ライフサイエンスコーパス: leukocidin

1 mmon toxin genes, including Panton-Valentine leukocidin.

2 ec) typing, and PCR for the Panton-Valentine leukocidin.

3 shock syndrome toxin 1 and Panton-Valentine leukocidin.

4 yard regions as well as the Panton-Valentine leukocidin.

5 ll as toxic shock toxin and Panton-Valentine leukocidin.

6 shock syndrome toxin 1, and Panton-Valentine leukocidin.

7 B and HlgCB as major secreted staphylococcal leukocidins.

8 (DI = 0.566), positive for Panton-Valentine leukocidin (96.3%), and resistant to erythromycin (94.1%

9 Here we demonstrate that leukocidin A/B (LukAB) is required and sufficient for th

10 ement receptor 3, as a cellular receptor for leukocidin A/B (LukAB), an important toxin that contribu

11 In this study, we report that leukocidin A/B (LukAB), the most divergent member of the

12 peron, which encodes the recently identified leukocidin AB (LukAB).

13 igericin and the Staphylococcus aureus toxin leukocidin AB (LukAB).

14 A-MRSA, with an emphasis on Panton-Valentine leukocidin, alpha-hemolysin, and the recently discovered

15 nd translation of genes for Panton-Valentine leukocidin, alpha-hemolysin, and toxic-shock syndrome to

16 uced and prolonged mRNA for Panton-Valentine leukocidin, alpha-toxin, and toxic-shock syndrome toxin

17 , however, in expression of Panton-Valentine leukocidin and in the degree of inflammatory lung damage

18 a number of toxins, such as Panton-Valentine leukocidin and LukAB, that have specificity for human re

19 train with genes coding for Panton-Valentine leukocidin and the arginine catabolic mobile element.

20 A; all carried the gene for Panton-Valentine leukocidin and the gene complex for staphylococcal-casse

21 Although leukocidins and staphylococcal alpha-hemolysin share par

22 e vaginal isolate was mecA, Panton-Valentine leukocidin, and staphylococcal enterotoxin B and C negat

23 aureus which encode enterotoxins, exotoxins, leukocidins, and leukotoxins not found in S. epidermidis

24 Bicomponent pore-forming leukocidins are a family of potent toxins secreted by St

25 alt bridges, not found in other bi-component leukocidins, are essential for dimer formation in soluti

26 ructure of the oligomeric pore formed by the leukocidin examined here has diverged significantly from

27 ma to lungs made friable by Panton-Valentine leukocidin expressing S. aureus infection.

28 Panton-Valentine leukocidin expressing S. aureus pneumonia can cause seve

29 ients with sputum-confirmed Panton-Valentine leukocidin expressing S. aureus pneumonia managed with e

30 management of patients with Panton-Valentine leukocidin expressing S. aureus pneumonia with extracorp

31 xperience and outcomes with Panton-Valentine Leukocidin expressing S. aureus pneumonia.

32 Panton-Valentine leukocidin expressing Staphylococcus aureus pneumonia, a

33 d 2, and two proteins identified as putative leukocidin F and S subunits of the two-component leukoto

34 likely to be infected with Panton-Valentine leukocidin gene (pvl)-constitutive MRSA (19% versus 56%;

35 IV, 145 (35.9%) carried the Panton-Valentine leukocidin genes (PVL+), and 162 (40.1%) were identified

36 Cape Verde showed that (i) Panton-Valentine leukocidin genes were present in 35% of the isolates and

37 exotoxin gene profiles (eg, Panton Valentine leukocidin genes) compared with health care-associated i

38 Until now, six different leukocidins have been described, some of which are host

39 genes which included those for enterotoxins, leukocidins, hemolysins, and surface proteins and severa

40 and cannot produce virulence factors such as leukocidins, hemolysins, or the antioxidant staphyloxant

41 lence factors, particularly Panton-Valentine leukocidin, is common in CA-MRSA, emphasizing its potent

42 Staphylococcal leukocidin (Luk) and alpha-hemolysin (alphaHL) are membe

43 as the receptor for the S. aureus hemolytic leukocidins LukED and HlgAB.

44 e genes encoding the F and S components of a leukocidin, LukF (HlgB) and LukS (HlgC), a pore-forming

45 identify and characterise a novel S. aureus leukocidin; LukPQ.

46 mponent pore-forming toxins Panton-Valentine leukocidin LukSF-PV (PVL) and gamma-hemolysin CB (HlgCB)

47 Neither Panton-Valentine leukocidin nor protein A expression was essential, but i

48 The bi-component leukocidins of Staphylococcus aureus are important virul

49 es tested were positive for Panton-Valentine leukocidin, of which 90% carried staphylococcal chromoso

50 sis (PFGE), spa typing, and Panton-Valentine leukocidin PCR.

51 In addition, the leukocidin pore is weakly cation selective and exhibits

52 Therefore, if the leukocidin pore were a cylinder, its diameter would be a

53 ed arcA and opp3, and 1 was Panton-Valentine leukocidin positive (PVL(+)).

54 solates belonged to the CC8/Panton-Valentine leukocidin-positive (PVL(+)) group of S. aureus clone US

55 e mec (SCCmec) type IV, and Panton-Valentine leukocidin-positive clustered separately from those that

56 of ciprofloxacin-sensitive Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus

57 Panton-Valentine leukocidin-positive USA300 strains caused 5 of the last

58 vasive infections caused by Panton-Valentine leukocidin-positive, community-associated, methicillin-r

59 Despite the loss of leukocidin production and staphyloxanthin biosynthesis,

60 ysins (HlgAB and HlgCB) and Panton-Valentine leukocidin (PVL or LukSF) were shown to assemble from so

61 ) and isolates positive for Panton-Valentine leukocidin (PVL) (P = 0.008).

62 coccal exotoxins, including Panton-Valentine leukocidin (PVL) and alpha-hemolysin (Hla), although sup

63 ed all strains were USA300, Panton-Valentine leukocidin (PVL) and arginine catabolic mobile element (

64 pa) typing and detection of Panton-Valentine leukocidin (PVL) and scn genes.

65 s aureus strains expressing Panton-Valentine leukocidin (PVL) are associated with severe skin and sof

66 ureus (MRSA) expressing the Panton-Valentine leukocidin (PVL) are rampant, but the contribution of PV

67 nent CA-MRSA strain encodes Panton-Valentine leukocidin (PVL) cytotoxin genes, belongs to pulsed fiel

68 some mec (SCCmec) types and Panton-Valentine leukocidin (PVL) gene carriage were compared among suspe

69 The lukF/lukS Panton-Valentine leukocidin (PVL) genes did not directly correlate with t

70 microdilution, detection of Panton-Valentine leukocidin (PVL) genes, arginine catabolic mobile elemen

71 , as well as assays for the Panton-Valentine leukocidin (PVL) genes, the protein A gene (spa), and ar

72 sociated with SCCmec IV and Panton-Valentine leukocidin (PVL) genes.

73 sition of the phage-encoded Panton-Valentine leukocidin (PVL) genes.

74 ted for the presence of the Panton-Valentine leukocidin (PVL) genes.

75 The role of the Panton Valentine leukocidin (PVL) in CA-MRSA pathogenesis is a matter of

76 The role of Panton-Valentine leukocidin (PVL) in determining the severity and outcome

77 The role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus infections is

78 sThe role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis i

79 The Panton-Valentine leukocidin (PVL) is a cytotoxin expressed by many methic

80 have hypothesized that the Panton-Valentine leukocidin (PVL) is a key virulence determinant in CA-MR

81 The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by str

82 Panton-Valentine leukocidin (PVL) is a two-component cytolytic toxin epid

83 The S. aureus toxin Panton-Valentine leukocidin (PVL) is most likely causative for necrotizin

84 or a bacteriophage encoding Panton-Valentine leukocidin (PVL) lysogenized into its chromosome (propha

85 al susceptibility patterns, Panton-Valentine leukocidin (PVL) occurrence, and staphylococcal cassette

86 The impact of Panton-Valentine leukocidin (PVL) on the outcome in Staphylococcus aureus

87 mec type IV, and 61.5% were Panton Valentine leukocidin (PVL) positive.

88 Panton-Valentine leukocidin (PVL) production by methicillin-resistant Sta

89 l strains were subjected to Panton-Valentine leukocidin (PVL) screening, and SCCmec, pulsed-field gel

90 USA300 secretes Panton-Valentine leukocidin (PVL) toxin, which is associated with highly

91 Panton-Valentine leukocidin (PVL) was present in 21.9%, and vancomycin he

92 PV and lukF-PV encoding the Panton-Valentine leukocidin (PVL) were present in all CAMRSA SSTI isolate

93 Panton-Valentine leukocidin (PVL), a bacteriophage encoded toxin that has

94 Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered

95 CA-MRSA strains, expresses Panton-Valentine leukocidin (PVL), a pore-forming toxin that targets poly

96 were compared with those of Panton-Valentine leukocidin (PVL), a well-characterized S. aureus leukoto

97 detection of genes encoding Panton-Valentine leukocidin (PVL), and antimicrobial resistance determina

98 olic mobile element (ACME), Panton-Valentine leukocidin (PVL), and other toxins that may contribute t

99 )mec type IV, the genes for Panton-Valentine leukocidin (PVL), and the enterotoxin Q and K genes.

100 STI CA-MRSA strains produce Panton-Valentine leukocidin (PVL), but its contribution to CA-MRSA pathog

101 whether a virulence factor, Panton-Valentine leukocidin (PVL), could account for the high rates of MR

102 Panton-Valentine leukocidin (PVL), encoded by the lukSF-PV genes, is a pu

103 A single toxin, Panton-Valentine leukocidin (PVL), has been linked by epidemiological stu

104 virulence factors, such as Panton-Valentine leukocidin (PVL), have been proposed to drive this epide

105 cytolytic toxins, including Panton-Valentine leukocidin (PVL), leukotoxin GH (LukGH; also known as Lu

106 [SCCmecIV]) and carried the Panton-Valentine leukocidin (pvl), lukD, and lukE genes, but no other tox

107 the USA300 characteristics Panton-Valentine leukocidin (PVL), SCCmec IVa, the arginine catabolic mob

108 la), delta-hemolysin (Hld), Panton Valentine leukocidin (PVL), staphylococcal enterotoxin C-1 (SEC-1)

109 phoresis (PFGE) and PCR for Panton-Valentine leukocidin (PVL), the arginine catabolic mobile element

110 mecA and mupA and those for Panton-Valentine leukocidin (PVL), USA300, and USA400.

111 gene, encoding part of the Panton-Valentine leukocidin (PVL), was observed in the codY mutant.

112 MRSA LAC(WT) USA300 and its Panton-Valentine leukocidin (PVL)- and alpha-hemolysin (Hla)-negative iso

113 esistance, SCCmec type, and Panton-Valentine leukocidin (PVL)-producing genes on an S. aureus genome.

114 es for the virulence factor Panton-Valentine leukocidin (PVL).

115 in, secreted proteases, and Panton-Valentine leukocidin (PVL).

116 ns harboring genes encoding Panton-Valentine leukocidin (PVL).

117 arA, alpha-toxin (hla), and Panton-Valentine leukocidin (pvl).

118 , alpha-hemolysin (Hla) and Panton-Valentine leukocidin (PVL; LukF-PV/LukS-PV subunits), both premier

119 ype, toxin genes (e.g., for Panton-Valentine leukocidin [PVL]), and staphylococcal cassette chromosom

120 hereby challenging the current paradigm that leukocidin specificity is driven solely by the S-compone

121 romosome mec (SCCmec) type, Panton-Valentine leukocidin status, and multilocus sequence type.

122 We observed that, unlike other leukocidin subunits, recombinant LukH and LukG had low s

123 well as for the design of drugs antagonizing leukocidin toxicity.

124 to detect mecA, mecC, vanA, Panton-Valentine Leukocidin toxin (PVL), and toxic shock syndrome toxin-1

125 SCCmec type IV and the Panton-Valentine leukocidin toxin gene were detected in 98 percent of MRS

126 lates were positive for the Panton-Valentine leukocidin toxin genes and agr I.

127 ed 4 h after infection, and Panton-Valentine leukocidin was maximally expressed 72 h after infection,

128 e pore-forming properties of the recombinant leukocidin were also investigated with planar lipid bila

129 secreted toxins, including Panton-Valentine leukocidin, were highly expressed during superficial and

130 riage of the genes encoding Panton-Valentine leukocidin, while common among MRSA of PFGE type USA300,