ライフサイエンスコーパス: leucine zipper domain

1 l-terminal TALIN homology region but not the leucine zipper domain.

2 ic extension onto the N terminus of the CREB leucine zipper domain.

3 logy with the murine species and retains the leucine zipper domain.

4 mutation of leucines to arginines within the leucine zipper domain.

5 e addition of ubiquitin moieties to the ATF3 leucine zipper domain.

6 e NF-kappaB members RelB and p52 through its leucine zipper domain.

7 vimentin interacted with ATF4 with its first leucine zipper domain.

8 BP-beta but occurred independently of CREB's leucine zipper domain.

9 ch required the participation of a conserved leucine zipper domain.

10 don 2140 (R2140C) downstream of the putative leucine zipper domain.

11 cell lines that overexpress Par-4 and/or its leucine zipper domain.

12 teractions that take place mainly within the leucine zipper domain.

13 MYOC interactions occurred mainly within the leucine zipper domain.

14 n amino acids 117-166, a region containing a leucine zipper domain.

15 dicated that the interaction was through its leucine-zipper domain.

16 contains four coiled-coil and two N-terminal leucine zipper domains.

17 y proteins characterized by basic region and leucine zipper domains.

18 myocardin physically associate via conserved leucine zipper domains.

19 iated through binding of linked antiparallel leucine-zipper domains.

20 RGD is fused to the C-terminus of a leucine zipper domain A, and this fusion polypeptide is

21 REBP-1 containing the basic helix-loop-helix-leucine zipper domain (amino acids 300-389) was required

22 l analysis showed that the amino-terminal H4 leucine zipper domain (amino acids 55-93), as well as H4

23 Here we report that two leucine zipper domains (amino acids 501-522 and 557-571)

24 MLK2 and MLK3 each contain an SH3 domain, a leucine zipper domain and a potential Rac/Cdc42 GTPase-b

25 his effect of TLS-CHOP required a functional leucine zipper domain and correlated with its ability to

26 n, CgCbf1, contains a basic-helix-loop-helix leucine zipper domain and has features similar to those

27 par-4 contains a putative leucine zipper domain and is specifically upregulated du

28 he pro-apoptotic protein Par-4 via the Par-4 leucine zipper domain and phosphorylates Par-4 to inhibi

29 complexes, Par-4 interacts with TOP1 via its leucine zipper domain and sequesters TOP1 from the DNA.

30 endent upon DNA binding via its basic region-leucine zipper domain and slows G1 progression by intera

31 rtic acid between the basic helix-loop-helix leucine zipper domain and the first trans-membrane domai

32 erved Asp between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain

33 Ste4-SAM is adjacent to a trimeric leucine zipper domain and we have shown previously that

34 is a proline-rich protein that contains two leucine zipper domains and a highly conserved C-terminal

35 hat p12(I) forms dimers through two putative leucine zipper domains and that its stability is augment

36 of simple sequestration of ATF4 by the CHOP leucine zipper domain, and chromatin immunoprecipitation

37 C-terminal half of Cbl with and without the leucine zipper domain, and in cells using Myc and green

38 table aldo-keto reductase, two alpha-helical leucine zipper domains, and a randomly coiled domain.

39 These leucine zipper domains are unique for the presence of a

40 sequence of par-4 predicts a protein with a leucine zipper domain at its carboxy terminus.

41 ta-1, -2, and -3, which share a common basic-leucine zipper domain at their C-terminus, but are disti

42 gnificantly higher than that of its isolated leucine zipper domain: at 20 degrees C it is 1.45microM

43 e of poly(ethylene) glycol (PEG) and another leucine zipper domain B (B-PEG).

44 Prior studies revealed that the basic leucine zipper domain (b-ZIP) of transcription factor AT

45 dlf1 encodes a protein with a basic leucine zipper domain belonging to an evolutionarily con

46 The predicted protein contains a leucine zipper domain but lacks a DNA-binding domain.

47 ing proteins, including members of the basic leucine zipper domain (bZIP) family.

48 tical for axon fragment fusion and the basic leucine zipper domain (bZip) protein CREB (cAMP response

49 basic DNA-recognition segment and the basic leucine zipper domain (bZIP).

50 A leucine zipper domain can replace NC in Gag and still le

51 Fusions containing dimeric and tetrameric leucine zipper domains can be distinguished based on the

52 1b splices the mRNA-encoding bZIP60, a basic leucine-zipper domain containing transcription factor as

53 ntagonizing transcription factor (AATF) is a leucine zipper domain-containing protein that has antiap

54 Thus, the leucine zipper domain enables c-Cbl to homodimerize, and

55 In contrast, their kinase and leucine zipper domains exhibited relatively conserved fu

56 The proteins consist of terminal leucine zipper domains flanking a central, flexible, wat

57 omain was required, in addition to the basic leucine zipper domain, for DNA binding activity.

58 ble into a hydrogel material as the terminal leucine zipper domains form interprotein coiled-coil cro

59 K8beta protein is missing only a C-terminal leucine zipper domain from the K-bZIP, its expression an

60 The assay uses the leucine zipper domains from the mammalian transcription

61 elta(389-418), and L389A/L396A c-Myb) of the leucine zipper domain had increased stability.

62 ity of interleukin-6, suggest that the C/EBP leucine zipper domain has a role in C/EBP function beyon

63 etected an NH(2)-terminal PKGI fragment with leucine zipper domain immunoreactivity in the cytosol an

64 directly and selectively with Par-4 via the leucine zipper domain in neural cells.

65 To assess the role of this leucine zipper domain in S-induced cell-to-cell fusion,

66 These results implicate the leucine zipper domain in some function other than dimeri

67 ls by an interaction between coiled-coil and leucine zipper domains in the two proteins.

68 in interacted specifically only with the DLK leucine zipper domain; in contrast, DLK NH(2)-terminal r

69 consistently blocked by co-expression of the leucine zipper domain, indicating that the effect of Par

70 However, the DLK leucine zipper domain interacted specifically only with

71 o show that DLK dimerization mediated by the leucine zipper domain is prerequisite for DLK activity a

72 These findings suggest that the leucine zipper domain is required for the Par-4 protein

73 s of spermatocytes and spermatids and that a leucine zipper domain is required to target speriolin to

74 ermed Z(WT)) that has NC-p1-p6 replaced by a leucine zipper domain is resistant to dominant-negative

75 -hybrid system, we show that deletion of the leucine zipper domain is sufficient to abolish Cbl homod

76 eletion of 10 amino acid residues within the leucine zipper domain is sufficient to block beta(1)Pix

77 he folding behavior of the well-studied GCN4 leucine-zipper domain is more complex than was previousl

78 al half of Nrl, which contains the basic and leucine zipper domains, is sufficient for DNA binding.

79 ucleic acid-binding domain with a dimerizing leucine zipper domain leads to the assembly of RNA-free

80 Par-4 contains a leucine zipper domain (Leu.zip) that presumably mediates

81 KK gamma interaction requires two homologous leucine zipper domains located within IKK gamma.

82 n and one nuclear export signal (NES) in the leucine zipper domain (named LZ-NES).

83 es for a 237-amino-acid protein with a basic-leucine zipper domain near its C terminus and an acidic

84 ltransferase, interacts with the octapeptide/leucine zipper domain of AF10, and this region has been

85 The leucine zipper domain of ATF3 appears indispensable for

86 The ATF3-AR interaction requires the leucine zipper domain of ATF3 that independently binds t

87 Deletion analysis showed that the leucine zipper domain of ATF4 is critical for Runx2 acti

88 We also found that the basic leucine zipper domain of c-Jun and a short sequence clos

89 nd DNA binding, the well characterized basic leucine zipper domain of c-Jun functions in transcriptio

90 Interestingly, the isolated basic leucine zipper domain of c-Jun was able to derepress TFI

91 Here we show that the basic leucine zipper domain of c-Jun, which allows for DNA bin

92 We mapped this interaction to the basic leucine zipper domain of C/EBPalpha and a region adjacen

93 eight proteins derived from the basic region leucine zipper domain of chicken VBP, the mammalian TEF

94 ation of a critical Arg residue in the basic-leucine zipper domain of either Fos or Jun yielded singl

95 and GM-Rbeta extracellular domains with the leucine zipper domain of either the Fos or Jun molecule.

96 Chimeric constructs of JDP2 carrying the leucine zipper domain of Fos, GCN4 or EB1 fail to transf

97 Replacing helix I with the entire leucine zipper domain of GCN4 (residues 250 to 281) prod

98 missing in v-Ski, can be substituted by the leucine zipper domain of GCN4.

99 tructed mutant E2A-HLF proteins in which the leucine zipper domain of HLF was extended by one helical

100 1 (KLC1) as a binding partner for the second leucine zipper domain of JLP using yeast two-hybrid scre

101 We further demonstrate that the leucine zipper domain of K-bZIP is required for Rta bind

102 and a nuclear exporting signal (NES) in the leucine zipper domain of Nrf2.

103 Since the leucine zipper domain of Par-4 (Leu.zip) may mediate pro

104 ost importantly, ectopic coexpression of the leucine zipper domain of Par-4 inhibited the ability of

105 nt negative regulator of Par-4 activity (the leucine zipper domain of Par-4).

106 ength Par-4, but not mutants that lacked the leucine zipper domain of Par-4, conferred enhanced sensi

107 The leucine zipper domain of SPRK has been shown to be neces

108 coiled-coil peptide, GCN4-p1, the 33-residue leucine zipper domain of the transcriptional activator G

109 GCN4-p1, a 33-residue segment comprising the leucine zipper domain of the transcriptional activator G

110 This minimal Gag construct contained the leucine zipper domain of the yeast transcription factor

111 The basic leucine zipper domain of the yeast transcription factor

112 We also show that an intact leucine zipper domain of UL84 is required for a stable i

113 tro interaction domain encompassed the basic leucine zipper domain of ZTA.

114 amino acid residues between the basic region-leucine zipper domains of Fos and Jun reversed the bindi

115 ding in complexes formed by the basic region-leucine zipper domains of Fos and Jun with the DNA bindi

116 Both the activation and basic leucine zipper domains of Jun were required for the tran

117 inositol pyrophosphate kinase and the basic leucine zipper domains of KCS1 are required for INO1 exp

118 nteractions require the helix-loop-helix and leucine zipper domains of MRG15.

119 on of CBP as well as the transactivation and leucine zipper domains of Z.

120 deletion of glutamic acid (DeltaE250) in the leucine-zipper domain of Foxp3 causes a loss of hyporesp

121 of this single glutamic acid residue in the leucine-zipper domain of Foxp3.

122 2-residue alpha-helical peptide based on the leucine-zipper domain of the yeast transcription factor

123 calization signal and basic helix-loop-helix/leucine-zipper domains of ChREBP were essential for the

124 These results indicate that the leucine zipper domain plays a role in S-induced cell-to-

125 Maf is a basic domain/leucine zipper domain protein originally identified as a

126 Recent studies indicated that the leucine zipper domain protein Par-4 induces apoptosis in

127 ember of the ATF/CREB subfamily of the basic leucine zipper domain proteins, is expressed predominant

128 Deletion of the carboxy-terminal leucine zipper domain relaxed the constraint and permitt

129 C protein of 40 S hnRNP complexes contains a leucine-zipper domain, residues 180-207, and that a 40 r

130 ells, replacement of NC with a dimer-forming leucine zipper domain restores budding of spherical part

131 Deletion of leucine zipper domain results in a loss of transcription

132 e demonstrate that CED-6 dimerizes through a leucine zipper domain that is immediately adjacent to th

133 Both FLX and FLX4 contain leucine zipper domains that facilitate interaction with

134 rvation of the ability of C/EBP basic region-leucine zipper domains to confer lipopolysaccharide indu

135 ors is based on the shared capacity of their leucine zipper domains to interact with non-AP1 factors

136 ellular transcription factors, which use the leucine-zipper domain to form a specific dimer before th

137 shown that the Par-4 protein binds, via its leucine zipper domain, to the zinc finger domain of Wilm

138 f the SPM domain to the helix-loop-helix and leucine zipper domains used for homotypic and heterotypi

139 re that included NLS2 but not the C-terminal leucine zipper domain was necessary and sufficient to in

140 ine coronavirus spike (S) protein contains a leucine zipper domain which is highly conserved among co

141 4l structure involves tetramerization of the leucine zipper domain which is situated approximately 30

142 When fused with the c-jun leucine zipper domain, which binds heparin and forms hom

143 orylation site (Ser(133)) but lack the basic/leucine zipper domain, which is essential for binding to

144 rm, DLK-1S, that shares identical kinase and leucine zipper domains with the previously described lon

145 Motif searches reveal a leucine zipper domain within a conserved N-terminal regi

146 s response-4 (Par-4), a protein containing a leucine zipper domain within a death domain, is up-regul

147 open reading frame of 228 amino acids with a leucine zipper domain within its C terminus, a transmemb

148 A novel protein containing multiple leucine zipper domains without any significant homology