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1                                         Even less is known about a potential role for BEZ in treating
2                                 In contrast, less is known about a second, extensive superfamily of P
3                            In contrast, much less is known about Abeta effects at inhibitory synapses
4  steady swimming are well characterized, far less is known about acceleration.
5  neuronal growth cones is well-studied, much less is known about actin organization and dynamics alon
6                                     However, less is known about actomyosin bundle formation and orga
7                                              Less is known about ADHD treatment in adolescents.
8  morphogenesis has been intensively studied, less is known about AJ dynamics in other circumstances.
9                                              Less is known about altered mitochondrial function in th
10                               By comparison, less is known about antibody binding to nonenveloped vir
11 2F5 has been extensively characterized, much less is known about antibody m66.6 or antibody m66, a cl
12 educed risk of developing breast cancer, but less is known about associations with other common malig
13                                              Less is known about attempted suicide and whether psychi
14 have been extensively studied in humans, but less is known about B cells that become activated but do
15  bats is characterized at the genomic level, less is known about bat IFN-mediated transcriptional res
16  nitrogen cycling in temperate forest soils, less is known about biotic controls over phosphorus (P)
17                            By contrast, much less is known about cancer-causing mutations in non-codi
18 exposure to Delta9-tetrahydrocannabinol, but less is known about cannabis use and brain morphometry i
19 lar mechanisms guiding metastatic migration, less is known about cellular energy regulation and utili
20 ed radiotherapy (RT) -related SMN risks, but less is known about chemotherapy-related risks.
21 chanisms related to its reinforcing effects, less is known about clinically relevant mechanisms that
22 lso tuned to natural spatial statistics, but less is known about coding in higher order neurons in in
23 rtic stenosis who are at high surgical risk, less is known about comparative outcomes among patients
24 ular movements shape developing embryos, far less is known about coordinated cellular movements that
25 ygen isotopes in the shells of this species, less is known about delta(15)N values within their shell
26 een dissected with exquisite precision, much less is known about dsRNA.
27  as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations.
28 ct of intensive study in mammalian cells but less is known about effects of splicing on changing the
29                                          Far less is known about electron uptake via microbial extrac
30     While well studied at the species level, less is known about factors affecting the preferred temp
31  layered central nucleus is well-documented, less is known about functional compartments in the neigh
32 ures have been extensively studied, however, less is known about G4 motifs in mRNAs, especially in th
33  NMDAR activity have been well studied, much less is known about gene expression changes that occur u
34 fluencing cross-sectional lung function, but less is known about genes influencing longitudinal chang
35 ith bone mineral density (BMD) in adults but less is known about genetic influences specific to bone
36 f GluN2A- and GluN2B-containing NMDARs, much less is known about GluN2D-containing NMDARs.
37 rythroid cells or hepatocytes; however, much less is known about heme metabolism in other cell types.
38 dynamics regulate protein function, but much less is known about how biomolecule-solvent interactions
39 rocesses to support rapid proliferation, but less is known about how cancer cells alter metabolism to
40                                Comparatively less is known about how cells adhere to and exert forces
41 ely well understood at the structural level, less is known about how CSL interacts with corepressors.
42 f dissolved inorganic N (DIN) among streams, less is known about how delta(15)N of PUCs varies over t
43                                However, much less is known about how deprivation-induced synaptic mod
44  patients with atrial fibrillation (AF), but less is known about how diabetes influences outcomes amo
45                             In contrast, far less is known about how different neuronal cell types ar
46                                         Even less is known about how exit through these pathways affe
47                                              Less is known about how generalists respond to climate-a
48 ful events with cues in the environment, far less is known about how humans learn to associate these
49  these drives are currently being uncovered, less is known about how hunger and thirst interact.
50 nts born at the borderline of viability, but less is known about how increased rates of survival amon
51 ations underlying stimulus-guided movements, less is known about how internal goals - critical driver
52 noma, and corneal epithelial cells; however, less is known about how it is inherently regulated in co
53                                     However, less is known about how item and associative memories ar
54                                         Much less is known about how local ensembles function in infe
55 ortical asymmetries have been characterized, less is known about how persistent cytoplasmic asymmetri
56 lities of modern humans are well-documented, less is known about how personality traits have evolved
57                          However, relatively less is known about how PlGF represses the expression of
58                                              Less is known about how proteins emerging from different
59                                     However, less is known about how RAGE is involved in the pathogen
60 h-fidelity pols have been well studied, much less is known about how some pols achieve medium or low
61                                              Less is known about how spore germination is controlled
62                                However, much less is known about how such phosphorylation of E-Cadher
63 microbes play key roles in host defense, but less is known about how symbiotic microbes mediate patho
64 al organ identity are well studied, but much less is known about how the flower is partitioned into f
65                                     However, less is known about how the ordering of these bonds affe
66                                     However, less is known about how the plasmatocyte pool of the LG
67 out the functions of the kinases in mitosis, less is known about how the three isoforms function to c
68 rs carbon cycling across diverse ecosystems, less is known about how these changes are linked to the
69 itro DNA-binding and structural studies, but less is known about how these rules apply in vivo.
70                                              Less is known about how these structures communicate wit
71 e of temperature and nutrients in isolation, less is known about how these two factors interact to in
72  chronic inflammation in muscular dystrophy, less is known about how they are mechanistically linked
73 cular septal defects (VSDs), are common, yet less is known about how they arise than rarer heart defe
74 other chromatin modifying machines, but much less is known about how they assemble and whether stable
75 P)-binding cassette (ABC) transporters, much less is known about how they selectively recognize subst
76 4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes t
77                                However, much less is known about how WRKY TFs affect plant-specialize
78                                     However, less is known about human virus-specific Tfh cells or th
79                        However, surprisingly less is known about its atomic and electronic structure
80 ntral role in the activation of the BCR, but less is known about its contribution to the survival and
81 anched actin is relatively well studied, but less is known about its disassembly and how this influen
82 es not reduce mortality or hospitalizations, less is known about its effect on health status.
83 ortant for reward-seeking behaviors, however less is known about its function in non-homeostatic feed
84 e role of Bub3 in checkpoint activation, but less is known about its functions apart from the spindle
85 ng as a new type of lysine modification, but less is known about its overall regulatory role.
86                                              Less is known about its prognostic value in patients wit
87 f SMARCA4 at gene promoters is well-studied, less is known about its role in higher-order genome orga
88 ng from choice outcomes is well established, less is known about its role in learning the action cost
89  and phagocytosis have been clearly defined, less is known about its role in malaria immunity.
90 d the killing of target cells; however, much less is known about its role in NK cells.
91 cal for reward processing, but significantly less is known about its role in punishment avoidance.
92 the role of dopamine in value learning, much less is known about its role in using established value
93 ryonic development are well established, but less is known about its roles during trophoblast develop
94                                     Yet, far less is known about LAMP-2C function.
95                                              Less is known about late survival.
96 tive PNA state since the mid-1850s, but much less is known about long-term PNA variability.
97 been well documented in children and adults, less is known about long-term risks of adult obesity for
98                                              Less is known about longer-term mitochondrial behavior s
99 e key cells that initiate lung inflammation, less is known about lung macrophage phenotype and matura
100  on arterial mechanics is extensive, but far less is known about mechanisms controlling mechanical pr
101 oietic macrophages and dendritic cells, much less is known about microglia, resident tissue macrophag
102 f homotypic chains has been well elucidated, less is known about mixed chains.
103 ing a prominent role in DNA repair, but much less is known about mono-ADP-ribosylation.
104                                Although much less is known about neuronal migration in species with a
105 d both structurally and mechanistically, far less is known about non-histone acetyltransferase enzyme
106                                         Much less is known about on its sweetness and crunchiness, wh
107                            In contrast, much less is known about other repeats, such as local repeats
108 bcellular localization have been identified, less is known about phosphatases that control clock prot
109 hat activate NKCC2 have been identified, but less is known about phosphatases that deactivate NKCC2.
110  these processes is increasingly understood, less is known about post-transcriptional control of gene
111                                     However, less is known about potential concomitant effects on the
112 and dynamically regulated on yeast mRNA, but less is known about Psi presence, regulation, and biogen
113                                 By contrast, less is known about quantitative resistance loci, partic
114 ailable for individual receptors dimers, but less is known about receptor clusters that form in plasm
115 tion of cortical areas have been identified, less is known about regulators that direct acquisition o
116 control premature transcription termination, less is known about regulatory mechanisms employed by Es
117 guidance cues have been extensively studied, less is known about responses to combination of signals
118  from human and chimpanzee adenoviruses, far less is known about rhesus monkey adenoviruses.
119 duced mortality after acute ischemic stroke, less is known about severe obesity.
120  the emergency department (ED) are admitted, less is known about short-term outcomes and demand for s
121                                          But less is known about specific molecular targets of AGE an
122 SSA have focused on marine environments, far less is known about SSA transported inland.
123  phenomenologically understood, considerably less is known about strain hardening (the nonlinear elas
124                                          Far less is known about surface-dwelling (epigeic) rodents w
125                                     However, less is known about synaptic sources differentiating PCs
126 r understanding stress effects on the brain, less is known about the amygdala, a key brain area invol
127              Compared to other viruses, much less is known about the antiviral effect of IFITM3 on al
128  well described in the pediatric population, less is known about the appropriate work-up and treatmen
129 olatile metabolites have been reported, much less is known about the aroma given off by the fruit, wh
130                                              Less is known about the association between SES and mort
131  failure with reduced ejection fraction, but less is known about the association in heart failure wit
132 hronic kidney disease and improved survival, less is known about the associations of obesity with ris
133                                     However, less is known about the biophysical and structural chang
134 ral correlates of visuomotor transformation, less is known about the brain regions that accommodate v
135 d microenvironments for 3D culture of cells, less is known about the changes that occur over time, es
136  II) promoters has been extensively studied, less is known about the chromatin structure at pol III p
137 ovian behavior has been extensively studied, less is known about the circuitry underlying more active
138 ated by ipsilateral excitatory interneurons, less is known about the commissural excitatory interneur
139 communities for free-living species, yet far less is known about the composition of symbiont communit
140 died extensively in well-mixed environments, less is known about the consequences of crosstalk in spa
141 nd functioning has been intensively studied, less is known about the consequences of long-term preven
142 ls in tumor immunology has been established, less is known about the contribution of B cells.
143 viral proteins essential for cVAC formation, less is known about the contribution of cellular factors
144                                              Less is known about the contribution of Hippo signaling
145 lae are increasingly well characterized, but less is known about the contribution of proteins that lo
146 orcement contingencies are assured, however, less is known about the contribution of these regions to
147 se the risk of suicide including depression, less is known about the corresponding changes in molecul
148                                              Less is known about the developmental and genetic bases
149                                However, much less is known about the developmental origins of pigment
150 iofilms have been well studied, considerably less is known about the dynamics of mixed- Candida speci
151 evelopment of psychosis is well established, less is known about the effect of continued versus disco
152                                              Less is known about the effect of weight change.
153 f virus adaptive fitness landscapes and even less is known about the effect that different host speci
154 eprivation or pattern recognition receptors, less is known about the effects of cell-mediated immunit
155 n by local signals is intensely studied, but less is known about the effects of hormonal signals on s
156 sal and glycolysis are well established, but less is known about the effects of hypoxia and iron defi
157 ies have focused on the fish consumers, much less is known about the effects of MeHg on the fish them
158                                              Less is known about the effects of single, punctuated ev
159                                     However, less is known about the effects of steroid administratio
160 ach, not bringing snacks into the home), but less is known about the effects of these practices on ch
161                                     However, less is known about the end-of-life costs of specific di
162                                              Less is known about the extent of within-host virus dive
163 acute alcohol effects is well characterized, less is known about the extent to which it alters respon
164                                              Less is known about the extent to which methylation is d
165 ed in IL-27 induction are well studied, much less is known about the factors that negatively impact I
166                                However, much less is known about the fate and structure of CPPs withi
167 mechanisms underlying convergent phenotypes, less is known about the frequency and predictability wit
168 und at low to moderate frequencies and while less is known about the frequency of resistant genotypes
169  colon cancer have been intensively studied, less is known about the function and implications of NPP
170  individual DA neurons during learning, much less is known about the functional changes in the microc
171  eye movements are implemented in the brain, less is known about the functional interactions between
172                                              Less is known about the functions of an unconventional m
173 y conserved and well characterized, but much less is known about the functions of the tails of histon
174                                         Even less is known about the genetic factors that confer thes
175 n extensively characterized in T cells, much less is known about the glycosylation of serine/threonin
176                                     Although less is known about the homeostatic function of M2-like
177 mans, different DC subsets express IDO1, but less is known about the IDO1-related enzyme IDO2.
178  alcohol is a risk factor for breast cancer, less is known about the impact of episodic heavy drinkin
179 ole of feed-forward hierarchical processing, less is known about the impact of top-down signals on co
180 ion are reasonably well understood, although less is known about the impacts of invasion.
181 cancer cell invasion and dissemination, much less is known about the importance of MET in the later s
182  on emotional memories is well studied, much less is known about the influence of the emotional state
183 nt for offspring glucose tolerance; however, less is known about the influence on offspring adiposity
184                                              Less is known about the initial molecular response and a
185 the context of infectious diseases, however, less is known about the interplay between autophagy and
186 ory cell recruitment during atherosclerosis, less is known about the intrinsic pathways that countera
187 s are increasingly well-understood, but much less is known about the kinetics of such assembly phenom
188                                              Less is known about the leadership skills of senior char
189 early after nephrectomy are well documented, less is known about the long-term glomerular dynamics in
190 mediated gene activation is well understood, less is known about the mechanisms for repression at RA-
191                                         Much less is known about the mechanisms of orientation select
192 ygen species (ROS) after radiation; however, less is known about the mechanisms underlying amplificat
193 ell cycle have been extensively studied, but less is known about the mechanisms underlying the metabo
194 y a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sens
195 ts and adults with bulimia nervosa (BN), but less is known about the microstructure of white matter i
196 s from endosymbiont to host is well studied, less is known about the migration of eukaryotic genes fr
197 ctron microscopy and x-ray diffraction, much less is known about the molecular driving forces underly
198 ss-of-cell polarity and JNK activation, much less is known about the molecular mechanism by which abe
199 hil migration from circulation into tissues, less is known about the molecular mechanisms that regula
200 IG-I regulation are already well understood, less is known about the more enigmatic melanoma differen
201 ction selection in the mammalian brain, much less is known about the nature of the information being
202                                              Less is known about the nature, prevalence, and conserva
203                                         Even less is known about the neurodevelopmental origins of in
204 ying temperature sensation and gentle touch, less is known about the neurons specific for mechanical
205                                However, much less is known about the output properties of individual
206 cused on these neurotoxic proteins, but much less is known about the pathogenic roles of the respondi
207 ful situations are well understood, but much less is known about the pathways that link vlPAG activit
208                                     However, less is known about the performance of spICP-MS for dete
209     In nanoscale colloidal systems, however, less is known about the physical rules governing their s
210                                     However, less is known about the physiologic function of APP outs
211 the Kennedy pathway is well established, but less is known about the physiological functions of PC.
212                                     However, less is known about the possible familial associations o
213                                         Much less is known about the potential effects of climate cha
214                                              Less is known about the potential of IL-6 in regulating
215 microglia has recently been elucidated, much less is known about the precursors, the underlying trans
216 all the genes in the Drosophila genome, much less is known about the properties of the encoded protei
217                                     However, less is known about the prospective course of ADHD into
218  turnover across terrestrial ecosystems, but less is known about the quantitative and qualitative pro
219 nd high-income countries is well documented, less is known about the reasons for this inequity, which
220                                     However, less is known about the regions required for client rele
221 nder laboratory-controlled light conditions, less is known about the regulation of photosynthesis und
222 t the antioxidant activity of citrus juices, less is known about the relationship with physicochemica
223 ll-understood in metallic ferromagnets, much less is known about the relevance of different physical
224 tudied in yeast and animal systems, but much less is known about the replication programs of plants.
225                                         Much less is known about the responses of endothelial cells t
226                                     However, less is known about the role of complement during normal
227 nal regulation of stem cell differentiation, less is known about the role of dynamic cytosolic cues.
228                                However, much less is known about the role of H3K36me3 in transcriptio
229 ole in the activation of mature B cells, but less is known about the role of IL-4 in B cell maturatio
230                                However, much less is known about the role of kallikreins, in particul
231 pears to suppress brain repair after stroke, less is known about the role of phasic (synaptic) GABA d
232 eraction, which has been well characterized, less is known about the role of SCs in NMJ formation and
233                                              Less is known about the role of tetrahydrobiopterin in l
234 ent of many neurological disorders, but much less is known about the role of the blood-brain barrier
235 vestigated extensively in Lewy body disease, less is known about the role of this synaptic protein in
236 essential antiparasite immune effector, much less is known about the role of type I interferons (IFN-
237 ted as regulators of metastatic progression, less is known about the roles and mechanisms of RNA-bind
238 y-induced gene expression is widely studied, less is known about the roles of RNA binding proteins (R
239  has been extensively studied; however, much less is known about the salt-dependent ion excess of the
240 s mitotic spindles scale with cell size, but less is known about the scaling of actin structures with
241 d and domains of its component Gag proteins, less is known about the sequence of events leading to fo
242                                     However, less is known about the short-term effects of H and CF o
243 of hypoxia-induced adaptive gene expression, less is known about the signalling mechanisms regulating
244 nd to vary greatly between species, but much less is known about the somatic mutation rate in multice
245                                     However, less is known about the specificity of CD4+ TH responses
246                                However, much less is known about the structural behaviour of supercri
247                                              Less is known about the structure of the open CD4-bound
248 ve defensive responses (e.g., freezing), but less is known about the substrates of active defensive r
249                                         Much less is known about the synaptic mechanisms involved in
250                                         Much less is known about the synaptic target neurons outside
251                Compared to fatty acids, much less is known about the synthesis of phospholipids, whic
252  systems have been studied extensively, much less is known about the systems that reside and function
253 f brain activity in smokers' brains, however less is known about the temporal dynamics within smokers
254                                         Even less is known about the thermodynamics of biomolecule-so
255 and Mg2+ have been studied extensively, much less is known about the third most abundant cation in ba
256                            In contrast, much less is known about the toxicity of TDCPP and FM 550.
257 ateral RGC identity has been identified, but less is known about the transcriptional regulation of co
258 e been characterised for many plant species, less is known about the transcripts produced in other pl
259 hannels are activated by small molecules but less is known about the underlying gating mechanisms.
260 tive role in postpartum depression; however, less is known about the underlying mechanisms by which t
261  microbiome is rapidly acquired after birth, less is known about the viral microbiome (or 'virome'),
262                                              Less is known about the virome in these diseases.
263 ytes has been investigated extensively, much less is known about their assembly.
264                                         Much less is known about their benefits for adult health.
265  viral load during chronic viral infections, less is known about their differentiation and transcript
266 s target tumor antigen-specific T cells, but less is known about their effects on natural killer (NK)
267                                              Less is known about their expression and function in lym
268                                     However, less is known about their genome-wide transcriptional an
269 ians have been extensively examined [3], but less is known about their gut microbiotas.
270  have been evaluated in several studies, but less is known about their influence on the risk of diabe
271 ne responses has been well established, much less is known about their involvement in autophagy in re
272 cal regulators of neuronal excitability, but less is known about their possible roles in synaptic pla
273 ctured BPA analogues are widely used but far less is known about their potential toxicity or estrogen
274 ough their projections to striatum, but much less is known about their projections to prefrontal cort
275 e extracellular ligand-binding domain (LBD), less is known about their regulation of the ion channel
276 OA) via the ammonia monooxygenase gene amoA, less is known about their small-scale variation and if a
277 are well characterized in cancer cells, much less is known about their status in normal cells.
278  has been extensively studied, comparatively less is known about their transcription and translation.
279 activity through next-generation sequencing, less is known about their upstream regulation.
280 e well-characterized in model organisms, but less is known about these basic aspects of cell biology
281                                              Less is known about these disparities in patients with h
282                                              Less is known about these relationships in sub-Saharan A
283                                              Less is known about this association in patients with HF
284                                          Far less is known about this transition at the subnational l
285                                     However, less is known about thrombin generation kinetics and tra
286 n of an equilibrium is well understood, much less is known about tipping of oscillations (limit cycle
287 ts to elevation are well understood, but far less is known about trait distributional responses to el
288 about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migratio
289 eps of optic nerve pathfinding, however much less is known about transcription factors regulating thi
290 asic understanding of axonal transport, much less is known about transport in dendrites.
291                                However, much less is known about tropospheric mid-level clouds as the
292                                              Less is known about value (cost vs quality).
293  is associated with adverse health; however, less is known about vulnerable/sensitive populations, wh
294                                         Much less is known about weaker interactions and transient co
295 erized in cochlear nerve terminals, but much less is known about whether excess glutamate signaling a
296  by respiration even under basal conditions, less is known about whether inhibitory local circuit act
297                                              Less is known about whether maternal nutrition states du
298  via dopaminergic mechanisms within the NAc, less is known about whether phasic dopamine (DA) signali
299 esponse, mainly by releasing TNF-alpha, much less is known about whether/how this metalloprotease reg
300  the target promoters regulated by YY1, much less is known about YY1 regulation through post-translat

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