ライフサイエンスコーパス: level of circulating

1 istration, FAT-ATTAC mice show near-knockout levels of circulating adipokines and markedly reduced le

2 ) mice exhibited reduced fat mass, decreased levels of circulating adipokines, improved insulin sensi

3 rmal white adipose tissue (dWAT) and reduced levels of circulating adiponectin.

4 Furthermore, no change in levels of circulating adrenaline was observed with L-NMM

5 and plasma cell development, as well as the levels of circulating Ag-specific Abs during a primary c

6 trate that reduced AGE intake leads to lower levels of circulating AGE and to improved insulin sensit

7 We found increased levels of circulating aged CD56(+) CD28(-) T cells in pa

8 Serum analysis demonstrated high levels of circulating alloantibodies with broad cross-re

9 ighest tertile of mammographic density, high levels of circulating alpha-carotene, beta-cryptoxanthin

10 pSTAT3(-/-) mice, with significantly reduced levels of circulating and airspace acute-phase proteins,

11 Cxcr3(-/-) mice revealed increased levels of circulating and brain CXCL10 after experimenta

12 sphorus due to abnormal bone metabolism; low levels of circulating and locally produced inhibitors; i

13 reased muscle proteolysis and also decreases levels of circulating and skeletal muscle IGF-1.

14 hormone (LH) and correspondingly attenuated levels of circulating androgens and estrogens.

15 These findings suggest that lower levels of circulating androgens and the potentiating eff

16 eceptor activation persists despite castrate levels of circulating androgens.

17 ogenesis may permit tumors to circumvent low levels of circulating androgens.

18 Increased levels of circulating angiopoietin-2 correlate with mark

19 Animal studies suggest that increased levels of circulating angiotensin II (AngII) could contr

20 using the ratio of urinary egg excretion to levels of circulating anodic antigen, a Schistosoma-spec

21 st levels of SLE disease activity and recent levels of circulating anti-double-stranded DNA.

22 Levels of circulating anti-flagellin IgG were induced in

23 umor-associated Neu5Gc can interact with low levels of circulating anti-Neu5Gc antibodies, thereby fa

24 gluten containing diet demonstrate that the levels of circulating anti-tTG IgA and anti-TGe IgA in D

25 The subsequent increase and decrease in levels of circulating anti-type VII collagen autoantibod

26 experimental tumor growth is enhanced by low levels of circulating antibodies directed against the no

27 Though basal levels of circulating antibodies were significantly elev

28 The level of circulating antibody-secreting cells that make

29 cells and serum aminotransferase and to the level of circulating antibody.

30 A rabbit model demonstrated that the level of circulating antigen correlated with the tissue

31 of PBMC from infected patients despite high levels of circulating antigen and virus replication sugg

32 erculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of spe

33 on or synthesized in the kidney, but not the level of circulating APOL1, probably mediates APOL1-asso

34 d renal function in nondiabetic individuals, levels of circulating APOL1 did not associate with micro

35 with significant (P < 0.05) increases in the level of circulating apolipoprotein AI (Apo A-I) (4.0 ve

36 Elevated levels of circulating asymmetric and symmetric dimethyla

37 Elevated levels of circulating ATP and ADP are especially associa

38 s, orally administered PCI-32765 reduced the level of circulating autoantibodies and completely suppr

39 We evaluated T cell responses to insulin, levels of circulating autoantibodies against insulin, an

40 ory autoimmune disorder associated with high levels of circulating autoantibodies and immune complexe

41 utoimmunity is most commonly examined by the levels of circulating autoantibodies in clinical practic

42 DKO mice had high levels of circulating autoantibodies.

43 lomerulonephritis, proteinurea, and elevated levels of circulating autoantibodies.

44 lymphoid tissues to maintain stable relative levels of circulating B cell subsets, and a potential me

45 s with chronic lymphocytic leukemia and high levels of circulating B cells can lead to removal of CD2

46 Because most patients with PAD have high levels of circulating BAFF, the increase in BAFF concent

47 Level of circulating bDNA before treatment could identif

48 althy, malaria-exposed children had elevated levels of circulating bicyclo-PGE2/TNF-alpha, compared w

49 Determining levels of circulating biomarkers may be the most powerfu

50 Interestingly, we detected a high level of circulating BMP10 in WT and Bmp9-KO pups.

51 on tumor samples, and blood was analyzed for levels of circulating BRAF V600.

52 Neonatal diabetes was characterized by low levels of circulating C-peptide with very low to undetec

53 e complex disease, whereas those with a high level of circulating C3 had well-preserved glomerular st

54 Therapeutic levels of circulating canine FIX activity (3.5%-8%) show

55 increased starvation sensitivity, and lower levels of circulating carbohydrate.

56 This study sought to investigate plasma levels of circulating cardiac natriuretic peptides, atri

57 Taken together, our results suggest that the level of circulating catalytic IgG under pathological co

58 ice display increased adiposity despite high levels of circulating catecholamines and leptin.

59 issue mass or activation because of elevated levels of circulating catecholamines.

60 and consequently Blimp1 CKO mice had higher levels of circulating CCL8, resulting in increased neutr

61 Our results suggest that higher levels of circulating CD11b(+) cells and neutrophils are

62 lammatory response characterized by elevated levels of circulating CD14(+), CD16(+), CD4(+), and CD8(

63 Levels of circulating CD34+ CD133+ bone marrow-derived p

64 On average, 6-fold elevated levels of circulating CD34+ cells and colony-forming uni

65 his study, patients who historically had low levels of circulating CD4(+) T cells were most likely to

66 tically, can induce AGMs to sustain very low levels of circulating CD4(+) T cells without showing sig

67 c decay in viremia and a significant rise in levels of circulating CD4(+) T cells.

68 meta-analysis shows that a reduction in the levels of circulating cells putatively provided with vas

69 ate in these mice was associated with higher levels of circulating chemokine (C-C motif) ligand 2 (CC

70 ung involvement, patients with ILD show high levels of circulating Chit1 activity that correlate with

71 Western diet rich in saturated fat is a high level of circulating cholesterol.

72 ssibility of an inverse relationship between levels of circulating cholesterol in neonates and IHPS r

73 cellular effects of elevated and suppressed levels of circulating cholesterol on the normal prostate

74 SNPs previously found to be associated with levels of circulating cholesterol.

75 We found that physiologic levels of circulating chromogranin A (CgA), a protein se

76 V-seropositive subjects developed detectable levels of circulating CMV DNA (DNAemia), and 5 of 17 VZV

77 atients with active retinitis, had increased levels of circulating CMV-specific CD8(+) T cells with "

78 wild-type and Per3(-/-) mice showed elevated levels of circulating corticosterone and increased hippo

79 beta-HSD1 expression corresponded to reduced levels of circulating corticosterone and weight loss in

80 glucose intolerance and constitutively high levels of circulating corticosterone, suggesting reduced

81 dback inhibition and manifested as increased levels of circulating cortisol.

82 r results support the hypothesis that higher levels of circulating CRP are associated with increased

83 lomerular immune complex deposits and higher levels of circulating cryoglobulins, IgG2a, IgG2b, and I

84 This is based on high levels of circulating CSF-1 in patient sera with aggress

85 ith chronic and acute HF may have measurable levels of circulating cTn, whose detection and magnitude

86 Levels of circulating CXCL13 were higher in those vaccin

87 Increased levels of circulating CXCL4 are associated with immune-m

88 Together our data support that increased levels of circulating CXCL4 may contribute to immune dys

89 evels of soluble Abeta are elevated and that levels of circulating cytokine and chemokine signatures

90 oinflammatory RNA transcripts, and increased levels of circulating cytokines and chemokines.

91 e, Toxoplasma appears to specifically impact levels of circulating cytokines, and our results may par

92 y-life DENV vaccine in populations with high levels of circulating DENV antibodies and suggests the u

93 n of Wnt inhibitor family members and higher levels of circulating Dickkopf-1 (Dkk1), sclerostin, and

94 Higher levels of circulating DJ-1 were associated with increase

95 Although the levels of circulating DNA and nucleosomes (indicative of

96 Plasma levels of circulating donor strain-reactive IgG antibodi

97 erular basement membrane thickening, reduced levels of circulating dsDNA autoantibodies and total ser

98 The authors detected 3- to 4-fold higher levels of circulating EDA in cord blood than in adult se

99 kely to be the functional allele influencing levels of circulating endogenous sex hormones and outcom

100 strate that the adenoviral induction of high levels of circulating endostatin significantly inhibits

101 acute vasculitis (n=12) had markedly higher levels of circulating endothelial microvesicles, identif

102 Indeed, the levels of circulating endothelial progenitor cells were

103 Subclinical levels of circulating endotoxin are associated with the

104 oductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individua

105 We observed high sustained levels of circulating, engineered cells at 1 year after

106 n capillaries are exposed to prolonged, high levels of circulating enzyme.

107 -5; and p < 0.001, r = 0.4901 for IL-13) and levels of circulating eosinophils (p < 0.0116, r = 0.565

108 ve suggested an inverse relationship between levels of circulating EPCs/CACs and the presence of CAD

109 Increased levels of circulating Epo lead to reticulocytosis, polyc

110 (EpoR) are required for maintaining adequate levels of circulating erythrocytes during embryogenesis

111 are strongly implicated in sensing the high levels of circulating estradiol on proestrus to activate

112 phase of the estrous cycle with the highest levels of circulating estradiol, and produced a dose-dep

113 pression in ovarian granulosa cells dictates levels of circulating estrogen in premenopausal women, a

114 Moreover, increasing the levels of circulating estrogens sufficed to promote the

115 ients with more advanced disease show higher levels of circulating exosomal miR-193a.

116 dystrophy, exhibit a substantial decrease in levels of circulating exosomal miRNAs.

117 ramuscular injection resulted in therapeutic levels of circulating Factor IX in mice.

118 Although levels of circulating factor VIII in untreated VWF(-/-)

119 hondrial glutathione in liver, and decreased levels of circulating fatty acyl-carnitines.

120 High levels of circulating FeLV-specific effector CTLs appear

121 er pregnancy to test the hypothesis that the levels of circulating fetal DNA correlate with arthritis

122 Elevated levels of circulating FFAs are associated with obesity,

123 trains, each with distinct etiology for high levels of circulating FGF23, onto a Cyp24-null backgroun

124 Elevated levels of circulating fibrinogen are associated with an

125 b(AEK) mice were generated that carry normal levels of circulating fibrinogen but lack the capacity f

126 mic population that increases in response to levels of circulating Flt3L.

127 Low levels of circulating free eculizumab (<50 microg/mL) co

128 characterized by hepatic steatosis, elevated levels of circulating free fatty acids (FFA), endoplasmi

129 duction, but this increase also elevates the levels of circulating free fatty acids and thus causes I

130 pyruvate derived from glycine that increases levels of circulating free fatty acids through extra-NE

131 Increased levels of circulating free heme, a by-product of Plasmod

132 JDP2 null females had increased levels of circulating FSH and higher expression of the F

133 Therefore, modestly increasing the levels of circulating full-length adiponectin completely

134 eishmanial Th1-cell-type response: increased levels of circulating gamma interferon, accelerated gran

135 Elevated levels of circulating glucocorticoid therefore promote a

136 hat hypothalamic malonyl-CoA responds to the level of circulating glucose and leptin, both of which a

137 Capsaicin treatment also increased the levels of circulating glucose and triglycerides and nega

138 Levels of circulating glucose are tightly regulated.

139 re subjected to blood analysis to detect the level of circulating glutathione in its reduced (GSH) an

140 subjected to a blood analysis to detect the level of circulating glutathione in its reduced and oxid

141 Patients with glaucoma exhibit low levels of circulating glutathione, suggesting a general

142 ctase (MTHFR) gene lead to markedly elevated levels of circulating Hcy-thiolactone.

143 bility to process and present Ag despite low levels of circulating HEL.

144 lation of Erfe in Th3/+ mice restored normal levels of circulating hepcidin at 6 weeks of age, sugges

145 High levels of circulating high density lipoprotein (HDL) and

146 hemia/reperfusion (I/R) injury, we show that levels of circulating histones are significantly higher

147 we observed a direct correlation between the levels of circulating histones in patients and the abili

148 Low levels of circulating HMW adiponectin appear to increase

149 inks between the growth of neurofibromas and levels of circulating hormones: neurofibromas often firs

150 Lower levels of circulating hProinsulin-B10 were obtained from

151 the CD49d-blocking antibody natalizumab) on levels of circulating HSPCs after a single dose of antib

152 Finally, high levels of circulating HSV-2-specific CD8(+) T cells, but

153 e of inflammation accompanying EAE, the high level of circulating human CRP that is achieved in CRP-t

154 hout liver implant, as assessed by change in levels of circulating human immunoglobulins and by histo

155 vement in overall survival, and reduction in levels of circulating human paraprotein were observed in

156 females, multiparous females have measurable levels of circulating HY-specific tetramer-positive T ly

157 oteinuria, glomerular C3 deposition, and the level of circulating ICs.

158 c disease (CD) patients usually present high levels of circulating IgA antibodies directed to differe

159 s study, we report that 129/Sv mice had high levels of circulating IgE, increased expression of the h

160 clusion, these results show that despite low levels of circulating IGF-1, insulin sensitivity in LID

161 y detected disease, suggesting that reducing levels of circulating IGF-I might not prevent the initia

162 logical and clinical nephritis with elevated levels of circulating IgG anti-dsDNA autoantibodies and

163 acquired PS-specific memory B cells, but not levels of circulating IgG at time of pneumococcal exposu

164 s, the effects of class II MHC expression on levels of circulating IgG autoantibodies were found to b

165 3(-/-) MRL/MpJ-Fas(lp) mice showed increased levels of circulating IgG-IgA immune complexes at 20 wee

166 in FcgammaRIII-KO was accompanied by higher levels of circulating IgM/IgG alloantibodies and SAP tha

167 ased IL-17-producing cells and increased the level of circulating IL-10.

168 Elevated levels of circulating IL-10 were also detected in sera f

169 neutrophilia that correlated with increased levels of circulating IL-17 and granulocyte colony-stimu

170 Elevated levels of circulating IL-18 were also seen in patients w

171 Patients with cystinosis had higher levels of circulating IL-1beta and IL-18 compared with c

172 ration of IL-21 plasmid DNA resulted in high levels of circulating IL-21 in vivo.

173 Patients had increased levels of circulating IL6 (3.86 [2.84-4.95] vs. 1.66 [1.

174 showed poorer survival in patients with high levels of circulating IL6.

175 , no significant differences in preoperative levels of circulating immune cells were detected between

176 A 10-fold increase in the mean level of circulating immunoglobulins against protein-bou

177 The levels of circulating immunoglobulins against 3-nitrotyr

178 were associated with a marked diminution of levels of circulating inflammatory cytokines that are co

179 oblast ablation was associated with elevated levels of circulating inflammatory cytokines, including

180 he 13 wks following ICU discharge had higher levels of circulating inflammatory markers (IL-6 and C-r

181 The relationship between levels of circulating inflammatory markers and risk of p

182 , we assessed the association between weekly levels of circulating influenza virus and counts of outc

183 compatible with an observed increase in the level of circulating insulin.

184 increased circulating insulin and depressed levels of circulating insulin-like growth factor binding

185 SS) immunopathology because of the increased levels of circulating interleukin (IL)-17 in pSS.

186 vior, reduction of body weight, and elevated levels of circulating interleukin 6.

187 ients with visceral leishmaniasis, increased levels of circulating interleukin-6 (IL-6) regularly acc

188 rdiovascular disease (CVD) and have elevated levels of circulating intermediate (CD14(++)CD16(+)) mon

189 tivation, involves a marked reduction in the levels of circulating iron, coupled with iron sequestrat

190 BLEO-injured il17a(-/-) mice had diminished levels of circulating Krebs Von Den Lungen 6 (alveolar e

191 It regulates the levels of circulating LDL cholesterol and is considered

192 and it is associated with elevated baseline levels of circulating leptin in normal, nonseptic patien

193 These high levels of circulating leptin receptor bind leptin and li

194 asting, there is a dramatic reduction of the levels of circulating leptin, an adipokine with proinfla

195 AgRP neurons are more responsive to low levels of circulating leptin, but they are also more pro

196 At baseline, sickle mice had elevated levels of circulating leukocytes and soluble vascular ce

197 ice lacking GalNAc-4-ST1 exhibited increased levels of circulating LH.

198 Our data showed that high levels of circulating lipids for a prolonged period elev

199 Despite high levels of circulating lipids, the postprandial python he

200 olymorphisms (SNPs) associated with abnormal levels of circulating lipids.

201 obial translocation as indicated by elevated levels of circulating lipopolysaccharide (LPS), LPS-bind

202 trafficking and metabolism, and in modulated levels of circulating lipoprotein-cholesterol and trigly

203 vents, including death, in persons with high levels of circulating Loa loa microfilariae.

204 cells, and this occurs in the face of lower levels of circulating low-density lipoprotein cholestero

205 Elevated levels of circulating low-density lipoprotein cholestero

206 ytes with an IFNalpha phenotype and elevated levels of circulating LPS.

207 ase activity, elevated S1P levels, and lower levels of circulating lymphocytes.

208 ir in these infants is associated with lower levels of circulating markers of oxidative stress than r

209 eep deprivation and assessed inflammation by levels of circulating markers.

210 thies is a possible consequence of increased levels of circulating mature reticulocytes expressing in

211 Finally, in humans, lower levels of circulating MBL were accompanied by enhanced m

212 tralizing antibodies show 2.3-fold decreased levels of circulating MCP-1.

213 There was a trend toward lower levels of circulating mDC2s with increasing allergy and

214 meostatic mechanism maintains a steady-state level of circulating MDSC in tumor-bearing individuals.

215 tabolites, and the risk of formation of high levels of circulating metabolites in preclinical species

216 immune tolerance to the parasite, with high levels of circulating microfilariae, few clinical sympto

217 Elevated levels of circulating microparticles are associated with

218 nts with unstable carotid plaque have higher levels of circulating microparticles compared to patient

219 Increased CPB duration yielded in higher levels of circulating mitochondrial (mt)DNA, soluble thr

220 The levels of circulating mitochondrial DNA (mtDNA) in patie

221 within 24 hours after ICU admission, and the levels of circulating mitochondrial DNA were quantified

222 antiangiogenic plasma profile, and elevated levels of circulating monocytes and T, but not B, lympho

223 High levels of circulating MPA 48 hours after injection were

224 Preimmunization resulted in high levels of circulating NAb and prevented transduction by

225 The patients had reduced levels of circulating NAD.

226 at elderly macaques have significantly lower levels of circulating naive CD4(+) T cells, naive CD8(+)

227 Notably, because high levels of circulating NAMPT are found in obese and diabe

228 Hantavirus infection induced high systemic levels of circulating NETs in patients and this systemic

229 The level of circulating NO-related products probably determ

230 ocoa was associated with acute elevations in levels of circulating NO species, an enhanced FMD respon

231 Acute EVD was characterized by reduced levels of circulating nonclassical CD16(+) monocytes wit

232 tes led to an approximately 80% reduction in levels of circulating normal AAT, demonstrating potentia

233 e exposed to cold temperatures had increased levels of circulating NPs as well as higher expression o

234 We observed a 27% reduction in the levels of circulating NT-proANP (p < 0.001, maximal at 6

235 re normal physiological states with elevated levels of circulating oestrogen.

236 Low levels of circulating or brain DHA are associated with v

237 icient in the IL-1 receptor also had reduced levels of circulating P-selectin, similar to those obser

238 We found high levels of circulating PDGF-BB in platelet-poor plasma sa

239 y 24 hours postinoculation, a time when high levels of circulating pegylated IFN-alpha were still pre

240 Virally suppressed children had normal levels of circulating plasmacytoid and myeloid DCs and t

241 s indicated by high Mx1 expression), and low levels of circulating plasmacytoid dendritic cells (as o

242 This study examined whether reduced levels of circulating PPi, an antimineralization factor,

243 conditions, and MDD patients exhibit higher levels of circulating pro-inflammatory cytokines.

244 sis, splenomegaly, BM failure, and decreased levels of circulating proatherogenic cells in mice fed a

245 Dialysis patients have higher levels of circulating procoagulant MVs than healthy cont

246 In patients with risk factors, high levels of circulating progenitor cells increase event-fr

247 lethality, growth retardation, and elevated level of circulating proinflammatory cytokines.

248 erosclerosis, despite having highly elevated levels of circulating proinflammatory cytokines.

249 f this study was to investigate whether high levels of circulating proprotein convertase subtilisin k

250 protein C due to genetic mutations or a low level of circulating protein C increase the risk of veno

251 ing mammary glands resulted in reductions in levels of circulating PTHrP and 1,25-dihydroxy vitamin D

252 se resistin, designed to acutely elevate the levels of circulating resistin up to those observed in t

253 Given elevated levels of circulating sAPP-alpha in some patients with a

254 ted with low-grade inflammation and elevated levels of circulating saturated fatty acids, which trigg

255 Under normal levels of circulating serotonin, the proliferative activ

256 adult mice as (i) a disproportionately high level of circulating serum insulin for a given glucose c

257 e Stat5 during late pregnancy despite normal levels of circulating serum prolactin and pituitary prol

258 High levels of circulating soluble CD40 ligand (sCD40L) are f

259 Clinically, the levels of circulating soluble ST2, commonly considered a

260 phenotype and that mutants display increased levels of circulating sugar, along with augmented expres

261 d before their seasonal enlargement) and the levels of circulating T during their rut, suggesting tha

262 ing the tissue-specific responses to similar levels of circulating T(3).

263 Although ROSA22 homozygote males have normal levels of circulating testosterone and display normal ma

264 Higher levels of circulating testosterone were associated with

265 and no reproductive behavior, and have basal levels of circulating testosterone.

266 and no reproductive behavior, and have basal levels of circulating testosterone.

267 AnnV+) was strongly associated with elevated levels of circulating TF (r =.46, P =.002).

268 These findings suggest that high levels of circulating TF may be the mechanism of action

269 To investigate the effect of low levels of circulating TF, whole blood (+/-100 fM added T

270 Mice with TF-positive tumors and elevated levels of circulating TF-positive MPs had increased thro

271 ound that patients with cancer have elevated levels of circulating TF-positive MPs.

272 brin content, and there was no difference in levels of circulating thrombin-antithrombin complexes.

273 iciency of TP leads to dramatically elevated levels of circulating thymidine and deoxyuridine.

274 action of localized PTU toxicity and altered levels of circulating thyroid hormone contribute to PTU-

275 pulmonary fibrosis had significantly higher levels of circulating TN-C compared with SSc patients wi

276 High levels of circulating TNF and its receptors, TNFR1 and T

277 And the level of circulating Treg was as an independent factor a

278 animals are able to counteract the increased levels of circulating trehalose induced by a high sugar

279 Higher-than-normal levels of circulating triglycerides are a risk factor fo

280 n-like 4 (ANGPTL4), has been shown to reduce levels of circulating triglycerides.

281 We tested the hypothesis that the level of circulating tumor cells can predict survival in

282 the variables in the statistical model, the levels of circulating tumor cells at baseline and at the

283 Outcomes were assessed according to levels of circulating tumor cells at baseline, before th

284 with measurable metastatic breast cancer for levels of circulating tumor cells both before the patien

285 Patients in a training set with levels of circulating tumor cells equal to or higher tha

286 mph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduc

287 and exhibited severe lung injury and higher levels of circulating tumor necrosis factor-alpha (TNFal

288 that SLE patients had significantly elevated levels of circulating U1 and/or Y1 RNA compared with hea

289 ant sedation with midazolam, and reduced the levels of circulating unbound venom.

290 We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxi

291 There were significantly higher levels of circulating vaspin (P < 0.05), vaspin mRNA (P

292 iator of this effect was an elevation in the levels of circulating VEGF.

293 asymptomatic latent infection with very low levels of circulating virus in the peripheral blood of i

294 low viral loads on the basis of their stable levels of circulating virus.

295 CLYBL that has been associated with reduced levels of circulating vitamin B12.

296 Low levels of circulating vitamin D are associated with dive

297 Although high levels of circulating VP can increase blood pressure, th

298 but not control animals, revealed normalized levels of circulating VWF that persisted for at least 1

299 GST-deficient mice (GSTpi(-/-)) have higher levels of circulating white blood cells, with similar pr

300 s predisposing to liver disease, whereas low levels of circulating Z alpha1-antitrypsin lead to emphy