ライフサイエンスコーパス: lid

1 the CA-to-OA ratio and proptosis (P<0.001), lid fissure (P = 0.004), and intraocular pressure (P<0.0

2 e major subassemblies of the proteasome--19S lid, 19S base, and 20S core--associate with the activate

3 multiprotein complex that resembles the 19S lid of the 26S proteasome, plays a central role in the r

4 was determined for telangiectasias (40.6%), lid debris (50.9%), gland dropout (42.8%), and acini app

5 ates, including the free Rpn12 subunit and a lid particle (LP) containing the remaining eight subunit

6 ive site cleft between the core domain and a lid subdomain.

7 tric unit suggesting that they function as a lid controlling substrate entry and product exit from th

8 Recurrence was defined as a lid height less than 50% of the initial postoperative li

9 It is proposed that this domain serves as a lid that covers the internal substrate channeling cavity

10 y active state with the B-domain acting as a lid to cover the active site.

11 located in a flexible loop that behaves as a lid to the active site, and the lysine residue is requir

12 ation of the regular GST dimer and acts as a lid, which closes upon glutathione binding.

13 the gain of function mutant N111G assumed a lid conformation similar to AngII-bound wild-type AT1R.

14 s the kinase to phosphatase switch because a lid mutation that decreased ADP binding compromised PhoQ

15 onsisting of open microchannels covered by a lid of a liquid fluorocarbon, was used.

16 Each monomer contains a lid motif that can clamp the C-terminal tail of its dime

17 A loop encloses leucine and forms a lid-latch mechanism required for binding.

18 However, a lid conformation was induced by [Sar(1),Gln(2),Ile(8)] A

19 Furthermore, this study identifies a lid-loop as general feature for substrate turnover in ac

20 This residue is situated in a lid region that covers the enzyme's active site.

21 In contrast, AngII did not induce a lid conformation in ECL2 in the loss of function D281A m

22 e entrance, while another domain acts like a lid, opening and closing access to the hydrophobic tunne

23 that prefers to cover the active site like a lid.

24 haracterized by two timescales (because of a lid on GID1 that can open and close slowly relative to G

25 rse of optimization, including addition of a lid structure, gradually reshaped the pocket for more ef

26 strate release can occur in the absence of a lid, and lid closure can occur without substrate release

27 attractant in the microchannels by placing a lid with chemoattractant onto the base of the device.

28 Analysis suggested that a lid conformation similar to that of ECL2 in rhodopsin wa

29 When using a lid to cover the pot during cooking, the model was still

30 eef were packaged in PLA trays closed with a lid made of PLA film and for comparison purposed in a co

31 rms a monomeric bowl-shaped structure with a lid-like PDZ domain connected by a substrate-sensing hin

32 2 (MDM2) has a phosphorylation site within a lid motif at Ser17 whose phosphomimetic mutation to Asp1

33 In contrast, mutations designed to alter a "lid" domain that covers the catalytic pocket of a class

34 as with a peptide segment that serves as a "lid" to close off the active site following substrate bi

35 bes around a central pivot and opening of a "lid" region that facilitates substrate recruitment.

36 LSD's slow binding kinetics may be due to a "lid" formed by extracellular loop 2 (EL2) at the entranc

37 lled adverse environment exposure, no active lid margin disease, and Schirmer test (mm/5 min) >1 and

38 In contrast, ATP binding to the AMP-lid induces global domain closing, preventing further su

39 An amphipathic lid loop from the nitrilase domain interacts with the pe

40 ely correlated with proptosis (P<0.0001) and lid fissure (P<0.045).

41 ce (kappa(w) = 0.23, 95% CI = 0.14-0.32) and lid debris (kappa(w) = 0.24, 0.16-0.32) to moderate agre

42 examination compared to acini appearance and lid debris.

43 particles (19S RPs) subdivided into base and lid subcomplexes.

44 The RP is divisible into base and lid subcomplexes.

45 s for the linkage between lid biogenesis and lid-base joining.

46 erate scarring of the tarsal conjunctiva and lid margins and also moderate dry eyes with severe photo

47 bition of the motor commands to both eye and lid muscles.

48 t bind with similar affinity to full lid and lid-truncated MDM2 constructs, interact additionally thr

49 lease can occur in the absence of a lid, and lid closure can occur without substrate release.

50 se, mediating both stable binding to LP2 and lid-base joining.

51 cluding impaired convergence, nystagmus, and lid or pupil abnormalities.

52 s, site-directed mutations of the pocket and lid loop led to significantly reduced enzyme activity, s

53 outcome, symblepharon, tear film status, and lid abnormalities were comparable between the 3 groups.

54 uggesting that the pocket-like structure and lid loop are involved in the recognition of 1,4-type sub

55 d Bacillus UGLs, a pocket-like structure and lid loop at subsite +1 are characteristic of Phep_2830.

56 dies, nocifensive responses (eye swiping and lid closure) were quantified following cornea menthol ap

57 mulsions were stored in a PLA pack (tray and lid).

58 ional equilibrium of the membrane-associated lid domain of MGL to favour closed conformations of the

59 xists in an autoinhibited state with the ATP lid bound to the nucleotide-binding pocket.

60 e array models, and it suggests that the ATP lid of CheA may be poised to interact with receptors and

61 ATP binding displaces the ATP lid that signals the cis-bound ATP status to the neighbo

62 We found that groups that target the ATP-lid portion of the catalytic domain, such as a six-membe

63 venting further substrate binding to the ATP-lid site.

64 easome suggests that Nas6 controls both base-lid affinity and base-CP affinity through steric hindran

65 olysis, Nas6 obstructs base-CP, but not base-lid, association.

66 that the Nas6 chaperone also obstructs base-lid association.

67 not be hydrolyzed, Nas6 interferes with base-lid, but not base-CP, association.

68 Control of ocular inflammation before lid surgery was achieved in all cases.

69 Immunosuppressive treatment before lid surgery was used in all cases for a mean of 15.1 mon

70 he mechanistic basis for the linkage between lid biogenesis and lid-base joining.

71 contrast, visual deprivation with binocular lid suturing resulted in increased visual homotopic corr

72 nction in the folding cycle, triggering both lid closure and substrate release into the central chamb

73 e associated with inflammatory edema of both lids.

74 Central lid margins do not touch in spontaneous blinks because t

75 s a simple and effective way to characterize lid contour abnormalities.

76 ioisosteres of benzoic acid induced a closed-lid conformation, had slower release in the presence of

77 s supply a morphological basis for conjugate lid movements.

78 itial substrate binding to the corresponding lid site, the opposing lid is maintained open and access

79 study of the opening and closing of the Ddl lid loop informs future structure-based design efforts t

80 eat and gas pressure resulting in a deformed lid, in material expelled through that deformation, and

81 ese residues are mutated in genetic disease, lid displacement was hypothesized to be an important fea

82 conformational ensembles for the disordered lid region of the N-terminal domain of the oncoprotein M

83 tabilizes apo-MDM2 globally or the displaced lid locally.

84 ubunits, and the Rpn12 tail then helps drive lid-base joining.

85 Finally, an increased mobility of the DxnB2 lid may contribute to the enzyme's ability to hydrolyze

86 hielded from soluble substrates by a dynamic lid until it interacts with HDL to allow transesterifica

87 handed parallel beta-helix with an elaborate lid structure.

88 ations on the lid tested here nor the entire lid deletion has any significant impact on gamma-secreta

89 hat loss of latch interactions or the entire lid enhanced activity against soluble ester substrates,

90 the two leading edges of lateral epidermis ("lids" of the eye).

91 Excellent lid height was assessed as a marginal reflex distance (M

92 a greater probability of achieving excellent lid height: treatment using levator muscle resection (LM

93 e crystal structure of LCAT with an extended lid that blocks access to the active site, consistent wi

94 with sudden onset of ocular pain, upper eye lid swelling, proptosis and diplopia after a commercial

95 Assimilation of the final lid subunit, Rpn12, triggers a large-scale conformationa

96 TIM-barrel, which might serve as a flexible lid for the active site.

97 ulated along the opening of the two flexible lid domains for apo and holo ADK as well as for all sing

98 s biogenesis, is the presence of a flexible "lid" anchored in the active site.

99 oligonucleotide/oligosaccharide binding fold lid domain over the GTP-binding site provide snapshots o

100 rrence of complications were as follows: for lid margin ulceration and corneal epithelial defects, 25

101 molten layer capped by an impermeable frozen lid that is the base of the lithosphere.

102 rs for MDM2 constructs that include the full lid correlates with interactions between ligand hydropho

103 ors, that bind with similar affinity to full lid and lid-truncated MDM2 constructs, interact addition

104 t to these active movements, the N. gracilis lid oscillation requires neither mechanical preloading n

105 impact-driven oscillation of the N. gracilis lid represents a new kind of rapid plant movement with a

106 d betaSBD and releasing of the alpha-helical lid that covers the substrate-binding cleft in the SBD.

107 enabling the movements of the alpha-helical lid with respect to the beta-sandwich.

108 subdomain of the SBD, the SBD alpha-helical lid, and the conserved hydrophobic interdomain linker en

109 elements as follows: ATP-binding and helical lid domains (conserved among AAA+ proteins) and a tetram

110 een the NBD and SBD, and between the helical lid and the beta subdomain of the SBD.

111 Additionally, we find that the helical lid of DnaK is a highly dynamic unit of the structure in

112 et cups and baskets covered by alpha-helical lids, to multi-alpha-helical bundles and layers.

113 e structures reveal no basis for the "hinged lid"-based fast inactivation, seen in eukaryotic Nav cha

114 en) and inactive (closed) states of the hMGL lid domain in controlling substrate access to the enzyme

115 h reduced expression of the Jarid1a homolog, lid, had lowered Per expression and similarly altered ci

116 hydrolyze PCB metabolites, highlighting how lid architecture contributes to substrate specificity in

117 nd bound to p53 TAD (17-29) peptide identify lid states compatible with previous NMR measurements.

118 Hsp90, Cdc37 is thought to bind an important lid structure in the ATPase domain of Hsp90 and inhibit

119 the chambers whereas in Group II a built-in lid closes the chambers.

120 A built-in lid encapsulates substrate proteins within the central c

121 om extant CPNs, but are closed by a built-in lid like Group II CPNs.

122 n archaea and eukaryotes, contain a built-in lid that opens and closes over the central chamber.

123 haperonin containing TCP-1), uses a built-in lid to mediate protein folding in an enclosed central ca

124 in, which resembles a barrel with a built-in lid, can be reprogrammed to open and close on illuminati

125 ce evaluation in children with EB to include lid margin evaluation using a recognized classification

126 Using Schirmer information, lid plugging, and meibomian quality to define objective

127 oduct, lipid X, unveiling a unique insertion lid above the conserved architecture of calcineurin-like

128 6.5 years since the lens insertion, lid eversion revealed a 'foreign body' retained beneath

129 we present the atomic model of the isolated lid sub-complex, as determined by cryo-electron microsco

130 uriosity as both the chaperonin cage and its lid are encoded by multiple genes, in contrast to the si

131 oups (type II and type III) and that of its "lid" mutant and proposed a role of the "lid" as a protec

132 the ternary complex incorporates into larger lid precursors.

133 ed that the maximum amplitude of the lateral lid flare sign occurred at 60 degrees from the vertical

134 DX) mass spectrometry revealed that the LCAT lid is extremely dynamic in solution.

135 ates fall within the same four distinct loop/lid regions near the active site.

136 the keratinized portion of the central lower lid.

137 ft, is effective for the management of lower lid retraction in patients with Graves ophthalmopathy.

138 Prolonged lower lid swelling and slight puffy appearance were noted for

139 trode was placed on the surface of the lower lid on the opposite eye.

140 ication of an anti-slip coating to the lower lid surface reduced prey capture in the field.

141 a proportion of partial glands in the lower lid, and acini appearance by the presence/absence of gra

142 may alter tear distribution along the lower lid.

143 ts, 2 eyes of 1 patient presented with lower lid ectropion, and 2 eyes of 2 patients presented with c

144 MDM2 lid deletion, but not Asp17 mutation, induced a blue shi

145 Remarkably, the MDM2 lid region is shown to adopt distinct conformational sta

146 en magnetic field, convective mantle, mobile lid tectonics, oceans of liquid water, dynamic climate a

147 sis in which the conformation of this mobile lid domain is energetically coupled to ligand binding, r

148 in PV-cell-evoked responses after monocular lid suture is restricted to the critical period for ODP

149 Visual modification with monocular lid suturing reduced correlation between left and right

150 ale conformational remodeling of the nascent lid that drives RP assembly, in part by relieving steric

151 These findings indicate that the NCT lid is not an essential element necessary for gamma-secr

152 d through its interaction with a neighboring lid subunit, Rpn5.

153 o gave fully informed consent and who had no lid malpositions or canalicular pathology.

154 The low sample volume requirements and novel lid-based method for initiating the gradient of chemoatt

155 e cap to open and close while the nucleotide lid remains shut.

156 though the PI-PLC active site has no obvious lid, molecular-dynamics simulations suggest that correla

157 nd FABP5 were expressed in hair follicles of lid skin in both groups, whereas the CRABP2 and FABP5 we

158 d acini appearance, and slit-lamp grading of lid debris and telangiectasias were conducted on 410 pos

159 aim of this study is to present a method of lid laxity evaluation and investigate whether there is a

160 A classification of FES is proposed based on lid laxity.

161 aited with 50 g of fish, with a white opaque lid with circular entrance holes.

162 to the corresponding lid site, the opposing lid is maintained open and accessible for subsequent sub

163 eficiency, symblepharon, ankyloblepharon, or lid-related complications.

164 colonizing the nasopharynx or conjunctiva or lid margin to be a reservoir for recurrent keratitis sug

165 unctivalization), history of conjunctival or lid surgery, and requirement for systemic immunotherapy

166 LP2 only upon correct assembly of all other lid subunits, and the Rpn12 tail then helps drive lid-ba

167 ble Rpn12 incorporation depends on all other lid subunits, indicating that Rpn12 distinguishes LP2 fr

168 rom the underside of the canopy-like pitcher lid into the fluid-filled trap below.

169 stal surface on the underside of the pitcher lid and utilises the impact of rain drops to 'flick' ins

170 e represents a novel function of the pitcher lid.

171 was a transparent box, with a white plastic lid on top, perforated with 10 conical entrance holes, p

172 ried out directly 48 through the Petri plate lid); fourthly, the germination parameters determined we

173 , meibomian gland quality, orifice plugging, lid vascularity) between patients with PTSD or depressio

174 PNLIP beta5-loop and decreased by the PNLIP lid domain.

175 Any chimera on PNLIP with the PNLIPRP2 lid domain or beta5-loop had decreased triglyceride lipa

176 nd dynamics of the nucleotide binding pocket lid.

177 t less than 50% of the initial postoperative lid height.

178 Gland dropout and potentially lid telangiectasia grading from a photograph are more re

179 Rpn12 incorporation thus links proper lid assembly to subsequent assembly steps.

180 Rpn3 and Rpn7 into the assembling proteasome lid.

181 peat present in the P. falciparum proteasome lid subunit 6, Rpn6.

182 with conserved orthologues in the proteasome lid complex and COP9 signalosome.

183 ng in other complexes, but in the proteasome lid they are uniquely deployed for recognizing separate

184 athic helix, which then acts as a protective lid over the signal.

185 ALKBH5 shares a nucleotide recognition lid and conserved active site residues with other NAOXs.

186 ceptor structures have the N-terminal region lid region bound in a helical conformation mimicking the

187 , and progressive supranuclear palsy-related lid retraction, frequent square-wave jerks and supranucl

188 three mutations that replaced the 11-residue lid domain with one, two, and three glycine residues.

189 time variation of flow dynamics for a rigid-lid cavity problem under both up-scaled and down-scaled

190 We report several lid intermediates, including the free Rpn12 subunit and

191 onic failure (18/362 eyes, 5.0%) were severe lid disease (odds ratio [OR], 6.1; 95% confidence interv

192 An S-shaped lid deformity was evident, and 2 of the 3 cases demonstr

193 e inclusion of an evolutionarily significant lid domain (G51PEKN in E. coli enzyme; approximately 2.4

194 c DNA that unveil a dynamic Tdp2 active site lid and deep substrate binding trench well-suited for en

195 Cys-249 resides on a mobile active site lid at the C terminus, within a K(R/T)ECG(L/I)H motif.

196 hat the enzyme contains a mobile active site lid domain that undergoes a transition between an open,

197 olled modulation of the enzyme's active site lid structure, while fully maintaining thermostability.

198 ups altered conformations of the active site lid, as evidenced by X-ray crystallography, and showed s

199 defining the conformation of the active site lid, the enzyme's ability to stabilize the reaction inte

200 2 cm x 1.5 cm on the chip, and a glass slide lid prevented evaporation.

201 One recent technology, sliding lid for immobilized droplet extractions (SLIDE), present

202 ice layer convects in the so-called sluggish lid regime, a unique convective mode not previously defi

203 ng that Rpn12 distinguishes LP2 from smaller lid subcomplexes.

204 pattern was consistent with ligand-specific "lid" conformations of ECL2.

205 Additionally, we report the split-lid technique, a procedural improvement if fornix access

206 ructure provides a view of the sortase SrtC1 lid displacement while having structural elements simila

207 burial of early Martian crust in a stagnant-lid tectonic regime, in which the lithosphere comprised

208 tion preparation to include use of a sterile lid speculum and povidone iodine (5%).

209 e substrate-binding cavity and the substrate lid of mortalin were necessary for these physical intera

210 proteasome is assembled via the nine-subunit lid, nine-subunit base, and 28-subunit core particle (CP

211 cking the bound structure of p53, suggesting lid region association induces receptor conformations su

212 ligand hydrophobic groups and the C-terminal lid region that is already partially ordered in apo MDM2

213 The N-terminal lid region of MDM2 modulates interactions with p53 via c

214 gh their solubilizing groups with N-terminal lid residues that are more disordered in apo MDM2.

215 of Ser17 phosphorylation in the N-terminal "lid" (residues 1-24) of MDM2.

216 eal fluorescein staining, Schirmer's I test, lid margin assessment, corneal sensitivity, in vivo corn

217 The lid covering the nucleotide-binding pocket of PhoQ gover

218 e as a flexible anchoring device for all the lid subunits.

219 substrate-binding sites are exposed, and the lid is open in both the ATP-free and ATP-bound prehydrol

220 -millisecond time scale and may serve as the lid of the preQ(1)-binding pocket.

221 ly conserved C terminus of Rpn12 bridges the lid and base, mediating both stable binding to LP2 and l

222 or dry), insects were captured mainly by the lid, the peristome, or the inner pitcher wall, respectiv

223 lases identified the NC-loop, connecting the lid to the alpha/beta-hydrolase core domain, as a determ

224 red with several bacterial counterparts, the lid loop in the crystal structure of hGGT1 adopts an ope

225 y the (15-29)p53 peptide fully displaces the lid and renders it completely disordered in the peptide-

226 that the inactivity is due to a role for the lid domain in the formation of the fully closed state of

227 a new heterologous expression system for the lid to delineate the complete subunit architecture of th

228 in the flaps of HIV-1 protease that form the lid over the catalytic cleft play a significant role in

229 The inter-RRM linker forms the lid of the nucleobase pocket and we show using structure

230 he other side by an arginine anchor from the lid into the core.

231 , there is an overall decrease in HDX in the lid and adjacent regions of the protein, consistent with

232 utations at highly conserved residues in the lid region inNCT-deficient cells, and then assessed thei

233 onent is the reactive Cys 110 residue in the lid region that forms a hemithioactetal intermediate wit

234 interaction with hydrophobic residues in the lid.

235 were most sorbed and preferentially into the lid through the emulsion headspace.

236 is proposal, we expressed NCT that lacks the lid entirely, or a variety of NCT variants that harbor m

237 In yeast and mammals, the lid appears to assemble completely before attaching to t

238 asome regulatory particle, consisting of the lid and base subcomplexes, recognizes and processes poly

239 ntributes marginally to the stability of the lid conformation in apo-MDM2, neither modification stabi

240 To more fully investigate the roles of the lid domain in PEPCK function, we introduced three mutati

241 vious studies showed that the closure of the lid domain stabilizes the reaction intermediate and prot

242 ron density for the first alpha-helix of the lid domain was poorly defined in the dimeric DxnB2 struc

243 In the absence of the lid domain, the enzyme is unable to achieve the fully cl

244 ubstrates and a nonsymmetric behavior of the lid domains.

245 15 degrees , and 0 degrees ) sectors of the lid fissure.

246 ments that occur during incorporation of the lid into the 26S holoenzyme, which ultimately activates

247 The underside of the lid is coated with friction-reducing wax crystals, makin

248 at subsite +1, and aromatic residues of the lid loop are required for stacking interactions with sub

249 t form the oxyanion hole and movement of the lid loop region when the active site is occupied.

250 ry was not due to a mechanical effect of the lid on the eye (e.g., from blinks).

251 uring the initial downstroke, the tip of the lid reached peak velocities similar to fast animal motio

252 f catalysis, and promotes the opening of the lid to achieve optimal product release.

253 Large conformational rearrangements of the lid upon holoenzyme formation suggest allosteric regulat

254 resulting in the closed conformation of the lid, necessary for correct substrate positioning, becomi

255 etween the "open" and "closed" states of the lid-like NCT with respect to a hydrophilic loop 1 (HL1)

256 der loops, but is partially dependent on the lid loop.

257 sults show that neither the mutations on the lid tested here nor the entire lid deletion has any sign

258 urofibromatosis type 1 may be present on the lid, brow, or face of an infant or child, a circumstance

259 Unlike TEs from other PKSs, the lid is fixed in an open conformation on one side by dime

260 ocols within the SLIDE by simply resting the lid over the various sample droplets.

261 h the joining of two large subcomplexes, the lid and base.

262 cle (RP) consisting of two subcomplexes, the lid and the base.

263 Rpn2 is rigid, supporting the lid, while Rpn1 is conformationally variable, positioned

264 Of the surface loops tested, the lid domain and the beta5-loop influenced activity agains

265 video and laser vibrometry revealed that the lid acts as a torsional spring system, driven by rain dr

266 We conclude that the lid domain and beta5-loop contribute to substrate specif

267 We found that the lid is partially structured in apo-MDM2 and occludes p53

268 Prior to the lid's incorporation into the proteasome, Rpn11 deubiquit

269 e, thereby directing prey mainly towards the lid.

270 ilis pitchers secreted more nectar under the lid and less on the peristome, thereby directing prey ma

271 he Rpt-CP interface is reconfigured when the lid complex joins the nascent proteasome to form the mat

272 served in the ATPh conformation, whereas the lid is more similar to the ATP-gammaS bound state.

273 ough steric hindrance; Nas6 clashes with the lid in the ATP-hydrolysis-blocked proteasome, but clashe

274 ordinated movements of both the eyes and the lids, e.g., in vertical saccades, TMS produced a synchro

275 not touch in spontaneous blinks because the lids are not aligned.

276 d to grade the extent of misalignment of the lids in the z-axis.

277 This so-called overblinking of the lids was classified using a 5-grade scale (0 = aligned;

278 The "lid" of the RP (consisting of Rpn3/5/6/7/8/9/11/12) is o

279 its "lid" mutant and proposed a role of the "lid" as a protector of the active-site hydrophobic envir

280 However, the mechanistic details of the "lid" displacement, suggested to be a critical prelude fo

281 e catalytic channel of SENP1, including the 'lid' residue Trp465, exhibit dynamics over a range of ti

282 ished by Rpn11, a deubiquitinase within the 'lid' sub-complex.

283 = 6, for peripheral necrosis) or through-the-lid revisions (n = 2, for central necrosis).

284 The closing of this lid fully engages the substrate in the active site with

285 n predicted to increase the mobility of this lid greatly accelerates LSD's binding kinetics and selec

286 m toxin offers a novel nonsurgical answer to lid retraction, but may be complicated by overcorrection

287 with demonstrated ability to order the TrmD lid in the absence of tRNA.

288 Upon substrate binding, a tryptophan lid (residues 724-WNW-726) closes on the substrate.

289 ting distance of 6mm between nozzle and tube lid.

290 nd the other active site covered by a unique lid.

291 The presence of the unique lid domain, the lack of reduction by NAD(P)H, and the sl

292 Participants had upper lid trachomatous trichiasis with one or more eyelashes t

293 d to measure the conventional midpupil upper lid distance (MPLD) and 12 oblique MPLDs on each 15 degr

294 Mean grade of upper lid overblink was 3.0 +/- 0.9.

295 y and involved the tarsus of the right upper lid.

296 o described the sinuous outline of the upper lid margin, sometimes called Herbert's sign, as a diagno

297 s giant fornix syndrome, senile sunken upper lids, and prostaglandin-associated periorbitopathy have

298 ated with a platewide high-seismic velocity "lid" overlying lowered velocities, consistent with therm

299 Patients with lid disease, central ALK, and peripheral grafts were at

300 entified 11 operated eyes of 7 patients with lid malposition resulting from mucous membrane pemphigoi

301 nked to the small-molecule inhibitor without lid displacement.