ライフサイエンスコーパス: left-right asymmetry

1 soderm and endoderm and the specification of left-right asymmetry.

2 ulting initially in smaller somites and then left-right asymmetry.

3 indicating a defect in the determination of left-right asymmetry.

4 isms are characterized by dorsal-ventral and left-right asymmetry.

5 the mouse node initiates the development of left-right asymmetry.

6 nd late (cardiac looping) aspects of cardiac left-right asymmetry.

7 ilar to that of the notochord in maintaining left-right asymmetry.

8 Notch2 receptors exhibit multiple defects in left-right asymmetry.

9 at is required for visceral and diencephalic left-right asymmetry.

10 tream of these genes in the determination of left-right asymmetry.

11 ght-junction protein in the determination of left-right asymmetry.

12 TL for size, 25 QTL for shape, and 5 QTL for left-right asymmetry.

13 f Hensen's node, and establishment of normal left-right asymmetry.

14 thways and mechanisms involved in generating left-right asymmetry.

15 nents of the molecular cascade that regulate left-right asymmetry.

16 ion events are required for establishment of left-right asymmetry.

17 ctivation that leads to the establishment of left-right asymmetry.

18 nic pattern including bilateral symmetry and left-right asymmetry.

19 essor Dan have not before been implicated in left-right asymmetry.

20 ing ciliary development and determination of left-right asymmetry.

21 rly embryo are needed to consistently orient left-right asymmetry.

22 stream of XNR-1 in the pathway that patterns left-right asymmetry.

23 itus consistent with random determination of left-right asymmetry.

24 establishment of dorsal-ventral polarity and left-right asymmetry.

25 ls to and from Hensen's node in establishing left-right asymmetry.

26 double mutants, leading to randomization of left-right asymmetry.

27 de, which is essential for the initiation of left-right asymmetry.

28 and hspb12, have roles in the development of left-right asymmetry.

29 Tgif2 have holoprosencephaly and defects in left-right asymmetry.

30 redundant functions in the establishment of left-right asymmetry.

31 in required for craniofacial development and left-right asymmetry.

32 tterns correlated with tissue, position, and left-right asymmetry.

33 KV development perturbed asymmetric flow and left-right asymmetry.

34 ecular conservation of mechanisms initiating left-right asymmetry.

35 ing of cilia and subsequent determination of left-right asymmetry.

36 ead to the failure to successfully establish left-right asymmetry.

37 specific internal or external features with left-right asymmetry.

38 idline-derived signals required to establish left/right asymmetry.

39 and neural tube defects but also defects in left/right asymmetry.

40 lamus) of larval zebrafish displays distinct left-right asymmetries.

41 in both the establishment and maintenance of left-right asymmetries.

42 rsal midline cell types and establishment of left-right asymmetry [21-25].

43 n the brain, we find that early diencephalic left-right asymmetry also requires Southpaw activity.

44 trajectories nonparametrically and assessed left-right asymmetries and sexual dimorphisms.

45 ssociated with defects in the development of left-right asymmetry and cardiac looping.

46 hus essential for nonrandom determination of left-right asymmetry and development of ciliated cells.

47 rly embryonic structure that is required for left-right asymmetry and for generation of the axial mid

48 tions: seahorse is required for establishing left-right asymmetry and for preventing kidney cyst form

49 posterior patterning, and retinoids regulate left-right asymmetry and gut looping/rotation.

50 Kupffer's vesicle promotes left-right asymmetry and iguana mutant embryos had left-

51 which inversin protein motifs contribute to left-right asymmetry and kidney development.

52 The bases of pulmonary left-right asymmetry and laterality have also been inves

53 cluding mesoderm formation, establishment of left-right asymmetry and neural patterning [1-8].

54 Delta)2-3(beta)Gal), which causes defects in left-right asymmetry and other abnormalities during embr

55 Such a template could help to determine left-right asymmetry and planar polarity in development.

56 eviously classified GRK5 as a determinant of left-right asymmetry and proper heart development using

57 Dnahc5 is required for the specification of left-right asymmetry and suggest that the PCD-causing Dn

58 identify a direct Ca(2+)-sensitive target in left-right asymmetry and supports a model in which membr

59 ooping during the establishment of embryonic left-right asymmetry, and both NB250 and NB260, as well

60 r development of dorsal axial structures and left-right asymmetry, and suggest that Nodal signals act

61 tch signaling is essential for generation of left-right asymmetry, and that the Notch pathway acts up

62 is also required for the development of the left-right asymmetry, and that this requirement is evolu

63 Although left-right asymmetries are common features of nervous sy

64 have been identified, the mechanism by which left-right asymmetries are established during embryogene

65 Left-right asymmetries are most likely a universal featu

66 d to a model of how visceral organ and brain left-right asymmetry are coordinated during embryogenesi

67 the main body axis and the determination of left-right asymmetry are fundamental aspects of vertebra

68 suggested that the early and late events of left-right asymmetry are separable.

69 The mechanisms by which functional left/right asymmetry arises in morphologically symmetric

70 t between the PCP-based orienting system and left-right asymmetry, as well as between the oriented ce

71 We have identified sequential left-right asymmetries at the poles, which bias the buck

72 of flectin is significantly decreased, with left-right asymmetry becoming less discernible or absent

73 ators localize to the centrosome but show no left-right asymmetry before polarization.

74 ese data reveal a critical role for pitx2 in left-right asymmetry but indicate that pitx2 may functio

75 a role in the development of C. intestinalis left-right asymmetry but that this would have to be in a

76 tinoic-acid-deficient embryos exhibit somite left-right asymmetry, but it remains unclear how retinoi

77 ey role in the genetic cascade that controls left-right asymmetry, but its involvement in left-right

78 ftward fluid flow required for initiation of left-right asymmetry, but little is known about the morp

79 onic hedgehog are also restored, as is their left/right asymmetry, but goosecoid expression is not.

80 ce die at birth and exhibit randomization of left-right asymmetry, cardiac anomalies, and glomerular

81 he development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation o

82 to regulate cell movement, neural cell fate, left-right asymmetry, cell cycle, and apoptosis.

83 ling as well as their ability to correct the left-right asymmetry defect upon Grk5l knockdown in zebr

84 which was reflected by hearing, vision, and left-right asymmetry defects as well as decreased Hedgeh

85 hydrocephaly, curved body, kidney cysts and left-right asymmetry defects, reminiscent of zebrafish m

86 pronephric cyst formation, hydrocephalus and left-right asymmetry defects.

87 nt of the pericardial sac and, most notably, left-right asymmetry defects.

88 ight asymmetry and iguana mutant embryos had left-right asymmetry defects.

89 henotype including kidney cyst formation and left-right asymmetry defects.

90 ar-genetic abnormality associated with human left-right-asymmetry defects.

91 ockdown induces kidney cysts, hydrocephalus, left/right asymmetry defects, and strong dorsal axis cur

92 ired for normal brain development and proper left-right asymmetry, defects that are qualitatively sim

93 way acts upstream of Nodal expression during left-right asymmetry determination in mice.

94 nail family gene function, such as a role in left-right asymmetry determination, appear to be evoluti

95 ivation of Snai1 function exhibit defects in left-right asymmetry determination.

96 rom a genetic screen for defects in neuronal left/right asymmetry display a loss of the ASEL-specific

97 equired for establishment and maintenance of left-right asymmetry during early embryogenesis in zebra

98 critical regulator of endoderm formation and left-right asymmetry during early zebrafish development

99 Invariant patterning of left-right asymmetry during embryogenesis depends upon a

100 all vertebrates, humans establish anatomical left-right asymmetry during embryogenesis.

101 s that has been implicated in the control of left-right asymmetry during organogenesis.

102 The process that establishes left-right asymmetry during vertebrate development invol

103 re necessary for the establishment of normal left-right asymmetry during vertebrate embryogenesis.

104 axy results from failure to establish normal left/right asymmetry during embryonic development.

105 y results from a failure to establish normal left-right asymmetry early in embryonic development.

106 ositioning that is essential to mouse embryo left-right asymmetry establishment.

107 Inactivation of the left-right asymmetry gene Pitx2 has been shown, in mice,

108 ing gastrulation and also may play a role in left-right asymmetry generation in the post-gastrula emb

109 nisms that direct this handed development of left-right asymmetries have been elusive, but recent stu

110 Left-right asymmetries have likely evolved to make optim

111 e components of the pathway that establishes left-right asymmetry have been identified in diverse ani

112 Current models of left-right asymmetry hold that an early asymmetric signa

113 lr) mutants exhibit kidney cysts, randomized left-right asymmetry, hydrocephalus, and rod outer segme

114 ft > right asymmetry in CPD, and a layer III left < right asymmetry in cell size.

115 ed in control brains, but not WS, a layer IV left > right asymmetry in CPD, and a layer III left < ri

116 A left > right asymmetry in thickness of the cortical mant

117 Left-right asymmetries in brains are usually minor or cr

118 Do early cues influence left-right asymmetries in other animals?

119 tilt of the primitive gut tube, imparted by left-right asymmetries in the architecture of the dorsal

120 chirality of midgut looping is determined by left-right asymmetries in the cellular architecture of t

121 ies persist in mature leaves, and we observe left-right asymmetries in the superficially bilaterally

122 Zebrafish have prominent left-right asymmetries in their epithalamus that have be

123 he BMP type I receptor ACVRI in establishing left-right asymmetry in chimeric mouse embryos.

124 vealing that nematodes share a mechanism for left-right asymmetry in common with vertebrates.

125 During the establishment of left-right asymmetry in early vertebrate development, No

126 ciliates, but perhaps also in development of left-right asymmetry in general.

127 ly "split" OVX + E2 females exhibit a marked left-right asymmetry in immunoreactive c-Fos expression

128 plays a primary role in the establishment of left-right asymmetry in mice by directly regulating expr

129 There was left-right asymmetry in multiple regions of interest, pa

130 A left-right asymmetry in neuronal function is specified s

131 n a split-belt treadmill, which can impose a left-right asymmetry in step lengths.

132 lar blastocoel, culminate in a morphological left-right asymmetry in the 2-cell embryo, which precede

133 ed in the development of multiple organs and left-right asymmetry in the body plan.

134 em, has emerged as a valuable model to study left-right asymmetry in the brain.

135 unication through gap junctions to establish left-right asymmetry in the central nervous system of th

136 A molecular pathway leading to left-right asymmetry in the chick embryo has been descri

137 odal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.

138 ns, and synaptic connectivity, including the left-right asymmetry in the connectivity of some neurons

139 riptional factor Pitx2 is a key regulator of left-right asymmetry in the developing gut.

140 nexin gap-junction protein NSY-5 coordinates left-right asymmetry in the developing nervous system of

141 domain protein Lulu/Epb4.1l5 is required for left-right asymmetry in the early mouse embryo.

142 ly overlapping molecular pathways regulating left-right asymmetry in the head and trunk of the embryo

143 er genes previously shown to be required for left-right asymmetry in the mouse, lulu is not required

144 These studies indicate an inherent left-right asymmetry in the Q neuroblasts with regard to

145 , there is no direct evidence for functional left-right asymmetry in their limb control--handedness--

146 Most of the molecules known to regulate left-right asymmetry in vertebrate embryos are expressed

147 Establishment of left-right asymmetry in vertebrates involves cilia as es

148 Establishment of left-right asymmetry in vertebrates requires nodal, Wnt-

149 ownstream transcription target that mediates left-right asymmetry in vertebrates.

150 ystematic effect of gender on the pattern of left-right asymmetry in VMPC.

151 eral plate mesoderm during the patterning of left-right asymmetry in Xenopus embryos.

152 al mesoderm and is required for establishing left/right asymmetries in the zebrafish embryo.

153 The current results reveal a left/right asymmetry in parietal lobe function.

154 ted in mesodermal and neural patterning, and left-right asymmetry, in mouse, frog, and chicken embryo

155 Additionally, they displayed defects in left-right asymmetry including ambiguous expression of s

156 The reproducibility of left/right asymmetry indices and putamen-to-caudate rati

157 Biased left-right asymmetry is a fascinating and medically impo

158 The specification of left-right asymmetry is an evolutionarily conserved deve

159 Generation of left-right asymmetry is an integral part of the establis

160 identity of the gene and the means by which left-right asymmetry is established in snails remain unk

161 discuss recent advances in understanding how left-right asymmetry is generated and utilized across th

162 Left-right asymmetry is initiated during chick embryogen

163 Our results indicate that this left-right asymmetry is specified within the two sister

164 AWC left-right asymmetry is stochastic: in each animal, eith

165 m of functions, including the development of left-right asymmetry, kidney function, cerebrospinal flu

166 n of the embryo, the first overt evidence of left/right asymmetry (L/R), are observed at early somite

167 Functional left/right asymmetry ("laterality") is a fundamental fea

168 to the Pitx2 homeobox gene, a developmental left-right asymmetry (LRA) gene.

169 e the relation between somitogenesis and the left-right asymmetry machinery in RA-deficient embryos.

170 that the involvement of the Nodal pathway in left-right asymmetry might have been an ancestral featur

171 sis with implications for the development of left-right asymmetry not only in ciliates, but perhaps a

172 Visceral left-right asymmetry occurs in all vertebrates, but the

173 f pigment and blastocoelar cells, randomized left-right asymmetry of coelomic pouches, and disorganiz

174 -linked heterotaxy, a disorder with abnormal left-right asymmetry of organs.

175 The left-right asymmetry of snails, including the direction

176 ress this lack of data, the authors assessed left-right asymmetry of the anterior and posterior aspec

177 e cilia are guiding the establishment of the left-right asymmetry of the body in the vertebrate left-

178 development at the embryonic node, determine left-right asymmetry of the body.

179 pithelia in Kupffer's vesicle, which directs left-right asymmetry of the embryo; the otic vesicles, w

180 cleotide-mediated depletion of XCR2 disrupts left-right asymmetry of the heart and gut.

181 rafish laminin beta1a (lamb1a) that disrupts left-right asymmetry of the liver and pancreas.

182 Thus, Pitx2 is required for left-right asymmetry of the lungs but not other organs.

183 As the left-right asymmetry of the pancreas is also affected, s

184 is a fundamental feature of angiogenesis and left-right asymmetry of the vascular network.

185 g kidney cyst formation and for establishing left-right asymmetry of the vertebrate body plan.

186 Invariant left-right asymmetry of the visceral organs is a fundame

187 The specification of left-right asymmetry of the visceral organs is precisely

188 dal function produces a randomization of the left-right asymmetry of visceral organs.

189 microRNA termed lsy-6 controls this neuronal left/right asymmetry of chemosensory receptor expression

190 t-right axis (situs inversus), can randomize left-right asymmetries, or can "rescue" a perturbed left

191 that a major function of the Pitx2-mediated left right asymmetry pathway is to pattern the aortic ar

192 Left-right asymmetry persists as the heart fields coales

193 ia, with upper-airways recurrent infections, left-right asymmetry perturbations, and fertility defect

194 nt had higher measured shape range (5:1) and left-right asymmetry prevalence (4:1).

195 e QL and QR neuroblast lineages migrate with left-right asymmetry; QL and its descendants migrate pos

196 Consistent left-right asymmetry requires specific ion currents.

197 spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement

198 Pelvic-reduced fish show the same left-right asymmetry seen in Pitx1 knockout mice, but do

199 n, a crucial developmental process linked to left-right asymmetry specification.

200 for PIERCE1 in the symmetry-breaking step of left-right asymmetry specification.

201 2, Vg1/GDF1 and Nodal are also key actors in left-right asymmetry, suggesting that the same ancient p

202 ated cytoarchitectural SDApc parameter shows left-right asymmetry, suggesting the SDApc has an intima

203 fter spinalization induced a reversal of the left/right asymmetries, suggesting that new plastic chan

204 oskeletal mechanism for the establishment of left-right asymmetry that is based on myosin contraction

205 standing the molecular mechanisms regulating left-right asymmetry, the final events of asymmetric org

206 es that propagate the signals that establish left-right asymmetry: the nodal-related gene southpaw (s

207 tanding of the early signals which establish left-right asymmetry, they leave unanswered the interest

208 also affected, southpaw appears to regulate left-right asymmetry throughout a large part of the embr

209 The first known left-right asymmetry to occur in the mouse embryo is a l

210 An exaggerated left > right asymmetry was detected in females in anteri

211 A large left-right asymmetry was present in the angular gyrus an

212 veral genes critical in the establishment of left/right asymmetry were expressed preferentially in ve

213 function is required for the development of left-right asymmetry, whereas left-right laterality is d

214 ditional double null embryos have defects in left-right asymmetry, which are also alleviated by reduc

215 dal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops functio