ライフサイエンスコーパス: lethally

1 cted in waterways at concentrations that are lethally and sublethally toxic to aquatic organisms.

2 sible to compare physiological parameters in lethally challenged animals and survivors.

3 crificed for analysis of immune responses or lethally challenged by intranasal inoculation with vacci

4 Clinical signs in the lethally challenged mice included seizures, convulsions,

5 The immunized mice were lethally challenged with C. posadasii through either an

6 up to 6 h after viral inoculation) with mice lethally challenged with HSV-2 delayed disease onset and

7 were vaccinated with VSVDeltaG/Dual and were lethally challenged with ZEBOV or ANDV.

8 Lethally conditioned mice received transplants of major

9 survive doses of total-body irradiation that lethally deplete hematopoietic progenitor populations in

10 We rescued cells lethally depleted of endogenous Cdk1 with an exogenous C

11 nhanced ZIKV and DENV infection in vitro and lethally enhanced DENV disease in mice.

12 gases, where susceptible persons may develop lethally high body temperatures.

13 not altered in wild-type animals exposed to lethally high H2S or in hif-1(ia04) mutants that die whe

14 antiretroviral deoxycytidine deaminase that lethally hypermutates human immunodeficiency virus type

15 creased iron availability in serum occurs in lethally ill ICU patients and should trigger prospective

16 This virus is unique in its ability to lethally infect both mammals and insects.

17 dy, we compared the host immune responses of lethally infected and vaccinated mice to highlight the h

18 elecoxib treatment prolonged the survival of lethally infected animals.

19 nti-inflammatory agents in protection of the lethally infected mice by H1N1 or H5N1 influenza viruses

20 and temporal changes in NK and NKT cells in lethally infected mice correlated with higher NK cell cy

21 Unexpectedly, depletion of neutrophils from lethally infected mice enhanced bacterial elimination, d

22 Lethally infected mice given influenza virus-specific CD

23 lethally infected mice, splenic T cells from lethally infected mice produced significantly lower leve

24 leukocytes were isolated from the brains of lethally infected mice, 88% of these cells were identifi

25 nti-capsular 3E5 MAb prolong the survival of lethally infected mice, whereas the 3E5 IgG3 MAb does no

26 ot sufficient to provide early protection to lethally infected mice.

27 D4 T cells protected a significant number of lethally infected RAG(-/-) mice, demonstrating the prote

28 Furthermore, compared to lethally infected sham controls, neutrophil depletion in

29 of PD-1 significantly increased survival of lethally infected wild-type mice.

30 on of the neutralizing IgM MAb to A/JCr mice lethally infected with B. anthracis strain Sterne had no

31 d KC significantly enhanced survival of mice lethally infected with C. albicans.

32 Sixteen rhesus monkeys were lethally infected with MARV or RAVV and treated with NP

33 ceptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that pro

34 ,3-dimethyl-1-butanol (DMB), is shown to non-lethally inhibit TMA formation from cultured microbes, t

35 positive astrocytes in the hippocampus of 26 lethally intoxicated drug addicts and 35 matched control

36 (C57BL/6 + SJL/J) after transplantation into lethally irradiated (8.5 Gy) BALB/c recipients (H2(d)).

37 ing human APOE3/3 or APOE4/4 donor mice into lethally irradiated 5-month-old APPswe/PS1DeltaE9 mice.

38 homozygous deficient for EP2 (EP2(-/-)) into lethally irradiated 5-month-old wild-type or APPswe-PS1D

39 nsplanted uniparental fetal liver cells into lethally irradiated adult mice to test their capacity to

40 es multilineage hematopoietic engraftment of lethally irradiated adult mice.

41 t HSC that engraft upon transplantation into lethally irradiated adult mice.

42 These progenitors engraft lethally irradiated adults and contribute to long-term,

43 lanted with 1 x 10(7) bone marrow cells into lethally irradiated AKR/J recipients.

44 ted mouse bone marrow or purified HSCs, into lethally irradiated allogeneic recipients and determined

45 m GKO donor mice induced more severe GVHD in lethally irradiated allogeneic recipients compared to th

46 -gal A and transplanted into sublethally and lethally irradiated alpha-gal A-deficient mice.

47 transfer of the G9C8 clone or by chimerizing lethally irradiated ALR or reciprocal (ALR x NOD)F1 reci

48 Recipient C57BL/6 (H2b) mice were lethally irradiated and given transplants of bone marrow

49 Subsequently, the mice were lethally irradiated and received lymphocytes including m

50 Eight-week-old BXSB mice were lethally irradiated and reconstituted with BALB/c (H-2(d

51 poietic cells, Tie2-Cre/LoxP-PTP1B mice were lethally irradiated and reconstituted with bone marrow f

52 cipate in SGVHD, C3H/HeN recipient mice were lethally irradiated and transplanted with BM from normal

53 ipoprotein E (apoE)(-/-) recipient mice were lethally irradiated and transplanted with COX-1(-/-) bon

54 either Bmpr2(R899X) mutant or controls, were lethally irradiated and transplanted with either control

55 Female mice (6 wk old) were lethally irradiated and transplanted with male bone marr

56 C57/BL6 (H2K(b)) recipient mice were lethally irradiated and underwent cotransplantation with

57 Rats with subtotal nephrectomies were lethally irradiated and underwent salvage transplantatio

58 apacity to achieve long-term repopulation in lethally irradiated animals and the ability to different

59 fetal liver cells also fail to radioprotect lethally irradiated animals and they compete poorly in r

60 al irradiation, and increase the survival of lethally irradiated animals following allogeneic HPC tra

61 ease GVHD mortality in either sublethally or lethally irradiated animals that received graded doses o

62 1(+) cells primed by C3a engrafted faster in lethally irradiated animals.

63 riched with autologous peripheral blood into lethally irradiated animals.

64 Egr1(+/-), Apc(del/+) bone marrow cells into lethally irradiated Apc(del/+) recipients resulted in ra

65 ere used to replace the circulating cells of lethally irradiated ApoE -/- mice.

66 crophage SR-BI were created by transplanting lethally irradiated apoE-deficient mice with bone marrow

67 Lethally irradiated B10.BR mice transplanted with major

68 ritoneal cavity B-1a cells were recovered in lethally irradiated B6.Sle2 mice reconstituted with B6.I

69 R5(-/-) or wild-type C57BL/6 (B6) T cells to lethally irradiated B6D2 recipients.

70 nalyze CD8(+) and CD4(+) T cell responses in lethally irradiated BALB.B and CXB-2 recipients, which s

71 on in skin during development of Scl GVHD in lethally irradiated BALB/c (H-2d) mice transplanted with

72 PD-treated splenocytes were infused into lethally irradiated BALB/c (same-party) or C3H/HeJ (thir

73 All lethally irradiated BALB/c mice inoculated with BCL1 cel

74 Lethally irradiated BALB/c/nu/nu mice were injected intr

75 nting B10.D2 bone marrow and spleen cells to lethally irradiated BALB/cJ mice, is a model for human s

76 nd diminished multilineage reconstitution in lethally irradiated bone marrow recipients.

77 Lethally irradiated C3FeB6F(1) hosts received BMT from e

78 of acute graft-versus-host disease (GVHD) in lethally irradiated C57BL/6 (H-2b) recipient mice transp

79 ow cells from lpr mice (which lack Fas) into lethally irradiated C57BL/6 mice (MyFas(-) group) or vic

80 Lethally irradiated C57BL/6 mice were transplanted with

81 e marrow (BM)-chimeric mice by transplanting lethally irradiated C57BL/6 mice with congenic VDR or wi

82 transduced SP cells successfully repopulated lethally irradiated C57BL/6 mice, animals where there is

83 populated multiple hematopoietic lineages of lethally irradiated C57BL/6-CD45.2 mice.

84 transplanted viable clones individually into lethally irradiated C57BL/6-Ly-5.1 mice.

85 Lethally irradiated C57BL/6J and B6.129P2-Nos2(tm1Lau)/J

86 owing syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPCs are of donor orig

87 Lethally irradiated CBA mice received BMT from allogenei

88 e the RI lines, and the mixtures repopulated lethally irradiated CByB6F1 recipients.

89 etermine LC lineage origin, we reconstituted lethally irradiated CD45.2 mice with rigorously purified

90 nderlying reduced viability, we investigated lethally irradiated CD62E(-/-) mice that were reconstitu

91 products in vivo, we inoculated rabbits with lethally irradiated cell lines expressing the wild-type

92 We immunized mice i.p. with lethally irradiated cells of the colon adenocarcinoma li

93 We reconstituted lethally irradiated congenic mice with bone marrow proge

94 ons derived from these candidate HSCs into a lethally irradiated congenic non-EGFP mouse.

95 ls received heart and kidney allografts from lethally irradiated donors (n=7); group 5 animals receiv

96 genitors per tibia of WT HSPCs injected into lethally irradiated Fancg(-/-) recipients.

97 xpression were created by transplantation of lethally irradiated female LDLR(-/-) mice with LPL(-/-)

98 tion of macrophage LRP(-/-) bone marrow into lethally irradiated female LDLR(-/-) recipient mice resu

99 Lethally irradiated female mice were rescued by a BM tra

100 galactosyltransferase and transplanted into lethally irradiated gal knockout mice.

101 s, alone or mixed with wild-type cells, into lethally irradiated healthy mice.

102 -cell resolution, whereby the bone marrow of lethally irradiated host animals is reconstituted with E

103 atopoiesis and allowed long-term survival of lethally irradiated host animals.

104 impaired in their capacity to reconstitute a lethally irradiated host.

105 lantation of Bv8 null fetal liver cells into lethally irradiated hosts also reduced metastasis.

106 er, Ripk1(-/-) progenitors failed to engraft lethally irradiated hosts properly.

107 lls and adoptive transfer of thymocytes into lethally irradiated hosts suggested that recent thymic e

108 (HSCs) lacking SOD2 are capable of rescuing lethally irradiated hosts, but reconstituted animals dis

109 When transferred into lethally irradiated hosts, E2A-deficient hematopoietic p

110 icient hematopoietic stem cells reconstitute lethally irradiated hosts, p38alpha function is not requ

111 ng bone marrow reconstitution experiments of lethally irradiated hosts, we have defined the extent an

112 expansion, as a single HSC may reconstitute lethally irradiated hosts.

113 with fluorescent PKH26 dye and injected into lethally irradiated hosts.

114 splanted cNeoblasts restored regeneration in lethally irradiated hosts.

115 n sublethally irradiated immunodeficient and lethally irradiated immunocompetent mice.

116 mory anti-Gal B cells were administered into lethally irradiated KO mice, together with syngeneic wil

117 ow-derived murine DC were exposed to various lethally irradiated Lactobacillus spp. and resultant cul

118 To confine MPO expression to macrophages, we lethally irradiated LDL receptor-deficient mice and repo

119 row transplantation experiments performed in lethally irradiated LDL-R null female mice, reconstitute

120 /-) or wild-type mice were transplanted into lethally irradiated Ldlr(-/-) mice.

121 om littermate controls was transplanted into lethally irradiated low density lipoprotein receptor Ldl

122 either FucT-VII(-/-)GFP(+) bone marrow into lethally irradiated low-density lipoprotein receptor low

123 mice die by 3 weeks of age, this study used lethally irradiated low-density lipoprotein receptor-def

124 population for long-term engrafting cells in lethally irradiated Ly-5.2 mice.

125 kyrin-1 promoter vectors, were injected into lethally irradiated Ly5.2 recipients.

126 icient lymphocytes by adoptive transfer into lethally irradiated mature lymphocyte-deficient recombin

127 own that bone marrow cells transplanted into lethally irradiated mdx mice, the mouse model of DMD, ca

128 ismatched T cell-deficient C57BL/6 mice into lethally irradiated MHC-matched B6.H-2(g7) recipients, w

129 /+).BDC2.5 or NOD.Rag1(-/-).BDC2.5 mice into lethally irradiated MHC-mismatched H-2(b) C57BL/6 or MHC

130 ther intra bone marrow or intravenously into lethally irradiated MHC-mismatched recipient mice.

131 produce graft-versus-host disease (GVHD) in lethally irradiated MHC-mismatched recipients.

132 fect of DDT-deficient HSCs in reconstituting lethally irradiated mice and a strong competitive disadv

133 engraftment and enhanced overall survival in lethally irradiated mice by mitigating damage to the BM

134 ells and stromal cells, is transplanted into lethally irradiated mice deleted of both the p55 and p75

135 t the mouse homologue, murine CMV (MCMV), in lethally irradiated mice given allogeneic purified hemat

136 juvenile myelomonocytic leukemia (JMML) and lethally irradiated mice given transplants with homozygo

137 In lethally irradiated mice injected with donor congenic bo

138 inhibits graft-versus-host disease (GVHD) in lethally irradiated mice receiving allogeneic hematopoie

139 Finally, the hematopoietic reconstitution of lethally irradiated mice receiving transplanted BM monon

140 In lethally irradiated mice reconstituted with bone marrow

141 is associated with cachexia and mortality in lethally irradiated mice reconstituted with dominant neg

142 Lethally irradiated mice reconstituted with Gnai2(-/-) b

143 on of RIP to immune homeostasis, we examined lethally irradiated mice reconstituted with rip-/- hemat

144 Since lethally irradiated mice reconstituted with SYK-deficien

145 ietic stem cells mobilized by SB-251353 into lethally irradiated mice resulted in faster neutrophil a

146 of 5,000 lentivirus-transduced SP cells into lethally irradiated mice resulted in long-term expressio

147 e other hand, transfer of WT BM into BAFF-/- lethally irradiated mice resulted only in minimal recons

148 murine BM cells covered with PMPs engrafted lethally irradiated mice significantly faster than those

149 e so-called side population (SP) cells, into lethally irradiated mice subsequently rendered ischemic

150 Here, we show that in lethally irradiated mice that had received BM transplant

151 bited microcytic, hypochromic anemia, as did lethally irradiated mice that received a transplant of S

152 unctional natural killer (NK) compartment in lethally irradiated mice that received bone marrow cells

153 is lentiviral vector design was evaluated in lethally irradiated mice that received transplants of tr

154 fer following long-term transplantation into lethally irradiated mice transgenic for HLA-DR4.

155 Lethally irradiated mice transplanted with 2 x 10(6) FL,

156 Lethally irradiated mice transplanted with bone marrow c

157 Here, all lethally irradiated mice transplanted with Dnmt3a-delete

158 Lethally irradiated mice were reconstituted with murine

159 del of soft tissue ischemia was developed in lethally irradiated mice with BM reconstituted from eith

160 Dll4, in mice was explored by reconstituting lethally irradiated mice with bone marrow (BM) cells tra

161 P-selectin(-/-) and apoE(-/-)P-selectin(+/+) lethally irradiated mice with bone marrow of either geno

162 ouse model of JMML through reconstitution of lethally irradiated mice with hematopoietic stem cells h

163 em that are radioprotective, we transplanted lethally irradiated mice with purified progenitors: comm

164 capacity to reject bone marrow allografts in lethally irradiated mice without prior sensitization.

165 d to express RUNX1-ETO and transplanted into lethally irradiated mice, and a high penetrance of AML w

166 ulate all major peripheral blood lineages in lethally irradiated mice, but the origin of this activit

167 from protecting hematopoietic progenitors in lethally irradiated mice, indicating involvement of a fa

168 r:bone marrow cell mixtures were placed into lethally irradiated mice, only treatment of these mixtur

169 When transplanted into lethally irradiated mice, single gene-marked murine SP c

170 When these cells are injected into lethally irradiated mice, they engraft transiently in a

171 me near nestin(+) MSCs in the bone marrow of lethally irradiated mice, whereas in vivo nestin(+) cell

172 tilineage reconstitution when transferred to lethally irradiated mice.

173 oietic progenitor cells used to reconstitute lethally irradiated mice.

174 cell lympholeukemias when transplanted into lethally irradiated mice.

175 of donor hematopoietic cells to radioprotect lethally irradiated mice.

176 to reconstitute the hematopoietic system of lethally irradiated mice.

177 duced the number of HSPCs required to rescue lethally irradiated mice.

178 ncompatible bone marrow cell (BMC) grafts in lethally irradiated mice.

179 did not expand as did their counterparts in lethally irradiated mice.

180 of hematopoietic progenitors in vitro and in lethally irradiated mice.

181 d-type (wt) fetal liver (FL) stem cells into lethally irradiated mice.

182 dye and can reconstitute the bone marrow of lethally irradiated mice.

183 obilized peripheral blood stem cells rescued lethally irradiated mice.

184 ow and spleen, and thereby prevent death, in lethally irradiated mice.

185 e capable of hematopoietic reconstitution of lethally irradiated mice.

186 s capable of hematopoietic reconstitution of lethally irradiated mice.

187 fractions by flow sorting, and injected into lethally irradiated mice.

188 reject H2(b) bone marrow cell allografts in lethally irradiated mice.

189 uted multilineage long-term hematopoiesis in lethally irradiated mice.

190 c stem/progenitor cells used to reconstitute lethally irradiated mice.

191 to reconstitute the hematopoietic system of lethally irradiated mice.

192 HSCs from ossicles were able to reconstitute lethally irradiated mice.

193 econstitution of the hematopoietic system in lethally irradiated mice.

194 on of bone marrow and are able to repopulate lethally irradiated mice.

195 marrow, but not wild-type bone marrow, into lethally irradiated MMTV-PyVmT mice (a model of metastat

196 ed self-renewal in serial transplantation of lethally irradiated mouse recipients both in the presenc

197 8 h and tested for engraftment capacity in a lethally irradiated murine competitive transplant model.

198 ice (BALB/c and C3H/HEJ) were immunized with lethally irradiated murine leukemia cells expressing cel

199 istocompatibility complex class I-mismatched lethally irradiated murine model.

200 ized that flagellin could ameliorate GVHD in lethally irradiated murine models of allogeneic HSCT.

201 We used a lethally irradiated murine SCT model (B6 --> bm1) to eva

202 en fluorescent protein (GFP)-marked HSC into lethally irradiated nontransgenic recipients.

203 etically marked adult mouse bone marrow into lethally irradiated normal adult hosts, donor-derived ce

204 In lethally irradiated normal mice that were reconstituted

205 bone marrow chimeras made by reconstituting lethally irradiated normal mice with bone marrow taken f

206 prevent graft-versus-host disease (GVHD) in lethally irradiated or nonirradiated allogeneic recipien

207 ined populations of BM cells were tracked in lethally irradiated or nonirradiated mice at 1, 3, 6, an

208 The wild-type mouse was either uninjured or lethally irradiated or received intratracheal elastase o

209 o test this hypothesis, IPS was induced in a lethally irradiated parent --> F1 mouse BMT model.

210 Using a lethally irradiated parent --> F1 mouse IPS model, we sh

211 acute graft-versus-host disease (GVHD) in a lethally irradiated parent into F1 (B6-->B6D2F1) BMT mod

212 epopulating lymphoid and myeloid lineages of lethally irradiated primary and secondary hosts, with de

213 ells, these cells produced reconstitution in lethally irradiated primary, secondary, and tertiary mur

214 in tertiary hosts and could not radioprotect lethally irradiated quaternary recipients.

215 ferent viruses were transplanted into either lethally irradiated Rag-1-deficient animals or Artemis k

216 actively transcribed were transplanted into lethally irradiated recipient female mice.

217 Serial BM transplantation into lethally irradiated recipient mice indicated an essentia

218 Limiting dilution reconstitution of lethally irradiated recipient mice with 100% transduced,

219 f myeloproliferative neoplasms, we engrafted lethally irradiated recipient mice with bone marrow cell

220 ed by reconstitution of the immune system of lethally irradiated recipient mice with retrovirus-infec

221 ted HSPCs to reconstitute the bone marrow in lethally irradiated recipient mice.

222 MHC class I-deficient bone marrow cells into lethally irradiated recipient mice.

223 performed bone marrow transplantations into lethally irradiated recipient mice.

224 rostinil and forskolin, enhanced survival of lethally irradiated recipient mice.

225 Rce1(-/-) fetal liver cells rescued lethally irradiated recipients and manifested normal lon

226 d Shp2-deficient HSCs failed to reconstitute lethally irradiated recipients because of defects in hom

227 ed from adult bone marrow and transferred to lethally irradiated recipients clearly give rise to B-2,

228 m congenic controls and used to reconstitute lethally irradiated recipients for analysis of long-term

229 MDSCs transferred to lethally irradiated recipients of allogeneic donor hemat

230 tation of 500 HSCs from old p53+/m mice into lethally irradiated recipients resulted in reduced engra

231 ntation of transduced bone marrow cells into lethally irradiated recipients showed that the percentag

232 Lethally irradiated recipients were reconstituted with p

233 uted the bone marrow and peripheral blood of lethally irradiated recipients with B lineage cells with

234 toxic injury, and HO-1(+/-) HSCs repopulated lethally irradiated recipients with more rapid kinetics.

235 cell phenotype, provided radioprotection to lethally irradiated recipients, and enhanced in vivo rep

236 of CD31+ Lin- c-kit- cells fails to protect lethally irradiated recipients, while CD31+ Lin- c-kit+

237 cells provides short-term radioprotection of lethally irradiated recipients, whose progressive anemia

238 m H2 identical healthy mice could not rescue lethally irradiated recipients.

239 nitored tumor onset and overall pathology in lethally irradiated recipients.

240 ion assays, 100 such cells reconstituted all lethally irradiated recipients.

241 splantation of mutant fetal liver cells into lethally irradiated recipients.

242 ls alone could not produce reconstitution in lethally irradiated recipients.

243 rying the human fancc cDNA and injected into lethally irradiated recipients.

244 ells failed to reconstitute hematopoiesis in lethally irradiated recipients.

245 nsplanted necdin-null fetal liver cells into lethally irradiated recipients.

246 00-deficient HSC were unable to reconstitute lethally irradiated recipients.

247 ely reconstitute the hematopoietic system of lethally irradiated recipients.

248 for survival following transplantation into lethally irradiated recipients.

249 B502 also showed radioprotective activity in lethally irradiated rhesus monkeys.

250 In the current study, we used lethally irradiated S. aureus as a model multicomponent

251 tly extended lifespan, increased survival of lethally irradiated secondary recipients transplanted wi

252 sick mice along with B6 bone marrow cells to lethally irradiated syngeneic B6 mice, the secondary rec

253 y of infection of 100, and transplanted into lethally irradiated syngeneic mice.

254 e marrow coexpressing TEL-PDGFRB and AE into lethally irradiated syngeneic mice.

255 either Jak2 wild-type (wt) or Jak2V617F into lethally irradiated syngeneic recipient mice.

256 Reconstitution of lethally irradiated syngeneic recipients with BM transdu

257 on, we transplanted normal marrow cells into lethally irradiated Tpo(-/-) and Tpo(+/+) mice and quant

258 een fluorescent protein-expressing mice into lethally irradiated transgenic mice followed by subseque

259 bone marrow cells were transplanted into two lethally irradiated transgenic mouse models of HD that u

260 t introduction of wild-type (WT) marrow into lethally irradiated TSP2 KO mice did not rescue the blee

261 d 65.0% fewer inflammatory cells (P<0.05) in lethally irradiated wild type mice reconstituted with CX

262 ese mechanisms, the hematopoietic systems of lethally irradiated wild-type (WT) mice were reconstitut

263 tor GRko for immunological reconstitution of lethally irradiated wild-type (WT) mice.

264 er combined HSC and MPC transplantation into lethally irradiated wild-type (WT) mice.

265 ntation of KLF4(-/-) fetal livers cells into lethally irradiated wild-type mice completely lacked cir

266 Surprisingly, lethally irradiated wild-type mice reconstituted with CX

267 ation of recombinant, soluble Thbd or aPC to lethally irradiated wild-type mice resulted in an accele

268 selectin-dependent rolling, we reconstituted lethally irradiated wild-type mice with PSGL-1-/- bone m

269 8(-/-) unfractionated bone marrow cells into lethally irradiated wild-type mice, resulting in approxi

270 ration, as BAFF-/- BM cells transferred into lethally irradiated WT mice gave rise to normal numbers

271 Lethally irradiated WT mice reconstituted with a 50:50 m

272 red bone marrow cells from Id cDKO mice into lethally irradiated WT mice.

273 that expressed the neutrophil marker Gr-1 in lethally irradiated WT or Rac2(-/-) recipients of Rac2(-

274 leukocytes when adoptively transferred into lethally irradiated WT recipients.

275 KO bone marrow cells failed to radioprotect lethally irradiated WT recipients.

276 Vaccination with lethally irradiated, AdsGRP94-infected 4T1 cells complet

277 IL-6 transgenic knockout mice were lethally irradiated, and their bone marrow was reconstit

278 Adult C57BL/6J mice were lethally irradiated, and then received a transplant of p

279 Lethally irradiated, atherosclerosis-prone, low-density

280 rom apolipoprotein e-/- x stat1-/- mice into lethally irradiated, atherosclerosis-susceptible apolipo

281 yte-associated antigen 4 or vaccination with lethally irradiated, autologous tumor cells engineered t

282 Vaccination with lethally irradiated, autologous tumor cells engineered t

283 Lethally irradiated, established mixed BALB/c--> B6 chim

284 Lethally irradiated, male WASP- animals that received tr

285 BM) cells resulted in bioluminescent foci in lethally irradiated, syngeneic recipients.

286 ecipients deficient in IL-6 (IL-6(-/-)) were lethally irradiated, then rescued with 10(7) donor bone

287 clerotic lesions, female LDLR(-/-) mice were lethally irradiated, transplanted with LPL(-/-) (n = 14)

288 fic protein surfactant protein C (Sp-C) were lethally irradiated, transplanted with sex mismatched wi

289 Lethally irradiated, virus-infected cells were used as v

290 were generated after the recipient mice were lethally irradiated.

291 We found that lethally- irradiated lymphocyte-deficient C57BL/6 (B6).g

292 ) cells that engrafted primary and secondary lethally-irradiated mice, and human CD34(+) cells that c

293 re-engineered to attack, kill, but also non-lethally manipulate the physiologies of bacteria.

294 sential components of the immune system that lethally mutate viral pathogens and somatically mutate i

295 whereas its close relative, APOBEC3G (A3G), lethally mutates the genomes of retroviral pathogens suc

296 iated genome regions that were on their own "lethally recombinant." Surprisingly, mixed inoculations

297 nto a layer of a larger number of unlabeled, lethally treated melanoma cells.

298 In lethally treated mice, Cas-1 activity remained elevated

299 nd adult males and females were not affected lethally until pCO2 concentrations >/=3000 muatm.

300 s are best accounted for by a combination of lethally warm, shallow waters and anoxic deep waters tha