ライフサイエンスコーパス: lens placode

1 fate of cells in the zebrafish and mammalian lens placode.

2 crystallin and die before the formation of a lens placode.

3 rom pre-lens ectoderm stages to invaginating lens placode.

4 n the ectodermal cells that give rise to the lens placode.

5 um wider than, but including, the developing lens placode.

6 optic vesicles are inefficient at inducing a lens placode.

7 as a model, we have uncovered evidence that lens placode AC may be partially dependent on apically p

8 rates, Pax6 is required for formation of the lens placode, an ectodermal thickening that precedes len

9 alleles results in impaired induction of the lens placode, an ocular phenotype that includes anophtha

10 P0-initiated transcripts predominate in lens placode and corneal and conjunctival epithelia, whe

11 at semaphorin3A (Sema3A) is expressed in the lens placode and epithelium continuously throughout eye

12 essential for Pax6 enhancer activity in the lens placode and its derivatives in transgenic mouse emb

13 expressed in the developing brain and in the lens placode and later restricted exclusively to the ant

14 on and specification were defective, and the lens placode and lens were absent.

15 that expression of Pax6 is biallelic in the lens placode and optic vesicle.

16 sed in this early eye field and later in the lens placode and optic vesicle.

17 rsors into restricted lineages including the lens placode and the oral ectoderm (pituitary precursor)

18 omain of ectoderm first thickens to form the lens placode and then invaginates to form the lens pit.

19 ic vesicle maintain Xlens1 expression in the lens placode; and (4) Xlens1 expression is downregulated

20 Conditional deletion of Sox2 in the lens placode arrests lens development at the pit stage.

21 ectoderm showed defects in formation of the lens placode at E9.5 but in addition, showed reduced lev

22 B-crystallin transcripts are present in the lens placode at E9.5.

23 er does not eliminate Pax6 production in the lens placode but results in a diminished level that, in

24 g was initially elevated in the invaginating lens placode, but by the lens vesicle stage, ERK phospho

25 RhoA mutant lens placode cells are both longer and less apically con

26 By contrast, Rac1 mutant lens placode cells are shorter and more apically restric

27 is to provide essential survival signals to lens placode cells.

28 on of Pnn resulted in severe malformation of lens placode-derived tissues including cornea and lens.

29 ens formation, indicating a role for BMP7 in lens placode development.

30 an being constrained to a fixed area and the lens placode did not form.

31 o suggests that Pax6 enhancers active in the lens placode drive expression in distinct subdomains, an

32 d Meis2 bind a specific sequence in the Pax6 lens placode enhancer that is required for its activity.

33 he surface ectoderm region that includes the lens placode expressed 12 out of 19 possible Wnt ligands

34 onoallelic expression of Pax6 at the time of lens placode formation accounts for the 50% reduction in

35 Pax6 is essential for both lens placode formation and subsequent stages of lens mor

36 al threshold of PAX6 protein is required for lens placode formation and that the time in development

37 rmed that the cellular events that accompany lens placode formation in chicken embryos also occur in

38 s in chicken embryos supported the view that lens placode formation occurs because the extracellular

39 We then showed that the failure of lens placode formation when the transcription factor, Pa

40 e surface ectoderm was sufficient to explain lens placode formation.

41 6 or control morpholinos before the onset of lens placode formation.

42 nent of the genetic mechanism(s) controlling lens placode formation.

43 during development of the early eye when the lens placode forms the lens pit.

44 In striking contrast, ablation of the lens placode gave rise to optic vesicles that underwent

45 ion of BMP7 antagonists during the period of lens placode induction inhibits lens formation, indicati

46 present in the head ectoderm at the time of lens placode induction.

47 mp7 functions upstream of Pax6 and regulates lens placode induction.

48 on of chicken embryos resulted in failure of lens placode invagination and production of delta-crysta

49 tion from the embryonic day (E)10.5 stage of lens placode invagination to E12.5 lens primary fiber ce

50 This argues that Pax6 expression in the lens placode is controlled by the ectoderm enhancer and

51 However, the formation of the lens placode is delayed.

52 l cells that accompanies invagination of the lens placode is dependent on Shroom3, a molecule previou

53 ng pathway which is expressed in prospective lens placode, is absent in Sey/Sey embryos but initially

54 Lens placodes lacking Fgfr1 and 2 were thinner than in w

55 e of ectodermal expression of Sox2, an early lens placode marker.

56 the mammal, cells in the teleost peripheral lens placode migrated to the anterior lens mass and diff

57 Cells in the central lens placode migrated to the posterior lens mass and dif

58 The epithelial cells of the invaginating lens placode normally elongate and change from a cylindr

59 d anterior (adenohypophyseal, olfactory, and lens) placodes of vertebrates.

60 as P1-initiated transcripts are expressed in lens placode, optic vesicle and CNS, and only weakly in

61 not detected in the ak/ak mice either in the lens placode or at later developmental stages of the len

62 These include a thinner lens placode, reduced placodal cell proliferation, and a

63 The epithelium of the lens placode remains in close apposition to the epitheli

64 of Bmpr1a caused increased cell death in the lens placode, resulting in the formation of smaller lens

65 sion is lost just prior to the time when the lens placode should appear, while in Pax6-deficient (Sey

66 we examined the expression of several early lens placode-specific markers in Bmp7 mutant embryos.

67 g anterior chamber structures, including the lens placode, the iris and ciliary region and the prospe

68 ic gene expression and are excluded from the lens placode to cluster in the head ectoderm.

69 pmental pathway controlling formation of the lens placode, we examined the expression of several earl

70 signaling converge on Pax6 expression in the lens placode with the Foxe3 and Sox2 genes lying downstr