ライフサイエンスコーパス: left heart

1 clinical consequences as those affecting the left heart.

2 elopmental defect referred to as hypoplastic left heart.

3 rophysiologic ablation procedures within the left heart.

4 ructures principally affected in hypoplastic left heart.

5 ventricular septal defects, and hypoplastic left heart.

6 ent/degreasing agent exposure in hypoplastic left heart, 4.6%; 5) sympathomimetics in coarctation of

7 s or about patterns of reintervention on the left heart after neonatal BAVP.

8 Hydraulic forces are a consequence of left heart anatomy and aid LV diastolic filling.

9 Microspheres are injected directly into the left heart and a reference tissue is used to calculate r

10 Is defined for the cavities of the right and left heart and for the descending aorta by comparing the

11 ral plate mesoderm and, subsequently, in the left heart and gut of mouse, chick and Xenopus embryos.

12 ratio is associated with underfilling of the left heart and low cardiac output.

13 MYH6 mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejecti

14 For the left heart and the coronary arteries, there were no sign

15 chocardiography in patients with hypoplastic left heart and their first-degree relatives identified 5

16 eart with the anatomically-supposedly-normal left heart and to derive from cardiac magnetic resonance

17 ns (endocardial cushion defects, hypoplastic left heart, and aberrant trabeculation) observed in pati

18 Additional left heart anomalies were present in 82 patients (76%).

19 The molecular underpinnings of hypoplastic left heart are poorly understood.

20 In contrast, partial left heart bypass is more complex but virtually eliminat

21 the descending thoracic aorta using partial left heart bypass that has evolved over the past 25 year

22 c aorta can be safely repaired using partial left heart bypass.

23 Of the 41 patients with abnormal MPI, 18 had left heart catheterization (9 were false-positive); ther

24 referred for diagnostic evaluation underwent left heart catheterization and coronary angiography from

25 Simultaneous left heart catheterization and Doppler echocardiography

26 rticipants undergoing simultaneous right and left heart catheterization and estimated associations of

27 nus [CS]) in 9 patients undergoing right and left heart catheterization as part of their CHF assessme

28 tissue Doppler imaging, simultaneously with left heart catheterization before and after NSRT.

29 n the 1950s of the transseptal technique for left heart catheterization is described.

30 icant for elevated troponins, and subsequent left heart catheterization revealed findings consistent

31 For patients with abnormal MPI, left heart catheterization were reviewed if performed.

32 underwent simultaneous echocardiography and left heart catheterization with pressure-conductance ins

33 The 25 HOCM patients had left heart catheterization, and 16 were re-examined afte

34 kers, left ventricular hypertrophy, previous left heart catheterization, and higher exposure to dialy

35 At the time of right and left heart catheterization, stents were placed in pulmon

36 Ten patients underwent right and left heart catheterization.

37 Ten adult patients underwent right- and left-heart catheterization.

38 entury, commencing with pressure tracings in left heart chambers with the use of needle puncture in t

39 icates a surplus leaflet area that adapts to left-heart changes.

40 chararacteristics of both the right and the left heart correlate with disease severity and outcome i

41 assessment of surgical repair (21 patients), left heart decompression (12 patients), myocarditis/card

42 ry pressure, its association with increasing left heart diastolic pressures and systemic vascular sti

43 bnormal mitral valve (MV) and MR can lead to left heart dilation, with consequent compression of the

44 erial hypertension (n = 142; 61%); group II, left heart disease (n = 31; 14%); group III, respiratory

45 capillary pulmonary hypertension (Cpc-PH) in left heart disease (PH-LHD).

46 -term results, even in patients with complex left heart disease and multiple prior interventions.

47 Some patients present with risk factors for left heart disease but pre-capillary PH, whereas patient

48 cal correction of tricuspid regurgitation in left heart disease can definitively improve clinical out

49 revalence of obesity, diabetes mellitus, and left heart disease compared with patients with Ipc-PH.

50 Additional left heart disease in the complex group included subaort

51 more common group of patients with PH due to left heart disease is challenging because there are few

52 eased pulmonary venous pressure secondary to left heart disease is the most common cause of pulmonary

53 e hypothesis that an increased prevalence of left heart disease might explain the higher mortality in

54 the total PH cohort and in PH not related to left heart disease occurrence of AF was associated with

55 The diagnosis of PH due to left heart disease relies on a clinical probability asse

56 (PH) is a common and morbid complication of left heart disease with 2 subtypes: isolated post-capill

57 The presence of left heart disease, although more common in PAH-Scl, was

58 dary causes of PASP elevation, most commonly left heart disease, are far more prevalent than isolated

59 l TR, either isolated or in combination with left heart disease, is associated with unfavorable natur

60 result from a number of disorders, including left heart disease, lung disease, and chronic thromboemb

61 atients were excluded if PH was secondary to left heart disease, not present before surgery, or the p

62 urs in 12% to 13% of patients with PH due to left heart disease.

63 sk of death in PAH-Scl after controlling for left heart disease.

64 and prevalence, severity, and chronicity of left heart disease.

65 e in simple aortic valve disease and complex left heart disease.

66 tcapillary pulmonary hypertension because of left heart disease.

67 al tricuspid regurgitation in the setting of left heart disease.

68 AH from pulmonary venous hypertension due to left heart disease; and (4) understanding the appropriat

69 = 421), atypical IPAH (>/=3 risk factors for left heart disease; n = 139), and PH-HFpEF (n = 226) rec

70 ients with typical IPAH (<3 risk factors for left heart disease; n = 421), atypical IPAH (>/=3 risk f

71 hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms,

72 sensus view is that reduced flow through the left heart during development is a key factor in the dev

73 n in the 2 groups, whereas a predominance of left heart dysfunction was observed in patients with PAH

74 rmance deteriorated, ultimately resulting in left heart failure (decompensated hypertrophy).

75 55), pulmonary arterial hypertension without left heart failure (n=18), and control subjects (n=30) u

76 n hemodynamic abnormalities in patients with left heart failure and global and regional lung perfusio

77 hors highlight differences between right and left heart failure and outline key areas of future inves

78 Contrasting with the major attention that left heart failure has received, right heart failure rem

79 onally relevant heart disease, predominantly left heart failure in combination with right heart failu

80 In PH due to left heart failure the prevalence of AF was particularly

81 and comorbidities such as coronary disease, left heart failure, and chronic obstructive pulmonary di

82 monary edema, high-altitude pulmonary edema, left heart failure, and overinflation of the lung.

83 ympathetic stimulation have been reported in left heart failure, but whether it would be beneficial f

84 een implicated in the development of chronic left heart failure, data describing such metabolic remod

85 nts with kidney failure and may be driven by left heart failure, high cardiac output from arterioveno

86 diac investigation revealed a combination of left heart failure, right heart failure and moderate-to-

87 y role of beta-blockers in the management of left heart failure, some authors have proposed to use th

88 ion in determining pulmonary hemodynamics in left heart failure.

89 rtality in acute or chronic lung disease and left heart failure.

90 clops, lefty2 and pitx2 are expressed in the left heart field; and cyclops and pitx2 are expressed in

91 ight and left atria arise from the right and left heart fields.

92 forces render PAOP inaccurate as an index of left heart filling pressure, resulting in misleading ass

93 sumes that this pressure accurately reflects left heart filling pressure.

94 e left ventricle, and selectively toward the left heart follows the direction of capillary perfusion

95 The left heart function was assessed 4 weeks postoperatively

96 tal balloon aortic valvuloplasty may improve left heart growth and function, possibly preventing evol

97 deal fetal and cannula positioning, prevents left heart growth arrest, and may result in normal ventr

98 tration that a successful valvotomy promotes left heart growth in utero.

99 Resumed left heart growth led to a 2-ventricle circulation at bi

100 se who declined the procedure, while ongoing left heart growth was seen in successful cases.

101 Eight had hypoplastic left heart (HLH) syndrome, 10 had pulmonary atresia, and

102 stage 21 to reduce LV volume load and create left heart hypoplasia.

103 can produce structural malformations such as left heart hypoplasia.

104 ging because unbalance entails a spectrum of left heart hypoplasia.

105 Therefore, congenital or acquired left-heart inflow/outflow obstructive lesions and congen

106 microbubbles after reperfusion from a single left heart injection performed during coronary occlusion

107 Hypoplastic left heart is a severe human congenital heart defect cha

108 Interestingly, in the left heart, Kir6.2 protein and its immunohistochemical d

109 gement strategy intended to rehabilitate the left heart (LH) in patients with LH hypoplasia who have

110 s of this study were to assess the growth of left heart (LH) structures, to evaluate midterm outcomes

111 ystem and its interaction with the right and left heart may be more useful.

112 Left heart morphology over time suggests less age-relate

113 Patients with >/=2 areas of left heart obstruction or hypoplasia, diagnosed at </=3

114 hat is frequently associated with additional left heart obstructions.

115 esult of this unexpected finding, associated left heart obstructive lesions and pulmonary and left ve

116 versed atrial shunting was found with severe left heart obstructive lesions, including 19 with hypopl

117 ventricular repair for infants with multiple left heart obstructive lesions.

118 ventricular repair for infants with multiple left heart obstructive lesions.

119 wn to be inapplicable to patients with other left heart obstructive lesions.

120 ily represented by patients with cyanotic or left heart obstructive lesions.

121 surgical strategy in patients with multiple left heart obstructive or hypoplastic lesions often must

122 y epinephrine to the anterior surface of the left heart of swine in either point-sourced or distribut

123 Although associated with left heart pathologies, functional tricuspid regurgitati

124 dicated by an association of the hypoplastic left heart phenotype with terminal 11q deletions that sp

125 Left heart pressures are elevated with exercise in subje

126 iencephalon and developing gut and pitx2a in left heart primordium.

127 Right heart pressures and flow and left heart PV relations (conductance catheter) were meas

128 PH was present without substantial left heart remodeling: the mean left ventricular ejectio

129 and the limiting of transeptal access to the left heart should it be required for the later treatment

130 Larger left heart structures and higher left ventricular pressu

131 logists rated the visualization of right and left heart structures and the degree of streak artifacts

132 olecular mechanisms leading to hypoplasia of left heart structures are unknown.

133 With advancing gestation, growth arrest of left heart structures became evident in fetuses developi

134 tervention demonstrated growth arrest of the left heart structures in unsuccessful cases and in those

135 Among early survivors, initially small left heart structures may be associated with worse subac

136 le is known about the growth and function of left heart structures or about patterns of reinterventio

137 Morphometric measurements of the left heart structures were obtained, and comparisons wer

138 there was no difference for visualization of left heart structures.

139 impact of intervention on in utero growth of left heart structures.

140 itation (FTR) is often left untreated during left heart surgery.

141 Diagnoses were hypoplastic left heart syndrome (66%), other congenital heart diseas

142 ight ventricle (66% vs. 36%) and hypoplastic left heart syndrome (HLHS) (47% vs. 13%).

143 taged reconstructive surgery for hypoplastic left heart syndrome (HLHS) and assess current outcome fo

144 ned to identify disease loci for hypoplastic left heart syndrome (HLHS) and evaluate the genetic rela

145 arctation of the aorta (COA) and hypoplastic left heart syndrome (HLHS) are congenital cardiovascular

146 of stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS) has improved coincident with

147 flow patterns in the fetus with hypoplastic left heart syndrome (HLHS) have been correlated with res

148 Results of staged palliation for hypoplastic left heart syndrome (HLHS) have improved in recent years

149 es for preoperative infants with hypoplastic left heart syndrome (HLHS) include increased inspired ni

150 Hypoplastic left heart syndrome (HLHS) is a fatal congenital heart d

151 Hypoplastic left heart syndrome (HLHS) is a severe cardiac malformat

152 Hypoplastic left heart syndrome (HLHS) is among the most severe form

153 after the Norwood operation for hypoplastic left heart syndrome (HLHS) is critical to early survival

154 Hypoplastic left heart syndrome (HLHS) is frequently diagnosed prena

155 ity) in families identified by a hypoplastic left heart syndrome (HLHS) proband.

156 of fetal aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS) requires identification of fe

157 e regurgitation in children with hypoplastic left heart syndrome (HLHS) undergoing staged surgical re

158 ctors for one-year mortality for hypoplastic left heart syndrome (HLHS) using intention-to-treat anal

159 Hypoplastic left heart syndrome (HLHS) with intact or very restricti

160 of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threatening CHD prima

161 Here, we show that hypoplastic left heart syndrome (HLHS), a severe CHD, is multigenic

162 nt type in staged palliation for hypoplastic left heart syndrome (HLHS), and strategies for selective

163 stage of surgical palliation of hypoplastic left heart syndrome (HLHS), the NO, includes augmentatio

164 unprecedented high frequency of hypoplastic left heart syndrome (HLHS).

165 ssion of aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS).

166 after staged reconstruction for hypoplastic left heart syndrome (HLHS).

167 e optimal treatment strategy for hypoplastic left heart syndrome (HLHS).

168 rgone reconstructive surgery for hypoplastic left heart syndrome (HLHS).

169 with post-stage I palliation for hypoplastic left heart syndrome (HLHS).

170 genital heart disease, including hypoplastic left heart syndrome (HLHS).

171 ttempt to prevent progression to hypoplastic left heart syndrome (HLHS).

172 nnection (TCPC) in children with hypoplastic left heart syndrome (HLHS).

173 h, management, and outcomes than hypoplastic left heart syndrome (HLHS).

174 drainage (HR, 4.0; P<0.001) and hypoplastic left heart syndrome (HR, 2.0; P=0.01).

175 Fifty-two patients with hypoplastic left heart syndrome (median age, 6.6; range 2.9-22.2 yea

176 n of tricuspid atresia (n = 13), hypoplastic left heart syndrome (n = 10) or other forms of functiona

177 ), tetralogy of Fallot (n = 66), hypoplastic left heart syndrome (n = 51), and coarctation of the aor

178 Diagnoses were hypoplastic left heart syndrome (n=346), tricuspid atresia (n=103),

179 The most common diagnosis was hypoplastic left heart syndrome (n=80, 36.7%).

180 .002), the anatomic diagnoses of hypoplastic left heart syndrome (P<0.001) and "other complex" (P=0.0

181 scores included the diagnoses of hypoplastic left heart syndrome (P=0.004) and "other complex" (P=0.0

182 e for follow-up of patients with hypoplastic left heart syndrome after Fontan palliation.

183 Hypoplastic left heart syndrome anatomic subtype did not influence s

184 Infants born with hypoplastic left heart syndrome and an intact or highly restrictive

185 r the treatment of neonates with hypoplastic left heart syndrome and an intact or restrictive atrial

186 ns of FOXF1 were associated with hypoplastic left heart syndrome and gastrointestinal atresias, proba

187 gate the outcome in infants with hypoplastic left heart syndrome and intact atrial septum and to eval

188 n, outcome for infants born with hypoplastic left heart syndrome and intact atrial septum is poor.

189 ment of outcomes in fetuses with hypoplastic left heart syndrome and intact atrial septum.

190 t 26 to 34 weeks' gestation with hypoplastic left heart syndrome and intact or highly restrictive atr

191 A diagnosis of hypoplastic left heart syndrome and longer operative support times w

192 and nitrogen dioxide and between hypoplastic left heart syndrome and particulate matter were supporte

193 ess in the 3-stage palliation of hypoplastic left heart syndrome and related single right ventricular

194 rvival, particularly in cases of hypoplastic left heart syndrome and single ventricle.

195 ith aortic stenosis and evolving hypoplastic left heart syndrome and, in a subset of cases, appeared

196 Patients with hypoplastic left heart syndrome are at higher risk of failure.

197 r was positively associated with hypoplastic left heart syndrome but inversely associated with atrial

198 First-stage palliation of hypoplastic left heart syndrome has been performed as a hybrid proce

199 Surgical management of hypoplastic left heart syndrome has changed the prognosis of the con

200 d a home surveillance system for hypoplastic left heart syndrome improves outcomes.

201 The proportion with hypoplastic left heart syndrome increased from 1/173 (1%) before 199

202 Hypoplastic left heart syndrome is a rare congenital heart defect in

203 Hypoplastic left heart syndrome is a severe form of cardiovascular m

204 r (RV) function in patients with hypoplastic left heart syndrome is important during long-term follow

205 odified Blalock-Taussig shunt in hypoplastic left heart syndrome or variants is currently in progress

206 d indices of RV contractility in hypoplastic left heart syndrome patients after Fontan palliation.

207 , and Hybrid, currently used for hypoplastic left heart syndrome pose a risk of myocardial injury at

208 improvement in surgical results, hypoplastic left heart syndrome remains one of the congenital heart

209 Their role in management of hypoplastic left heart syndrome remains to be defined, especially as

210 Of 316 infants with hypoplastic left heart syndrome seen at our center over a 6.5-year p

211 re was 79% (95% CI, 61%-89%) for hypoplastic left heart syndrome versus 92% (95% CI, 87%-95%) for oth

212 Hypoplastic left heart syndrome was the primary predictor of Fontan

213 Infants with hypoplastic left heart syndrome were smaller in all measured dimensi

214 tricle predictably progresses to hypoplastic left heart syndrome when associated with certain physiol

215 ng hypotheses: (1) patients with hypoplastic left heart syndrome who develop significant tricuspid re

216 e reviewed for 138 children with hypoplastic left heart syndrome who underwent stage I surgical palli

217 achieves stage 1 palliation for hypoplastic left heart syndrome with different flow characteristics

218 "Hypoplastic left heart syndrome" is an unsatisfactory term describin

219 associated with smaller HC, eg, hypoplastic left heart syndrome, -0.39 (95% CI, -0.58 to -0.21); com

220 ctive lesions, including 19 with hypoplastic left heart syndrome, 3 with critical aortic stenosis, 2

221 survival varied by defect type: hypoplastic left heart syndrome, 38.0% (95% confidence interval, 32.

222 The rarest CHD found was hypoplastic left heart syndrome, a phenotype never seen in mice prev

223 teries, interrupted aortic arch, hypoplastic left heart syndrome, and aortic coarctation, but in no p

224 r ORs for atrial septal defects, hypoplastic left heart syndrome, aortic stenosis, pulmonic stenosis,

225 single-ventricle palliation for hypoplastic left heart syndrome, attrition after the Norwood procedu

226 osis of aortic stenosis/evolving hypoplastic left heart syndrome, more than twice as many were discha

227 ptal defect, aortic coarctation, hypoplastic left heart syndrome, patent ductus arteriosus, valvar pu

228 Patients with hypoplastic left heart syndrome, pulmonary atresia intact ventricula

229 In the hypoplastic left heart syndrome, severe restriction at the atrial le

230 surgery in infant patients with hypoplastic left heart syndrome, where surgical removal of EFE tissu

231 going first-stage palliation for hypoplastic left heart syndrome.

232 al aortic stenosis with evolving hypoplastic left heart syndrome.

233 possibly preventing evolution to hypoplastic left heart syndrome.

234 ernative management strategy for hypoplastic left heart syndrome.

235 congenital heart disease such as hypoplastic left heart syndrome.

236 he survival of infants born with hypoplastic left heart syndrome.

237 ervention, to severe, as seen in hypoplastic left heart syndrome.

238 valve, aortic root dilation, or hypoplastic left heart syndrome.

239 entricle defects, in particular, hypoplastic left heart syndrome.

240 treatment of children born with hypoplastic left heart syndrome.

241 was performed for palliation of hypoplastic left heart syndrome.

242 ternative palliative surgery for hypoplastic left heart syndrome.

243 tal defects to a high of 28% for hypoplastic left heart syndrome.

244 of heterogeneous origin, such as hypoplastic left heart syndrome.

245 ongenital heart disease, such as hypoplastic left heart syndrome.

246 st, and these primarily focus on hypoplastic left heart syndrome.

247 luding the first mouse models of hypoplastic left heart syndrome.

248 interstage AVVR in children with hypoplastic left heart syndrome.

249 r under the unsatisfactory term "hypoplastic left heart syndrome."

250 nt type in staged palliation for hypoplastic left heart syndrome; strategies for SCP.

251 ge from 13.6% (four factors) for hypoplastic left heart to 30.2% (seven factors) for transposition of

252 cally successful aortic valvuloplasty alters left heart valvar growth in fetuses with aortic stenosis

253 al of 539 consecutive patients with previous left heart valve procedure (time interval from valve pro

254 cant tricuspid regurgitation (TR) late after left heart valve procedure is frequent and associated wi

255 sess the impact of significant TR late after left heart valve procedure.

256 endently associated with survival late after left heart valve procedure.

257 ulticenter study to compare the frequency of left heart valve regurgitations in diabetic patients exp

258 h a significant increase in the frequency of left heart valve regurgitations in diabetic patients.

259 elative risk (odds ratio) of mild or greater left heart valve regurgitations were significantly incre

260 measure was the frequency of mild or greater left heart valve regurgitations.

261 tricuspid annuloplasty is recommended during left-heart valve surgery when the tricuspid annulus (TA)

262 s identification of fetuses with salvageable left hearts who would progress to HLHS if left untreated

263 identify genetic determinants of hypoplastic left heart with latent right ventricular dysfunction in

264 Left heart workload was unchanged.