ライフサイエンスコーパス: lengthy

1 ceptibility to polymyxins is problematic and lengthy.

2 ay is necessary because the current assay is lengthy.

3 ns is becoming more complex, fragmented, and lengthy.

4 red to acquire a hologram with OSH is rather lengthy.

5 ttenuated phase 2 but not phase 1, whereas a lengthy (30 min) incubation in Ca2+-free physiological s

6 ime-of-flight techniques was associated with lengthy acquisition times and artifactual signal losses.

7 t used routinely as the result of artifacts, lengthy acquisition, and processing, a 3D-MTEE probe was

8 ls suitable for the compact accommodation of lengthy acyl chains.

9 patients with central vision loss suggest a lengthy adjustment period, but the nature and dynamics o

10 mptoms, which impair functioning and require lengthy admission.

11 The acyl moiety of acyl-CoA can be bulky or lengthy, allowing a large extent of diversity in new der

12 ial diversity in complex samples without the lengthy analysis and/or high cost associated with high-t

13 ngs, including extensive sample handling and lengthy analysis times.

14 rane protein is a critical step and can be a lengthy and "protein-expensive" process.

15 is that starting ART in many countries is a lengthy and burdensome process, imposing long waits and

16 Current tuberculosis therapy is lengthy and consists of multiple antimicrobials, which c

17 Current therapy of TB is lengthy and consists of multiple expensive antibiotics,

18 gene should be taken into account to prevent lengthy and costly research trials.

19 methodologies used to discover them are both lengthy and costly.

20 methods for describing critical residues are lengthy and costly; therefore, there is a need for compu

21 However, drug development is lengthy and costs are staggering.

22 sis control programs has been limited by the lengthy and cumbersome nature of current chemotherapeuti

23 is the customary procedure, which involves a lengthy and cumbersome second-order (in wave-amplitude)

24 n of atrophic maxillae with bone grafts is a lengthy and demanding procedure.

25 datasets, greatly simplifying this otherwise lengthy and difficult process and assuring optimal infor

26 Despite high prevalence, lengthy and dramatic features, PS as well as autonomic s

27 a, males instinctively pursue females with a lengthy and elaborate courtship ritual triggered by acti

28 in such fields as pediatrics, and avoids the lengthy and expensive process of modifying U.S. Food and

29 ller scale experiments without repetition of lengthy and expensive RCTs.

30 Drug development in cancer research is lengthy and expensive.

31 urrent preexposure vaccination schedules are lengthy and expensive.

32 erived from the SAE cell line, we identified lengthy and highly conserved gene-specific nucleotide se

33 Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocor

34 he process to make a glass chip, however, is lengthy and inconvenient, with the most difficult step o

35 Production of transgenic pigs, however, is a lengthy and inefficient process that hinders research us

36 This has typically been achieved through lengthy and intricate ex situ procedures.

37 the typical detection procedures are rather lengthy and involve the use of labeled secondary antibod

38 tems using slab gel electrophoresis requires lengthy and labor-intensive procedures.

39 A lengthy and laborious procedure is an additional challen

40 x, followed by much slower binding of a more lengthy and less flexible domain (domain 2) to Cdk2.

41 omplex polycyclic architectures that require lengthy and low-yielding syntheses; for example, one glu

42 drug regimens for treating tuberculosis are lengthy and onerous, and hence complicated by poor adher

43 elective synthesis of Trp analogues is often lengthy and requires the use of protecting groups, enzym

44 In contrast to the lengthy and small-scale "flask in the sun" procedures of

45 owever, from slow analysis time and required lengthy and stringent purification of hybridization prob

46 n during chronic HCV, but treatment is still lengthy and SVR rates are suboptimal.

47 eaction pathway(s) for these conversions are lengthy and unclear.

48 The first exon is lengthy and untranslated, and the second exon, which inc

49 orted syntheses of these compounds are quite lengthy, and every chemical step costs time and energy,

50 However, the methods can be complex, lengthy, and expensive.

51 ver, full genome sequencing is still costly, lengthy, and labor intensive.

52 s in the developing world are often complex, lengthy, and not transparent.

53 wever, the resulting protocol is tedious and lengthy, and requires too many user steps to be practica

54 time in the host is inconsistent with their lengthy antihyperalgesia.

55 s and medical staff should be prepared for a lengthy, arduous rehabilitation process.

56 rtably in the D pocket, incorporation of the lengthy Arg-3 is predicted to require local conformation

57 r 2, after radiation therapy, the PSA DT was lengthy at 1.82 years, significantly longer (P = .0025)

58 Larval midges survive the lengthy austral winter encased in ice, and when the ice

59 s transplanted sensory neurons to regenerate lengthy axons and enhances the ability of a trophic fact

60 witch into an active growth state and extend lengthy axons down the nerve.

61 nglion (DRG) neurons were able to regenerate lengthy axons within the reactive glial environment of t

62 s at other genetic loci without the need for lengthy backcrossing.

63 The lengthy biodegradation half-life of EtFOSE and recalcitr

64 By 17 hours, novel, lengthy cable structures are evident, and these are prim

65 dependent techniques also frequently require lengthy calibration steps for each cell or cell type mea

66 dure, however, has limitations in that it is lengthy, can be inconsistent, and is prone to nonspecifi

67 c MAPs as mitotic synchrony is eroded during lengthy cellulase treatment.

68 entasaccharide that is synthesized through a lengthy chemical process.

69 Patients who have TB require lengthy chemotherapy, possibly because of poor penetrati

70 We also demonstrate that lengthy chromatographic separation is no longer required

71 RM) quantification methods have necessitated lengthy chromatography to obtain accurate quantification

72 d does not require chromogenic substrates or lengthy chromatography, was successfully benchmarked aga

73 uids and fogging occlude the lens, requiring lengthy cleaning procedures that include irrigation, tis

74 atients by providing realistic estimates for lengthy clinical development timelines and positioning c

75 and emerging cancer drugs without a need for lengthy clinical studies.

76 institutions complying with HIPAA by adding lengthy, complex language to their research consent docu

77 standard treatment for tuberculosis (TB) is lengthy, complex, and significantly toxic.

78 r values affect the result before starting a lengthy computation, the user's learning curve is enhanc

79 s but suffer from several drawbacks, such as lengthy construction time and expression of viral genes.

80 Interestingly, a significant lengthy control of the gastrointestinal bleeding in one

81 Compared to lengthy conventional methods, Sherlock, Microlog, and Mi

82 risk of IA included prolonged hemodialysis, lengthy corticosteroid treatment posttransplant, and use

83 However, its lengthy data acquisition time greatly limits the wide bi

84 bers of reticulocytes per sample and require lengthy data acquisition times.

85 s into a single tool eliminates the need for lengthy data handling and parsing, significantly expedit

86 There is a lengthy delay in time from HT to CRP referral, though on

87 study demonstrates a malignant phenotype and lengthy delay to diagnosis in catecholaminergic polymorp

88 We link detailed local climate data to a lengthy demographic record, and combine both with a popu

89 e events were concentrated near ribbons, but lengthy depolarization also triggered release from more

90 izing synthetic networks in cells results in lengthy design-build-test cycles, minimal data collectio

91 rametric distribution, removing the need for lengthy development of novel methods for differently dis

92 Lengthy developmental programs generate cell diversity w

93 These results are consistent with a lengthy developmental time course for automatic sublexic

94 enomena that drives innovation rather than a lengthy device fabrication process that hinders it.

95 Based on thorough review and lengthy discussion, the work group proposed that the inf

96 apy studies in patients with stroke requires lengthy discussions about several issues unique to clini

97 are unusual enzymes, capable of recognizing lengthy DNA sequences and cleaving site-specifically wit

98 td intron-encoded endonuclease, recognizes a lengthy DNA target and initiates intron mobility by intr

99 ins have an identical motif structure of two lengthy domains in their C-terminal regions.

100 enomic DNA or RNA in rod-shaped viruses, the lengthy double-stranded genome of other viruses is packa

101 as new medicines for 7-12 years, due to the lengthy drug development and registration processes.

102 unpaired during elongation in vitro and that lengthy duplexes hinder polymerization through particula

103 syndrome with morphine is associated with a lengthy duration of therapy and hospitalization.

104 The lengthy duration required for culture growth and identif

105 g concern regarding its radiation burden and lengthy duration.

106 Hispanic patients were less likely to have a lengthy eligibility period as compared with other cohort

107 poral autocorrelation analysis of v detected lengthy episodes of high-velocity movement consistent wi

108 eutic application of human MSC (hMSC) is the lengthy ex vivo expansion time for preparing a sufficien

109 Lengthy expansions of trinucleotide repeats are found in

110 Where treatment is available, it is lengthy, expensive, and associated with poor adherence a

111 ymerase elongation rates is often done via a lengthy experimental process involving radiolabeled subs

112 icient to induce dissociation, and that even lengthy exposure of kinesin to the microtubule fails to

113 However, lengthy exposure times (>2-3 hr) to the transfection med

114 We speculate that this lengthy exposure to azole antifungal drugs may have caus

115 fe declines on a global scale, must confront lengthy exposure to environmental barriers before contac

116 hyma of the SN, but there was no evidence of lengthy extension of graft-derived neurites rostrally al

117 quence similarity, is robust to inclusion of lengthy extraneous flanking sequence and/or completely u

118 However, this mechanism, which requires a lengthy extrinsic incubation period before a short infec

119 It is not a substitute for more lengthy family history if more detail on diagnosis is re

120 The lengthy feathered tail of the new fossil provides insigh

121 Lengthy follow-up demonstrates a significant incidence o

122 The expense and lengthy follow-up periods for randomized clinical trials

123 es mellitus (DM) in adulthood because of the lengthy follow-up required.

124 Breast cancer heterogeneity dictates lengthy follow-up to assess outcomes.

125 n in this population with access to care and lengthy follow-up, only a fraction of expected viral hep

126 ders can be difficult and costly and require lengthy follow-up.

127 ghly complex and expensive, and they require lengthy follow-up.

128 RR-defective rad18Delta mutant stalls into a lengthy G2 arrest associated with the accumulation of si

129 ely used microarray analytical methods yield lengthy gene candidate lists that are difficult to apply

130 To determine the biological relevance of a lengthy gene list, the usual solution is to perform enri

131 ar double-stranded DNA viruses is that their lengthy genome is translocated with remarkable velocity

132 During replication, the lengthy genome of double-stranded DNA viruses is translo

133 with retro-orbital optic nerve crush injury, lengthy growth of severed retinal ganglion cell (RGC) ax

134 or substrate grain enlargement followed by a lengthy growth period.

135 This procedure removes the need for lengthy growth periods and traditional DNA isolation met

136 though an increasing number of examples with lengthy (>11 aa) peptides, presented mostly by HLA-B all

137 , without treatment, skin ulcers occur and a lengthy healing process may be observed associated with

138 e therefore suggest that digitoxin, with its lengthy history of human use, deserves consideration as

139 e the evolutionary puzzle of altruism have a lengthy history, and recent years have seen many importa

140 The main reason for lengthy hospital stay is bowel complication including pa

141 ted and 19% of permanent residents), and had lengthy hospitalizations (median [midspread] days = 87 [

142 in routine practice for people experiencing lengthy hospitalizations.

143 studied primarily from clinical outcomes in lengthy human studies.

144 ade 3/4 asparaginase-related toxicities were lengthy hyperbilirubinemia and transaminitis, occasional

145 because of their inability to cooperate with lengthy imaging procedures or painful treatments, form t

146 After lengthy immersion in a NaOH solution, most of the epoxy

147 rticularly appealing to tree breeders, where lengthy improvement cycles are the norm.

148 avily weighted on traditional endpoints from lengthy in vivo studies.

149 A lengthy incubation (>6 years) revealed iso-alkane biodeg

150 to 3 days for a single batch analysis due to lengthy incubation and digestion steps.

151 The probably lengthy incubation period makes it difficult to predict

152 -N-glycosylation protocols usually require a lengthy incubation time.

153 th media, specialized wash protocols and the lengthy incubation times required by other published rec

154 of media, require manual manipulations, have lengthy incubation times, are limited to one collection,

155 esidues, but this two-step reaction requires lengthy incubations and produces highly incomplete cleav

156 Lengthy incubations of routine analytical assays were re

157 The observation of considerably lengthy individual supramolecular polymer molecules indi

158 rasitophorous vacuole where it carries out a lengthy infectious cycle with minimal cytopathic effects

159 sm to sustain the host for completion of its lengthy infectious cycle.

160 te DVT or gastrointestinal prophylaxis (9%), lengthy initial operative procedures rather than damage

161 CTLs may be further subverted during lengthy interactions with tumor-associated macrophages (

162 Any technique that minimizes lengthy interruptions of chest compressions during the f

163 In cytokinesis, there is a lengthy interval between cleavage furrow ingression and

164 TLR-2 undergoes a lengthy intracellular maturation process with a half-lif

165 recent global dissemination in humans, (ii) lengthy intracellular quiescence, and (iii) active repli

166 However, SELEX is a lengthy, labor-intensive, iterative process requiring mu

167 icult to obtain, although they required more lengthy laboratory processing.

168 The lengthy lag phase before growth in an mgtC+ mgtB strain

169 CD4+ T cell expansion was nonlinear, with a lengthy lag phase followed by 2 days of explosive prolif

170 ps for heterologous prime-boost-boost can be lengthy, leaving the host vulnerable for an extensive pe

171 rge rate constant, considering the nominally lengthy linking bridge between the Au cores.

172 This topic is timely, given the lengthy list of immune checkpoint inhibitors and vaccine

173 charged with guideline development find the lengthy list of standards developed by such organization

174 throughout the world, rather than just be a lengthy listing of all available databases.

175 throughout the world, rather than just be a lengthy listing of all available databases.

176 throughout the world, rather than just be a lengthy listing of all available databases.

177 nctional evaluation of individual genes from lengthy lists of candidate genes from genomic data sets

178 Protein biomarker discovery produces lengthy lists of candidates that must subsequently be ve

179 case under existing antitrust doctrine, and lengthy litigation is possible.

180 e have previously demonstrated a complex and lengthy maturation of virus-specific antibody responses

181 ce, many patients still undergo multiple and lengthy medication trials before experiencing relief of

182 oblems with telephone communication, such as lengthy message menus.

183 RATIONALE: Lengthy, multidrug, toxic, and low-efficacy regimens lim

184 esult of multiple dysregulatory events, is a lengthy multistep process manifested by accrual of mutan

185 mited, mostly because of the painstaking and lengthy nature of the procedures currently used for thei

186 ed goldfish retinal ganglion cells to extend lengthy neurites and express the growth-associated prote

187 three ELa large cells and then continue in a lengthy neuronal pathway that traverses the ELa several

188 hetic routes to thionated NDIs are generally lengthy, nonselective, and low yielding and their polyme

189 secondary relaxation, necessitate relatively lengthy numerical calculations.

190 have been proposed, most are too expensive, lengthy or limited in specificity for clinical use.

191 Contaminated diced celery caused a baffling, lengthy outbreak of hospital-acquired listeriosis.

192 to the HLA-B*0702 and HLA-B*4402 restricted, lengthy peptides (>11 aa) arising from the B-cell ligand

193 The pharmacologic utility of lengthy peptides can be hindered by loss of bioactive st

194 nitially with manic excitement followed by a lengthy period of mutism, immobility, and food and fluid

195 ter age 14 years (late-onset blind), after a lengthy period of normal vision.

196 hosphorylation and dephosphorylation, with a lengthy period of phosphorylation preceding apoptosis in

197 that DN1 cells move very little during this lengthy period of proliferation and lineage commitment.

198 to be infected with a single serovar over a lengthy period.

199 tuberculosis relapse and reinfection over a lengthy period.

200 st patients require multiple injections over lengthy periods of time and the prevalence of treatable

201 Despite lengthy persistence of the stress and activation of apop

202 two growth stages are separated by an often lengthy phase of arrested growth, the so-called lag-phas

203 es to yield unnatural products from complex, lengthy plant pathways have not been widely explored.

204 these reviews are practically inaccessible: lengthy, poorly organized, and weakly summarized.

205 Human life history incorporates childhood, a lengthy post-weaning period of dependency.

206 s, such as surface phosphonation requiring a lengthy postprocessing annealing step at 140 degrees C w

207 nd eliminate the need for operator input and lengthy postprocessing.

208 A lengthy preclinical disease is predicted by these models

209 m environmental matrices requires the use of lengthy prefractionation steps and high-resolution mass

210 ime interval (deltat) between cessation of a lengthy preillumination of a sample and the actinic flas

211 We eliminate lengthy preparation procedures for direct functionalisat

212 tories subject the amplification products to lengthy probe hybridization procedures by Southern blott

213 Due to the lengthy procedure and the difficulties in removing DPCP

214 This approach is a lengthy procedure, especially in cereals.

215 To avoid such tedious and lengthy procedures, vacuum matrix-assisted laser desorpt

216 D) for pediatric antiretrovirals (ARVs) is a lengthy process and lags considerably behind drug develo

217 e simulation approaches due to the extremely lengthy process and very complex landscape.

218 um isolate using these standard methods is a lengthy process based on subjective data interpretation.

219 otypes in different accessions and/or by the lengthy process required to construct a particular mappi

220 Drug discovery is a high-risk, expensive and lengthy process taking at least 12 years and costing upw

221 inical evidence in the post-market stage - a lengthy process that often takes years, during which tim

222 Medication management in schizophrenia is a lengthy process, as the lack of clinical response can on

223 age fate among noncommitted progenitors is a lengthy process, the absence of B cell potential in earl

224 cooperative oncology group is a complex and lengthy process, with the majority of decision points ex

225 Activation of clinical trials is a lengthy process.

226 velopment of HIV drugs is an expensive and a lengthy process.

227 opment time for phase III clinical trials is lengthy, process laden, and highly variable.

228 ) currently requires expensive equipment and lengthy processing times to isolate and concentrate the

229 ension of NaOH-free olive debittering is its lengthy processing.

230 t overcomes need of complex instrumentation, lengthy protocols and surface modification of GNP.

231 d ELISA is difficult to prepare and involves lengthy protocols.

232 d because of their low levels of expression, lengthy purification procedures and poor recoveries.

233 ical interpretation of the spectra relies on lengthy quantum-chemical computations, which are difficu

234 nctionally limited by their sequestration to lengthy rCGG repeats.

235 These observations also suggest that the lengthy read-through RNAs postulated to be intermediates

236 t group I introns by binding to and cleaving lengthy recognition sequences that are typically centere

237 combination treatment allows for remarkably lengthy regeneration of certain subtypes of brainstem an

238 nerve autograft, ChABC treatment resulted in lengthy regeneration of serotonin-containing axons and o

239 P deserts (regions of low SNP incidence) and lengthy regions of linkage disequilibrium containing onl

240 logues cladribine and pentostatin results in lengthy remissions in nearly all patients with HCL, most

241 ng neurons of the rat hypothalamus discharge lengthy, repeating bursts of action potentials in respon

242 oncontaminated needle (53 [19%] of 282), too-lengthy reporting process (37 [13%] of 282), and associa

243 cular NHL, the R-CHOP combination provides a lengthy response duration in patients with relapsed or n

244 inherently lower diffusivities, suffer from lengthy response times and lower sensitivity, limiting t

245 on and familiarity of emotional memory after lengthy retention intervals.

246 n of retrieval processes, particularly after lengthy retention intervals.

247 Injured axons of the adult CNS undergo lengthy retraction from the initial site of axotomy afte

248 These results demonstrate that lengthy retroviral genomes can be packaged and that geno

249 short RNAs might facilitate the packaging of lengthy RNAs by heterodimerization, some experiments inv

250 g for manuscripts to undergo multiple, often lengthy, rounds of review, resulting in significant dela

251 MS-MS), but the measurement with ISEs avoids lengthy sample preconcentration, can be performed in sit

252 current methods for miRNA detection require lengthy sample preparation and amplification steps that

253 e from the fabric allows the omission of the lengthy sample preparation involved in extraction, there

254 es and the subsequent need for compensation, lengthy sample preparation, and multiple control tests t

255 ell extracts without tedious derivatization, lengthy sample preparation, and separation required by G

256 with diseases that do not permit time for a lengthy search.

257 ivatization, multiple purification steps, or lengthy separation times required by traditional GC-MS-

258 nd noncoding DNA fragments or on a number of lengthy sequence-typing methods.

259 ogenesis, permitting proper placement of the lengthy small intestine within the confines of the body

260 Tfp range from short, jerky displacements to lengthy, smooth ones.

261 This type of habituation to a lengthy stimulus has been recognized, behaviorally, but

262 Individuals in this population experience a lengthy struggle with disabling conditions in adulthood,

263 Nevertheless, these lengthy studies mandate the use of analytical methods wi

264 igh fecal bacterial counts) is preceded by a lengthy subclinical stage of disease.

265 place of donor blood during emergencies and lengthy surgeries.

266 uclear aggregates of mutant huntingtin, such lengthy survival does reveal cortical and striatal abnor

267 Nonetheless, the lengthy survival of Hdh (-/-) cells in adult chimeric mi

268 The lengthy syntheses encountered with earlier generations o

269 ased ketone (-)-6 was prepared in a somewhat lengthy synthesis (along with its monofluoro and geminal

270 ection of the benzoin carbonyl group and the lengthy synthesis.

271 e stages of the parasite's life cycle, but a lengthy synthetic route to these compounds may affect th

272 nhibitors has been underexplored, due to the lengthy synthetic routes and the lack of structure-activ

273 grochemistry, but their preparation requires lengthy synthetic sequences, which has likely limited th

274 enols, on the other hand, generally requires lengthy synthetic sequences.

275 can be achieved can be accepted, avoiding a lengthy systematic review.

276 Using substrates where lengthy targeted regions are excised, these modification

277 derlie particular phenotypes has been a very lengthy task that many laboratories could not afford bec

278 the potential of consumer electronics to cut lengthy test waiting times, giving patients on the spot

279 lysis reveals, however, that the addition of lengthy text often is unnecessary.

280 The L5-domain of Eg5 was sufficiently lengthy that portions of L5 could be located in proximit

281 Given how arduous and lengthy this process can be, we sought to determine whet

282 e of Pneumocystis in rat colonies, requiring lengthy time periods and/or postmortem tissue.

283 iversity are applied to samples collected in lengthy time series.

284 Unfortunately, they are usually too lengthy to be applied in time-resolved experiments perfo

285 reening of colonies by PCR, due to being too lengthy, too laborious or yielding poor quality DNA and

286 multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcom

287 to prevent protein degradation during their lengthy travels through the epididymis.

288 However, lengthy treatment courses and follow-up periods are not

289 The current status quo of the lengthy treatment duration and poor treatment outcomes a

290 associated with GBV, they typically require lengthy treatment programs that may limit scaling up in

291 t treatment options are plagued by toxicity, lengthy treatment regimens, and growing evidence of drug

292 granulomas could contribute to reducing the lengthy treatment required for tuberculosis and provide

293 have been discovered through serendipity or lengthy trials using known anticancer agents with simila

294 The lengthy tuberculosis treatment duration and poor treatme

295 or depressive disorder, even in persons with lengthy well intervals.

296 ork on the tens of minute time scale, become lengthy when hundreds of samples are to be analyzed.

297 mass spectrometry data, but analysis can be lengthy when thousands of compounds are detected in a si

298 need for extensive sample preparation or the lengthy window between infection and measurable immune r

299 RP are preserved into adult life such that a lengthy window of opportunity should exist for intervent

300 enhancement of dopamine efflux in lieu of a lengthy withdrawal period is uncommon, but can be attrib