ライフサイエンスコーパス: lethality

1 to the ROS-dependent component of antibiotic lethality.

2 or, reduced weight gain, and early postnatal lethality.

3 to early-onset cyst formation and postnatal lethality.

4 d with the same Wolbachia strain rescue this lethality.

5 ncoded by Pex genes, and result in childhood lethality.

6 e intestine did not cause any weight loss or lethality.

7 replication and attenuate cisplatin induced-lethality.

8 ) from the K-Ras locus resulted in embryonic lethality.

9 rpaA-null strains to identify the source of lethality.

10 ective ablation of cortex glia causes animal lethality.

11 ventral prefrontal connectivity and attempt lethality.

12 f primary microcephaly and resulted in early lethality.

13 iating clozapine-induced developmental delay/lethality.

14 f abnormal actin bundles and early embryonic lethality.

15 ka results in severe bone defects and larval lethality.

16 on, altered sugar accumulation, and seedling lethality.

17 poptosis, which eventually lead to embryonic lethality.

18 sive protein aggregation, growth arrest, and lethality.

19 ced DNA damage and failure to do so leads to lethality.

20 ossed to uninfected females causes embryonic lethality.

21 ractivation resulted in inflammation but not lethality.

22 rage of the vasculature leading to embryonic lethality.

23 n skin, are yet unknown because of embryonic lethality.

24 ll loss but recovered from infection without lethality.

25 of the TC-bound B12, do not confer embryonic lethality.

26 s alter both CVB3 intestinal replication and lethality.

27 ds to impaired vascularization and embryonic lethality.

28 enotypes ranging from reduced cell growth to lethality.

29 tion-excitation imbalances and in some cases lethality.

30 phenotype, with AOX protecting mice from LPS lethality.

31 challenge resulted in hypersusceptibility to lethality.

32 nd its ability to rescue ISCs from radiation lethality.

33 nnel TRPM7, which results in early embryonic lethality.

34 o 4 months to only several days, followed by lethality.

35 nduced mutagenesis rather than from enhanced lethality.

36 paralogs in mice results in early embryonic lethality.

37 cal respiratory disease but did not decrease lethality.

38 expression corresponded to the threshold for lethality.

39 f functional Zbtb24 leads to early embryonic lethality.

40 brile diseases in humans, often resulting in lethality.

41 AAV9-sgRNAs, thereby circumventing embryonic lethality.

42 in right ventricle hypoplasia and embryonic lethality.

43 es rather than meiotic drive or preferential lethality.

44 eletion of Mpc1 presented as early perinatal lethality.

45 ive lymphatic valve maturation, and complete lethality.

46 (referred to as G11) is sufficient to cause lethality.

47 hical and dose-dependent effect on premature lethality.

48 uscle growth and regeneration, and postnatal lethality.

49 e animals at 90% relative humidity prevented lethality.

50 ially lungs-at birth, and frequent perinatal lethality.

51 pread DNA double-strand breaks and synthetic lethality.

52 7 rescued macrophages from nigericin-induced lethality.

53 t centriole conversion and lead to embryonic lethality.

54 idermal differentiation, leading to neonatal lethality.

55 reatment with low doses of HU can cause cell lethality.

56 th the ROS-dependent component of antibiotic lethality.

57 rnosic acid were the cause for the synthetic lethality.

58 mation while also paradoxically causing cell lethality.

59 ascent DNA at stalled forks, leading to cell lethality.

60 formation, EF-P, suppress Deltarep DeltauvrD lethality.

61 ated with CLP have been hampered by neonatal lethality.

62 n cause severe disease, with up to 90% human lethality.

63 th severity of suicidal ideation and attempt lethality.

64 ation in an animal model of gammaherpesvirus lethality.

65 anomalies, skeletal dysplasia, and neonatal lethality.

66 ormones can alter both viral replication and lethality.

67 or F3 (F3(+/-) ) suppressed F5(L/L)Tfpi(+/-) lethality.

68 ation of mesendoderm, resulting in embryonic lethality.

69 oss of cerebellar Purkinje neurons and early lethality.

70 tor cells, resulting in anemia and embryonic lethality.

71 approved drugs designed to exploit synthetic lethality, a genetic concept proposed nearly a century a

72 uency than expected, consistent with partial lethality after embryonic day 12.

73 romotes tumor formation, it also causes cell lethality, although how lethality is triggered is unclea

74 though prior RNAi studies reported prevalent lethality among young gene knockdowns, our phylogenomic

75 s an aggressive neoplasm with almost uniform lethality and a 5-year survival rate of 7%.

76 -knockout mice suffer from partial embryonic lethality and a progeroid-like phenotype.

77 eks after fertilization; including perinatal lethality and abnormal behavior in surviving adults.

78 e knockout results in female-specific embryo lethality and abrogates Xist-mediated gene repression, h

79 alter microbial metabolism as part of their lethality and can damage mitochondria in mammalian cells

80 Synthetic lethality and collateral lethality are two well-validate

81 were to apply PD to obtain 5 d acute embryo lethality and developmental data and 30 d chronic embryo

82 mine the genetic architecture of hybrid seed lethality and directly test for loci with parent-of-orig

83 eered mutant CPK10(M141G) circumvents embryo lethality and enables conditional analyses of cpk10 cpk3

84 Lethality and eye phenotypes are rescued by the deAMPyla

85 of Atp6ap2 resulted in both male hemizygous lethality and female haploinsufficiency.

86 y, reanimating the gene to circumvent hisn6a lethality and hybrid incompatibility.

87 ughput screen for rescue of KCNJ5MUT-induced lethality and identified a series of macrolide antibioti

88 significantly increases alpha toxin-induced lethality and inhibits activation of light chain 3.

89 , we determined the contribution of IL-18 to lethality and its mechanism in a murine model of neonata

90 but additionally results in early embryonic lethality and neural tube closure defects.

91 rategy could be used to search for synthetic lethality and optimise combination protocol designs.

92 protected mice from influenza virus-induced lethality and reduced both proinflammatory cytokine gene

93 ant mouse models, with significant embryonic lethality and severe phenotypes in the complete knockout

94 r topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensitizes tumo

95 Pi, indicating this pathway drives synthetic lethality and that in its absence alternative repair mec

96 the preclinical discovery of PARPi synthetic lethality and the route to clinical approval provide int

97 ell apoptosis, parasitemia control, and host lethality and thus may provide important insights for pr

98 ecombination deficiency, which triggers cell lethality and, we propose, serves as a barrier that must

99 ation of RNase H2 and RAD52 led to synthetic lethality, and combined loss of RNase H2 and RAD51 induc

100 ged mice accelerated thymic aging, increased lethality, and delayed T-cell reconstitution postirradia

101 with documentation of suicidal behavior, its lethality, and suicidal ideation and intent.

102 ion of both CRTC2 and CRTC3 causes embryonic lethality, and that a single allele of either CRTC2 or C

103 represents a novel target for the synthetic lethality approach.

104 ercome insect Bt toxin resistance and confer lethality approaching that of the wild-type Bt toxin aga

105 times through their host until virulence and lethality are achieved.

106 Synthetic lethality and collateral lethality are two well-validated conceptual strategies f

107 e were protected from high-dose TCDD-induced lethality associated with a reduced inflammatory respons

108 tion suppressed the biorientation defect and lethality associated with deletion of a majority of its

109 inase 4 (PAK4) in the mouse causes embryonic lethality associated with heart and brain defects.

110 Lethality associates with embryonic defects that paralle

111 model and found that GSKIP deficiency caused lethality at birth.

112 RT2 in endothelial cells exhibited embryonic lethality at mid-gestation, with systemic congestion and

113 es during metamorphosis and leads to tadpole lethality at the climax of metamorphosis.

114 tered genome integrity might allow synthetic lethality-based options for targeted therapeutic interve

115 Lethality-based toxicity estimates are not adequate in t

116 resistant cancer cells to cisplatin-induced lethality, because it not only impairs DNA replication c

117 ally in cardiomyocytes resulted in embryonic lethality before embryonic day 12.5.

118 This sex-specific lethality benefits the bacteria because males are "dead

119 cancer cells and we demonstrate a synthetic lethality between ADT and PARP inhibition in vivo.

120 conserved function underlying the synthetic lethality between ARID1A and ARID1B.

121 These results suggest that synthetic lethality between ROCK inhibition and VHL deficiency is

122 mer interface mimotopes prevent superantigen lethality by blocking the superantigen-host costimulator

123 Lethality by MDRPa similarly decreased from 3.6% to 0%.

124 The exploitation of synthetic lethality by small-molecule targeting of pathways that m

125 Porcn-null mice are rescued from radiation lethality by treatment with WT but not Porcn-null bone m

126 ion of a promiscuous 'replacer' gene rescues lethality caused by inactivation of a 'target' gene.

127 n that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FADD.

128 us ubiquitin does not suppress developmental lethality caused by loss of endogenous USP5.

129 ction of W with scaling exponent Y [conflict lethality (CL)].

130 to 2015 were highly infectious in mice, with lethality comparable to that of the well-studied A/Anhui

131 Lethality correlated with severe myocardial dysfunction

132 owever, widespread hemorrhage and subsequent lethality does not occur until later stages, with absenc

133 flammation-associated tissue damage and host lethality driven by the pro-inflammatory cytokine IL-1be

134 ckout (cDKO) in adult mice resulted in acute lethality due to bone marrow failure and intestinal atro

135 e loss of EC Map4k4 in mice causes postnatal lethality due to chylothorax, suggesting that Map4k4 is

136 ectedly, male UTX-null mice escape embryonic lethality due to expression of UTY, a paralog that lacks

137 Germline Cic inactivation causes perinatal lethality due to lung differentiation defects.

138 lea vectors that, importantly, do not suffer lethality due to R. typhi infection.

139 l abrasions, blistering, and early postnatal lethality, due to a thinned epidermis with decreased des

140 Nlrp12(-/-) mice are protected from lethality during IAV infection and show decreased vascul

141 n combination with heroin, and can result in lethality during overdose.

142 -dependent manner, mice lacking Wdr47 showed lethality, extensive fiber defects, microcephaly, thinne

143 ensis Resistance is characterized by reduced lethality following high-dose intradermal infection, an

144 urative cancer treatment therapies and cause lethality following high-dose whole-thorax lung irradiat

145 mice exhibited systolic dysfunction and 30% lethality from abdominal aortic rupture.

146 at Naa10-null mice display partial embryonic lethality, growth retardation, brain disorders, and mate

147 and heterozygous mice also showed embryonic lethality (haploinsufficient lethality) observed only fo

148 However, genetic redundancy and lethality have made it challenging to define specific ro

149 Conceptually, synthetic lethality holds the promise of identifying non-intuitive

150 , because global HAX-1 deletion causes early lethality, how much endogenous HAX-1 contributes to PLN'

151 ogenic epilepsy, in line with the centrality-lethality hypothesis.

152 (such as aneuploidy) could escape embryonic lethality if the genome-wide burden of slightly deleteri

153 also rescues axonal outgrowth and perinatal lethality in a dose-dependent manner in mice lacking NMN

154 VNDT motif, is highly pathogenic and causes lethality in a mouse model.

155 azone) complexes could delay BoNT/A-mediated lethality in a rodent model, indicating their potential

156 ncreased micronuclei formation and synthetic lethality in ALT cells.

157 B/PltA/CdtB chimaeric toxin exhibits reduced lethality in an animal model, indicating that the host s

158 es in human cancer cell cultures and reduced lethality in an animal model.

159 by osteoblast-lineage cells; early embryonic lethality in Bag-1 null mice, however, has limited the i

160 extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inhibition.

161 auses dose-dependent developmental delay and lethality in Caenorhabditis elegans.

162 thermal titration calorimetry and to exhibit lethality in cells partially dependent on expression of

163 thepsin B, and caspases that mediate toxin's lethality in cells.

164 development is exemplified by the embryonic lethality in cFLIP-deficient animals.

165 Each gene additively augments embryonic lethality in crosses between infected males and uninfect

166 incompatibility, which results in embryonic lethality in crosses between infected males and uninfect

167 scovered a selfish element causing embryonic lethality in crosses between wild strains of the nematod

168 tigated the cellular basis of male embryonic lethality in D. melanogaster induced by Spiroplasma.

169 G2 disease risk alleles caused near-complete lethality in D. melanogaster, with no effect of the G0 n

170 ipid inflammatory pathway is responsible for lethality in F. novicida infection due to overproduction

171 ignaling blockade enhances radiation-induced lethality in HCC cells and xenografts.

172 filament length, were the cause of embryonic lethality in HSPB7 KOs.

173 ented recovery from MRV infection and led to lethality in infected animals, whereas B cell-deficient

174 ong to the family Filoviridae and cause high lethality in infected patients.

175 ngs can be exploited for eliciting synthetic lethality in metabolically stressed cancer cells using h

176 tosis, which results in a corresponding high lethality in mice after injection of these cells.

177 Finally, the reduction of acute GVHD lethality in mice that received Pdl1-/- donor cells did

178 uitous inactivation of Utf1 causes embryonic lethality in mice with a hybrid genetic background.

179 control was potent enough to cause embryonic lethality in mice, reminiscent of a genetic knockout of

180 er nutrient-deprived conditions and neonatal lethality in mice, which was associated with failure to

181 genomes but differed substantially in their lethality in mice.

182 results in respiratory failure and perinatal lethality in mice.

183 ng MYC blockade with PARPi yielded synthetic lethality in MYC-driven TNBC cells.

184 l molecule idasanutlin resulted in synthetic lethality in orthotopic glioblastoma xenograft models.

185 astoma determines prognosis, recurrence, and lethality in patients, but no master factor coordinating

186 of PARP1 resulted in dual cellular synthetic lethality in quiescent and proliferating immature leukem

187 sulted in overt phenotypic abnormalities and lethality in recipients, which facilitated evaluation of

188 ole in development, also prevented perinatal lethality in Ripk1(RHIM/RHIM) mice.

189 nockdown ameliorated tissue inflammation and lethality in Sf mice.

190 nce multiple m(6)A components enhance female lethality in Sxl sensitized backgrounds.

191 ction relative to control mice, and eventual lethality in the absence of cardiac fibrosis.

192 ongst targeted genes or to analyse synthetic lethality in the context of anticancer therapy.

193 ructure that correlate with pathogenesis and lethality in the Drosophila HD model.SIGNIFICANCE STATEM

194 tions and growth conditions that suppress LD lethality in the mutant background that support these co

195 tal arrest in frogs and zebrafish, embryonic lethality in transgenic mice, and lesions in mouse muscl

196 -mediated DNA repair yields potent synthetic lethality in triple-negative breast tumors and other agg

197 and Mcl-1 is sufficient to elicit synthetic lethality in tumors recalcitrant to therapy.

198 bition of cell death and increased embryonic lethality in unirradiated animals.

199 tocyte turnover, loss of gene repression and lethality-in mice receiving high doses of a recombinant

200 s sensitive to oxidative stress to MalE-LacZ lethality indicates that ROS contribute causally to cell

201 a DAT mutant background caused developmental lethality, indicating a toxic action not remedied by pha

202 rmed an intragenic screen for suppressors of lethality induced by expression of Synaptotagmin C2B Ca(

203 ese results show that HISN6-dependent hybrid lethality is a revertible epigenetic phenomenon and prov

204 c(E247G) mutant is lethal in Drosophila This lethality is cell-autonomous, as directed expression of

205 -) mice, demonstrating that F5(L/L)Tfpi(+/-) lethality is genetically suppressible.

206 in distant prostate cancer dissemination and lethality is ill defined.

207 hat in mice lipopolysaccharide (LPS)-induced lethality is prevented by genetic ablation of IFN signal

208 x ratio bias against females, and the female lethality is rescued by a second-site mutation in Tsix.

209 We show that this synthetic lethality is the result of defective crossover formation

210 Achieving robust cancer-specific lethality is the ultimate clinical goal.

211 it also causes cell lethality, although how lethality is triggered is unclear.

212 processes that detoxify ROS, conditional LD lethality likely results from inability of the mutant to

213 (aorta, brain and kidney), resulted in rapid lethality marked by weight loss, changes in nutritional

214 al therapeutic approaches based on synthetic lethality may improve cancer management.

215 r our understanding of fundamental synthetic lethality mechanisms and advance these findings beyond t

216 lls, protected immune-deficient mice against lethality, mediated bacterial clearance, and orchestrate

217 or, and social interaction deficits, but not lethality, memory, or motor deficits.

218 he defining features of JMML due to in utero lethality, nonhematopoietic expression, and the pervasiv

219 ency in glutamatergic neurons leads to early lethality, obesity, tremor, altered anxiety-like behavio

220 Together, our data explain the synthetic lethality observed between topoisomerase-induced DNA bre

221 It also reproduced the neonatal lethality observed in null mutants, indicating that the

222 howed embryonic lethality (haploinsufficient lethality) observed only for Vegfa and Dll4.

223 of donor ILC2s was effective in reducing the lethality of aGVHD and in treating lower GI tract diseas

224 oute of disease transmission can enhance the lethality of an already deadly pathogen.

225 crosslinked starch aerogel and led to slower lethality of Aspergillus parasiticus cells inoculated on

226 s background, loss of ATM leads to synthetic lethality of Brca1(S1598F) mice.

227 icient cells from DNA damage and rescues the lethality of Brca2-deficient embryonic stem cells.

228 s, and contribute to the diversification and lethality of cancers.

229 e phenocopies the blood-lymphatic mixing and lethality of CLEC-2 KO models, but not their hemostatic/

230 For example, because of early lethality of CXCR4(-/-) mice, and stage-specific require

231 tream metabolic events can contribute to the lethality of drugs or agents that interact with a primar

232 s medical importance given the incidence and lethality of gastric cancer worldwide.

233 ut the brain parenchyma, contributing to the lethality of GBM.

234 st caspases as hub proteins that mediate the lethality of multiple pathogenic agents.

235 p53 deletion prevents the embryonic lethality of normal tissues lacking Mdm2, suggesting tha

236 s of NBP35 in Arabidopsis to overcome embryo lethality of previously reported knockout mutations.

237 We found that the lethality of pulmonary F. tularensis LVS infection was e

238 type I IFN response, TLR7 contributed to the lethality of septicemic plague and was associated with t

239 y predator species, mitigation strategy, and lethality of strategies, but not livestock type.

240 1 isoforms Stx1A and Stx1B and the embryonic lethality of Stx1A/1B double knock-out (DKO) mice.

241 0.02; t = 3.63; P = .001) months and greater lethality of subsequent suicidal behavior (b = 0.08; t =

242 The lethality of the aggressive brain tumor glioblastoma mul

243 RNAi-lethal" genes and broadly confirmed the lethality of the former but the viability of the latter.

244 appears to affect the development and induce lethality of worms, in part, through modulating glucosyl

245 variant nor the novel variant p.G350R rescue lethality or other phenotypes.

246 e genes or domains with phenotypes masked by lethality or redundancy.

247 fly and mouse orthologous genes resulted in lethality or severe neurological defects reminiscent of

248 ty of the individual (for example, embryonic lethality) or results in profound loss of fitness.

249 ociated with suppression of F5(L/L)Tfpi(+/-) lethality (P = 1.7 x 10(-6)), suggesting that Actr2(p.R2

250 mes to a more severe spectrum with infantile lethality (p.Val112Glu).

251 te ATR pathway inactivation causes embryonic lethality, partial Hus1 impairment has been accomplished

252 This synthetic-lethality phenotype was as pronounced as that caused by

253 dation, brain disorders, and maternal effect lethality, phenotypes commonly observed in defective gen

254 and found that loss of Fdxr led to embryonic lethality potentially due to iron overload in developing

255 l lethal, in contrast to the early embryonic lethality previously reported for Rnaseh2b- or Rnaseh2c-

256 es, but not either alone, leads to embryonic lethality prior to the onset of their expression within

257 Its lethality, recent history of intentional use for mass po

258 n 3 d after ZIKV infection protected against lethality, reduced ZIKV levels in brains and testes, and

259 MalE-LacZ lethality requires molecular oxygen, and its expression

260 This lethality results from a pool of infectious virus in gli

261 of clozapine-induced developmental delay and lethality revealed 40 candidate genes, including sms-1,

262 gh inactivation of SCCRO in yeast results in lethality, SCCRO(-/-) mice are viable.

263 hat have thus far been unveiled by synthetic lethality screens.

264 that the predominant mechanism for MalE-LacZ lethality shares attributes with the ROS-dependent compo

265 nhibitor BIBF 1120 (BIBF) promoted synthetic lethality specifically in cells with the loss-of-functio

266 ed by mutp53 can be exploited in a synthetic lethality strategy, as depletion of another ATR activato

267 olating suppressors of spo11Delta spo12Delta lethality suggesting that Cdc55 might have a role in mei

268 i and Cd-Ni-Zn combinations in standard 48 h lethality tests.

269 potent at causing brain damage and postnatal lethality than MEX1-44.

270 aternal-zygotic mutants results in embryonic lethality that can be fully rescued with gdf3 RNA, demon

271 Insertional mutations resulted in embryo lethality that could be rescued by embryo-specific compl

272 DPH production, provides a prime 'collateral lethality' therapeutic strategy for the treatment of a s

273 sed largely localized pneumonia with limited lethality, thereby providing an alternative tool for stu

274 hat loss of Irgm1 in mice leads to increased lethality to bacterial infections as well as enhanced in

275 hemolymph-specific promoter increased fungal lethality to mosquitoes at spore dosages as low as one c

276 Our objective was to engender synthetic lethality to paclitaxel (PTX), the frontline treatment f

277 sepsis, whereas replenishing IL-18 increased lethality to sepsis or endotoxemia.

278 r pathways sensitized MPN cells to synthetic lethality triggered by PARP inhibitors.

279 Lethality was observed in both models due to a combined

280 vated in response to A3A activity, synthetic lethality was specific to ATR signaling via Chk1 and did

281 To bypass embryonic lethality we used Tie2CRE-mediated recombination to cond

282 atable transgene to rescue vri developmental lethality, we show that clock function persists after vr

283 ing housekeeping genes can confer collateral lethality, we sought to determine whether loss of the me

284 ically, sepsis-induced organ dysfunction and lethality were attributed to the interplay between infla

285 romised hematopoietic recovery and increased lethality were seen in Hdac8-deficient mice challenged w

286 mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why

287 pex1-3 conferred embryo lethality when homozygous, confirming that PEX1, like se

288 during development and can trigger perinatal lethality when its RHIM-dependent interactions are not r

289 double knockout (DKO) caused early embryonic lethality, whereas conditional Ssb1/Ssb2 double knockout

290 e to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation i

291 e medaka fish has been shown to cause larval lethality which is preceded by retinal defects that rese

292 iquitous Bcl7a knockout results in perinatal lethality, while genetic deletion of Bcl7a in postmitoti

293 N production, neutrophilia, lung injury, and lethality, while therapeutic administration of PEG-IFNla

294 of Hmmr-knockout mice, which suffer neonatal lethality with defective neural development and pleiotro

295 ed human cancer cell lines induced synthetic lethality with genotoxic chemotherapeutics, including PA

296 The map65-4 mutation caused synthetic lethality with map65-3 although map65-4 alone did not ca

297 actors in mice results in embryonic/neonatal lethality with rapid resorption of homozygous mutants, h

298 Both mouse models display similar perinatal lethality with respiratory insufficiency, reduced body w

299 e results in partial rescue of the perinatal lethality, with viable mice exhibiting white spotting on

300 proved to be susceptible to early postnatal lethality without obvious developmental abnormalities.