ライフサイエンスコーパス: leucyl-tRNA

1 85% of RNAP III transcription activity using leucyl-tRNA as a template.

2 rom Methanobacterium thermoautotrophicum and leucyl tRNA derived from Halobacterium sp. NRC-1 as an o

3 sma KIC enrichment most accurately predicted leucyl-tRNA enrichment, whereas plasma Leu enrichment wa

4 f E. coli TruA in complex with two different leucyl tRNAs in conjunction with functional assays and c

5 convenient and reliable surrogate measure of leucyl-tRNA in liver.

6 lytic turnover, thus inhibiting synthesis of leucyl-tRNA(Leu) and consequentially blocking protein sy

7 use HSPE71, Rat RhoGAP protein, S cerevisiae leucyl tRNA synthetase and S cerevisiae chromosome II OR

8 carboxy-terminal domain (Cterm) of human mt-leucyl tRNA synthetase rescues the pathologic phenotype

9 gnment we have analyzed the Candida albicans leucyl-tRNA synthetase (CaLeuRS) gene (CaCDC60).

10 Human mitochondrial leucyl-tRNA synthetase (hs mt LeuRS) achieves high amino

11 er the overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) in the cytoplasmic hybrid

12 Escherichia coli leucyl-tRNA synthetase (LeuRS) aminoacylates up to six d

13 Yeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron a

14 c and editing activities of Escherichia coli leucyl-tRNA synthetase (LeuRS) demonstrate that the enzy

15 Leucyl-tRNA synthetase (LeuRS) has been identified as a

16 Leucyl-tRNA synthetase (LeuRS) has evolved an editing fu

17 Mitochondrial leucyl-tRNA synthetase (LeuRS) in the yeast Saccharomyce

18 Leucyl-tRNA synthetase (LeuRS) is a class I enzyme, whic

19 Leucyl-tRNA synthetase (LeuRS) is an essential RNA splic

20 In one case, Mycoplasma mobile leucyl-tRNA synthetase (LeuRS) is uniquely missing its e

21 Leucyl-tRNA synthetase (LeuRS) misactivates non-leucine

22 Leucyl-tRNA synthetase (LeuRS) performs dual essential r

23 Leucyl-tRNA synthetase (LeuRS) relies on its editing fun

24 this biocontrol agent targets A. tumefaciens leucyl-tRNA synthetase (LeuRS), an essential enzyme for

25 In leucyl-tRNA synthetase (LeuRS), editing activities that

26 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetas

27 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetas

28 a unique tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer

29 thanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS).

30 synthetase (GluRS):tRNA(Glu) and an archaeal leucyl-tRNA synthetase (LeuRS):tRNA(Leu) complex.

31 lpha was found to form a stable complex with leucyl-tRNA synthetase (LeuRS; K(D) = 0.7 microM).

32 ulting from cancer-associated MTOR mutations.Leucyl-tRNA synthetase (LRS) is a leucine sensor of the

33 Leucyl-tRNA synthetase (LRS) is known to function as leu

34 The yeast mitochondrial leucyl-tRNA synthetase (ymLeuRS) performs dual essential

35 Binding of gold-labeled tRNA(Leu) places leucyl-tRNA synthetase and the bifunctional glutamyl-/pr

36 ein, different mutations in Escherichia coli leucyl-tRNA synthetase are combined to unmask the pretra

37 of onychomycosis, inhibits yeast cytoplasmic leucyl-tRNA synthetase by formation of a stable tRNA(Leu

38 he collective motion in Thermus thermophilus leucyl-tRNA synthetase by studying the low frequency nor

39 We present structures of leucyl-tRNA synthetase complexed with analogs of the dis

40 These mutations that altered or abolished leucyl-tRNA synthetase editing were introduced into comp

41 overcome this limitation, we have adapted a leucyl-tRNA synthetase from Methanobacterium thermoautot

42 n identified a mutation in the mitochondrial leucyl-tRNA synthetase gene (lrs-2) that impaired mitoch

43 ell, Bonfils et al. and Han et al. implicate leucyl-tRNA synthetase in this evolving story.

44 A point mutation in CP1 of class I leucyl-tRNA synthetase inactivates deacylase activity an

45 rving cells of leucine or treating them with leucyl-tRNA synthetase inhibitors did not elicit nuclear

46 ted that the transfer of human mitochondrial leucyl-tRNA synthetase into the cybrid cells carrying th

47 cid editing active site for Escherichia coli leucyl-tRNA synthetase resides within the CP1 domain tha

48 tational analysis within yeast mitochondrial leucyl-tRNA synthetase showed that the enzyme has mainta

49 ed conformational changes of T. thermophilus leucyl-tRNA synthetase upon substrate binding and analyz

50 red the refolding of the human mitochondrial leucyl-tRNA synthetase variant H324Q to that of wild typ

51 hreonine-rich region of the Escherichia coli leucyl-tRNA synthetase's CP1 domain that is hypothesized

52 4-Azaleucine, a competitive inhibitor of leucyl-tRNA synthetase, surprisingly triggered the heat

53 be aminoacylated by the human mitochondrial leucyl-tRNA synthetase, we examined the aminoacylation k

54 e mechanochemical motions in T. thermophilus leucyl-tRNA synthetase.

55 nate amino acids that can be misactivated by leucyl-tRNA synthetase.

56 he ser-tRNACAG and preventing binding of the leucyl-tRNA synthetase.

57 d mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase: homozygous c.1565C>A (p.Thr522As

58 y a constitutive protein complex composed of leucyl-tRNA-synthetase and folliculin, which regulates m

59 erminal domain extension is required by most leucyl-tRNA synthetases (LeuRS) for aminoacylation.

60 cluding a complex between prolyl-(ProRS) and leucyl-tRNA synthetases (LeuRS) in Methanothermobacter t

61 Aminoacylation and editing by leucyl-tRNA synthetases (LeuRS) require migration of the

62 Leucyl-tRNA synthetases (LeuRSs) have an essential role

63 Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in

64 ing pocket within the editing active site of leucyl-tRNA synthetases (LeuRSs).

65 Leucyl-tRNA synthetases have a hydrolytic active site th

66 is activated by methionyl-, isoleucyl-, and leucyl-tRNA synthetases in vivo.

67 editing of mischarged tRNA similar to other leucyl-tRNA synthetases.

68 out mischarging by glycyl-, glutaminyl-, and leucyl-tRNA synthetases.