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1 domain, and a variable number of C-terminal leucine-rich repeats.
2 ous work has shown that Elfn1 (extracellular leucine rich repeat and fibronectin Type III domain cont
3 s nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1 (NLRP1
4 o a pair of amino acids, 106 and 156, in the leucine-rich repeat and central domains and show these m
5 me of Ewing and showed unexpectedly that the leucine-rich repeat and Ig domain protein 1 (LINGO1) is
9 d nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NRLP3
10 ng and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3
11 nase kinases (MKKs) and rodent NLRP1B (NACHT leucine-rich repeat and pyrin domain-containing protein
12 ses an additional 33 amino acids between the leucine-rich repeats and carboxy-terminal low-complexity
13 tion is linked to carcinogenesis, and Lrig1 (leucine-rich repeats and Ig-like domains 1) marks a dist
14 The earring-shaped NLRP3 consists of curved leucine-rich-repeat and globular NACHT domains, and the
15 ere, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein
16 , nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin protein 3 complex, CASP1,
19 orrelated with reduced expression of LRRC26 (leucine rich repeat containing 26), the gamma subunit ma
20 d activation of pathways of beta-catenin and leucine rich repeat containing G protein-coupled recepto
21 Nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) is a unique NL
23 VASP, extended-synaptotagmin 2 [ESYT2], and leucine-rich repeat containing 15 [LRRC15]), and "isomer
24 nical events except stroke, the LRRC3B gene (leucine-rich repeat containing 3B) with myocardial infar
26 showing that multimers derived from LRRC8A (leucine-rich repeat containing 8A) gene are structural c
28 aR1 as a stereoselective activator for human leucine-rich repeat containing G protein-coupled recepto
30 tly characterized nucleotide-binding domain, leucine-rich repeat containing protein (NLR) that negati
32 xplore the role of nucleotide-binding domain leucine-rich repeat containing receptor family member NL
33 re the role of the nucleotide-binding domain leucine-rich repeat containing receptor family member Nl
34 he role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in diseas
36 (CITA), NLRC5 [nucleotide-binding domain and leucine-rich repeats containing (NLR) family, caspase ac
38 between 2 candidate genes, EMSY and LRRC32 (leucine-rich repeat-containing 32) but the functional me
39 (i.e. SEC61) and ER proteins (ribophorin I, leucine-rich repeat-containing 59 (LRRC59), and SEC62) p
40 ly defined, revealing that it belongs to the leucine-rich repeat-containing 8 (LRRC8) protein family.
42 In mice, specific nucleotide-binding domain, leucine-rich repeat-containing family, apoptosis inhibit
43 IPs) activate the nucleotide-binding domain, leucine-rich repeat-containing family, CARD domain-conta
44 , we report a pivotal role for the R-spondin/leucine-rich repeat-containing G protein-coupled recepto
46 rkers, epithelial cell adhesion molecule and leucine-rich repeat-containing G protein-coupled recepto
47 lycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled recepto
50 WNT/beta-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled recepto
51 ciated CpG was cg03566881 located within the leucine-rich repeat-containing G-protein coupled recepto
52 ified Wnt environment leads to activation of leucine-rich repeat-containing G-protein coupled recepto
54 rapidly growing adenomas containing LGR5(+) (leucine-rich repeat-containing G-protein coupled recepto
55 inct molecular markers, including Norrin and leucine-rich repeat-containing G-protein-coupled recepto
58 re we report that the abundant expression of leucine-rich repeat-containing G-protein-coupled recepto
59 R-spondins (Rspos) are endogenous ligands of leucine-rich repeat-containing G-protein-coupled recepto
63 d nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein (NLRP) 3 and pro-
64 cing mRNA expression of the BK gamma subunit leucine-rich repeat-containing protein 26 (LRRC26) and i
65 Here, we report a DNA repair suppressor, leucine-rich repeat-containing protein 31 (LRRC31), that
67 ator of reactive oxygen species (NRROS) is a leucine-rich repeat-containing protein that uniquely ass
68 are sensed by nucleotide binding domain and leucine-rich repeat-containing proteins (NLRs), which tr
69 a member of the LRIG family of transmembrane leucine-rich repeat-containing proteins, is a negative r
71 eotide-binding oligomerization domain (Nod), leucine-rich repeat-containing receptors (NLRs), and pyr
72 or cell surface molecules and identified the leucine-rich repeat-containing transmembrane protein kno
73 ionships between relaxin family peptides and leucine-rich repeat-containing, G protein-coupled recept
74 , Epithelial cell adhesion molecule (EpCAM), Leucine-rich repeated-containing G-protein coupled recep
75 ng on the NLRX1 (nucleotide-binding, lots of leucine-rich repeats-containing protein member X1)-TUFM
76 the contributions of two recently identified leucine-rich-repeat-containing (LRRC) regulatory gamma s
78 activation of the nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR), pyrin-dom
80 1 component (S519C16) of S519 with the first leucine-rich repeat domain (L1) of the insulin receptor.
81 alpha dissociation and unfolds the GPIbalpha leucine-rich repeat domain (LRRD) and juxtamembrane mech
83 through two identified binding sites in its leucine-rich repeat domain and regulating collagen fibri
87 nt interface specifically formed between the leucine-rich repeat domain of FBXL2 and PTAR1, which unm
88 flammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independ
89 tartan (trn), which encodes a transmembrane leucine-rich repeat domain protein that mediates cell-ce
90 domain gene product containing an N-terminal leucine-rich repeat domain, followed by a likely posttra
91 this study, we show that Scrib, through its leucine-rich repeat domain, forms a complex in vivo with
92 e plant can evolve nucleotide-binding domain-leucine-rich repeat domain-containing proteins to recogn
97 in NLRP1, encoding Nucleotide-Binding Domain Leucine-Rich Repeat Family Pyrin Domain-Containing 1.
98 tf13, defining it as an F-box protein of the leucine-rich-repeat family, and demonstrates how a novel
99 hibitor Flightless-1 and its binding partner leucine-rich repeat flightless-interacting protein 2.
100 The NLRs or NBS-LRRs (nucleotide-binding, leucine-rich-repeat) form the largest resistance gene fa
102 length, with the most significant being the leucine rich repeat gene, LRRC34 (p = 3.69 x 10(-18)).
103 d genes included 639 nucleotide-binding site leucine-rich repeat genes (NBS-LRRs), 290 receptor-like
104 and 56% (343) of 616 nucleotide-binding site-leucine-rich repeat genes harbored at least one Tnt1 ins
106 ponse proteins, including nucleotide-binding leucine-rich repeat immune receptors, oxidative and DNA
107 eptor-related alpha, flightless-1 (FLII) and leucine-rich-repeat-(in FLII)-interacting-protein-1 as a
108 h NLRP10 is the only NLR protein lacking the leucine rich repeats, it has been implicated in multiple
111 Pase domain Ras of complex proteins (ROC) of leucine rich repeat kinase 2 (LRRK2) result in an abnorm
130 ortem PD patients' substantia nigra; and (b) leucine-rich repeat kinase 2 (LRRK2) gene identified pat
134 The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied ex
136 emical studies implicate alpha-synuclein and leucine-rich repeat kinase 2 (LRRK2) in late-onset PD.
149 tions in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise t
150 We found that the Parkinson's disease gene, leucine-rich repeat kinase 2 (LRRK2), has an unexpected
151 unknown, but several genetic loci, including leucine-rich repeat kinase 2 (LRRK2), have been identifi
154 al effects of a common PD-linked mutation of leucine-rich repeat kinase 2 in the mouse hippocampus, a
158 cleotide variant (SNV) within the C-terminal leucine rich repeat (LRR) domain is responsible for the
160 a domain swap and point mutations, that the leucine-rich repeat (LRR) 5 region comprises an importan
162 most N-terminal domain of Reck binds to the leucine-rich repeat (LRR) and immunoglobulin (Ig) domain
164 SHR4z has significant homology to the short leucine-rich repeat (LRR) domain of SOMATIC EMBRYOGENESI
166 is repressed by a flanking substrate-binding leucine-rich repeat (LRR) domain when substrate is absen
168 PI)-ANCHORED PROTEINS (LLG) complexes, or by leucine-rich repeat (LRR) extensin proteins (LRXs).
172 port isolation and identification of a novel Leucine-Rich Repeat (LRR) protein that directly interact
175 The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin
176 n in the nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing (NLR) inflammasome
177 his study, we identified LRRC25, a member of leucine-rich repeat (LRR)-containing protein family, as
178 subgroup of nucleotide-binding domain (NBD), leucine-rich repeat (LRR)-containing proteins (NLRs) att
180 ated promoter::GUS transgenic plants for all leucine-rich repeat (LRR)-RLKs in Arabidopsis and analyz
182 I), an actin-binding protein that contains a leucine-rich-repeat (LRR), which binds R-ras and may reg
186 scaffold protein composed almost entirely by leucine-rich repeats (LRRs) and having an N-terminal reg
187 d cytoplasmic protein that contains multiple leucine-rich repeats (LRRs) and interacts with integrin-
188 c screen for genes encoding proteins bearing leucine-rich repeats (LRRs) and nucleotide-binding domai
189 usly expressed transmembrane protein with 17 leucine-rich repeats (LRRs) at its C-terminal end and is
191 idues on the concave surfaces of neighboring leucine-rich repeat modules assists in stabilizing the o
197 ost most of the conserved nucleotide-binding leucine-rich repeat (NLR) genes that are known to be inv
206 stance genes encoding nucleotide-binding and leucine-rich repeat (NLR) intracellular immune receptor
208 autoimmunity through the nucleotide-binding leucine-rich repeat (NLR) protein SUMM2 and the MAPK kin
209 ition of XopQ 1 (Roq1), a nucleotide-binding leucine-rich repeat (NLR) protein with a Toll-like inter
217 stance genes encoding for nucleotide-binding leucine-rich repeat (NLR) proteins hampers their predict
221 nce is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune
223 ivation of the nucleotide-binding domain and leucine-rich repeat (NLR) pyrin family domain 3 (NLRP3)
224 coding a coiled-coil nucleotide binding site Leucine-rich repeat (NLR) receptor protein that was alte
226 r proteins of the nucleotide-binding domain, leucine-rich repeat (NLR) superfamily to detect many typ
228 OUS MIX2 (DM2) nucleotide-binding domain and leucine-rich repeat (NLR)-encoding locus in A. thaliana.
229 existing phytohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity
230 ique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial
231 rs designated "nucleotide-binding domain and leucine-rich repeat" (NLR) proteins that translate patho
233 epigenetic regulation of nucleotide-binding leucine rich repeat or Nod-Like Receptor (NLR) genes as
237 r matrix component proline/arginine-rich end leucine-rich repeat protein (PRELP) is a novel antibacte
238 he EMT inducer Twist1 by enhancing F-box and leucine-rich repeat protein 14 (FBXL14)-mediated polyubi
241 ISLR2 (immunoglobulin superfamily containing leucine-rich repeat protein 2) and STRA6 (stimulated by
242 is capable of triggering NLRP3 (NLR-family, leucine-rich repeat protein 3) inflammasome activation a
243 usly unrecognized role for the transmembrane leucine-rich repeat protein Lapsyn in regulating mng dev
245 n this study, we demonstrated that PH domain leucine-rich repeat protein phosphatase (PHLPP), a novel
246 we identified pleckstrin homology domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) as a
247 that deletion of the gene encoding PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) prote
249 co-localization of Akt and PHLPP1 (PH domain leucine-rich repeat protein phosphatase isoform 1), a Se
250 iled multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoire involved in disea
251 1.2 encodes a coiled-coil nucleotide-binding leucine-rich repeat protein that in addition to potato a
252 rice gene Xa1, encoding a nucleotide-binding leucine-rich repeat protein, confers resistance against
254 c map of the entire folding landscape of the leucine-rich repeat protein, pp32 (Anp32), obtained by c
257 enes encoding coiled-coil nucleotide-binding leucine-rich repeat proteins designated CNL3 and CNL13.
258 ns, immunoglobulin superfamily proteins, and leucine-rich repeat proteins, as well as their associate
259 s in the expansion of nucleotide-binding and leucine-rich-repeat proteins (NLRs), the major disease-r
260 ulators of the nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 inflammaso
261 and activate the nucleotide-binding domain, leucine-rich repeat pyrin domain-containing 3 (NLRP3) in
262 1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (
265 ovo assembly of complete nucleotide-binding, leucine-rich repeat receptor (NLR) genes, their regulato
269 by direct binding to the membrane-localized leucine-rich repeat receptor kinases, PEP RECEPTOR1 (PEP
270 ant responses, we identified a corresponding leucine-rich repeat receptor, termed INR, specific to se
272 n of the plasma membrane-localized, atypical leucine-rich repeat receptor-like kinase POLLEN-SPECIFIC
273 d to a shoot receptor complex containing the leucine-rich repeat receptor-like kinase SUNN, triggerin
276 st to G protein activation in animals, plant leucine-rich repeat receptor-like kinases (LRR RLKs), no
277 nases expanded massively in land plants, and leucine-rich repeat receptor-like kinases (LRR-RLK) cons
280 the CLE family interacting with CLAVATA1 and leucine-rich repeat receptor-like kinases (LRR-RLKs).
282 ts in Arabidopsis, and identified HPCA1 as a leucine-rich-repeat receptor kinase belonging to a previ
284 Here we report FASCIATED EAR3 (FEA3), a leucine-rich-repeat receptor that functions in stem cell
285 s, RGF1 INSENSITIVEs (RGIs), a clade of five leucine-rich-repeat receptor-like kinases, in promoting
287 ction using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or in
288 innate immunity relies on nucleotide binding leucine-rich repeat receptors (NLRs) that recognize path
289 i, including proteins putatively involved in leucine-rich repeat recognition activity, second messeng
291 ike mechanism that employs flanking variable leucine-rich repeat sequences as templates in associatio
292 cluding genes putatively encoding NB-ARC and leucine-rich repeat sequences, protein kinases and defen
293 PR library targeting the immunity-associated leucine-rich repeat subfamily XII genes, heritable mutat
297 ds to two transcellular ligands: fibronectin leucine-rich repeat transmembrane proteins (FLRTs) and t
298 ules neurexin-1beta, neuroligin-1 (Nlg1) and leucine-rich-repeat transmembrane protein 2 (LRRTM2) in
299 LAT); B-cell CLL/lymphoma 11B (BCL11B); RGD, leucine-rich repeat, tropomodulin domain, and proline-ri
300 hocyte receptors (VLRs) composed of variable leucine-rich repeats, which are differentially expressed