ライフサイエンスコーパス: leukemia inhibitory factor

1 tor, vascular endothelial growth factor, and leukemia inhibitory factor).

2 B activation of E-cadherin was responsive to leukemia inhibitory factor.

3 cts of sweat gland-containing footpads or by leukemia inhibitory factor.

4 K2 induced by GH but not interferon-gamma or leukemia inhibitory factor.

5 onists like endothelin-1, phenylephrine, and leukemia inhibitory factor.

6 of the IL-6-type cytokines, IL-6, IL-11, and leukemia inhibitory factor.

7 sufficient to induce both interleukin-6 and leukemia inhibitory factor.

8 ptin sustains pluripotency in the absence of leukemia inhibitory factor.

9 L-17, increasing production of IFN-gamma and leukemia inhibitory factor.

10 f-renewal to differentiation upon removal of leukemia inhibitory factor.

11 , including interleukin 6, oncostatin M, and leukemia inhibitory factor.

12 ertrophic agonists such as phenylephrine and leukemia inhibitory factor.

13 s in the absence of feeder cells, serum, and leukemia inhibitory factor.

14 g conditions, specifically in the absence of leukemia inhibitory factor.

15 IL-6, IL-8, cyclooxygenase 1 (COX-1), COX-2, leukemia inhibitory factor 1, transforming growth factor

16 On this background, T3, NE, and leukemia inhibitory factor activate hypertrophy with dif

17 y, including ciliary neurotrophic factor and leukemia inhibitory factor, also cause a transient initi

18 ytokine receptor gp130 and the receptors for leukemia inhibitory factor and granulocyte colony-stimul

19 weeks in stromal cultures in the presence of leukemia inhibitory factor and IL-6.

20 ix production but opposite effects regarding leukemia inhibitory factor and insulin-like growth facto

21 -F442A fibroblasts with growth hormone (GH), leukemia inhibitory factor and interferon-gamma.

22 ses to other gp130-signaling cytokines (e.g. leukemia inhibitory factor and interleukin 11).

23 potency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum

24 newal of pluripotent cells in the absence of leukemia inhibitory factor, and directly regulated mouse

25 ctor-alpha, transforming growth factor-beta, leukemia inhibitory factor, and IL-11 did not increase b

26 amily cytokines ciliary neurotrophic factor, leukemia inhibitory factor, and IL-11 have been identifi

27 actors, such as ciliary neurotrophic factor, leukemia inhibitory factor, and insulin, that are essent

28 de IL-6, IL-11, ciliary neurotrophic factor, leukemia inhibitory factor, and oncostatin M (OSM).

29 -JAK/STAT3 signaling pathway, interleukin-6, leukemia inhibitory factor, and oncostatin M were elevat

30 hat stimulate megakaryopoiesis (IL-6, IL-11, leukemia inhibitory factor, and oncostatin M) bind to re

31 rative factors insulin-like growth factor 1, leukemia inhibitory factor, and urokinase-type plasminog

32 mbryonic stem cells by fibronectin, laminin, leukemia-inhibitory factor, and fibroblast growth factor

33 in Q344ter mice was slowed by Axokine and by leukemia inhibitory factor; and the degeneration in a fe

34 Oncostatin M (OSM) and leukemia inhibitory factor are pleiotropic cytokines tha

35 both by the induction of an "injury factor," leukemia inhibitory factor, as shown previously, and by

36 c factor (CNTF), Axokine (a mutein of CNTF), leukemia inhibitory factor, basic fibroblast growth fact

37 , application of factors that activate gp130/leukemia inhibitory factor beta (LIFbeta) heterodimeric

38 Notably, leukemia inhibitory factor, but not interferon-gamma, al

39 n of the differentiation-associated cytokine leukemia inhibitory factor by atopic fibroblasts.

40 s containing interleukin-3 (IL-3), IL-6, and leukemia inhibitory factor contained a mean of 75% of un

41 rs of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory factor cytokine family regulate glio

42 HepG2 cells stimulated with oncostatin M or leukemia inhibitory factor, cytokines which also use gp1

43 Here we report the production of leukemia inhibitory factor-dependent, so-called naive ty

44 Supplementation of KM with leukemia inhibitory factor elicited lineage restriction

45 In contrast, leukemia inhibitory factor fails to activate Akt or prom

46 of differentiation through the withdrawal of leukemia-inhibitory factor for 6 or more days.

47 n vitro differentiation following removal of leukemia inhibitory factor from the growth media.

48 lia can stably self-renew in the presence of leukemia inhibitory factor, GSK3 inhibitor (CHIR99021),

49 Leukemia inhibitory factor has been utilized to maintain

50 layers in the presence of human recombinant leukemia inhibitory factor, human recombinant basic fibr

51 not proliferate in the absence of exogenous leukemia inhibitory factor in an in vitro methylcellulos

52 sulin-like growth factor (IGF)-1, IGF-2, and leukemia inhibitory factor in medulloblastoma cells, but

53 n osteoblasts, also induce interleukin-6 and leukemia inhibitory factor in these cells.

54 he cytokines ciliary neurotrophic factor and leukemia inhibitory factor increases expression of endog

55 (NE) through a beta-adrenergic receptor, and leukemia inhibitory factor induced hypertrophy by a 20%

56 e of its soluble receptor), but not IL-1 nor leukemia inhibitory factor, induced Akt phosphorylation

57 le collagens, matrix metalloproteinases, and leukemia inhibitory factor, insulin-like growth factor 1

58 In response to GH and leukemia inhibitory factor, IRS-2 is immediately phospho

59 d transient stimulation of interleukin-6 and leukemia inhibitory factor is inhibited by actinomycin D

60 , but in some experiments minor increases in leukemia inhibitory factor levels were observed.

61 Cortical progenitors begin to interpret leukemia inhibitory factor (LIF) and bone morphogenetic

62 d underlying signal transduction pathways of leukemia inhibitory factor (LIF) and bone-morphogenic pr

63 The CDFs leukemia inhibitory factor (LIF) and ciliary neurotrophi

64 Our data indicate that leukemia inhibitory factor (LIF) and ciliary neurotrophi

65 ranscription factor pathway are activated by leukemia inhibitory factor (LIF) and contribute to mouse

66 Activation of the receptors for leukemia inhibitory factor (LIF) and IL-11 is essential

67 unts of the IL-6 family cytokines, including Leukemia inhibitory factor (LIF) and Interleukin 6 (IL-6

68 the expression of the neuropoietic cytokines leukemia inhibitory factor (LIF) and its receptor (LIFR)

69 Leukemia inhibitory factor (LIF) and LIF receptors are e

70 Leukemia inhibitory factor (LIF) and LIF receptors have

71 We have shown recently that leukemia inhibitory factor (LIF) and oncostatin M (OSM),

72 rferon (IFN), but retained responsiveness to leukemia inhibitory factor (LIF) and remained LIF depend

73 egulation of cell cycle-associated genes and leukemia inhibitory factor (Lif) and revealed alteration

74 te that cYes kinase activity is regulated by leukemia inhibitory factor (LIF) and serum and is down-r

75 t NPC patients had increased serum levels of leukemia inhibitory factor (LIF) and that higher LIF lev

76 vivo stem cell expansion are the addition of leukemia inhibitory factor (LIF) and the AC6.21 stromal

77 ences of nerve transection: the induction of leukemia inhibitory factor (LIF) and the reduction in th

78 We have found that leukemia inhibitory factor (LIF) and transforming growth

79 Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are IL-6 family members

80 onic stem cells in response to withdrawal of leukemia inhibitory factor (LIF) as a differentiation si

81 r identification of the IL-6 family cytokine leukemia inhibitory factor (LIF) as a serum predictor of

82 y upregulated with IL-6 pointed to STAT4 and leukemia inhibitory factor (LIF) as potentially linked.

83 ve determined the crystal structure of human leukemia inhibitory factor (LIF) bound to the cytokine b

84 The receptor for leukemia inhibitory factor (LIF) consists of two polypep

85 is a new member of the interleukin 6 (IL-6)/leukemia inhibitory factor (LIF) cytokines, which activa

86 ress DeltaEGFR each also express IL-6 and/or leukemia inhibitory factor (LIF) cytokines.

87 nterleukin-6 (IL-6), oncostatin M (OSM), and leukemia inhibitory factor (LIF) direct the formation of

88 The cytokine leukemia inhibitory factor (LIF) drives self-renewal of

89 Leukemia inhibitory factor (LIF) expression in the uteru

90 hat five of the up-regulated miRNAs targeted leukemia inhibitory factor (LIF) expression.

91 es of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory factor (LIF) family have been shown

92 Because leukemia inhibitory factor (LIF) has little or no effect

93 -2 mutation (Shp-2(Delta46-110)) demonstrate leukemia inhibitory factor (LIF) hypersensitivity and in

94 The role of the cytokine leukemia inhibitory factor (LIF) in axotomy-induced spro

95 Previous work has implicated the cytokine leukemia inhibitory factor (LIF) in cutaneous inflammati

96 PROK1 induces expression of leukemia inhibitory factor (LIF) in endometrial epitheli

97 We recently described the expression of leukemia inhibitory factor (LIF) in human fetal and muri

98 We have investigated the role of leukemia inhibitory factor (LIF) in postnatal neuronal d

99 At these doses, mRNA levels of leukemia inhibitory factor (LIF) increased.

100 ch NPs expand after H-I and to determine how leukemia inhibitory factor (LIF) insufficiency affects t

101 Leukemia inhibitory factor (LIF) is a cytokine involved

102 Leukemia inhibitory factor (LIF) is a pleiotropic cytoki

103 Leukemia inhibitory factor (LIF) is a pleiotropic neuroi

104 Here we demonstrate that leukemia inhibitory factor (LIF) is a potent endogenous

105 The uterine expression of leukemia inhibitory factor (LIF) is essential for embryo

106 Leukemia inhibitory factor (LIF) is produced by a large

107 Leukemia inhibitory factor (LIF) is required, but not su

108 erleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with

109 The cytokine leukemia inhibitory factor (LIF) modulates glial and neu

110 which ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) negatively regulate the

111 d the effects of overexpressing the cytokine leukemia inhibitory factor (LIF) on adult neurogenesis i

112 differentiation in response to withdrawal of leukemia inhibitory factor (LIF) or bone morphogenetic p

113 be induced in culture either by exposure to leukemia inhibitory factor (LIF) or by deprivation of ne

114 conditioned medium from mice lacking either leukemia inhibitory factor (LIF) or LIF and ciliary neur

115 stem (ES) cells in vitro requires exogenous leukemia inhibitory factor (LIF) or related cytokines.

116 erentiated pluripotent state is dependent on leukemia inhibitory factor (LIF) or related cytokines.

117 on-promoting conditions by the withdrawal of Leukemia Inhibitory Factor (LIF) or treatment with retin

118 Leukemia inhibitory factor (LIF) promotes differentiated

119 Leukemia inhibitory factor (LIF) promotes giant cell dif

120 eceptor complex, glycoprotein130 (gp130) and leukemia inhibitory factor (LIF) receptor, on cardiac fi

121 rophage chemoattractant protein-1 (MCP-1) or leukemia inhibitory factor (LIF) reduced this activity t

122 oid potential has indicated that exposure to leukemia inhibitory factor (LIF) results in the upregula

123 o exhibit increased Wnt expression, enhanced leukemia inhibitory factor (LIF) sensitivity, and reduce

124 Bone morphogenetic protein (BMP) and leukemia inhibitory factor (LIF) signaling both promote

125 sets suggested interaction between Tet1 and leukemia inhibitory factor (LIF) signaling.

126 how here that treatment of 3T3-L1 cells with leukemia inhibitory factor (LIF) stimulated Raf-1 activi

127 em (ES) cells, in which BMP4 synergizes with leukemia inhibitory factor (LIF) to maintain self-renewa

128 ations of basic fibroblast growth factor and leukemia inhibitory factor (LIF) to proliferate and unde

129 The addition of leukemia inhibitory factor (LIF) to purified CD34(+) thy

130 linked to the luciferase reporter, we showed leukemia inhibitory factor (LIF) to strongly potentiate

131 Previously, we reported that delivery of leukemia inhibitory factor (LIF) to the CNS stimulates t

132 gh it is generally accepted that addition of leukemia inhibitory factor (LIF) together with either se

133 Leukemia inhibitory factor (LIF) was critical for prolif

134 IL-6, sIL-6R, oncostatin M (OSM), IL-11, and leukemia inhibitory factor (LIF) was determined by rever

135 Ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) were investigated to te

136 ESCs) initiated normal differentiation after leukemia inhibitory factor (LIF) withdrawal but, unlike

137 4 and Dab2, and express much less Fgf5 after leukemia inhibitory factor (LIF) withdrawal.

138 heterogeneous onset of differentiation after leukemia inhibitory factor (LIF) withdrawal.

139 Leukemia inhibitory factor (LIF), a critical implantatio

140 n mice through transcriptional regulation of leukemia inhibitory factor (LIF), a cytokine crucial for

141 The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signalin

142 igated the mannose phosphorylation status of leukemia inhibitory factor (LIF), a previously identifie

143 One of these candidates is leukemia inhibitory factor (LIF), a pro-inflammatory cyt

144 onstrated that the proinflammatory cytokine, leukemia inhibitory factor (LIF), affects the hypothalam

145 Leukemia inhibitory factor (LIF), an interleukin-6 famil

146 ell types and includes interleukin-6 (IL-6), leukemia inhibitory factor (LIF), and granulocyte-colony

147 tokines, including IL-6, oncostatin M (OSM), leukemia inhibitory factor (LIF), and IL-11, have fibrog

148 Oncostatin M (OSM), leukemia inhibitory factor (LIF), and interleukin-6 (IL-

149 erleukin 6 (IL-6) family of cytokines, IL-6, leukemia inhibitory factor (LIF), and oncostatin M, act

150 itors were identified as oncostatin M (OSM), leukemia inhibitory factor (LIF), and transforming growt

151 gp130-signaling cytokines, IL-6, IL-11, and leukemia inhibitory factor (LIF), as well as with up-reg

152 in G418 and engineered to express zebrafish leukemia inhibitory factor (Lif), basic fibroblast growt

153 F) and significantly lower concentrations of leukemia inhibitory factor (LIF), basic fibroblast growt

154 In the presence of recombinant leukemia inhibitory factor (LIF), CAFC cloning efficienc

155 Activating ligands of gp130, including leukemia inhibitory factor (LIF), can block differentiat

156 cells or by one of the following cytokines: leukemia inhibitory factor (LIF), ciliary neurotrophic f

157 d by an excess of antibodies to IL-6, IL-11, leukemia inhibitory factor (LIF), gp130, stromal cell de

158 kin (IL)-6 family of cytokines (IL-6, IL-11, leukemia inhibitory factor (LIF), granulocyte colonystim

159 ting factor (G-CSF), stem cell factor (SCF), leukemia inhibitory factor (LIF), granulocyte-macrophage

160 uding ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF), induce the same phenot

161 Because leukemia inhibitory factor (LIF), like SDF-1, is secrete

162 he interleukin-6 (IL-6) family of cytokines, leukemia inhibitory factor (LIF), oncostatin M (OSM) and

163 e to interleukin-6 and -11 (IL-6 and IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), an

164 lly related proteins, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ci

165 6 (IL-6) family of cytokines, which includes Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ci

166 ocused on the activation of STATs 1 and 3 by leukemia inhibitory factor (LIF), oncostatin-M (OSM), an

167 members IL-11, IL-6, oncostatin M (OSM), and leukemia inhibitory factor (LIF), only OSM and LIF were

168 an undifferentiated state in the presence of leukemia inhibitory factor (LIF), or differentiate into

169 s for the receptors for growth hormone (GH), leukemia inhibitory factor (LIF), or interferon-gamma (I

170 ation of TNF, IL-1, and, to a lesser extent, leukemia inhibitory factor (LIF), produced a prompt and

171 IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory factor (LIF), signal via the common

172 in vitro with media containing the cytokine leukemia inhibitory factor (LIF), which propagates the p

173 The cytokine leukemia inhibitory factor (LIF), which stimulates MEK5

174 during delayed implantation and in pregnant, leukemia inhibitory factor (LIF)-deficient mice with imp

175 nic sympathetic axotomy leads to a prolonged leukemia inhibitory factor (LIF)-dependent activation of

176 viral or episomal reprogramming), which uses leukemia inhibitory factor (LIF)-expressing SNL feeders,

177 Leukemia inhibitory factor (LIF)-induced activation of J

178 h factor (FGF)-ERK1/2 pathway, PI3K-AKT, the leukemia inhibitory factor (LIF)-JAK-STAT3 axis, Wnt-GSK

179 SOCS-3 is a novel intracellular regulator of leukemia inhibitory factor (LIF)-mediated proopiomelanoc

180 early points of differentiation, conducting leukemia inhibitory factor (LIF)-stimulated biochemical

181 ignals for self-renewal are generated by the leukemia inhibitory factor (LIF).

182 with both epidermal growth factor (EGF) and leukemia inhibitory factor (LIF).

183 s and was identified by mass spectrometry as leukemia inhibitory factor (LIF).

184 ing intermediates following stimulation with leukemia inhibitory factor (LIF).

185 ophy and antiapoptotic phenotypes induced by leukemia inhibitory factor (LIF).

186 quencing of one such factor identified it as leukemia inhibitory factor (LIF).

187 by ciliary neurotrophic factor (CNTF) or by leukemia inhibitory factor (LIF).

188 an undifferentiated state in the presence of leukemia inhibitory factor (LIF).

189 to the differentiation suppressing effect of leukemia inhibitory factor (LIF).

190 ukin-6, interleukin-11, cardiotrophin-1, and leukemia inhibitory factor (LIF).

191 rleukin (IL)-3, IL-6, c-kit ligand (KL), and leukemia inhibitory factor (LIF).

192 ugh transcriptional up-regulation of uterine leukemia inhibitory factor (LIF).

193 but not at Thr308, in NRVMs stimulated with leukemia inhibitory factor (LIF).

194 c stem (ES) cells downstream of the cytokine leukemia inhibitory factor (LIF).

195 renewal and alleviates their requirement for leukemia inhibitory factor (LIF).

196 r pluripotency by the supplementation of the leukemia inhibitory factor (LIF).

197 ty in axons that is mediated by the cytokine leukemia inhibitory factor (LIF).

198 autocrine/paracrine pathway mediated by the leukemia inhibitory factor (LIF)/JAK/STAT pathway.

199 yer of ES cell aggregates independent of the leukemia inhibitory factor (LIF)/STAT3 pathway, it is la

200 ncy, which may occur in conjunction with the leukemia inhibitory factor (LIF)/Stat3 pathway.

201 Moreover, it provides a mechanism for how leukemia inhibitory factor (LIF)/STAT3 signaling reaches

202 Both cell types secreted leukemia inhibitory factor (Lif); however, whereas Stat3

203 d full-length globular proteins [mCherry and leukemia inhibitory factor (LIF)].

204 Leukemia-inhibitory factor (LIF) is a member of the inte

205 TGF-beta plus EGF synergistically increased leukemia-inhibitory factor (LIF), additively increased I

206 related cytokines (i.e., oncostatin M [OSM], leukemia inhibitory factor [LIF], and IL-11).

207 Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], in

208 tiated when cultured in the presence of LIF (leukemia inhibitory factor), little metabolism of exogen

209 In the absence of leukemia inhibitory factor, mouse ES cells give rise to

210 cultured in standard conditions (serum plus leukemia inhibitory factor) or ground-state conditions,

211 Leukemia inhibitory factor plays a major role in the ute

212 ther as a homodimer or as a heterodimer with Leukemia Inhibitory Factor Receptor (LIF-R).

213 gnal using heterodimers of gp130 with either leukemia inhibitory factor receptor (LIFR) (type I) or o

214 receptor complexes, glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR) alpha and gp1

215 described that consists of a heterodimer of leukemia inhibitory factor receptor (LIFR) and gp130.

216 studies and clinical validation, we identify leukemia inhibitory factor receptor (LIFR) as a breast c

217 ed a placenta-specific enhancer in the human leukemia inhibitory factor receptor (LIFR) gene and now

218 Knockout of the leukemia inhibitory factor receptor (LIFR) gene results

219 ytokine family and signals through the gp130/leukemia inhibitory factor receptor (LIFR) heterodimer.

220 igodendrocyte survival through activation of leukemia inhibitory factor receptor (LIFR) signaling is

221 ophic factor receptor alpha (CNTFRalpha) and leukemia inhibitory factor receptor (LIFR) was studied i

222 ocyte cell surface, but failed to detect the leukemia inhibitory factor receptor (LIFR).

223 th induction by OSM depends on both types I [leukemia inhibitory factor receptor (LIFR)] and II [OSM

224 rious cytoplasmic domains of either gp130 or leukemia inhibitory factor receptor alpha (LIFR) were us

225 The cytokine receptor subunits gp130, leukemia inhibitory factor receptor alpha (LIFRalpha), a

226 link between the PTEN-Akt-FOXO axis and the leukemia inhibitory factor receptor beta (LIFRbeta)-STAT

227 phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal tra

228 ressive effect by directly targeting p63 and leukemia inhibitory factor receptor in RMS cells, which

229 was caused by placental defect with enhanced leukemia inhibitory factor receptor signaling.

230 Similarly, a leukemia inhibitory factor receptor subunit beta (LIFRbe

231 We further demonstrate that one of these, leukemia inhibitory factor receptor, can initiate functi

232 cluded adiponectin, lumican, plasminogen and leukemia inhibitory factor receptor.

233 opment, including GATA4, c-kit receptor, and leukemia inhibitory factor receptor.

234 of granulocyte colony-stimulating factor and leukemia inhibitory factor receptors, which are normally

235 identify TFE3 and TFEB as cell type-specific leukemia inhibitory factor-responsive activators of E-ca

236 newal of embryonal stem cells in response to leukemia inhibitory factor signaling and for proliferati

237 They are dependent on leukemia inhibitory factor signaling for maintenance of

238 by the bone morphogenetic protein (BMP) and leukemia inhibitory factor signaling pathways and the ex

239 rocal relationship between PPARdelta-AKT and leukemia inhibitory factor-STAT3 signaling pathways serv

240 Shp2 deficiency leads to upregulation of leukemia inhibitory factor-stimulated phosphatidylinosit

241 of mouse ES cells by removal of the cytokine leukemia inhibitory factor, there is a global increase i

242 We conclude that LIGHT overrides Leukemia inhibitory factor to induce ES cell differentia

243 rgy with host ciliary neurotrophic factor or leukemia inhibitory factor to promote neuronal survival

244 biquitously when cultured in the presence of leukemia inhibitory factor to suppress differentiation.

245 Ciliary neurotrophic factor and leukemia inhibitory factor, two cytokines critical to th

246 g hematopoietic lineages after withdrawal of leukemia inhibitory factor, using in vitro colony format

247 the fundamental role of fibroblast-secreted leukemia inhibitory factor was assessed by using small i

248 Although no change in leukemia inhibitory factor was observed throughout the d

249 actor alpha, interleukin 1 (IL-1), IL-6, and leukemia inhibitory factor, was markedly enhanced during

250 Levels of oncostatin M (OSM) and leukemia inhibitory factor were analyzed in patients wit

251 Two cytokines, interleukin-6 and leukemia inhibitory factor, which can induce phosphoryla

252 When PI3K/AKT1 signaling declines following leukemia inhibitory factor withdrawal, active GSK3beta a

253 f Cdk2ap1 in mESCs resulted in abrogation of leukemia inhibitory factor withdrawal-induced differenti

254 pression by osteoblasts of interleukin-6 and leukemia inhibitory factor without affecting the 16 othe