ライフサイエンスコーパス: licensing

1 Licensing consists of the loading of the hexameric MCM2-

2 Licensing is restricted to G1 phase of the cell cycle, b

3 Licensing serves as a gateway from the embryonic process

4 -S progression, possibly by functioning as a licensing factor for DNA replication.

5 hen present on the chromatin, may serve as a licensing factor for estrogen-ESR1-mediated interactions

6 cus, the present results establish PTIP as a licensing factor for humoral immunity that acts at sever

7 As such, Htm1p-Pdi1p is suited to act as a licensing factor that monitors folding in the ER lumen a

8 This mutant Ly49A caused a licensing defect in NK cells, but the surface expression

9 o centrioles during anaphase is considered a licensing event for the next round of centriole duplicat

10 ), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 t

11 and inhibited by TCR-blockade, suggesting a licensing interaction involving the TCR and FcgammaR.

12 inhibition of mitosis coupled with aberrant licensing of S-phase entry.

13 tion necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural

14 Adaptive licensing for DR tuberculosis based on 2-month sputum cu

15 ed when analysing a longer time period after licensing.

16 Studies after licensing have provided new insights into these vaccines

17 Immunobridging studies allowed licensing of the vaccines for use starting at age 9 year

18 comply with the pertinent accreditation and licensing requirements.

19 ests globally, environmental assessments and licensing must considered both on- and off-lease sources

20 e varies according to their availability and licensing status.

21 he formation of Msh2-Msh6 sliding clamps and licensing the formation of Msh2-Msh6-Mlh1-Pms1 ternary c

22 ale usage maps can be used in consenting and licensing of anthropogenic developments to determine loc

23 ed an abbreviated pathway for developing and licensing biosimilar and interchangeable biological prod

24 creasingly reaching advanced development and licensing stages, providing new tools to fill previously

25 data requirements for their development and licensing, many clinicians, particularly oncologists, ar

26 ng its transcription by recruiting HDAC1 and licensing the removal of activating histone acetylation

27 ting the process of patenting inventions and licensing them to facilitate their use.

28 d IFN-gamma, accumulation of neutrophils and licensing and activation of other immune cell types in t

29 of tenure in the United States, patents, and licensing at universities, the current status of univers

30 examination, variation in state practice and licensing regulations, and issues surrounding the establ

31 S stimulation, and also in cross-priming and licensing cytotoxic T cell killers in vivo.

32 results in premature meiotic progression and licensing of homology-independent SC assembly.

33 we posit the need for medical societies and licensing boards to bring this issue to the forefront of

34 increasingly rigorous training, testing, and licensing processes introduced in top medical schools an

35 /f(-) was largely dependent on effective APC licensing via CD40 signaling.

36 activation events, a process referred to as licensing.

37 d target cell, a process that we refer to as licensing.

38 the weaker -Q(35) alleles, indicating better licensing of KIR2DL2/L3(+) NK cells with the stronger al

39 PV, detailed forecasting of tOPV needs, bOPV licensing, scaling up of bOPV production and procurement

40 e ischaemic stroke in randomised trials, but licensing is restrictive and use varies widely.

41 cilitates restoration of genome integrity by licensing chromatin to concentrate genome caretaker prot

42 (+) T cells promote CD8(+) T cell priming by licensing dendritic cells (DCs) via CD40-CD154 interacti

43 rovide critical help within this process, by licensing dendritic cells to prime CD8Treg cells, howeve

44 Patients worldwide would be well served by licensing of new regimens for multidrug-resistant tuberc

45 s work alters our view of how ATP is used by licensing factors to assemble pre-RCs.

46 Under current Health Canada licensing requirements, a demonstration of bioequivalenc

47 triggers conformational changes in Cascade, licensing Cas3 to bind.

48 Furthermore, the timing of the CD4Treg licensing of dendritic cells and the spatial competition

49 , strongly supports the hypothesis that Cdt1 licensing activity is regulated by periodic interaction

50 -activated JNK kinases and also for the Cdt1 licensing factor that ensures that DNA is replicated exa

51 ndent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of I

52 s, such as STAT signaling and dendritic cell licensing throughout the splenic parenchyma.

53 with distinct affinities, affecting NK cell licensing and inhibition.

54 seemingly conflicting input affects NK cell licensing and repertoire formation in mixed hematopoieti

55 Furthermore, regulation by NK cell licensing helps to safeguard against TNFSF14 production

56 ) cells and specifically the role of NK cell licensing is not well understood in ESC rejection.

57 luated the effect of human and mouse NK cell licensing on early stages of natural cytotoxicity.

58 Thus, NK cell licensing through Ly49 involves specific interactions wi

59 ested a role for cis interaction for NK cell licensing, adoptive NK cell transfer experiments support

60 is and in trans, are both needed for NK cell licensing.

61 tical for Ly49A- and Ly49C-dependent NK cell licensing.

62 ss to NK cells by a process known as NK cell licensing/education.

63 hich of these interactions regulates NK-cell licensing is not yet clear.

64 cells, which occur independently of NK-cell licensing via Ly49-MHC interactions.

65 ed pulp of the spleen during induced NK-cell licensing, and there were no differences in maturation o

66 s I on hematopoietic cells regulates NK-cell licensing, which is not associated with other obvious ph

67 dominant role of GrB in pDC-dependent T cell licensing.

68 lated TCR-mediated activation of MAIT cells, licensing them to dramatically increase Th1 cytokines an

69 RING-E2 approximately UBL catalytic center, licensing the acceptor lysine, and influencing E2 reacti

70 gression trigger the initiation of centriole licensing through centriole disengagement, at which poin

71 tion of Aurora kinases A and B and chromatin licensing and DNA replication factor 1 may explain the r

72 plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque

73 in DNA replication regulation by controlling licensing.

74 Thus, ER-mitochondria contacts coordinate licensing of mtDNA synthesis with division to distribute

75 sts in the future will need to consider data licensing before they embark upon re-using such content

76 DC "licensing" through iMyD88/CD40 may represent a mechanism

77 link was established between IL-6-dependent licensing of tumor vessels for Tem trafficking and apopt

78 ite is involved in Ly49A- or Ly49C-dependent licensing.

79 hese findings reveal that there are distinct licensing requirements for processing of IL-18 versus IL

80 ow helicase activity is regulated during DNA licensing, with implications for cell cycle control of D

81 which together provide new insights into DNA licensing.

82 nisms that redefine our understanding of DNA licensing.

83 largely due to failed degradation of the DNA licensing protein, CDT-1, and premature spermatogenesis.

84 the association between ADHD and both driver licensing and crash involvement and whether it varies by

85 In the United States, graduated driver licensing (GDL) systems allow full, unrestricted licensu

86 enagers; nevertheless, most Graduated Driver Licensing programs have provisions that require supervis

87 en linked with New Jersey's statewide driver licensing and crash databases for 2004 through 2014.

88 As part of the drug licensing process for new CDI therapies, a pediatric inv

89 We therefore propose a "dual-licensing" model of centriole duplication, in which Asl

90 ate of protection of 0.35 mug/mL used during licensing.

91 t, inhibition of Kin28 attenuates elongation-licensing signals, resulting in Pol II accumulation at t

92 unknown and thus neglected in environmental licensing.

93 knowledge gap and impediment to the eventual licensing of new antiviral drugs and vaccines for NIRVs.

94 ues, whereas they are more likely to exhibit licensing when they think concretely about what they hav

95 roved training of staff and routine facility licensing inspections that scrutinize infection control

96 nd Drug Administration industry guidance for licensing of antidiabetic drugs greatly increased the nu

97 used to estimate adjusted hazard ratios for licensing and crash outcomes through age 25 years.

98 In C57BL/6 mice, Dazl is required for licensing.

99 hus can be used without any requirements for licensing or software purchase.

100 India (DCGI), the Indian NRA responsible for licensing vaccines.

101 We have formulated four rules for licensing data for open drug discovery, which we propose

102 while retaining subunits that maintain fork licensing and direct reassembly to the appropriate locat

103 sruption of messenger RNA splicing; and (ii) licensing of expanded C9orf72 pre-messenger RNA for nucl

104 Impaired licensing of origins of replication during the G1 phase

105 egg extracts, Idas-Geminin is less active in licensing inhibition compared with a Geminin-Geminin hom

106 After this most recent change in licensing, we review the outcomes from clinical trials i

107 Geminin is thought to be involved in licensing replication by promoting the accumulation of C

108 Cdt1 plays a key role in licensing DNA for replication.

109 ipated and novel requirement for CD200R1 in "licensing" pro-inflammatory functions of TLR2 and in lim

110 it (UreB) is required for NLRP3 inflammasome licensing.

111 is critical for NK-cell effector inhibition, licensing, and receptor repertoire development.

112 Since its initial licensing for use in adults and adolescents 12 years of

113 of geminin by DeltaCdt1_193-447, which lacks licensing activity and degradation sequences, causes cel

114 eins are loaded onto chromatin, with maximal licensing observed just prior to S phase onset.

115 Here, we uncover a novel mechanism licensing transcription in human mesenchymal stem cells

116 Mechanistically, licensing was largely imparted by changes in the posttra

117 We found that Ly49C-mediated licensing induced a split effect on NK cell functions, w

118 A new study suggests that small-RNA-mediated licensing of competitive interactions between transcript

119 x, age, medical school country, U.S. Medical Licensing Examination Step, and ABIM Internal Medicine C

120 status and were obtained from state medical licensing board sites and online medical facility and pr

121 h ABSITE scores: prior United States Medical Licensing Examination (USMLE) 1 and 2 scores (per 1-poin

122 IDSA ITE scores, prior United States Medical Licensing Examination (USMLE) scores, ABIM Internal Medi

123 r variables, including United States Medical Licensing Examination (USMLE) Step 1 score, Alpha Omega

124 es (range, 12-30), and United States Medical Licensing Examination (USMLE) Step 2 scores, adjusted fo

125 were pass rates on the United States Medical Licensing Examination (USMLE) Step examinations and grad

126 d significantly higher United States Medical Licensing Examination scores (mean [SD] step 1 score, 23

127 or publications; a low United States Medical Licensing Examination Step 1 score; and non-membership i

128 Men had higher United States Medical Licensing Examination Step 1 scores (238.0 vs 230.1; P <

129 tion included a PGY-2, United States Medical Licensing Examination step 2 score, year 1 American Boar

130 Average US Medical Licensing Examination Step 1 scores were 239 +/- 14 and

131 first-attempt failing scores) on US Medical Licensing Examination Step 2 Clinical Knowledge were mor

132 rst-attempt passing scores on the US Medical Licensing Examination Step l and/or Step 2 CK.

133 without inhibitory receptors for self-MHC ("licensing").

134 In cancer models, licensing of gammadelta T cells by tumor-reactive mAbs p

135 evidence for both moral contagion and moral licensing.

136 tion by their target Ag and a process named "licensing." In this study, we analyzed these processes i

137 accepted scored higher on Canadian national licensing examinations.

138 In conclusion, NK licensing mediated by KIR2DL2/3 and HLA-C1 elicits a nov

139 o investigated Ly49A- and Ly49C-dependent NK licensing in murine beta2m-deficient mice that are trans

140 a neutralization resulted in detection of NK licensing effects.

141 Thus, NK licensing behavior to MCMV corresponds to the donor, and

142 by Cdc6 is required to release nonproductive licensing intermediates.

143 The absence of licensing is assumed to explain the block to DNA replica

144 s, nucleocytoplasmic compartmentalization of licensing factors ensures that DNA replication occurs on

145 cal adjuvants and the cost and complexity of licensing new adjuvants for human use.

146 essively to ensure that the disappearance of licensing inhibitors coincides exactly with a peak of Cd

147 This study unravels multifaceted effects of licensing on NK cell populations and their functions.

148 o confirmation of the physiologic effects of licensing with differential effects of NK subsets on ant

149 transgenic mice to investigate the impact of licensing through this inhibitory receptor in precursor

150 ity theory by treating the implementation of Licensing Act (2003) as a natural experiment in alcohol

151 in the persistent presence of high levels of licensing proteins by relying on changing interactions b

152 DNA rereplication can be induced by loss of licensing control at cellular replication origins, or by

153 d autoreactive T cells required a process of licensing in the lung revealed an unexpected relationshi

154 evision of costly and laborious processes of licensing and regulation of new antibiotics, and address

155 rticipation in WHO-convened joint reviews of licensing dossiers, as well as pragmatic application of

156 function is better characterized in terms of licensing inferences to opaque generic content than in t

157 hat naive CD8(+) T cells remain dependent on licensing by APCs and CD4(+) T cells, and it may therefo

158 n of graft survival, a function dependent on licensing by gut microflora.

159 etimes it liberates them to do the opposite (licensing)?

160 al NK cell repertoire, known as education or licensing, is a complex process mediated through inhibit

161 ynamic process known as NK cell education or licensing.

162 al requirements both before and after origin licensing.

163 rmally high levels of replication and origin licensing factors and are likely poised for genome re-re

164 These sites are selected by origin licensing, during which the core enzyme of the eukaryoti

165 ltransferases may be recruited during origin licensing.

166 covered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G

167 e in ATP hydrolysis are competent for origin licensing.

168 of the DNA sequence requirements for origin licensing.

169 itive to replication stress, and full origin licensing ensures their correct differentiation and func

170 tant developmental impact of impaired origin licensing.

171 replication, suggesting increment in origin licensing and re-replication.

172 nsistent with the role of Cyclin A in origin licensing.

173 some maintenance (MCM)3 that limiting origin licensing in vivo affects the functionality of hematopoi

174 However, the mechanisms of origin licensing and helicase activation are poorly understood.

175 ivity that is critical for preventing origin licensing in DNA-damaged cells.

176 y promotes bud formation and prevents origin licensing so that DNA cannot rereplicate between bud for

177 Thus, rapid origin licensing is an intrinsic characteristic of stem cells t

178 The separation of DNA replication origin licensing and activation in the cell cycle is essential

179 xpected to compromise DNA replication origin licensing and result in elevated rates of genome damage

180 o be achieved by limiting replication origin licensing and thereby restricting the firing of each rep

181 ouble hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DN

182 proteins involved in DNA replication origin licensing may explain the deleterious consequences of CS

183 essential for eukaryotic replication origin licensing, however, it is poorly understood how CDC6 act

184 reduce the ability of Cdt1 to support origin licensing.

185 origins, an essential process termed origin licensing.

186 in with hypomorphic expression of the origin licensing factor mini-chromosome maintenance (MCM)3 that

187 This origin licensing requires loading two Mcm2-7 helicases around o

188 n timing can be reset subsequently to origin licensing.

189 but the molecular mechanism of this origin 'licensing' is still poorly understood.

190 Knockdown of the replication origin-licensing factor CDT1 eliminates both stress-induced rer

191 terms, and we have added a statement to our licensing policy stipulating that anyone, including comm

192 ould expand their criteria to treat patents, licensing, and commercialization activity by faculty as

193 ddressed, as well as current practice in pre-licensing trials, the increasing problems of polypharmac

194 DNA replication depends on a preceding licensing event by Cdt1 and Cdc6.

195 ittle in vivo evidence for this preferential licensing across mouse strains with different MHC haplot

196 th competence to load COSA-1 requiring prior licensing.

197 Rapid licensing in stem cells is caused by accumulation of the

198 ponsiveness of activating NK cell receptors (licensing) and modifies the repertoire of MHC-I receptor

199 Therefore, MHC polymorphism regulates licensing and detection of viral targets by distinct sub

200 because of availability, cost, or regulatory licensing.

201 Barriers include reimbursement, licensing, and fear of litigation.

202 s during G1 phase, suggestive of reiterative licensing.

203 the recruiting transcription and replication licensing factors coordinates the transcriptional and DN

204 nsation, DNA damage response and replication licensing.

205 BO1) plays a crucial role in DNA replication licensing and cell proliferation, yet its molecular regu

206 dramatically decreased MCM7 DNA replication licensing and induced cell growth arrest.

207 is an essential component of DNA replication licensing complex.

208 h predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replicatio

209 ession, including a critical DNA replication licensing factor CDT1.

210 Cdt1 DNA replication licensing factor is part of the pre-replication complex

211 easomal degradation of Cdt1 (DNA replication licensing factor), p21 (cyclin-dependent kinase [CDK] in

212 MCM7 is one of the pivotal DNA replication licensing factors in controlling DNA synthesis and cell

213 DNA replication licensing is now understood to be the pathway that leads

214 , but its role in regulating DNA replication licensing is unclear.

215 t does not bind RACK1 has no DNA replication licensing or oncogenic transformation activity.

216 2) function during origin of DNA replication licensing, dependent on Suv4-20h1/2 activity.

217 teins play critical roles in DNA replication licensing, initiation and elongation.

218 complex), which mediates pre-DNA replication licensing--contains a bromo adjacent homology (BAH) doma

219 by depleting Cdt1, an essential replication licensing factor, partially rescued emi1 deficiency-indu

220 l in which ORC1 mutations impair replication licensing, slowing cell cycle progression and consequent

221 DT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromati

222 complex, implicating defects in replication licensing as the cause of a genetic syndrome with distin

223 the first comprehensive view of replication licensing in vivo, using video microscopy of Caenorhabdi

224 g DNA rereplication upon loss of replication licensing through the activation of the S-phase checkpoi

225 on requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replicatio

226 latory mechanisms of prokaryotic replication licensing.

227 yonic cells are able to regulate replication licensing in the persistent presence of high levels of l

228 l cycle progression that targets replication licensing factors, also targets the p12 subunit of Pol d

229 nome encodes two homologs of the replication licensing factor CDC10 Target1 (CDT1), and overexpressio

230 The replication licensing factor CDC6 recruits the MCM2-7 replicative he

231 E3 ubiquitin ligase include the replication licensing factor Cdt1 and the cyclin-dependent kinase (C

232 Several proteins, including the replication licensing factor CDT1 and the histone methyltransferase

233 ex genotype group is a defective replication-licensing complex.

234 ene proximity relies on both DNA replication-licensing and actual DNA replication activity.

235 e (Mcm) proteins are part of the replication-licensing complex that is loaded onto chromatin during t

236 MAPC suppression required licensing and proceeded via IDO-mediated tryptophan cata

237 ologic activity may not be innate, requiring licensing by their microenvironment.

238 sh involvement and whether it varies by sex, licensing age, and/or being prescribed ADHD medication a

239 (95% CI, 1.25-1.48) and did not vary by sex, licensing age, or over time.

240 ting public access, the new policies specify licensing terms for reuse of content by third parties, i

241 ll, and no ambiguity was found about states' licensing powers.

242 ability to study NK cells with synchronized licensing.

243 tor function by an education process termed "licensing" mediated by inhibitory Ly49 receptors which r

244 an MHC-dependent educational process termed "licensing." For example, Ly49A(+) NK cells become licens

245 ompetence through an unclear process termed "licensing." Ly49C is the main self-specific inhibitory L

246 Thus, we demonstrated that licensing of dysbiotic microbiota is a critical componen

247 Importantly, we found that licensing of cytokine production was mediated by paracri

248 ystem of mouse CMV infection, indicated that licensing did not play a major role in the NK cell antiv

249 lication cycle, raising the possibility that licensing of centrosome duplication occurs by modulating

250 We propose that licensing by Ab is a mechanism whereby the adaptive prop

251 The licensing of direct-acting antivirals heralds a new era

252 The licensing of herpes zoster vaccine has demonstrated that

253 The licensing of ipilimumab and sipuleucel-T for cancer, and

254 Compared with individuals without ADHD, the licensing probability of individuals with ADHD 6 months

255 gainst replicative stress is provided by the licensing of thousands of origins in G1 that are not nec

256 population of NK cells as determined by the licensing patterns of donor MHC-I haplotypes, resulted i

257 Sfi1 C-terminal (Sfi1-CT) dimerization, the licensing step for SPB duplication.

258 of protection of 0.35 mug/mL has enabled the licensing of effective new PCVs, serotype-specific corre

259 lizing drug activity, and would expedite the licensing of new treatment regimens.

260 empt to subvert this block by expressing the licensing control factors Cdc18 and Cdt1 during the inte

261 Following the licensing of an injectable vaccine, we consider the rela

262 covered a single phosphorylation site in the licensing factor M18BP1 and a cyclin A binding site in t

263 well as de novo stabilizing mutations in the licensing inhibitor, GMNN, cause MGS.

264 ctive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intesti

265 These steps include the licensing of DCs by the microbiota, their activation and

266 uture of increased database integration, the licensing of the data may be a hurdle that hampers progr

267 ion (MBT), including a marked decline of the licensing factor XCdc6.

268 its known functions in the regulation of the licensing of replication origins and expanding the scope

269 y the helper macrophages, reminiscent of the licensing role of helper T cells in antiviral adaptive i

270 atin during G1 phase and is dependent on the licensing factor Cdt1.

271 f proinflammatory conditions to override the licensing mechanism.

272 Analysis found no evidence that the Licensing Act (2003) affected the overall volume of viol

273 UBXN-3/FAF1 binds to the licensing factor CDT-1 and additional ubiquitylated prot

274 eatments can be found to either speed up the licensing process, or increase the spatial competitivene

275 Geminin interacts with the licensing factor Cdt1 to prevent untimely replication an

276 In this study, we show that the "licensing" of NK cells, determined by the presence of KI

277 ent long-range resection altogether, thereby licensing NHEJ at collapsed forks.

278 all expected value of control (EVC), thereby licensing the associated cognitive effort.

279 sequence site on the CTLA4 promoter, thereby licensing CBP/p300-mediated histone acetylation and loca

280 11 endonuclease initiates resection, thereby licensing HR followed by MRE11 exonuclease and EXO1/BLM

281 er its interaction with mature TACE, thereby licensing its proteolytic activity.

282 , mediating protective immunity both through licensing of cellular effectors of the innate immune sys

283 induction of oral tolerance to DNFB through licensing tolerogenic gut DCs.

284 Thus, licensing controls signals as proximal as inside-out sig

285 ient peripheral T cells have a defect in TNF licensing after TCR/CD28 stimulation.

286 igen and prime CD8 T cells after exposure to licensing stimuli, such as an agonistic anti-CD40 antibo

287 Loss of 53BP1 caused hypersensitivity to licensing inhibition when replication origins were remov

288 improvements in overall survival leading to licensing for the treatment of metastatic castration-res

289 03 and December 2004 prospectively linked to licensing and police-reported crash data, with an averag

290 ecent data with respect to issues related to licensing, thereby providing a framework for unifying co

291 that PGCs of both XX and XY fetuses undergo licensing, an active developmental transition that enabl

292 In all, tested organs donor cells undergo "licensing" for pathogenicity, consisting of vigorous inc

293 induced CD8(+) memory T-cell expansions upon licensing by CD4(+) T cells, and primed naive CD8(+) T c

294 re on moderators of moral consistency versus licensing effects using five conceptual themes: construa

295 loading in live human cells using an in vivo licensing assay on the basis of fluorescence recovery af

296 the notion that the lung is the organ where "licensing" for pathogenicity takes place is based on bia

297 the notion that the lung is the organ where "licensing" takes place.

298 onut" designs), leaving it ambiguous whether licensing was observed.

299 ility of binding to self-MHC consistent with licensing.

300 SU1 and pPSU2 plasmids are available without licensing restrictions to nonprofit academic users, affo