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1                                              Licensing consists of the loading of the hexameric MCM2-
2                                              Licensing is restricted to G1 phase of the cell cycle, b
3                                              Licensing serves as a gateway from the embryonic process
4 -S progression, possibly by functioning as a licensing factor for DNA replication.
5 hen present on the chromatin, may serve as a licensing factor for estrogen-ESR1-mediated interactions
6 cus, the present results establish PTIP as a licensing factor for humoral immunity that acts at sever
7   As such, Htm1p-Pdi1p is suited to act as a licensing factor that monitors folding in the ER lumen a
8                   This mutant Ly49A caused a licensing defect in NK cells, but the surface expression
9 o centrioles during anaphase is considered a licensing event for the next round of centriole duplicat
10 ), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 t
11  and inhibited by TCR-blockade, suggesting a licensing interaction involving the TCR and FcgammaR.
12  inhibition of mitosis coupled with aberrant licensing of S-phase entry.
13 tion necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural
14                                     Adaptive licensing for DR tuberculosis based on 2-month sputum cu
15 ed when analysing a longer time period after licensing.
16                                Studies after licensing have provided new insights into these vaccines
17               Immunobridging studies allowed licensing of the vaccines for use starting at age 9 year
18  comply with the pertinent accreditation and licensing requirements.
19 ests globally, environmental assessments and licensing must considered both on- and off-lease sources
20 e varies according to their availability and licensing status.
21 he formation of Msh2-Msh6 sliding clamps and licensing the formation of Msh2-Msh6-Mlh1-Pms1 ternary c
22 ale usage maps can be used in consenting and licensing of anthropogenic developments to determine loc
23 ed an abbreviated pathway for developing and licensing biosimilar and interchangeable biological prod
24 creasingly reaching advanced development and licensing stages, providing new tools to fill previously
25  data requirements for their development and licensing, many clinicians, particularly oncologists, ar
26 ng its transcription by recruiting HDAC1 and licensing the removal of activating histone acetylation
27 ting the process of patenting inventions and licensing them to facilitate their use.
28 d IFN-gamma, accumulation of neutrophils and licensing and activation of other immune cell types in t
29 of tenure in the United States, patents, and licensing at universities, the current status of univers
30 examination, variation in state practice and licensing regulations, and issues surrounding the establ
31 S stimulation, and also in cross-priming and licensing cytotoxic T cell killers in vivo.
32 results in premature meiotic progression and licensing of homology-independent SC assembly.
33  we posit the need for medical societies and licensing boards to bring this issue to the forefront of
34 increasingly rigorous training, testing, and licensing processes introduced in top medical schools an
35 /f(-) was largely dependent on effective APC licensing via CD40 signaling.
36  activation events, a process referred to as licensing.
37 d target cell, a process that we refer to as licensing.
38 the weaker -Q(35) alleles, indicating better licensing of KIR2DL2/L3(+) NK cells with the stronger al
39 PV, detailed forecasting of tOPV needs, bOPV licensing, scaling up of bOPV production and procurement
40 e ischaemic stroke in randomised trials, but licensing is restrictive and use varies widely.
41 cilitates restoration of genome integrity by licensing chromatin to concentrate genome caretaker prot
42 (+) T cells promote CD8(+) T cell priming by licensing dendritic cells (DCs) via CD40-CD154 interacti
43 rovide critical help within this process, by licensing dendritic cells to prime CD8Treg cells, howeve
44   Patients worldwide would be well served by licensing of new regimens for multidrug-resistant tuberc
45 s work alters our view of how ATP is used by licensing factors to assemble pre-RCs.
46                  Under current Health Canada licensing requirements, a demonstration of bioequivalenc
47  triggers conformational changes in Cascade, licensing Cas3 to bind.
48       Furthermore, the timing of the CD4Treg licensing of dendritic cells and the spatial competition
49 , strongly supports the hypothesis that Cdt1 licensing activity is regulated by periodic interaction
50 -activated JNK kinases and also for the Cdt1 licensing factor that ensures that DNA is replicated exa
51 ndent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of I
52 s, such as STAT signaling and dendritic cell licensing throughout the splenic parenchyma.
53  with distinct affinities, affecting NK cell licensing and inhibition.
54  seemingly conflicting input affects NK cell licensing and repertoire formation in mixed hematopoieti
55           Furthermore, regulation by NK cell licensing helps to safeguard against TNFSF14 production
56 ) cells and specifically the role of NK cell licensing is not well understood in ESC rejection.
57 luated the effect of human and mouse NK cell licensing on early stages of natural cytotoxicity.
58                                Thus, NK cell licensing through Ly49 involves specific interactions wi
59 ested a role for cis interaction for NK cell licensing, adoptive NK cell transfer experiments support
60 is and in trans, are both needed for NK cell licensing.
61 tical for Ly49A- and Ly49C-dependent NK cell licensing.
62 ss to NK cells by a process known as NK cell licensing/education.
63 hich of these interactions regulates NK-cell licensing is not yet clear.
64  cells, which occur independently of NK-cell licensing via Ly49-MHC interactions.
65 ed pulp of the spleen during induced NK-cell licensing, and there were no differences in maturation o
66 s I on hematopoietic cells regulates NK-cell licensing, which is not associated with other obvious ph
67 dominant role of GrB in pDC-dependent T cell licensing.
68 lated TCR-mediated activation of MAIT cells, licensing them to dramatically increase Th1 cytokines an
69  RING-E2 approximately UBL catalytic center, licensing the acceptor lysine, and influencing E2 reacti
70 gression trigger the initiation of centriole licensing through centriole disengagement, at which poin
71 tion of Aurora kinases A and B and chromatin licensing and DNA replication factor 1 may explain the r
72 plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque
73 in DNA replication regulation by controlling licensing.
74    Thus, ER-mitochondria contacts coordinate licensing of mtDNA synthesis with division to distribute
75 sts in the future will need to consider data licensing before they embark upon re-using such content
76                                          DC "licensing" through iMyD88/CD40 may represent a mechanism
77  link was established between IL-6-dependent licensing of tumor vessels for Tem trafficking and apopt
78 ite is involved in Ly49A- or Ly49C-dependent licensing.
79 hese findings reveal that there are distinct licensing requirements for processing of IL-18 versus IL
80 ow helicase activity is regulated during DNA licensing, with implications for cell cycle control of D
81 which together provide new insights into DNA licensing.
82 nisms that redefine our understanding of DNA licensing.
83 largely due to failed degradation of the DNA licensing protein, CDT-1, and premature spermatogenesis.
84 the association between ADHD and both driver licensing and crash involvement and whether it varies by
85       In the United States, graduated driver licensing (GDL) systems allow full, unrestricted licensu
86 enagers; nevertheless, most Graduated Driver Licensing programs have provisions that require supervis
87 en linked with New Jersey's statewide driver licensing and crash databases for 2004 through 2014.
88                          As part of the drug licensing process for new CDI therapies, a pediatric inv
89                 We therefore propose a "dual-licensing" model of centriole duplication, in which Asl
90 ate of protection of 0.35 mug/mL used during licensing.
91 t, inhibition of Kin28 attenuates elongation-licensing signals, resulting in Pol II accumulation at t
92  unknown and thus neglected in environmental licensing.
93 knowledge gap and impediment to the eventual licensing of new antiviral drugs and vaccines for NIRVs.
94 ues, whereas they are more likely to exhibit licensing when they think concretely about what they hav
95 roved training of staff and routine facility licensing inspections that scrutinize infection control
96 nd Drug Administration industry guidance for licensing of antidiabetic drugs greatly increased the nu
97  used to estimate adjusted hazard ratios for licensing and crash outcomes through age 25 years.
98        In C57BL/6 mice, Dazl is required for licensing.
99 hus can be used without any requirements for licensing or software purchase.
100 India (DCGI), the Indian NRA responsible for licensing vaccines.
101            We have formulated four rules for licensing data for open drug discovery, which we propose
102  while retaining subunits that maintain fork licensing and direct reassembly to the appropriate locat
103 sruption of messenger RNA splicing; and (ii) licensing of expanded C9orf72 pre-messenger RNA for nucl
104                                     Impaired licensing of origins of replication during the G1 phase
105 egg extracts, Idas-Geminin is less active in licensing inhibition compared with a Geminin-Geminin hom
106             After this most recent change in licensing, we review the outcomes from clinical trials i
107         Geminin is thought to be involved in licensing replication by promoting the accumulation of C
108                     Cdt1 plays a key role in licensing DNA for replication.
109 ipated and novel requirement for CD200R1 in "licensing" pro-inflammatory functions of TLR2 and in lim
110 it (UreB) is required for NLRP3 inflammasome licensing.
111 is critical for NK-cell effector inhibition, licensing, and receptor repertoire development.
112                            Since its initial licensing for use in adults and adolescents 12 years of
113 of geminin by DeltaCdt1_193-447, which lacks licensing activity and degradation sequences, causes cel
114 eins are loaded onto chromatin, with maximal licensing observed just prior to S phase onset.
115           Here, we uncover a novel mechanism licensing transcription in human mesenchymal stem cells
116                             Mechanistically, licensing was largely imparted by changes in the posttra
117                 We found that Ly49C-mediated licensing induced a split effect on NK cell functions, w
118 A new study suggests that small-RNA-mediated licensing of competitive interactions between transcript
119 x, age, medical school country, U.S. Medical Licensing Examination Step, and ABIM Internal Medicine C
120  status and were obtained from state medical licensing board sites and online medical facility and pr
121 h ABSITE scores: prior United States Medical Licensing Examination (USMLE) 1 and 2 scores (per 1-poin
122 IDSA ITE scores, prior United States Medical Licensing Examination (USMLE) scores, ABIM Internal Medi
123 r variables, including United States Medical Licensing Examination (USMLE) Step 1 score, Alpha Omega
124 es (range, 12-30), and United States Medical Licensing Examination (USMLE) Step 2 scores, adjusted fo
125 were pass rates on the United States Medical Licensing Examination (USMLE) Step examinations and grad
126 d significantly higher United States Medical Licensing Examination scores (mean [SD] step 1 score, 23
127 or publications; a low United States Medical Licensing Examination Step 1 score; and non-membership i
128         Men had higher United States Medical Licensing Examination Step 1 scores (238.0 vs 230.1; P <
129 tion included a PGY-2, United States Medical Licensing Examination step 2 score, year 1 American Boar
130                           Average US Medical Licensing Examination Step 1 scores were 239 +/- 14 and
131  first-attempt failing scores) on US Medical Licensing Examination Step 2 Clinical Knowledge were mor
132 rst-attempt passing scores on the US Medical Licensing Examination Step l and/or Step 2 CK.
133  without inhibitory receptors for self-MHC ("licensing").
134                            In cancer models, licensing of gammadelta T cells by tumor-reactive mAbs p
135  evidence for both moral contagion and moral licensing.
136 tion by their target Ag and a process named "licensing." In this study, we analyzed these processes i
137  accepted scored higher on Canadian national licensing examinations.
138                            In conclusion, NK licensing mediated by KIR2DL2/3 and HLA-C1 elicits a nov
139 o investigated Ly49A- and Ly49C-dependent NK licensing in murine beta2m-deficient mice that are trans
140 a neutralization resulted in detection of NK licensing effects.
141                                     Thus, NK licensing behavior to MCMV corresponds to the donor, and
142 by Cdc6 is required to release nonproductive licensing intermediates.
143                               The absence of licensing is assumed to explain the block to DNA replica
144 s, nucleocytoplasmic compartmentalization of licensing factors ensures that DNA replication occurs on
145 cal adjuvants and the cost and complexity of licensing new adjuvants for human use.
146 essively to ensure that the disappearance of licensing inhibitors coincides exactly with a peak of Cd
147  This study unravels multifaceted effects of licensing on NK cell populations and their functions.
148 o confirmation of the physiologic effects of licensing with differential effects of NK subsets on ant
149 transgenic mice to investigate the impact of licensing through this inhibitory receptor in precursor
150 ity theory by treating the implementation of Licensing Act (2003) as a natural experiment in alcohol
151 in the persistent presence of high levels of licensing proteins by relying on changing interactions b
152  DNA rereplication can be induced by loss of licensing control at cellular replication origins, or by
153 d autoreactive T cells required a process of licensing in the lung revealed an unexpected relationshi
154 evision of costly and laborious processes of licensing and regulation of new antibiotics, and address
155 rticipation in WHO-convened joint reviews of licensing dossiers, as well as pragmatic application of
156 function is better characterized in terms of licensing inferences to opaque generic content than in t
157 hat naive CD8(+) T cells remain dependent on licensing by APCs and CD4(+) T cells, and it may therefo
158 n of graft survival, a function dependent on licensing by gut microflora.
159 etimes it liberates them to do the opposite (licensing)?
160 al NK cell repertoire, known as education or licensing, is a complex process mediated through inhibit
161 ynamic process known as NK cell education or licensing.
162 al requirements both before and after origin licensing.
163 rmally high levels of replication and origin licensing factors and are likely poised for genome re-re
164           These sites are selected by origin licensing, during which the core enzyme of the eukaryoti
165 ltransferases may be recruited during origin licensing.
166 covered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G
167 e in ATP hydrolysis are competent for origin licensing.
168  of the DNA sequence requirements for origin licensing.
169 itive to replication stress, and full origin licensing ensures their correct differentiation and func
170 tant developmental impact of impaired origin licensing.
171  replication, suggesting increment in origin licensing and re-replication.
172 nsistent with the role of Cyclin A in origin licensing.
173 some maintenance (MCM)3 that limiting origin licensing in vivo affects the functionality of hematopoi
174            However, the mechanisms of origin licensing and helicase activation are poorly understood.
175 ivity that is critical for preventing origin licensing in DNA-damaged cells.
176 y promotes bud formation and prevents origin licensing so that DNA cannot rereplicate between bud for
177                           Thus, rapid origin licensing is an intrinsic characteristic of stem cells t
178     The separation of DNA replication origin licensing and activation in the cell cycle is essential
179 xpected to compromise DNA replication origin licensing and result in elevated rates of genome damage
180 o be achieved by limiting replication origin licensing and thereby restricting the firing of each rep
181 ouble hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DN
182  proteins involved in DNA replication origin licensing may explain the deleterious consequences of CS
183  essential for eukaryotic replication origin licensing, however, it is poorly understood how CDC6 act
184 reduce the ability of Cdt1 to support origin licensing.
185  origins, an essential process termed origin licensing.
186 in with hypomorphic expression of the origin licensing factor mini-chromosome maintenance (MCM)3 that
187                                  This origin licensing requires loading two Mcm2-7 helicases around o
188 n timing can be reset subsequently to origin licensing.
189  but the molecular mechanism of this origin 'licensing' is still poorly understood.
190          Knockdown of the replication origin-licensing factor CDT1 eliminates both stress-induced rer
191  terms, and we have added a statement to our licensing policy stipulating that anyone, including comm
192 ould expand their criteria to treat patents, licensing, and commercialization activity by faculty as
193 ddressed, as well as current practice in pre-licensing trials, the increasing problems of polypharmac
194       DNA replication depends on a preceding licensing event by Cdt1 and Cdc6.
195 ittle in vivo evidence for this preferential licensing across mouse strains with different MHC haplot
196 th competence to load COSA-1 requiring prior licensing.
197                                        Rapid licensing in stem cells is caused by accumulation of the
198 ponsiveness of activating NK cell receptors (licensing) and modifies the repertoire of MHC-I receptor
199        Therefore, MHC polymorphism regulates licensing and detection of viral targets by distinct sub
200 because of availability, cost, or regulatory licensing.
201              Barriers include reimbursement, licensing, and fear of litigation.
202 s during G1 phase, suggestive of reiterative licensing.
203 the recruiting transcription and replication licensing factors coordinates the transcriptional and DN
204 nsation, DNA damage response and replication licensing.
205 BO1) plays a crucial role in DNA replication licensing and cell proliferation, yet its molecular regu
206  dramatically decreased MCM7 DNA replication licensing and induced cell growth arrest.
207 is an essential component of DNA replication licensing complex.
208 h predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replicatio
209 ession, including a critical DNA replication licensing factor CDT1.
210                         Cdt1 DNA replication licensing factor is part of the pre-replication complex
211 easomal degradation of Cdt1 (DNA replication licensing factor), p21 (cyclin-dependent kinase [CDK] in
212   MCM7 is one of the pivotal DNA replication licensing factors in controlling DNA synthesis and cell
213                              DNA replication licensing is now understood to be the pathway that leads
214 , but its role in regulating DNA replication licensing is unclear.
215 t does not bind RACK1 has no DNA replication licensing or oncogenic transformation activity.
216 2) function during origin of DNA replication licensing, dependent on Suv4-20h1/2 activity.
217 teins play critical roles in DNA replication licensing, initiation and elongation.
218 complex), which mediates pre-DNA replication licensing--contains a bromo adjacent homology (BAH) doma
219  by depleting Cdt1, an essential replication licensing factor, partially rescued emi1 deficiency-indu
220 l in which ORC1 mutations impair replication licensing, slowing cell cycle progression and consequent
221 DT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromati
222  complex, implicating defects in replication licensing as the cause of a genetic syndrome with distin
223  the first comprehensive view of replication licensing in vivo, using video microscopy of Caenorhabdi
224 g DNA rereplication upon loss of replication licensing through the activation of the S-phase checkpoi
225 on requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replicatio
226 latory mechanisms of prokaryotic replication licensing.
227 yonic cells are able to regulate replication licensing in the persistent presence of high levels of l
228 l cycle progression that targets replication licensing factors, also targets the p12 subunit of Pol d
229 nome encodes two homologs of the replication licensing factor CDC10 Target1 (CDT1), and overexpressio
230                              The replication licensing factor CDC6 recruits the MCM2-7 replicative he
231  E3 ubiquitin ligase include the replication licensing factor Cdt1 and the cyclin-dependent kinase (C
232  Several proteins, including the replication licensing factor CDT1 and the histone methyltransferase
233 ex genotype group is a defective replication-licensing complex.
234 ene proximity relies on both DNA replication-licensing and actual DNA replication activity.
235 e (Mcm) proteins are part of the replication-licensing complex that is loaded onto chromatin during t
236                    MAPC suppression required licensing and proceeded via IDO-mediated tryptophan cata
237 ologic activity may not be innate, requiring licensing by their microenvironment.
238 sh involvement and whether it varies by sex, licensing age, and/or being prescribed ADHD medication a
239 (95% CI, 1.25-1.48) and did not vary by sex, licensing age, or over time.
240 ting public access, the new policies specify licensing terms for reuse of content by third parties, i
241 ll, and no ambiguity was found about states' licensing powers.
242  ability to study NK cells with synchronized licensing.
243 tor function by an education process termed "licensing" mediated by inhibitory Ly49 receptors which r
244 an MHC-dependent educational process termed "licensing." For example, Ly49A(+) NK cells become licens
245 ompetence through an unclear process termed "licensing." Ly49C is the main self-specific inhibitory L
246                   Thus, we demonstrated that licensing of dysbiotic microbiota is a critical componen
247                   Importantly, we found that licensing of cytokine production was mediated by paracri
248 ystem of mouse CMV infection, indicated that licensing did not play a major role in the NK cell antiv
249 lication cycle, raising the possibility that licensing of centrosome duplication occurs by modulating
250                              We propose that licensing by Ab is a mechanism whereby the adaptive prop
251                                          The licensing of direct-acting antivirals heralds a new era
252                                          The licensing of herpes zoster vaccine has demonstrated that
253                                          The licensing of ipilimumab and sipuleucel-T for cancer, and
254  Compared with individuals without ADHD, the licensing probability of individuals with ADHD 6 months
255 gainst replicative stress is provided by the licensing of thousands of origins in G1 that are not nec
256  population of NK cells as determined by the licensing patterns of donor MHC-I haplotypes, resulted i
257  Sfi1 C-terminal (Sfi1-CT) dimerization, the licensing step for SPB duplication.
258 of protection of 0.35 mug/mL has enabled the licensing of effective new PCVs, serotype-specific corre
259 lizing drug activity, and would expedite the licensing of new treatment regimens.
260 empt to subvert this block by expressing the licensing control factors Cdc18 and Cdt1 during the inte
261                                Following the licensing of an injectable vaccine, we consider the rela
262 covered a single phosphorylation site in the licensing factor M18BP1 and a cyclin A binding site in t
263 well as de novo stabilizing mutations in the licensing inhibitor, GMNN, cause MGS.
264 ctive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intesti
265                      These steps include the licensing of DCs by the microbiota, their activation and
266 uture of increased database integration, the licensing of the data may be a hurdle that hampers progr
267 ion (MBT), including a marked decline of the licensing factor XCdc6.
268 its known functions in the regulation of the licensing of replication origins and expanding the scope
269 y the helper macrophages, reminiscent of the licensing role of helper T cells in antiviral adaptive i
270 atin during G1 phase and is dependent on the licensing factor Cdt1.
271 f proinflammatory conditions to override the licensing mechanism.
272          Analysis found no evidence that the Licensing Act (2003) affected the overall volume of viol
273                     UBXN-3/FAF1 binds to the licensing factor CDT-1 and additional ubiquitylated prot
274 eatments can be found to either speed up the licensing process, or increase the spatial competitivene
275                   Geminin interacts with the licensing factor Cdt1 to prevent untimely replication an
276             In this study, we show that the "licensing" of NK cells, determined by the presence of KI
277 ent long-range resection altogether, thereby licensing NHEJ at collapsed forks.
278 all expected value of control (EVC), thereby licensing the associated cognitive effort.
279 sequence site on the CTLA4 promoter, thereby licensing CBP/p300-mediated histone acetylation and loca
280 11 endonuclease initiates resection, thereby licensing HR followed by MRE11 exonuclease and EXO1/BLM
281 er its interaction with mature TACE, thereby licensing its proteolytic activity.
282 , mediating protective immunity both through licensing of cellular effectors of the innate immune sys
283  induction of oral tolerance to DNFB through licensing tolerogenic gut DCs.
284                                        Thus, licensing controls signals as proximal as inside-out sig
285 ient peripheral T cells have a defect in TNF licensing after TCR/CD28 stimulation.
286 igen and prime CD8 T cells after exposure to licensing stimuli, such as an agonistic anti-CD40 antibo
287     Loss of 53BP1 caused hypersensitivity to licensing inhibition when replication origins were remov
288  improvements in overall survival leading to licensing for the treatment of metastatic castration-res
289 03 and December 2004 prospectively linked to licensing and police-reported crash data, with an averag
290 ecent data with respect to issues related to licensing, thereby providing a framework for unifying co
291  that PGCs of both XX and XY fetuses undergo licensing, an active developmental transition that enabl
292   In all, tested organs donor cells undergo "licensing" for pathogenicity, consisting of vigorous inc
293 induced CD8(+) memory T-cell expansions upon licensing by CD4(+) T cells, and primed naive CD8(+) T c
294 re on moderators of moral consistency versus licensing effects using five conceptual themes: construa
295 loading in live human cells using an in vivo licensing assay on the basis of fluorescence recovery af
296 the notion that the lung is the organ where "licensing" for pathogenicity takes place is based on bia
297 the notion that the lung is the organ where "licensing" takes place.
298 onut" designs), leaving it ambiguous whether licensing was observed.
299 ility of binding to self-MHC consistent with licensing.
300 SU1 and pPSU2 plasmids are available without licensing restrictions to nonprofit academic users, affo

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