ライフサイエンスコーパス: lethal disease

1 successfully treating this almost invariably lethal disease.

2 of H1 and H5 subtypes and protect mice from lethal disease.

3 tment of pancreatic adenocarcinoma, a highly lethal disease.

4 ave failed to protect nonhuman primates from lethal disease.

5 block tumor progression is critical for this lethal disease.

6 mmune responses that protect animals against lethal disease.

7 Pancreatic ductal adenocarcinoma (PDA) is a lethal disease.

8 ent in OX40 signals still eventually develop lethal disease.

9 represent therapeutic targets in this highly lethal disease.

10 , effective, and targeted therapies for this lethal disease.

11 -induced inflammation and protecting against lethal disease.

12 f these inflammatory cytokines prevented the lethal disease.

13 al and appealing therapeutic target for this lethal disease.

14 and that CD4+ T cells were unable to induce lethal disease.

15 more likely (95% CI, 2.3 to 128) to develop lethal disease.

16 gral to the hallmark invasive nature of this lethal disease.

17 olved in T-cell exhaustion and prevention of lethal disease.

18 ally heterogeneous, ranging from indolent to lethal disease.

19 hts into the development of this potentially lethal disease.

20 was able to completely protect rabbits from lethal disease.

21 asive bladder cancer (MIBC) is a potentially lethal disease.

22 e and its ramifications for the cure of this lethal disease.

23 cerns about the potential pandemic spread of lethal disease.

24 to either a mild, self-limiting infection or lethal disease.

25 ants which lead to either viral clearance or lethal disease.

26 velopment of therapeutic approaches for this lethal disease.

27 alignant melanoma is a common and frequently lethal disease.

28 y and economically costly, and a potentially lethal disease.

29 SmCC of the GI tract is a rare and lethal disease.

30 key sera protected 100% of the hamsters from lethal disease.

31 linically silent encephalitis into uniformly lethal disease.

32 ating that antibodies alone can protect from lethal disease.

33 mbinant allele was associated with perinatal lethal disease.

34 ly protected from the development of acutely lethal disease.

35 with FK-506 were not protected from acutely lethal disease.

36 iagnose, and treat this rare but potentially lethal disease.

37 induce lymphocyte proliferation and acutely lethal disease.

38 drocortisone results in an acute, fulminant, lethal disease.

39 ective therapies are needed for this rapidly lethal disease.

40 mostly harmless endemic virus gives rise to lethal disease.

41 mpt to improve the cure rate for this highly lethal disease.

42 rgp120-immunized animals were protected from lethal disease.

43 ed 100% of guinea pigs against JUNV and GTOV lethal disease.

44 pport productive EBOV replication or develop lethal disease.

45 its therapeutic potential in combatting this lethal disease.

46 eras to treat a specific, identifiable, and lethal disease.

47 prostate cancer with biochemical relapse and lethal disease.

48 dvanced breast cancers that have resulted in lethal disease.

49 he great need for better treatments for this lethal disease.

50 ation for more effective treatments for this lethal disease.

51 not protect Mavs(-/-) mice from WNV-induced lethal disease.

52 le-strand breaks in DNA, and cause invasive, lethal disease.

53 sponse, resistant mice became susceptible to lethal disease.

54 entially be repurposed for treatment of this lethal disease.

55 viable alternative in the treatment of this lethal disease.

56 ptions and the poor prognosis of this common lethal disease.

57 ed follow-up and an emphasis on advanced and lethal disease.

58 d in the clinical care of patients with this lethal disease.

59 lls is needed to effectively protect against lethal disease.

60 Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease.

61 radicating smallpox, one of the world's most lethal diseases.

62 ment of hepatocellular carcinoma (HCC), both lethal diseases.

63 echanism of pathogenesis in these common and lethal diseases.

64 in life is associated with severe, sometimes lethal, disease.

65 ts exhibited moderate to severe, potentially lethal, disease.

66 Peripartum cardiomyopathy is a rare lethal disease about which little is known.

67 virus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species.

68 tected 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and

69 of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors,

70 Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a resul

71 completely protected mice of three ages from lethal disease and effected more-rapid virus clearance.

72 dd further detrimental effects to an already lethal disease and jeopardise clinical outcomes.

73 virus pose the threat of pandemic spread of lethal disease and make it a priority to develop safe an

74 treatment, which protected all animals from lethal disease and reduced serum and tissue viral loads

75 H7N9 viruses, including association between lethal disease and spread to the alveolar spaces and kid

76 s is thus central to the development of this lethal disease, and, more generally, could play an impor

77 Thus, rather than being solely a lethal disease, anthrax often occurs as a sublethal infe

78 d new insights into the pathogenesis of this lethal disease are urgently needed.

79 of the inability to distinguish potentially lethal disease at diagnosis.

80 ure significantly improved the prediction of lethal disease beyond knowing whether the Gleason score

81 BOV GP) are implicated in protection against lethal disease, but the characteristics of the human ant

82 within T-cell activation pathways to prevent lethal disease by inappropriate responses against dissem

83 It causes a lethal disease called myxomatosis in European rabbits bu

84 bacterial pathogen that causes a potentially lethal disease called tularemia.

85 evere combined immunodeficiency (XSCID) is a lethal disease caused by a defect in the gene encoding t

86 intranasal administration protects mice from lethal disease caused by a number of different influenza

87 Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in t

88 Rabies is a lethal disease caused by neurotropic viruses that are en

89 This is the first report of lethal disease caused by SNV in an adult small-animal mo

90 Classic galactosemia is a potentially lethal disease caused by the dysfunction of galactose 1-

91 Lethal disease caused by the fungus Cryptococcus neoform

92 oach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found tha

93 f pancreatic ductal adenocarcinoma, a highly lethal disease characterized by a robust fibroinflammato

94 Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin li

95 Pulmonary arterial hypertension (PAH) is a lethal disease characterized by excessive proliferation

96 human respiratory coronaviruses cause acute lethal disease characterized by exuberant inflammatory r

97 y death) syndrome is a recessively inherited lethal disease characterized by fetal growth retardation

98 ight chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid

99 nfection of FK506-treated mice resulted in a lethal disease characterized by viremia, lack of serocon

100 Pancreatic cancer is an almost uniformly lethal disease, characterized by late diagnosis, early m

101 ight loss, whereas 11SB23 produces acute and lethal disease closely resembling that observed with Cri

102 8 to 10; RR, 1.22; 95% CI, 1.03 to 1.45) and lethal disease (death or distant metastasis; RR, 1.19; 9

103 In humanized mice, lethal disease develops, characterized by histopathologi

104 th low doses of virus results in a uniformly lethal disease even though little infection is detected

105 amide, prolongs survival, but resistance and lethal disease eventually prevail.

106 a Gram-negative bacterium that causes acute, lethal disease following inhalation.

107 , intracellular bacterium that causes acute, lethal disease following inhalation.

108 bacterial dose required to produce an acute lethal disease following intraperitoneal infection of mi

109 frican swine fever is a contagious and often lethal disease for domestic pigs with a significant econ

110 -grade serous ovarian carcinoma (HGSOC) is a lethal disease for which improved screening and treatmen

111 Pancreatic cancer is a highly lethal disease, for which mortality closely parallels in

112 We found that Muc2-deficient mice succumb to lethal disease from ETBF colonization in a B. fragilis t

113 CeMV outbreaks of lethal disease have repeatedly been observed in Europe,

114 VV caused lethal disease in all mouse strains.

115 is a strong correlate of protection against lethal disease in animals.

116 hemorrhagic fever virus (SHFV) causes highly lethal disease in Asian macaques resembling human illnes

117 Cystic fibrosis is the most common inherited lethal disease in Caucasians.

118 lphaherpesvirus, is the causative agent of a lethal disease in chickens characterized by generalized

119 uctal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strat

120 t ASFV strains cause a highly infectious and lethal disease in domestic pigs for which there is no va

121 ypanosomes are ancient eukaryotes that cause lethal disease in humans and cattle.

122 atory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exac

123 a wide range of animals and causes a severe, lethal disease in humans.

124 ses are dermatotropic DNA viruses that cause lethal disease in humans.

125 adenocarcinoma (PDAC) is an almost uniformly lethal disease in humans.

126 pecies and are capable of causing severe and lethal disease in humans.

127 mice but was completely defective in causing lethal disease in IL-1R(-/-) mice, indicating that the p

128 However, they do not cause lethal disease in immunocompetent mice unless they are a

129 y the massively increased bacterial load and lethal disease in interferon-gamma knockout mice.

130 le to replicate at high temperature or cause lethal disease in mice.

131 nt viruses replicate slowly and do not cause lethal disease in mice.

132 from RQ to YE (YE-Nef) both induce an acute lethal disease in monkeys.

133 f either component was sufficient to prevent lethal disease in Muc2-deficient mice.

134 ogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated

135 humans despite the fact that REBOV can cause lethal disease in nonhuman primates.

136 an swine fever virus (ASFV) can cause highly lethal disease in pigs and is becoming a global threat.

137 del organism Ceratonova shasta, which causes lethal disease in salmonids.

138 , unlike Malawi-Lil-20/1-Delta9GL, induced a lethal disease in swine like parental ASFV-G.

139 l inoculation, but only MX/7218 virus caused lethal disease in this species.

140 utations, one of which resulted in perinatal lethal disease in three families, were associated with c

141 While B. bronchiseptica causes lethal disease in TLR4-deficient mice, B. pertussis and

142 virus (CMV) satRNA that induces an epidemic lethal disease in tomato.

143 Testudinid herpesvirus 3 (TeHV-3) causes a lethal disease in tortoises, several species of which ar

144 Ebola virus (EBOV) causes lethal disease in up to 90% of EBOV-infected humans.

145 er virus (CDV) and rabies virus (RABV) cause lethal disease in wild and domestic carnivores.

146 It is a highly lethal disease in women and men, and new treatments are

147 nted DIV vaccine provides protection against lethal disease in young animals following homologous and

148 uding slow bee paralysis virus (SBPV), cause lethal diseases in honeybees and bumblebees, resulting i

149 Kinetoplastid parasites cause lethal diseases in humans and animals.

150 e highly infectious pathogens that can cause lethal diseases in various species of fish.

151 tibody, transformed transient myocarditis to lethal disease, in association with widespread polymorph

152 Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, in part, because of the lack of effectiv

153 all types of blood cell--can treat numerous lethal diseases, including leukaemias and lymphomas.

154 In rabbits, protection from lethal disease is induced by intradermal injection of va

155 rd improving detection and treatment of this lethal disease is to understand its origin.

156 ns (such as studies of late-onset or rapidly lethal diseases), it may be more practical to identify f

157 In lethal diseases like cancer, where new therapies are oft

158 macaques unexpectedly survived this usually lethal disease, making it possible to compare physiologi

159 absence of perforin, vaccination resulted in lethal disease mediated by dysregulated CD8(+) T cell ex

160 sults in an asymptomatic infection; the only lethal disease model for a pathogenic hantavirus is Ande

161 l muscular dystrophy, a much more severe and lethal disease model, does not improve all aspects of mu

162 e prophylaxis strategies in the ANDV/hamster lethal disease model.

163 allenge dosages (1.0 x 10(4) PFU) in the rat lethal disease model.

164 ia-specific CD8 T cells eradicated otherwise lethal disease more efficiently than wild-type cells and

165 Anthrax, a potentially lethal disease of animals and humans, is caused by the G

166 virus 3 (CyHV-3) is the causative agent of a lethal disease of carp and encodes for an Il10 homolog (

167 etiological agent of a contagious and often lethal disease of domestic pigs that has significant eco

168 (ASFV) is the etiological agent of an often lethal disease of domestic pigs.

169 Feline infectious peritonitis is a lethal disease of felids caused by systemic infection wi

170 r virus (ASFV) causes a contagious and often lethal disease of feral and domestic swine.

171 ), the etiological agent of a severe, highly lethal disease of swine.

172 s marinus is the causative agent of Dermo, a lethal disease of the eastern oyster Crassostrea virgini

173 Juvenile myelomonocytic leukemia (JMML) is a lethal disease of young children characterized by hypers

174 high degree of infectivity but did not cause lethal disease or exhibit extrapulmonary virus spread.

175 < 0.001) compared with not recurrent and not lethal disease (P-heterogeneity < 0.001).

176 nt peritoneal mesothelioma (DMPM), a rapidly lethal disease, poorly responsive to conventional therap

177 have been partially or fully characterized, lethal disease predominantly involves a variety of strai

178 g ML-IAP expression by immunohistochemistry, lethal disease progression was associated with the loss

179 While RB loss was associated with lethal disease, RB-deficient tumors had no proliferative

180 ry, facilitating long-term remission of this lethal disease.Significance: Coordinated neoadjuvant and

181 e 7B2 null, but not the PC2 null, exhibits a lethal disease state.

182 osphorylation of proteins is associated with lethal diseases such as cancer.

183 f critical importance in diagnosis of common lethal diseases such as malaria, tuberculosis, HIV, and

184 ic ductal adenocarcinoma (PDA) constitutes a lethal disease that affects >30,000 people annually in t

185 gue (BT) is a debilitating and in many cases lethal disease that affects ruminants of economic import

186 ted with ANDV, but not SNV, develop a highly lethal disease that closely resembles HPS in humans.

187 Pancreatic cancer is a highly lethal disease that has seen little headway in diagnosis

188 Infective endocarditis is a potentially lethal disease that has undergone major changes in both

189 Pulmonary hypertension (PH) is a lethal disease that is associated with characteristic hi

190 Amyotrophic lateral sclerosis (ALS) is a lethal disease that is characterized by the relentless d

191 ter understanding of the development of this lethal disease that is currently without efficient treat

192 atic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical interventio

193 ed necrotising pancreatitis is a potentially lethal disease that nearly always requires intervention.

194 hospholipid syndrome (CAPS) is a potentially lethal disease that presents with rapidly progressive mu

195 s) are a group of genetically heterogeneous, lethal diseases that are characterized by neuronal, hepa

196 Phenotypes range from complete resistance to lethal disease to severe hemorrhagic fever characterized

197 heir hosts, which range from severe and even lethal disease to subclinical or nonpathogenic infection

198 ludes the definitive assignment of this male-lethal disease to the X chromosome and the mapping of a

199 from the Old World bringing novel and hence, lethal diseases to the New World, a foretaste, perhaps,

200 ctious bacterium that causes the potentially lethal disease tularemia.

201 ts in peroxisome biogenesis are the cause of lethal diseases typified by Zellweger syndrome.

202 explain why the risks from this potentially lethal disease vary according to location and age.

203 Whereas lethal disease was observed in immunodeficient mice, tum

204 Lethal disease was routinely observed in RNase L(-/-) PK

205 te promyelocytic leukemia, formerly a highly lethal disease, was recently shown to be highly responsi

206 ntify potential therapeutic targets for this lethal disease we investigated the contribution of B cel

207 Neither EIAV(17SU) nor EIAV(17TM) produced lethal disease when administered at infectious doses tha

208 These antibodies protected guinea pigs from lethal disease when given post-virus challenge.

209 nits (NAU)/kg of FFP-protected hamsters from lethal disease when given up to 8 days after intranasal

210 Medulloblastoma is a highly lethal disease when it recurs.

211 VL in the hamster is a progressive, lethal disease which very closely mimics active human di

212 d in animals experiencing lung pathology and lethal disease, while the same animals experienced downr

213 pted Zaire ebolavirus (ZEBOV) caused rapidly lethal disease; wild-type ZEBOV and Sudan Ebolavirus and

214 Oral squamous cell carcinoma (OSCC) is a lethal disease with a 5-year mortality rate of around 50

215 eatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival rate of 4%.

216 e of Carvallo, termed Car(68), resulted in a lethal disease with a 63% mortality rate.

217 Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug resp

218 Ovarian cancer is a highly lethal disease with metastases present in the majority o

219 sceptible to infection with LASV and develop lethal disease with pathology similar to that reported i

220 Pancreatic cancer is a lethal disease with poor prognosis.

221 Metastatic breast cancer remains a lethal disease with poorly understood molecular mechanis

222 Acute pancreatitis is a potentially lethal disease, with a rising incidence in the Western w

223 95% CIs of total, advanced, high-grade, and lethal disease, with adjustment for a variety of possibl

224 Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, with surgery being the only curative mod