ライフサイエンスコーパス: lethal

1 nfections with 10 IFU of wild-type ZIKV were lethal.

2 ritical for health and mis-metabolism can be lethal.

3 , reversion in K33S-GPC rCan is likely to be lethal.

4 n of the CXCR4 gene in mice is embryonically lethal.

5 tion of either gene in mice is embryonically lethal.

6 emoval in RNase H-deficient bacteria becomes lethal.

7 , and blindness, which could collectively be lethal.

8 lethal to a cell but a single defect is non-lethal.

9 virus infection in Drosophila to one that is lethal.

10 ing disease, and the outcomes are frequently lethal.

11 , these proteins' key function is to prevent lethal accumulation of mislocalized lipoproteins.

12 lpiA is essential for enhancing survival in lethal acidic conditions.

13 rains, can still show substantial adverse or lethal actions in the brain.

14 sed human patients can develop severe, often lethal adenovirus infections.

15 on provide high levels of protection against lethal aerosol challenge with B. mallei ATCC 23344, it a

16 show that anti-VEGFR-3 treatment ameliorates lethal aGVHD and identifies the lymphatic vasculature as

17 Furthermore, we identified a lethal allele of MCM10 that stimulates initial DNA unwin

18 -dart Phyllobates terribilis frogs sequester lethal amounts of steroidal alkaloid batrachotoxin (BTX)

19 ents of Leishmaniasis, a disease that can be lethal and affects 12 million people worldwide.

20 ual-knockout libraries to identify synthetic lethal and buffering gene pairs across multiple cell typ

21 -binding region of bpl-1 are maternal-effect lethal and cause defects in embryonic polarity establish

22 Exposure to the toxin can be lethal and cause significant pathology in humans.

23 yme-dead KI (Mll4(KI/KI)) mice are embryonic lethal and die around E10.5, which phenocopies Mll4 knoc

24 tic ductal adenocarcinoma (PDAC) is a highly lethal and disseminating cancer resistant to therapy, in

25 A) is essential for the transport of anthrax lethal and edema toxins into human cells.

26 Eating disorders are lethal and heritable; however, the underlying genetic fa

27 Murine Inpp5e ablation is embryonically lethal and recapitulates JBTS, including neural tube def

28 s of temperature and hydrostatic pressure on lethal and sublethal (respiration rate, antioxidant enzy

29 s achieved first at activity levels close to lethal and was accompanied by biologic effects that redu

30 The lethal, and only, defect in KIR2DP1 is a nucleotide dele

31 genic cells in bacterial populations survive lethal antibiotic doses once bacteria consume nutrients

32 African horse sickness virus (AHSV) is a lethal arbovirus of equids that is transmitted between h

33 ts without intervention), and if there was a lethal arrhythmia alarm (1.2 minutes [95% CI, -0.6 to 2.

34 by a kinase domain mutation (D849V) develop lethal autoinflammation.

35 Placement of 1.688(X) repeats opposite a lethal autosomal deletion achieves partial rescue of mal

36 (0.0167 mg/kg) markedly improved survival in lethal bacteremic sepsis and aspiration pneumonia models

37 While the native toxin is extremely lethal, bioengineering of BoNT has the potential to elim

38 hich is necessary for accurately positioning lethal bites on prey, was mediated by a central amygdala

39 Glioblastoma is a highly lethal brain cancer that frequently recurs in proximity

40 In mice, Adar1 mutations are embryonic lethal but are rescued by mutation of the Mda5 or Mavs g

41 cking out Ctcf in mouse embryonic neurons is lethal by neonatal age, but the effects of CTCF deficien

42 Glioblastoma is a universally lethal cancer with a median survival time of approximate

43 Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisad

44 iac action potential and potentially trigger lethal cardiac arrhythmias.

45 insulin-mediated severe hypoglycemia induces lethal cardiac arrhythmias.

46 thal case and at 6 points over 7 days in the lethal case, after which all mice had died.

47 trauterine fetal intervention in potentially lethal cases.

48 cancer inevitably relapses and progresses to lethal castration-resistant prostate cancer (CRPC).

49 Regulatory T (T reg) cell deficiency causes lethal, CD4(+) T cell-driven autoimmune diseases.

50 sing recombinant viruses were protected from lethal CDV challenge.

51 orm uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance

52 ogy: how does a multicellular organism avoid lethal cellular collapse in the absence of liquid water?

53 hat mice maintained on a VLP diet succumb to lethal challenge at greater rates than mice maintained o

54 and conferred protective immunity against a lethal challenge dose of homologous influenza virus.

55 s), resulting in better protection against a lethal challenge than that seen with rLBNSE.

56 ses of peramivir rescued BALB scid mice from lethal challenge with BR/08, but did not result in compl

57 hese conjugates protected 75% of mice from a lethal challenge with H1N1 and prevented weight loss in

58 91 conferred full protection to mice against lethal challenge with H1N1, H3N2, and H5N1 strains, and

59 vaccination regimens protected mice against lethal challenge with mouse-adapted Ebola virus (ma-EBOV

60 e-cycle models primarily evaluate effects of lethal change.

61 equiring surgical repair at <7 days of life, lethal chromosomal anomaly, death within 48 hours, inabi

62 loid transformation, with a fully penetrant, lethal chronic myelomonocytic leukemia (CMML), which was

63 However, the burden of non-lethal complications associated with systemic sclerosis

64 ven exposure concentration, were higher, and lethal concentrations (50%; LC50) were 2.3-fold lower in

65 al tube and develop exencephaly, a perinatal lethal condition.

66 e phosphorylation (OXPHOS) are severe, often lethal, conditions.

67 ium infect millions of people each year with lethal consequences in immunocompromised populations.

68 Importantly, the lethal consequences of mSTAT3 inhibition are enhanced by

69 resistant to exogenously expressed dominant lethal D genes were experimentally evolved.

70 frequently, over what areas, and how rapidly lethal dehydration occurs; how EWL and die-off risk vary

71 could provide additional protection against lethal DENV infection.

72 amide, prolongs survival, but resistance and lethal disease eventually prevail.

73 frican swine fever is a contagious and often lethal disease for domestic pigs with a significant econ

74 We found that Muc2-deficient mice succumb to lethal disease from ETBF colonization in a B. fragilis t

75 uctal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strat

76 atory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exac

77 pecies and are capable of causing severe and lethal disease in humans.

78 ogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated

79 del organism Ceratonova shasta, which causes lethal disease in salmonids.

80 Pancreatic cancer is a lethal disease with poor prognosis.

81 viable alternative in the treatment of this lethal disease.

82 eras to treat a specific, identifiable, and lethal disease.

83 ry, facilitating long-term remission of this lethal disease.Significance: Coordinated neoadjuvant and

84 age a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabol

85 oliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 m

86 Based on these studies, the approximate lethal dose (ALD) exceeds 800 mug/dose and the NOAEL was

87 teins exhibit resistance to 10,000 times the lethal dose (LD50) of BoNT/A, and transfusion of these r

88 o possessed enhanced protection against high lethal dose challenges against homologous A/PR/8/34 and

89 is highly dangerous with an estimated human lethal dose of 0.1-1 mug/kg body weight.

90 livered 1, 2 or 3 days post-challenge with a lethal dose of EBOV.

91 These mice were protected against a lethal-dose toxin challenge, but Ty21a-vaccinated mice w

92 and intranasally challenged 24 h later with lethal doses of AA60 or Sw06.

93 hese red blood cells are resistant to highly lethal doses of BoNT/A.

94 mechanistic description of plant response to lethal drought that would improve predictive understandi

95 herapies have shown promise for treatment of lethal Ebola virus (EBOV) infections, but their species-

96 ynomolgus macaque non-human primate model of lethal EBOV infection.

97 ion caused mice to become susceptible to the lethal effects of HSV infection, with the virus spreadin

98 ng of glycolysis can circumvent the normally lethal effects of oxygen deprivation, a mechanism that c

99 al manipulation of social attributes and sub-lethal effects of pesticides on behaviour.

100 women and children and had disproportionate lethal effects on civilians, calling into question the u

101 )/K(+) channel blocker), was studied for pre-lethal effects.

102 parainfluenza viruses, as well as agents of lethal encephalitis like Nipah virus.

103 ng in severity from periodic "cold sores" to lethal encephalitis.

104 in TRAK1 (NM_001042646:c.287-2A > C), in six lethal encephalopathic patients from three unrelated fam

105 d pathogens, particularly viruses that cause lethal epidemics.

106 ing whether or not ice inside the cell was a lethal event.

107 The metalloproteinase anthrax lethal factor (LF) is secreted by Bacillus anthracis to

108 ynamics simulations of the permeation of the lethal factor (LF) N-terminal segment through the anthra

109 or protects macrophages from the toxicity of lethal factor.

110 ed maximal mitochondrial respiration) caused lethal fetal liver hematopoietic defects and hematopoiet

111 tations that disrupt these salt bridges were lethal for virus production, because the mutant proteins

112 ease (EVD) is a contagious, severe and often lethal form of hemorrhagic fever in humans.

113 Melanoma is a lethal form of skin cancer.

114 both; the release of Aedes carrying dominant lethal genes, such as the OX513A strain of A. aegypti; a

115 ied in a recent screen for A. aegypti larval lethal genes.

116 Synthetic lethal genetic analysis has identified MAT2A as an antic

117 tricular tachycardia (CPVT) is a potentially lethal genetic arrhythmia syndrome characterized by poly

118 inal muscular atrophy (SMA), the most common lethal genetic childhood motor neuron disease.

119 hole gut irradiation with these doses caused lethal GI syndrome, focal (5 mm) radiation of the intest

120 Ovarian cancer remains the most lethal gynecological malignant tumor.

121 ulations protects both mice and ferrets from lethal H5N1 homologous virus challenge.

122 mutation, designated dek38-Dsg, is embryonic lethal, has a defective basal endosperm transfer (BETL)

123 still provided 100% survival against 7 of 9 lethal heterologous influenza challenges.

124 date stimulated sterilizing immunity against lethal homologous challenge and complete protection agai

125 generate accurate preclinical models of this lethal human cancer.

126 ctal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensi

127 A sub-lethal hydrostatic pressure (HP) shock of approximately

128 n of Pax6 in beta cells of adult mice led to lethal hyperglycemia and ketosis that were attributed to

129 rus isolates from the 1990s induced a highly lethal immune collapse syndrome similar to septic shock.

130 e hematopoietic compartments that is rapidly lethal in adult animals.

131 w that arginine deprivation is synthetically lethal in argininosuccinate synthetase 1 (ASS1)-negative

132 Indeed, Sufu knock-out is lethal in mice, and recessive pathogenic variants of thi

133 CTCF deficiency in embryonic neurons is lethal in mice, but mice with postnatal CTCF depletion a

134 Because global knockout of Fst is perinatal lethal in mice, we generated a conditional knockout (cKO

135 GINS component-encoding genes are embryonic lethal in mice.

136 ally penetrant in an inbred strain but fully lethal in non-inbred mice.

137 We show that Usp36 depletion is lethal in preimplantation mouse embryos, where it blocks

138 s type 3 (PFIC3), a rare disease that can be lethal in the absence of liver transplantation.

139 emperature-sensitive splicing mutants become lethal in the presence of the drug under permissive temp

140 , mutating all Tyr1 residues to Phe (Y1F) is lethal in vertebrates but a related mutant has only a mi

141 rming beta subunit (SCS A-beta) is linked to lethal infantile Leigh or leigh-like syndrome.

142 and human macrophages and rescued mice from lethal infection.

143 D-RR4 protected Caenorhabditis elegans from lethal infections of P. aeruginosa and A. baumannii and

144 to effectively address highly pathogenic and lethal infections stemming from bacterial, fungal, and v

145 may be similarly significant in other highly lethal infections, suggesting that orienting the MP resp

146 s type I IFN response and did not ameliorate lethal inflammation.

147 pecific disruption of Thpok and Lrf causes a lethal inflammatory syndrome similar to that resulting f

148 s and achieved protective immunity against a lethal influenza challenge seven months post-immunizatio

149 protect against five different heterologous lethal influenza challenges.

150 aused a marked decrease in lung pathology in lethal influenza-challenged mice and improved protection

151 CRM197 and Hcp1, 100% of the mice survived a lethal inhalational challenge with B. pseudomallei Remar

152 ardial infarction has been the mitigation of lethal injury.

153 c liver exert the protective effects against lethal insults through conferring apoptosis resistance t

154 Here the authors find a synthetic lethal interaction between CDA and the microtubule-assoc

155 We found a synthetic lethal interaction between cytidine deaminase and microt

156 These results indicate a synthetic lethal interaction between the two terminal respiratory

157 Exploiting synthetic lethal interactions to target recurrent cohesin mutation

158 In addition to known synthetic-lethal interactions, this approach uncovered the chromat

159 identification of new, deleterious synthetic lethal interactions.

160 lls, which leads to the rapid development of lethal intrabronchiolar lesions.

161 nses, and afforded 100% protection against a lethal intracerebral dose of ZIKV (strain MR766).

162 Typhi, and survived lethal intranasal S. sonnei challenge.

163 The 50% lethal intraperitoneal dose of vaccinia virus (VACV) was

164 nal epithelial cells was preserved following lethal irradiation inducing RIGS.

165 promoting competitive repopulation following lethal irradiation.

166 HMP device fully protected the liver against lethal ischemia/reperfusion injury, allowing 100% surviv

167 Airdrive system to protect liver grafts from lethal ischemic damage before transplantation in a clini

168 ses have high levels of morbidity and can be lethal, it is important to understand how Toxoplasma tra

169 r modulation of protein levels for otherwise lethal knockouts (KOs).

170 However, as incubation temperatures near lethal levels, the natural growth rate of the population

171 dent accumulation of lipid hydroperoxides to lethal levels.

172 epatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents a

173 actors with additional roles in splicing are lethal, m(6)A-specific mutants are viable but present ce

174 ions in the M1 protein which complement this lethal M2 mutation by increasing the efficiency with whi

175 virus assembly were found to complement the lethal M2Y76A mutation.

176 tokine-mediated pathology during potentially lethal malaria infections.

177 S2 in adrenocortical carcinoma (ACC), a rare lethal malignancy in which aberrant Wnt/beta-catenin sig

178 Ovarian cancer is a lethal malignancy that has not seen a major therapeutic

179 ntification of metabolic alterations in this lethal malignancy, the metabolic dependencies of obesity

180 ose this motif restore growth to conditional-lethal MCM10 mutant cells.

181 e effective at minimizing the risk of highly lethal MDRPa infections.

182 hexia, characterized by muscle wasting, is a lethal metabolic syndrome with undefined etiology.

183 ience relapse with relentless progression to lethal metastatic castration-resistant prostate cancer (

184 The general perception was lethal mitigation strategies were more effective than no

185 Innovation in current or novel non-lethal mitigation strategies, and examples of efficacy,

186 nal, as demonstrated by raised survival in a lethal model of resection-induced liver failure.

187 ols (four of five animals survived in a 100% lethal model).

188 rs unparalleled protection against otherwise lethal models of sepsis.

189 ent for Duchenne muscular dystrophy (DMD), a lethal monogenic disorder caused by the loss of the larg

190 lian Las1 gene has been linked to congenital lethal motor neuron disease and X-linked intellectual di

191 lateral sclerosis (ALS) is a multifactorial lethal motor neuron disease with no known treatment.

192 vivo protection studies in mice against the lethal MRSA challenge indicated that at high concentrati

193 on involves recruitment of the male-specific lethal (MSL) complex to X-linked genes and modification

194 1,500-bp elements that recruit male-specific lethal (MSL) complexes to the X chromosome to upregulate

195 (chromatin-linked adaptor for male-specific lethal [MSL] proteins) zinc finger protein binds these G

196 H2 deficiency in FOXP3(+) T cells results in lethal multiorgan autoimmunity.

197 osin II heavy chain, and cells carrying this lethal mutation are defective in actomyosin ring assembl

198 udy as to how fish tolerate what is an early lethal mutation in mammals could facilitate improvement

199 ly and identified second-site suppressors of lethal mutations in SP.

200 Further, cells with proviruses containing lethal mutations upstream of CTL epitopes can also be re

201 beta-catenin in hematopoietic cells yielded lethal myeloid disease in a NUP98-HOXD13 mouse model of

202 PA is a potentially lethal neurometabolic disease with patients developing n

203 Botulism is a rare, sometimes lethal neuroparalytic illness.

204 a primary infection, one of whom developed a lethal nonmalignant illness.

205 interference (RNAi) response, and is neither lethal nor vertically transmitted.

206 ll renal cell carcinoma (CC-RCC) is the most lethal of all genitourinary cancers.

207 by Rickettsia rickettsii, is among the most lethal of all infectious diseases in the Americas.

208 Moreover, the lethal Ogden syndrome-associated mutation of human Naa10

209 neumocystis pneumonia (PCP) is a potentially lethal opportunistic infection that primary prophylaxis

210 ranchers reported being successful with non-lethal options such as herding, fencing, and stalling at

211 als showing the most potential among the non-lethal options.

212 d on assumptions that these aneuploidies are lethal or associated with poor quality of life, a view t

213 ecific cardiac regions of mice infected with lethal or nonlethal T. cruzi strains and doses.

214 following TLI/ATS/CTX compared with TLI/ATS, lethal or sublethal total body irradiation/ATS/CTX, or C

215 K5-treated virus resulted in weight loss and lethal outcomes.

216 y provides a therapeutic strategy for highly lethal ovarian cancer.

217 Lethal overexpression of actin results from mating this

218 We genetically cross two lethal parasites with distinct disease phenotypes, and i

219 ent and -independent lines uncover synthetic lethal partners of oncogenic Ras.

220 s sufficient to protect uninfected mice from lethal pathogen challenge.

221 Ebolavirus is a highly lethal pathogen, causing a severe hemorrhagic disease wi

222 udy can be applied to the conjugates of this lethal pathogen.

223 The infection of humans by lethal pathogens such as Ebola and other related viruses

224 Interventions that delay or prevent lethal pathologies will extend lifespan.

225 esults suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis

226 ment can be fully restored without feedback: Lethal patterning defects in lefty mutants can be rescue

227 ar basis by which AR promotes development of lethal PCa and nominate new avenues for therapeutic inte

228 leukemia transcription factors (Pbx) led to lethal PH in mice shortly after birth.

229 deletion of the p32 results in an embryonic lethal phenotype, mice heterozygous for p32 are resistan

230 a partially penetrant embryonic or perinatal lethal phenotype, with the production of an aberrant pro

231 sertional mutant of OsbZIP48 showed seedling-lethal phenotypes despite the fact that roots were more

232 conferring extreme temperature-sensitive and lethal phenotypes.

233 In 2012, cases of lethal pneumonia among Chinese miners prompted the isola

234 ared to bioprocessed IgG and protect against lethal pneumonia in mice.

235 eruginosa proteins confer protection against lethal pneumonia in mice.

236 membrane attack complex (MAC), which forms a lethal pore on the cellular surface of pathogenic bacter

237 sive sampling method may be invented for non-lethal prediction of ovary development and sex because o

238 Glioblastoma is the most common and lethal primary malignant brain tumor in adults.

239 elevate ROS past a previously hypothesised 'lethal pro-apoptotic threshold' to induce death; an obse

240 OPA1 deficiency in young mice results in non-lethal progressive mitochondrial dysfunction and loss of

241 however, the molecular processes driving its lethal properties have yet to be fully characterized.

242 ere less effective at protecting mice from a lethal pulmonary challenge with VACV.

243 nd pathogen - ranavirus - caused episodes of lethal ranavirosis.

244 gressions of established disease followed by lethal regrowth of more aggressive tumor cells.

245 species may help to overcome the problem of lethal resistance.

246 ajority of childhood solid tumors, including lethal rhabdoid tumors.

247 Our results show that the non-lethal risk cues differentially impeded prey reproductiv

248 rophages partially protected these mice from lethal SARS.

249 Here, we use a genome-wide RNAi-synthetic lethal screen and transcriptomic profiling to identify g

250 Here, we report a synthetic lethal screen with a library of deubiquitinases and iden

251 Of the 991 patients using lethal self-medication, 762 (77%) recipients had cancer,

252 Moreover, lethal self-targeting by CRISPR systems may contribute t

253 f autophagy in both cell types resulted in a lethal sepsis-like environment, which included tissue in

254 Cutaneous melanoma (CM) is the most lethal skin cancer.

255 Two genes are synthetically lethal (SL) when defects in both are lethal to a cell bu

256 neutrophil deployment protected mice against lethal soft tissue infection with Streptococcus pyogenes

257 The Ebola virus (Zaire) species is the most lethal species of all ebolaviruses in terms of mortality

258 enomes to identify molecular markers at this lethal stage of disease.

259 pted receptor function, is responsible for a lethal startle phenotype in a novel spontaneous mouse mu

260 ase to progress from a very early stage to a lethal state.

261 in WT and Cd36(-/-) mice infected with a non-lethal strain of Plasmodium yoelii Compared with Cd36(-/

262 tion strategies were more effective than non-lethal strategies, with guard animals showing the most p

263 that the female sex determination gene, Sex-lethal (Sxl), functions in central nervous system (CNS)

264 n from a skin pro-inflammatory response to a lethal systemic condition.

265 Lethal systemic fungal infections of Candida species are

266 entify viral transformation-driven synthetic lethal targets for therapeutic intervention.

267 esponse-attenuated strain, protected against lethal TB in macaques.

268 Damaged mitochondria pose a lethal threat to cells that necessitates their prompt re

269 t thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5(L) (F5(L/L)

270 s thymocyte development, which could lead to lethal thymic lymphoma.

271 tically lethal (SL) when defects in both are lethal to a cell but a single defect is non-lethal.

272 ons of key residues in these two motifs were lethal to B. burgdorferi.

273 septicemic plague, diseases that are rapidly lethal to most mammals, including humans.

274 injected i.p. with an acetaminophen dose not lethal to the control.

275 and survived a pulmonary challenge that was lethal to wild-type mice.

276 he C-terminal domain, which is necessary for lethal toxicity against lepidopteran insects.

277 However, potentially lethal toxicity associated with systemic administration

278 These two proteins combine to form anthrax lethal toxin (LT), whose proximal targets are mitogen-ac

279 Glioblastoma (GBM) is the most lethal type of human brain cancer, where deletions and m

280 ND DATA: ASDHs are still considered the most lethal type of traumatic brain injury.

281 8(+) T cell response and protected against a lethal VACV challenge.

282 munized IL-1R1(-/-) mice survived subsequent lethal VACV intranasal challenge, or defects of T cell a

283 protection and lung viral reduction against lethal viral challenge.

284 etiological agent of a contagious and often lethal viral disease of domestic pigs that has significa

285 simian hemorrhagic fever virus (SHFV) causes lethal viral hemorrhagic fever.

286 CE EBOV hemorrhagic fever is one of the most lethal viral infections and lacks a licensed vaccine.

287 roadening is functional using a heterologous lethal virus challenge in ferrets.

288 lmannii and Pinus contorta) that experienced lethal water stress in the field and in laboratory condi

289 etion of the gene encoding LAP1 is perinatal lethal, we explored its potential role in myogenic diffe

290 iency in its homolog ARID1B is synthetically lethal with ARID1A mutation.

291 ecreasing LptD assembly may be synthetically lethal with inhibitors of the Dsb pathway, potentiating

292 alignancy of the biliary tract and is highly lethal with less than 5% overall 5-year survival rate.

293 c agent has been identified as synthetically lethal with SMARCA4/BRG1 loss.

294 charide assembly, lptD4213, is synthetically lethal with the deletion of dsbB as well as with DsbB in

295 M) induced by Naegleria fowleri is extremely lethal, with mortality rates above 95%.

296 Gallbladder cancer is highly lethal, with notable differences in incidence by geograp

297 expressing Nipah G and F glycoproteins were lethal within the brain within a surprisingly short time

298 is that it is highly neurotropic and can be lethal within the brain.

299 a pigmenti (IP; MIM308300) is a severe, male-lethal, X-linked, dominant genodermatosis resulting from

300 I interferon receptor-deficient mice against lethal ZIKV challenge.