ライフサイエンスコーパス: library

1 and chemical derivatives not present in the library.

2 himera was further assessed with a substrate library.

3 adopt realistic cell models from the NEURON library.

4 resented in a highly diverse pHLA-A( *)02:01 library.

5 genes and the connections among strains in a library.

6 epresented by a random peptide phage display library.

7 sequence strings (k-mers) and an MLST allele library.

8 (PSSM, HMM) and the subject sequences in the library.

9 nome-wide, sequence-verified, arrayed CRISPR library.

10 MR screening of focused and diverse fragment libraries.

11 ectra (acquired in ddMS2 mode) with spectral libraries.

12 tations or accurate matches to mass spectral libraries.

13 bicyclic peptides from large random-sequence libraries.

14 ning by combining Cas9 with pooled guide RNA libraries.

15 ing; most DIA data analyses require spectral libraries.

16 rocessed and integrated with newly sequenced libraries.

17 their masses matched to the human metabolome libraries.

18 quence information from short-read scRNA-seq libraries.

19 after construction of 16S ribosomal RNA gene libraries.

20 d tentatively identified using mass spectral libraries.

21 limited by the incomplete coverage of these libraries.

22 igning screens and constructing bespoke gRNA libraries.

23 azone exchange to form dynamic combinatorial libraries.

24 s had consistent levels of expression in all libraries.

25 y directed evolution involving combinatorial libraries.

26 functional screening of an optimized 30-site library (2.15 x 10(9) variants) revealed reduced populat

27 ionization, despite the use of mass spectral libraries, a majority of the compounds remains unidentif

28 creened an aziridinyl 1,4-benzoquinone (ABQ) library against the causative agents of trypanosomiasis,

29 alleles share three mutations with the large-library alleles, which are known from previous work, but

30 ytoscape and Data Driven Document JavaScript libraries and can be used to relate genes to iTerms and

31 stone allows users to design oligonucleotide libraries and create successive versions of reference ge

32 al information for virtual screening (VS) of libraries and for structure-based drug design to identif

33 cautionary tale for screening small molecule libraries and provides insights into the structural plas

34 ction of complex random transposon insertion libraries and quantification of each mutant's abundance

35 plore this finding, we constructed interface libraries and selected them for improved stability or af

36 RNA synthesis of comprehensive single mutant libraries and targeted multiple mutant libraries is enab

37 etention time matches to the dansyl standard library and 2988 pairs with their masses matched to the

38 dex, MEDLINE, CINAHL, AMED, EMBASE, Cochrane Library and NHS Economic Evaluation Database, were searc

39 nic databases (MEDLINE, EMBASE, and Cochrane library) and meeting abstracts.

40 iplexed single-molecule screening of protein libraries, and should enable the in vitro directed evolu

41 om MEDLINE, Embase, Web of Science, Cochrane Library, and a manual search of bibliographies for studi

42 hen tested against an animal fecal reference library, and crAssphage genetic markers were highly abun

43 y screened 945 studies from PubMed, Cochrane Library, and Scopus databases and extracted data from 24

44 y screening against a P2' diverse SFTI-based library, and the most preferred residue at P2' was combi

45 A 3'-end-focused library approach cannot detect differential splicing, bu

46 DNA libraries are constructed using native genomic DNA from

47 These libraries are screened to identify the few variants that

48 ating the value of the naive rabbit antibody library as a rich and virtually unlimited source of rabb

49 Using long-insert jumping libraries at 105X mean physical coverage and linked-read

50 les to the creation of a synthetic diversity library based on natural frameworks with significantly d

51 A library based on the most active lead compound was made

52 N9, obtained by screening of a combinatorial library based on the ultra-stable Sso7d scaffold.

53 A global peptide library-based screening strategy revealed that the prote

54 ool for studying gene functions using strain libraries, but it suffers from throughput limitations.

55 ty and accuracy of matching to mass spectral libraries, but to date, there has been little attention

56 scovery, which reduces the size of screening libraries by decreasing complexity, has improved ligand

57 chemistry based method for generating RNAseq libraries called 'ClickSeq'.

58 gment ions extracted with a customized MS/MS library can provide as reliable quantitative data as the

59 MEDLINE, Cochrane Library, CINAHL, and trial registries through June 2016;

60 MEDLINE via Ovid, EMBASE, the Cochrane Library, CINAHL, and Web of Science through January 2017

61 sing a highly saturated transposon insertion library combined with next-generation sequencing and a m

62 otein samples at high throughputs or protein libraries compatible with multiplexed screening platform

63 lar interactions to construct a focused HTB1 library, complemented with an experimental platform base

64 strategy, our approach greatly increases the library complexity per unit of starting material, which

65 m that identifies compounds that differ from library compounds by a single "inert" structural compone

66 nearest-neighbor" compounds that differ from library compounds by a single chemical moiety.

67 oncept, we generate and sequence six sciHi-C libraries comprising a total of 10,696 single cells.

68 Using a 256-membered ANNNN comonomer library comprising 16 sublibraries modified with differe

69 latform allowed us to screen the Sigma LOPAC library consisting of 1280 compounds.

70 After optimizing library construction by analysing transcriptional start

71 nd a very simple, short ( approximately 4 h) library construction protocol.

72 es early in next-generation sequencing (NGS) library construction provides a way to identify and bioi

73 Typically, this requires library construction to vary the genetic parts controlli

74 ocol-including target primer design, variant library construction, and sequence verification-can be c

75 d from cell harvesting to the completion of library construction, up to a further 36 h for DNA seque

76 ons in nanotechnology, gene editing, and DNA library construction.

77 slocating peptides (SMTPs) selected from the library contained a 5-residue consensus motif, LRLLR in

78 tified using two accurate mass LC-QTOF-MS/MS libraries containing pesticides, pharmaceuticals, and ot

79 ata set, where we built a DDA-based spectral library containing consensus spectra for 1829 compounds.

80 PaVE also now contains an image library containing gross clinical and histopathological

81 e locked method using a GC-QTOF-MS pesticide library (containing exact mass fragments and retention t

82 We searched Global Health, Cochrane Library, Cumulative Index to Nursing and Allied Health L

83 es published in English, and in the Cochrane Library database without any restrictions.

84 ast in March 2017 in the PubMed and Cochrane Library databases for English-language original research

85 systematic review was conducted of Cochrane library databases, EMBASE, CINAHL, and MEDLINE in the pe

86 ng and Allied Health Literature and Cochrane Library databases.

87 over one million clones from metagenome DNA libraries derived from sixteen different environments fo

88 method, we developed a T7 phage display cDNA library derived from mRNA isolated from bronchoalveolar

89 Beginning with the library design, the entire protocol can be completed in

90 8 ChR chimeras chosen from a 118,098-variant library designed by SCHEMA recombination of three parent

91 on of CD4- 293T cells with a cDNA expression library developed from a podocyte cell line derived from

92 We constructed a phage library displaying variants of the substrate-like Schist

93 y not exploit the full potential of chemical libraries due to false negatives.

94 MEDLINE, Cochrane Library, EMBASE, and trial registries through October 20

95 Materials and Methods The Cochrane Library, Embase, Medline, and the Web of Science Core Co

96 rtantly, dual-labeled ribosome-nascent chain libraries enable single-molecule co-localization of geno

97 We screen a lentiviral library encoding approximately 100 million secreted and

98 mains with lengths up to 300 nucleotides and libraries encompassing up to 960 variants.

99 nations in a single solution-phase library x library experiment.

100 software to three currently available Python libraries for parsing NMR-STAR formatted files: PyStarLi

101 nal method used for screening drug compounds libraries for potential bioactivity.

102 We made our work available as libraries for the ImageJ distribution Fiji and for deplo

103 his study, we screened the FDA-approved drug library for agents that share significant similarity in

104 eus proteins, we have developed a global ion library for data-independent acquisition approaches empl

105 Creating a cDNA library for deep mRNA sequencing (mRNAseq) is generally

106 Preparation of the library for high-throughput DNA sequencing takes approxi

107 ngs, we previously screened a small molecule library for novel autophagy-enhancing factors that inhib

108 quences, which are converted to a sequencing library for paired-end sequencing.

109 In 16S rRNA gene Illumina libraries, four Pseudomonas sp. operational taxonomic un

110 peline, we assembled tissue-specific RNA-Seq libraries from 113 datasets and constructed 48 359 trans

111 this study, we generated metatranscriptomic libraries from actively growing thrombolites, a type of

112 DEEPER-Seq can create NGS libraries from as little as 20 pg DNA with PCR error cor

113 DNAs, we performed sequencing analysis in 26 libraries from three blood donors and negative controls.

114 in MEDLINE, EMBASE, CINAHL, and the Cochrane Library from 1998 through April 2014.

115 hod to construct multiple small sized CRISPR library from a single oligo pool generated by array synt

116 We make a single library from approximately 1 ng of high molecular weight

117 ch in PubMed, Embase, PsycINFO, and Cochrane Library from database inception to January 1, 2016.

118 ly, we used PECAN to build a plasma proteome library from DIA data and to query known sequence varian

119 igitalized Barcode Encrypted Single-stranded Library from Extremely Low (quality and quantity) DNA In

120 o screen a salt induced rice cDNA expression library from Hasawi.

121 , EMBASE, PsycINFO, CINAHL, and the Cochrane Library from inception through April 2017; reference lis

122 MEDLINE via PubMed, EMBASE, and The Cochrane Library from inception to March 2015, for studies report

123 ractions, which involves comparing Tn mutant libraries generated in different genetic backgrounds (e.

124 heterocyclic aromatics and the mass spectral library generated in this study can be used for future s

125 However, library generation capacity outpaces the rate of high-th

126 ll-specific biases in capture efficiency and library generation.

127 he synthesis and screening of small-molecule libraries have accelerated the discovery of chemical pro

128 he initial screen of small molecule compound libraries identified more than thirty hits that increase

129 search of Pubmed, PsycINFO and the Cochrane Library identified 29 articles for inclusion in the meta

130 ed annotation approach is to search spectral libraries in reference databases for matching metabolite

131 method is easy to implement and can generate libraries in three to four days.

132 describe a platform for phenotyping variant libraries in transfectable mammalian cell lines in two s

133 An ordered Tn library in strain AB5075 with insertions in every noness

134 d to isolate mimotopes from a 12-mer peptide library in successive selection rounds.

135 is, we used a bar-coded transposon insertion library in tandem with cell sorting to assess genome-wid

136 In addition, the library includes a demonstration of a method that uses p

137 terature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sou

138 terature (LILACS), World Health Organization Library Information System [WHOLIS], and Scopus) and sou

139 terature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sou

140 terature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sou

141 By transforming pooled CRISPR libraries into tomato (Solanum lycopersicum), collection

142 utant libraries and targeted multiple mutant libraries is enabling new multidimensional chemical appr

143 hemotype from screening a nonbiased fragment library is reported.

144 c KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-derived dendritic c

145 self-replicator from a dynamic combinatorial library made from a threonine containing peptide buildin

146 Furthermore, large image libraries may endow microscopes with capabilities beyond

147 coevolution and propagation of nonfunctional library members, as well as allowing positive and negati

148 iomarker panels from platelet RNA-sequencing libraries (n = 779).

149 ay now render current state-of-the-art lipid libraries obsolete.

150 Libraries of chemicals are applied to living systems, an

151 online tool to accelerate synthesis of large libraries of desired mutants through design and efficien

152 In this study, we applied IDUP to libraries of DNA-encoded bioactive compounds and DNA-tag

153 , high-throughput methods that generate vast libraries of epitopes have been applied.

154 usly been delineated using synthetic peptide libraries of fixed length, or single protein chains and

155 "design-build-test" cycle paradigm, massive libraries of genetically engineered microbes can be cons

156 g shape at the nanoscale can lead to broader libraries of quasi-two-dimensional materials.

157 n immunology and it is described how focused libraries of TAs have been used to discover the active p

158 ndividual labs to generate customized CRISPR libraries of variable size and coverage depth for functi

159 that utilises human proteome-derived peptide libraries of varying length, termed Proteomic Identifica

160 constructed a high-density transposon mutant library of >430,000 unique Tn5 insertions and measured m

161 malaria vaccine candidates, we constructed a library of 1,827P.

162 We screened a library of 1.9 x 10(7) with over 8500 possible non-synon

163 phenotypic screens on a NINDS small molecule library of 1040 drugs.

164 imary patient-derived lymphoma cells using a library of 106 US Food and Drug Administration (FDA)-app

165 A library of 15 2-alkyl-1,2-benzisoselenazol-3(2H)-ones wa

166 n enzyme-based method for the synthesis of a library of 15 different CS oligosaccharides.

167 droxamate linkers, which yielded an expanded library of 15 ferritin-MOFs with the expected body-cente

168 We report the first modular synthesis of a library of 20 halogenated phenazines (HP), utilizing the

169 To study their regulation, we generated a library of 209 different cytokines.

170 A library of 29 homologous Ru-based olefin metathesis cata

171 hput screening platform to screen a SICLOPPS library of 3.2 million cyclic hexapeptides for inhibitor

172 To establish the reliability of the assay, a library of 31 free HMOs, ranging in size from tri- to oc

173 Using a computational strategy on a library of 46 656 heparan sulfate hexasaccharides we ide

174 Here a small molecule library of 500,000 small molecule compounds was screened

175 s involved in MeCP2 silencing, we screened a library of 60,000 shRNAs using a cell line with a MeCP2

176 We first established a comprehensive peptide library of allergens from various commercial extracts as

177 mponent reaction to create a small but smart library of alpha-acyl aminocarboxamides and evaluated th

178 First, a library of antibacterial peptides is screened that combi

179 the testable sequence space within a peptide library of approximately 100 members for CDK1, CDK7, and

180 A library of aromatic carbamate derivatives based on the c

181 bly of small molecules have produced a large library of candidates for developing the biomedical appl

182 mology model of GPR171 to virtually screen a library of compounds.

183 our group and a congeneric PARP inhibitor, a library of derivatives was synthesized to discover the f

184 racterize tissue smears by comparison with a library of DESI mass spectra of pathologically determine

185 , we report a synthetic lethal screen with a library of deubiquitinases and identify USP39, which enc

186 For metabolite identification, a library of DnsHz-labeled standards was constructed, incl

187 We screened an existing combinatorial library of engineered ubiquitin variants for inhibitors

188 A library of human anti-EphA2 mAbs were screened and evalu

189 A small library of imidazole and imidazolium reactivators was su

190 ed through the action of Fe(2+) on a dynamic library of imines generated in situ via condensation of

191 ing studies such as the connectivity map and library of integrated network-based cellular signatures.

192 to ligands and can rank the affinities of a library of ligands.

193 f the M-(PM')n-M platform and presents a new library of long-wavelength absorbers that efficiently po

194 nd demonstrate the rational design of a vast library of multicomponent protein-rich structures that r

195 mbles of electrostatic potential files for a library of mutants to quantify the effects of perturbati

196 Screening of a 50000-member library of natural and synthetic compounds for sensitize

197 most representative molecules of an in house library of natural products, we have designed and synthe

198 complex forms, affords us with an exhaustive library of natural templates and free technologies to bo

199 We compared our dataset to a library of nirS sequences obtained previously from the s

200 A library of oligoquinolines was screened to identify anta

201 An annotated chemical library, the library of pharmacologically active compounds (LOPAC), w

202 ering approach to produce and screen a small library of potential constructs, in order to select for

203 y to select for a particular function from a library of protein variants inside cells, minimizing und

204 ing a saturating transposon insertion mutant library of S Typhimurium to immune serum identified a re

205 HER), published in The Lancet and the Public Library of Science (PLoS).

206 Here, using a library of short heparin polysaccharides modified at spe

207 We hybridized a library of short, terminally labeled probes to Ebola vir

208 ADAPT employs an enriched library of single-stranded oligodeoxynucleotides (ssODNs

209 s-wave lasing from CQD solids, expanding the library of solution-processed materials that may be capa

210 From a small library of sstr antagonists, the analog JR11 (Cpa-c[d-Cy

211 The embarrassingly rich library of structures emerging from this work reveals ve

212 A convenient synthesis of a library of tetrazoles through a novel and operationally

213 profiles, and built differential expression library of their transcripts under control and drought c

214 ariant was readily identified from a focused library of three enzymes, allowing for completion of the

215 structure of transformation products using a library of transformation reaction schemes.

216 hetic methodology that can rapidly provide a library of well-defined HS oligosaccharides.

217 Here we use a library of Xenopus tropicalis genomic sequences in bacte

218 These arrayed libraries offer the prospect for performing screens on i

219 ormed sequencing-based screening of an shRNA library on a panel of cancer cells of different origins

220 fully defined extracellular environment at a library-on-library scale.

221 ied by searching against a predefined glycan library owing to unanticipated modifications.

222 Four C libraries perform core operations in SeqLib: HTSlib for

223 and barcoding cells (1 d); and (iv) RNA-seq library preparation (2 d).

224 Because no library preparation is required, the technology permits

225 We then employed a nonspecific PCR-based library preparation method for sequencing on an Oxford N

226 Amplification-free library preparation provides single molecule sequences w

227 uding both small- and long-RNAs, in a single library preparation step.

228 With an improved library preparation strategy, our approach greatly incre

229 ort (50-bp) single-end reads and Nextera (R) library preparation yield reliable results.

230 After library preparation, bacteria produce partner proteins t

231 omposed of a novel DNA extraction, optimized library preparation, paired-end WGS, and an in-house-dev

232 through the screening of macrocyclic peptide libraries produced in E. coli cells.

233 The library provides an intuitive dictionary-based interface

234 We applied this ion library resource to investigate the time-resolved adapta

235 Complementation of RM1 with a genomic library revealed that the mutation occurred in a gene de

236 his study, screening of an in-house compound library revealed two sulfur-containing compounds which p

237 ed extracellular environment at a library-on-library scale.

238 Using a combined pooled-genome wide shRNA library screen and global proteomic profiling, we showed

239 we performed a small interfering RNA (siRNA) library screen targeting the 58 human DEAD-box RNA helic

240 phosphoproteomics with mammalian kinome cDNA library screen.

241 By cDNA library screening, we identified an immune cell-specific

242 A mass spectral library search algorithm that identifies compounds that

243 ed to conventional immunization or synthetic library selection strategies.

244 (Arabidopsis thaliana), the constructed LTR library showed excellent sensitivity and specificity.

245 xpanding the ZBG repertoire within inhibitor libraries, since relying on a single ZBG significantly d

246 endages was performed by scanning and matrix libraries synthesized by the multiple parallel synthesis

247 roughput functional assay to screen an siRNA library targeting 6,650 different cellular proteins.

248 Stereotaxic delivery of a virus library targeting genes commonly mutated in human cancer

249 From a single transformation with a CRISPR library targeting the immunity-associated leucine-rich r

250 tiple proteins in parallel using DNA-encoded library technology (ELT).

251 g molecular docking gives access to fragment libraries that are several orders of magnitude larger th

252 econd-generation human genome-wide CRISPR-KO libraries that included at least one of the improvements

253 implemented using an equimolar concentration library, the CaR-ESI-MS assay identified 100% of ligands

254 olution structural models through the BioLiP library, the COFACTOR server infers three categories of

255 An annotated chemical library, the library of pharmacologically active compoun

256 tion potential for designing focused protein libraries to be used in directed evolution.

257 We generate double-gene deletion libraries to demonstrate this technology, targeting anti

258 technique for analysis of transposon mutant libraries to determine conditional essentiality of a gen

259 enerate high-complexity pooled dual-knockout libraries to identify synthetic lethal and buffering gen

260 Spliceman2 integrates with RNAcompete motif libraries to provide a prediction of which trans -acting

261 fully automated algorithm that uses spectral libraries to query, validate and quantify peptidoforms i

262 ed a phage-displayed ubiquitin variant (UbV) library to develop inhibitors targeting the DUBs USP7 an

263 have utilized a high-diversity phage display library to engineer antibody fragments (Fabs) that can m

264 n the target protein and entries in the fold library to generate models.

265 ing dysbindin as bait against a cardiac cDNA library to identify the cardiac dysbindin interactome.

266 This method extends the scope of the library to include spectra of "nearest-neighbor" compoun

267 luent (n = 233) was used to generate a fecal library to perform community-based MST.

268 en gene expression estimates, independent of library type and across the full range of levels of expr

269 dentifying HCPs not represented in the assay library used for targeted, peptide-centric, data analysi

270 a from Serratia marcescens transposon mutant library used to identify genes that contribute to fitnes

271 MetaboDIA to build customized MS/MS spectral libraries using a user's own data dependent acquisition

272 One member of the library was azide-containing derivative 1j that was comp

273 This virtual library was compared with molecular databases of publish

274 The library was evaluated for inhibition of Mycobacterium tu

275 A library was prepared of tunable Janus particles possessi

276 A self-aggregated 48-membered dansyl library was screened against a series of metabolites in

277 An ordered transposon mutant library was screened, and 9 genes involved specifically

278 ed using high-resolution MS, and the peptide library was then used to identify prototypic and quantot

279 Using pooled lentiviral single-guide RNA libraries, we conducted a genome-wide loss-of-function g

280 By screening a peptide phage display library, we discovered a novel ligand (PDN1) that target

281 Through screening a short hairpin RNA library, we found that RARgamma was essential for TNF-in

282 16, we searched Pubmed, EMBASE, the Cochrane Library, Web of Science, CINAHL, and PsychINFO.

283 We searched PubMed, EMBASE, The Cochrane Library, Web of Science, LILACS, CINAHL, and SCOPUS for

284 These libraries were cherry-picked from all commercially avail

285 Three BAC libraries were constructed, fingerprinted, and integrate

286 The libraries were found to require a nucleophilic catalyst,

287 basis of 2,6-dipicolinic acid (DPA), several libraries were synthesized for structure-activity relati

288 SE, MEDLINE, Web of Science and the Cochrane Library were searched for relevant articles published to

289 , PsycINFO, CINAHL, EMBASE, and the Cochrane Library were searched from the inception of each databas

290 Pools from this library were then used for the batch transduction of bon

291 reely-available module of the popular PLUMED library, which enables the simultaneous determination of

292 Software libraries with a claim to be both domain-facing and cons

293 was developed to generate targeted barcoded libraries with minimal DNA input, flexible target select

294 errogating high quality and diverse scaffold libraries with verifiable folding and stability.

295 s issue, we design and analyse a CRISPR-Cas9 library with 10 variable-length guides per gene and thou

296 s a key feature, users can easily extend its library with new gene sets and genomic intervals.

297 focused histone deacetylase (HDAC) inhibitor library with peptoid-based cap groups and different zinc

298 We explore the TPS compound library with varying Cu/In ratio, using Helium Ion Micro

299 ible combinations in a single solution-phase library x library experiment.

300 ion quantification using DIA data using this library, yielding sensitive differential expression anal