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1 Licensing consists of the loading of the hexameric MCM2-
2 Licensing is restricted to G1 phase of the cell cycle, b
3 Licensing serves as a gateway from the embryonic process
5 hen present on the chromatin, may serve as a licensing factor for estrogen-ESR1-mediated interactions
6 cus, the present results establish PTIP as a licensing factor for humoral immunity that acts at sever
7 As such, Htm1p-Pdi1p is suited to act as a licensing factor that monitors folding in the ER lumen a
9 o centrioles during anaphase is considered a licensing event for the next round of centriole duplicat
10 ), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 t
11 and inhibited by TCR-blockade, suggesting a licensing interaction involving the TCR and FcgammaR.
13 tion necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural
19 ests globally, environmental assessments and licensing must considered both on- and off-lease sources
21 he formation of Msh2-Msh6 sliding clamps and licensing the formation of Msh2-Msh6-Mlh1-Pms1 ternary c
22 ale usage maps can be used in consenting and licensing of anthropogenic developments to determine loc
23 ed an abbreviated pathway for developing and licensing biosimilar and interchangeable biological prod
24 creasingly reaching advanced development and licensing stages, providing new tools to fill previously
25 data requirements for their development and licensing, many clinicians, particularly oncologists, ar
26 ng its transcription by recruiting HDAC1 and licensing the removal of activating histone acetylation
28 d IFN-gamma, accumulation of neutrophils and licensing and activation of other immune cell types in t
29 of tenure in the United States, patents, and licensing at universities, the current status of univers
30 examination, variation in state practice and licensing regulations, and issues surrounding the establ
33 we posit the need for medical societies and licensing boards to bring this issue to the forefront of
34 increasingly rigorous training, testing, and licensing processes introduced in top medical schools an
38 the weaker -Q(35) alleles, indicating better licensing of KIR2DL2/L3(+) NK cells with the stronger al
39 PV, detailed forecasting of tOPV needs, bOPV licensing, scaling up of bOPV production and procurement
41 cilitates restoration of genome integrity by licensing chromatin to concentrate genome caretaker prot
42 (+) T cells promote CD8(+) T cell priming by licensing dendritic cells (DCs) via CD40-CD154 interacti
43 rovide critical help within this process, by licensing dendritic cells to prime CD8Treg cells, howeve
44 Patients worldwide would be well served by licensing of new regimens for multidrug-resistant tuberc
49 , strongly supports the hypothesis that Cdt1 licensing activity is regulated by periodic interaction
50 -activated JNK kinases and also for the Cdt1 licensing factor that ensures that DNA is replicated exa
51 ndent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of I
54 seemingly conflicting input affects NK cell licensing and repertoire formation in mixed hematopoieti
59 ested a role for cis interaction for NK cell licensing, adoptive NK cell transfer experiments support
65 ed pulp of the spleen during induced NK-cell licensing, and there were no differences in maturation o
66 s I on hematopoietic cells regulates NK-cell licensing, which is not associated with other obvious ph
68 lated TCR-mediated activation of MAIT cells, licensing them to dramatically increase Th1 cytokines an
69 RING-E2 approximately UBL catalytic center, licensing the acceptor lysine, and influencing E2 reacti
70 gression trigger the initiation of centriole licensing through centriole disengagement, at which poin
71 tion of Aurora kinases A and B and chromatin licensing and DNA replication factor 1 may explain the r
72 plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque
74 Thus, ER-mitochondria contacts coordinate licensing of mtDNA synthesis with division to distribute
75 sts in the future will need to consider data licensing before they embark upon re-using such content
77 link was established between IL-6-dependent licensing of tumor vessels for Tem trafficking and apopt
79 hese findings reveal that there are distinct licensing requirements for processing of IL-18 versus IL
80 ow helicase activity is regulated during DNA licensing, with implications for cell cycle control of D
83 largely due to failed degradation of the DNA licensing protein, CDT-1, and premature spermatogenesis.
84 the association between ADHD and both driver licensing and crash involvement and whether it varies by
86 enagers; nevertheless, most Graduated Driver Licensing programs have provisions that require supervis
87 en linked with New Jersey's statewide driver licensing and crash databases for 2004 through 2014.
91 t, inhibition of Kin28 attenuates elongation-licensing signals, resulting in Pol II accumulation at t
93 knowledge gap and impediment to the eventual licensing of new antiviral drugs and vaccines for NIRVs.
94 ues, whereas they are more likely to exhibit licensing when they think concretely about what they hav
95 roved training of staff and routine facility licensing inspections that scrutinize infection control
96 nd Drug Administration industry guidance for licensing of antidiabetic drugs greatly increased the nu
102 while retaining subunits that maintain fork licensing and direct reassembly to the appropriate locat
103 sruption of messenger RNA splicing; and (ii) licensing of expanded C9orf72 pre-messenger RNA for nucl
105 egg extracts, Idas-Geminin is less active in licensing inhibition compared with a Geminin-Geminin hom
109 ipated and novel requirement for CD200R1 in "licensing" pro-inflammatory functions of TLR2 and in lim
113 of geminin by DeltaCdt1_193-447, which lacks licensing activity and degradation sequences, causes cel
118 A new study suggests that small-RNA-mediated licensing of competitive interactions between transcript
119 x, age, medical school country, U.S. Medical Licensing Examination Step, and ABIM Internal Medicine C
120 status and were obtained from state medical licensing board sites and online medical facility and pr
121 h ABSITE scores: prior United States Medical Licensing Examination (USMLE) 1 and 2 scores (per 1-poin
122 IDSA ITE scores, prior United States Medical Licensing Examination (USMLE) scores, ABIM Internal Medi
123 r variables, including United States Medical Licensing Examination (USMLE) Step 1 score, Alpha Omega
124 es (range, 12-30), and United States Medical Licensing Examination (USMLE) Step 2 scores, adjusted fo
125 were pass rates on the United States Medical Licensing Examination (USMLE) Step examinations and grad
126 d significantly higher United States Medical Licensing Examination scores (mean [SD] step 1 score, 23
127 or publications; a low United States Medical Licensing Examination Step 1 score; and non-membership i
129 tion included a PGY-2, United States Medical Licensing Examination step 2 score, year 1 American Boar
131 first-attempt failing scores) on US Medical Licensing Examination Step 2 Clinical Knowledge were mor
136 tion by their target Ag and a process named "licensing." In this study, we analyzed these processes i
139 o investigated Ly49A- and Ly49C-dependent NK licensing in murine beta2m-deficient mice that are trans
144 s, nucleocytoplasmic compartmentalization of licensing factors ensures that DNA replication occurs on
146 essively to ensure that the disappearance of licensing inhibitors coincides exactly with a peak of Cd
147 This study unravels multifaceted effects of licensing on NK cell populations and their functions.
148 o confirmation of the physiologic effects of licensing with differential effects of NK subsets on ant
149 transgenic mice to investigate the impact of licensing through this inhibitory receptor in precursor
150 ity theory by treating the implementation of Licensing Act (2003) as a natural experiment in alcohol
151 in the persistent presence of high levels of licensing proteins by relying on changing interactions b
152 DNA rereplication can be induced by loss of licensing control at cellular replication origins, or by
153 d autoreactive T cells required a process of licensing in the lung revealed an unexpected relationshi
154 evision of costly and laborious processes of licensing and regulation of new antibiotics, and address
155 rticipation in WHO-convened joint reviews of licensing dossiers, as well as pragmatic application of
156 function is better characterized in terms of licensing inferences to opaque generic content than in t
157 hat naive CD8(+) T cells remain dependent on licensing by APCs and CD4(+) T cells, and it may therefo
160 al NK cell repertoire, known as education or licensing, is a complex process mediated through inhibit
163 rmally high levels of replication and origin licensing factors and are likely poised for genome re-re
166 covered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G
169 itive to replication stress, and full origin licensing ensures their correct differentiation and func
173 some maintenance (MCM)3 that limiting origin licensing in vivo affects the functionality of hematopoi
176 y promotes bud formation and prevents origin licensing so that DNA cannot rereplicate between bud for
178 The separation of DNA replication origin licensing and activation in the cell cycle is essential
179 xpected to compromise DNA replication origin licensing and result in elevated rates of genome damage
180 o be achieved by limiting replication origin licensing and thereby restricting the firing of each rep
181 ouble hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DN
182 proteins involved in DNA replication origin licensing may explain the deleterious consequences of CS
183 essential for eukaryotic replication origin licensing, however, it is poorly understood how CDC6 act
186 in with hypomorphic expression of the origin licensing factor mini-chromosome maintenance (MCM)3 that
191 terms, and we have added a statement to our licensing policy stipulating that anyone, including comm
192 ould expand their criteria to treat patents, licensing, and commercialization activity by faculty as
193 ddressed, as well as current practice in pre-licensing trials, the increasing problems of polypharmac
195 ittle in vivo evidence for this preferential licensing across mouse strains with different MHC haplot
198 ponsiveness of activating NK cell receptors (licensing) and modifies the repertoire of MHC-I receptor
203 the recruiting transcription and replication licensing factors coordinates the transcriptional and DN
205 BO1) plays a crucial role in DNA replication licensing and cell proliferation, yet its molecular regu
208 h predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replicatio
211 easomal degradation of Cdt1 (DNA replication licensing factor), p21 (cyclin-dependent kinase [CDK] in
212 MCM7 is one of the pivotal DNA replication licensing factors in controlling DNA synthesis and cell
218 complex), which mediates pre-DNA replication licensing--contains a bromo adjacent homology (BAH) doma
219 by depleting Cdt1, an essential replication licensing factor, partially rescued emi1 deficiency-indu
220 l in which ORC1 mutations impair replication licensing, slowing cell cycle progression and consequent
221 DT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromati
222 complex, implicating defects in replication licensing as the cause of a genetic syndrome with distin
223 the first comprehensive view of replication licensing in vivo, using video microscopy of Caenorhabdi
224 g DNA rereplication upon loss of replication licensing through the activation of the S-phase checkpoi
225 on requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replicatio
227 yonic cells are able to regulate replication licensing in the persistent presence of high levels of l
228 l cycle progression that targets replication licensing factors, also targets the p12 subunit of Pol d
229 nome encodes two homologs of the replication licensing factor CDC10 Target1 (CDT1), and overexpressio
231 E3 ubiquitin ligase include the replication licensing factor Cdt1 and the cyclin-dependent kinase (C
232 Several proteins, including the replication licensing factor CDT1 and the histone methyltransferase
235 e (Mcm) proteins are part of the replication-licensing complex that is loaded onto chromatin during t
238 sh involvement and whether it varies by sex, licensing age, and/or being prescribed ADHD medication a
240 ting public access, the new policies specify licensing terms for reuse of content by third parties, i
243 tor function by an education process termed "licensing" mediated by inhibitory Ly49 receptors which r
244 an MHC-dependent educational process termed "licensing." For example, Ly49A(+) NK cells become licens
245 ompetence through an unclear process termed "licensing." Ly49C is the main self-specific inhibitory L
248 ystem of mouse CMV infection, indicated that licensing did not play a major role in the NK cell antiv
249 lication cycle, raising the possibility that licensing of centrosome duplication occurs by modulating
254 Compared with individuals without ADHD, the licensing probability of individuals with ADHD 6 months
255 gainst replicative stress is provided by the licensing of thousands of origins in G1 that are not nec
256 population of NK cells as determined by the licensing patterns of donor MHC-I haplotypes, resulted i
258 of protection of 0.35 mug/mL has enabled the licensing of effective new PCVs, serotype-specific corre
260 empt to subvert this block by expressing the licensing control factors Cdc18 and Cdt1 during the inte
262 covered a single phosphorylation site in the licensing factor M18BP1 and a cyclin A binding site in t
264 ctive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intesti
266 uture of increased database integration, the licensing of the data may be a hurdle that hampers progr
268 its known functions in the regulation of the licensing of replication origins and expanding the scope
269 y the helper macrophages, reminiscent of the licensing role of helper T cells in antiviral adaptive i
274 eatments can be found to either speed up the licensing process, or increase the spatial competitivene
279 sequence site on the CTLA4 promoter, thereby licensing CBP/p300-mediated histone acetylation and loca
280 11 endonuclease initiates resection, thereby licensing HR followed by MRE11 exonuclease and EXO1/BLM
282 , mediating protective immunity both through licensing of cellular effectors of the innate immune sys
286 igen and prime CD8 T cells after exposure to licensing stimuli, such as an agonistic anti-CD40 antibo
287 Loss of 53BP1 caused hypersensitivity to licensing inhibition when replication origins were remov
288 improvements in overall survival leading to licensing for the treatment of metastatic castration-res
289 03 and December 2004 prospectively linked to licensing and police-reported crash data, with an averag
290 ecent data with respect to issues related to licensing, thereby providing a framework for unifying co
291 that PGCs of both XX and XY fetuses undergo licensing, an active developmental transition that enabl
292 In all, tested organs donor cells undergo "licensing" for pathogenicity, consisting of vigorous inc
293 induced CD8(+) memory T-cell expansions upon licensing by CD4(+) T cells, and primed naive CD8(+) T c
294 re on moderators of moral consistency versus licensing effects using five conceptual themes: construa
295 loading in live human cells using an in vivo licensing assay on the basis of fluorescence recovery af
296 the notion that the lung is the organ where "licensing" for pathogenicity takes place is based on bia
300 SU1 and pPSU2 plasmids are available without licensing restrictions to nonprofit academic users, affo
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