, and early
292 esign an "educated guess" drug screen, which led to the identification of new, deleterious synthetic
293 stal packing would improve solubility, which led to a change from N-methylpyridone to a tetrahydropyr
294 opulations, even from distant species, which led to the acquisition by domesticated beans of adaptive
295 ted to the concentration in structure, which led to identification of "stochastic death" as the most
296 ed with either 1 or 10 ng venlafaxine, which led to a rapid reduction (90%) of this drug in the embry
300 ransplant has risen rapidly in recent years, led by the growth of magnetically levitated centrifugal
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