ライフサイエンスコーパス: leukotriene C4

1 axis to CCL19 that was restored by exogenous leukotriene C4 .

2 A with one of its physiological substrates, leukotriene C4.

3 pe I receptors by the physiological trigger, leukotriene C4.

4 secrete Th2-type cytokines (IL-4, IL-13) and leukotriene C4.

5 strates by MRP1 and abrogated the binding of leukotriene C4.

6 be further stimulated by anticancer drugs or leukotriene C4.

7 NA and had elevated transport activities for leukotriene C4.

8 tion of the membrane-derived lipid mediator, leukotriene C4.

9 Mast cell production of leukotriene C4 20 min after activation or IL-6 16 h afte

10 displayed elevated transport activities for leukotriene C4, a known substrate for MRP.

11 of metabolism to the 5-lipoxygenase products leukotriene C4 and 5-HETE and in A23187-treated cells to

12 as well as for the glutathione S-conjugates leukotriene C4 and azidophenacyl-S-glutathione.

13 ions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid

14 Zymosan-induced generation of leukotriene C4 and prostaglandin E2 was attenuated appro

15 and tumor necrosis factor-alpha, as well as leukotriene C4 and thromboxane B2, by human monocyte-der

16 port of the glutathione-platinum complex and leukotriene C4, and intracellular glutathione (GSH) leve

17 and 77 microM for daunorubicin, vincristine, leukotriene C4, APA-SG, and ATP, respectively.

18 Prostaglandin E2, prostaglandin I2, and leukotriene C4 are produced by cPLA2alpha+/+ but not cPL

19 activated receptor-2-dependent production of leukotrienes C4 associated with an overexpression of leu

20 ia significantly increased concentrations of leukotrienes C4, D4, and E4 and leukotriene B4, whereas

21 oup had consistently lower concentrations of leukotrienes C4, D4, and E4 than all other groups.

22 cyclin infusion suppressed concentrations of leukotrienes C4, D4, and E4, suggesting that endogenous

23 The levels of leukotriene B4, leukotriene C4/D4, 6-keto-prostaglandin F1alpha, and thr

24 choalveolar lavage levels of leukotriene B4, leukotriene C4/D4, and thromboxane B2 above those of sal

25 avage fluid was analyzed for leukotriene B4, leukotriene C4/D4, thromboxane B2, prostaglandin E2, 6 k

26 rved large conformational changes induced by leukotriene C4, explaining how substrate binding primes

27 with IL-5 or NGF did not affect C5a-induced leukotriene C4 generation or alter C5a-induced intracell

28 of this activity in mast cell degranulation, leukotriene C4 generation, and IL-6 production was exami

29 of these three cytokines on 18-h priming for leukotriene C4 generation, their ability to induce Fc(ep

30 idant GSH and the pro-inflammatory cysteinyl leukotriene C4 have been identified as key physiological

31 ted with the smooth muscle contraction since leukotriene C4, histamine and tachykinins, which all cau

32 able release of tumor necrosis factor-alpha, leukotriene C4, histamine, or serotonin.

33 eutrophils capable of leukotriene synthesis, leukotriene C4, leukotriene D4, 5-hydroperoxyeicosatetra

34 on of MCP-1 in normal animals was related to leukotriene C4 levels in the bronchoalveolar lavage and

35 ogen estradiol-glucuronide (E(2)17betaG) and leukotriene C4 (LTC(4)) significantly stimulated ABCC10

36 (f-Met-Leu-Phe; FMLP) induces the release of leukotriene C4 (LTC4) and histamine in human basophils.

37 Leukotriene C4 (LTC4) and its extracellular metabolites,

38 nhibitor, genistein.The peptidoleukotrienes, leukotriene C4 (LTC4) and leukotriene D4 (LTD4) also pro

39 se, we compared the contractile responses of leukotriene C4 (LTC4) and leukotriene D4 (LTD4) and thei

40 Orai3/Orai1 channels are gated by cytosolic leukotriene C4 (LTC4) and require STIM1 downstream LTC4

41 hydrophobic glutathione S-conjugates such as leukotriene C4 (LTC4) and S-dinitrophenyl glutathione (D

42 + T cells also caused augmented secretion of leukotriene C4 (LTC4) from eosinophils.

43 We have investigated the metabolism of leukotriene C4 (LTC4) in gamma-glutamyl transpeptidase (

44 ced activities of ATP-dependent transport of leukotriene C4 (LTC4) in plasma membrane vesicles.

45 Human basophils secrete histamine and leukotriene C4 (LTC4) in response to various stimuli, su

46 ion of MEK and ERK-2, which are required for leukotriene C4 (LTC4) release, and production of LTC4 wa

47 Leukotriene C4 (LTC4) synthase (LTC4S), an integral memb

48 Leukotriene C4 (LTC4) synthase catalyzes the conjugation

49 was to determine whether cytokines modulate leukotriene C4 (LTC4) synthase expression in mononuclear

50 hospholipase A2 (cPLA2), and (2) blockade of leukotriene C4 (LTC4) synthesis in isolated human eosino

51 A2-induced arachidonic acid (AA) release and leukotriene C4 (LTC4) synthesis in isolated human periph

52 a-glutamyl leukotrienase (GGL) that converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).

53 n and significantly affect the ATP-dependent leukotriene C4 (LTC4) transport.

54 653Y or Y1302W, did not affect ATP-dependent leukotriene C4 (LTC4) transport.

55 The cysteinyl leukotrienes (cys-LTs), leukotriene C4 (LTC4), a conjugation product of glutathi

56 hat airway challenges with the parent CysLT, leukotriene C4 (LTC4), given in combination with low-dos

57 Cysteinyl leukotrienes (cysLTs), leukotriene C4 (LTC4), LTD4, and LTE4 are proinflammator

58 down reduced conversion of leukotriene A4 to leukotriene C4 (LTC4), suggesting a role for the activit

59 2,4-dinitrophenyl S-glutathione (DNP-SG) and leukotriene C4 (LTC4), the antimetabolite methotrexate,

60 system has been implicated in the release of leukotriene C4 (LTC4), we examined the roles of P-gp and

61 mation of the proinflammatory lipid mediator leukotriene C4 (LTC4).

62 nzyme to generate the proinflammatory signal leukotriene C4 (LTC4).

63 ne, as well as for the glutathione conjugate leukotriene C4 (LTC4).

64 The cysteinyl leukotrienes-leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotrie

65 r functions; there was neither production of leukotriene C4 or superoxide anion nor any detectable de

66 Leukotriene C4 production by mast cells was not enhanced

67 induces lipid body formation and subsequent leukotriene C4 production mediated by endogenous PAF.

68 inophil-derived neurotoxin and low levels of leukotriene C4 production; the latter was significantly

69 had decreased proinflammatory activity in a leukotriene C4 release assay using N-formyl-Met-Leu-Phe-

70 -5R beta-chain and inhibited IL-5 priming of leukotriene C4 release by human basophils.

71 used large increases in arachidonic acid and leukotriene C4 release from neighboring human eosinophil

72 of C component (C5a), which does not induce leukotriene C4 release without prior IL-3 treatment.

73 eukin-8 release) and basophil (histamine and leukotriene C4 release) stimulation assays, but usually

74 Exogenous administration of leukotriene C4 restored trafficking of eosinophils to pa

75 ellular sensitivity also occurred when using leukotriene C4 secretion as a metric of the basophil res

76 ro-inflammatory mediators leukotriene B4 and leukotriene C4 Studies with small molecule inhibitors of

77 The deduced 150-amino-acid sequence of mouse leukotriene C4 synthase (differs from the human enzyme b

78 Leukotriene C4 synthase (EC 2.5.1.37) catalyzes the conj

79 We asked whether mRNA levels of leukotriene C4 synthase (LTC4 S), a key regulator of leu

80 Leukotriene C4 synthase (LTC4S) catalyzes the formation

81 The expression of leukotriene C4 synthase (LTC4S) was examined during the

82 The functional characteristics of leukotriene C4 synthase (LTC4S), which specifically conj

83 mitigated by deletions of either Cysltr2 or leukotriene C4 synthase (Ltc4s).

84 Mouse leukotriene C4 synthase cDNA is 667 bp in length, includ

85 eotide primers based on the translated human leukotriene C4 synthase cDNA sequence.

86 We have now cloned mouse leukotriene C4 synthase CDNA using the polymerase chain

87 in and suggest that the C-terminal domain of leukotriene C4 synthase may not be critical for its conj

88 Northern blot analysis indicated that the leukotriene C4 synthase RNA transcript is widely distrib

89 Human leukotriene C4 synthase shares substantial amino acid id

90 ive against both human and mouse recombinant leukotriene C4 synthase with IC50 values of 3.1 microM a

91 eicosanoid-forming enzymes, 5-lipoxygenase, leukotriene C4 synthase, and cyclooxygenase, were immuno

92 Deletion of leukotriene C4 synthase, the terminal enzyme needed to g

93 s were used to test chemotactic responses of leukotriene C4 synthase-deficient and control airway eos

94 -sensitized and ovalbumin aerosol-challenged leukotriene C4 synthase-deficient and control mice.

95 Leukotriene C4 synthase-deficient eosinophils exhibited

96 from distal alveolar lung was diminished in leukotriene C4 synthase-deficient mice compared with wil

97 f eosinophils to paratracheal lymph nodes in leukotriene C4 synthase-deficient mice.

98 sed retention of eosinophils in the lungs of leukotriene C4 synthase-deficient mice.

99 iacylglycerol lipase, 5-lipo-oxygenease, and leukotriene C4 synthase.

100 nase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.

101 Ser and Tyr50-->Phe) were conserved in mouse leukotriene C4 synthase.

102 Leukotriene-C4 synthase (LTC4S) generates LTC4 from arac

103 iene-synthesizing enzymes 5-lipoxygenase and leukotriene-C4-synthase.

104 These findings confirm that the leukotriene C4 synthases belong to a gene family that in

105 n mast cells to secrete histamine, PGD2, and leukotriene C4 upon subsequent passive sensitization wit

106 rophages, prostacyclin, prostaglandin E2 and leukotriene C4 were produced within minutes of C. albica