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2 nation, in which the vast majority of values lay within 1 sd of the consensus value, irrespective of
3 We designed over 300 ZF-TFs whose targets lie within 1 kb of the transcriptional start sites (TSSs
4 rt of a greater than 550-kb contig that must lie within 1 of the 11 sequence gaps currently remaining
8 ng N-linked glycosylation sites predicted to lie within 10 A of CD4 contact sites, the infectivity of
10 s that are predicted by homology modeling to lie within 2.8 A of each other at the interface between
12 cies, the majority of open chromatin regions lie within 3 kb upstream of a transcription start site i
14 tronic instances of their reverse complement lie within 380,084 nonoverlapping regions, typically 60-
18 Furthermore, this alcohol binding pocket lies within 7 A of Leu-120 and Gly-121, residues in whic
19 ferred directions or biases, with directions lying within 90 degrees of the bias direction nearly alw
20 netrating capability have been identified to lie within a 35-amino-acid region containing the nuclear
21 constraints, such as requiring GC-content to lie within a certain range, requiring the number of stro
22 Most planetary rings in the Solar System lie within a few radii of their host body, because at th
23 the 15q13.1 locus (rs1129038 and rs12913832) lie within a genomic region that has profound effects on
25 all segment of roughly a dozen residues that lie within a natively unstructured sub-domain of RNase E
26 pG loci associated with later risk of asthma lie within a NF-kappaB binding site and that methylation
27 to affinity cross-linking, was determined to lie within a periplasmic loop between transmembrane heli
29 imated from previous theoretical studies but lie within a reasonable range for phenyl rotation in hyd
31 s of cellular tropism and receptor targeting lie within a short peptide in the Vr1 region of the enve
32 pitopes were mapped, but all of the epitopes lie within a single major antigenic site, suggesting tha
33 mapped 12-amino acid immunodominant epitope lies within a "hinge" region between the N-terminal intr
36 involved in minus-strand DNA synthesis that lies within a 27-nucleotide region between DR2 and the 3
37 SVG-CRFR1 complex, residue 17 of the ligand lies within a 9 angstroms distance from residue 117 of t
41 The genetic lesion in the frimousse mutant lies within a connexin gene (cx-11) that is transiently
46 (LOD score = 7.5 at reduced penetrance) and lies within a founder haplotype that is also shared by 3
47 two C. sordellii strains revealed that tcsR lies within a genomic region that encodes TcsL, TcsH, an
49 ase-associated mutation in VAPB, VAPB(P56S), lies within a highly conserved N-terminal region of the
50 gle nucleotide polymorphism rs6983267, which lies within a MYC enhancer and confers colorectal cancer
52 vious studies suggested that the active site lies within a positively charged cleft formed at the sub
57 ies, the predicted optimal number of spacers lies within a range that agrees with experimentally-obse
58 mosome, but is unusual in that the attB site lies within a redundant repetitive element (REP13E12) of
62 h an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant
65 iability, model shortcomings, and because CA lies within a transition zone, where mid-latitude region
66 report that this high-affinity binding site lies within a unique extracytosolic, carboxyl-terminal d
67 that the highly conserved lower half of TM7 lies within a water-filled cavity easily accessible from
68 ion events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence whi
69 sensitive to transient point-source stimuli lying within a range of angles that are oblique with res
70 tial caspase consensus motifs in HDAC4, both lying within a region containing proline-, glutamic acid
71 Noting that the activities of many compounds lie within achievable blood concentrations, these result
74 GWAS-related single-nucleotide polymorphisms lie within an essential erythroid enhancer of the BCL11A
75 e genome sequences revealed that CYP1A genes lie within an extended region of conserved fine-scale sy
77 bility locus for psoriasis vulgaris (PV) and lies within an approximately 200 kb segment of the major
79 the 8q24 cancer-associated variant rs6983267 lies within an in vivo prostate enhancer whose expressio
81 tent (respectively, extinction prone) models lies within an open set of persistent (resp. extinction
84 By contrast, mRNA isoforms with 3' ends that lie within annotated 5'-UTRs were overrepresented in pol
87 determined that a second and a third hotspot lie within blade 5 of the SEMA domain and IPT domains 2-
88 also observe that the RNAP II molecules that lie within BMP4 have inappropriate persistence of serine
91 T cells to a nonpersistent virus (influenza) lie within CCR7(+)CD45RA(-) central memory, whereas memo
93 ough the causal variants in the 16p13 region lie within CLEC16A, DEXI is an unappreciated autoimmune
94 at less common, functional polymorphisms may lie within common haplotypes and drive gene-environment
98 as to data from other source databases that lie within ENCODE regions; this provides the user a comp
101 stant from the genes they regulate, but many lie within evolutionarily conserved regions (ECRs).
103 Structural models suggest that Arg(436) lies within five cytoplasmic portals of the 5-HT(3A) rec
104 pitope and the previously identified epitope lie within fragments contained in different vaccines, th
106 in monogenic or syndromic diabetes and genes lying within genomic regions associated with T2D common
107 e and normal phenotypic variation, but those lying within heavily duplicated, highly identical sequen
109 he NvAMD-associated synonymous polymorphisms lie within HtrA1's putative insulin-like growth factor 1
110 -331, the hydroxyl groups of the hexose only lie within hydrogen bonding distance to ordered water mo
116 jority of suppressor mutations were found to lie within nsrR, which encodes a nitric oxide (NO)-sensi
118 possible to say whether these multiple sites lie within one receptor or on two linked receptors of a
120 nzymes and that these residues are likely to lie within or immediately adjacent to the transmembrane
123 d V232F) associated with hMYH polyposis that lie within, or adjacent to, the putative hMSH6 binding d
124 at fail to bind to the ligand-occupied state lie within, or very close to, the integrin-fibronectin i
125 es Y263, C265, and K267 of the alpha1 region lie within overlapping ComA- and Spx-binding sites for a
127 The vast majority of bacterial diversity lies within phylum-level lineages called "candidate phyl
128 iously identified visual map, is observed to lie within posterior IPS and to share a foveal represent
130 ity of the system being in an attractor that lies within prescribed boundaries decreases approximatel
132 olecule within PrP-(23-33); the second motif lies within PrP-(98-110); and the third is contained wit
137 iants that affect disease susceptibility may lie within regulatory elements that influence gene expre
138 nd in many cases the final structural models lie within root mean square deviation of 1 approximately
139 was initially attributed to MYLIP, rs6924995 lies within RP1-13D10.2, an uncharacterized long noncodi
140 The endings of sensory receptor cells often lie within specialized compartments formed by glial cell
141 extensive tidal flats and salt marshes that lie within specific ranges of elevation, whereas interme
143 The dendrites of A- and B-group motoneurons lay within the oculomotor nucleus, but those of the C-gr
144 cts showed that the NGF-responsive sequences lay within the proximal -392 base pairs (bp) of PNMT pro
145 ore linear, and the KBC values approached or lay within the range of KOC values reported for SMT in 1
148 cks exist, no currently known Archean strata lie within the appropriate thermal maturity window for s
149 mline-derived PTEN missense mutations, which lie within the ATP-binding motifs, result in mutant PTEN
150 g in human and mouse ESCs and preferentially lie within the boundaries of topological domains for hum
153 unction and that the site of interaction may lie within the C-terminal portion that is common to all
155 we report that two genes, DSCR1 and DYRK1A , lie within the critical region of human chromosome 21 an
156 lent mutation, NPC1(I1061T), is predicted to lie within the cysteine-rich luminal domain and is assoc
159 g conditions on both aluminium and titanium, lie within the different ranges predicted for each metal
160 motaxis in vivo, suggesting that these sites lie within the docking site of an adaptation enzyme, Che
161 ssing neurons of the abdominal ganglion that lie within the expression pattern of the enhancer-trap l
167 ntal data imply that the regulatory elements lie within the interface between the FAD- and FMN-bindin
169 cPINK1 explains how PD-linked mutations that lie within the kinase domain result in hPINK1 loss-of-fu
170 Remarkably, retinopathy-associated mutations lie within the mechanical hinges of the conformational c
172 gh a pair of activation-energy barriers that lie within the membrane dielectric, near the inner (alph
173 containing 1913 alternative amino acids that lie within the molecular weight range of the encoded ami
174 ore conserved bases, though they did not all lie within the most broadly conserved portions of the re
176 to distinguish thin-section CT findings that lie within the normal range from those that represent ea
177 ins, the sorting determinants of proglucagon lie within the ordered hormone domains of glucagon and G
178 pid spike-inactivation cells, preferentially lie within the periventricular zone; the other cell type
179 ble for dimerization, folding, and stability lie within the predicted coiled-coil region of HBHA, whi
180 Three functional LEF-1/TCF binding sites lie within the promoter of the hAR gene as shown by CHIP
181 that Eeff(0) values for CoOx, MnOx, and NiOx lie within the range 1.9-2.1 V vs reversible hydrogen el
183 Aspects of symbolic arithmetic therefore lie within the reach of children who have learned no alg
186 glycosylation substrate recognition features lie within the reducing-end moiety of the O repeat and t
188 The majority of the constitutive mutations lie within the same residues of the N-terminal regulator
189 ues, such as piglet mortality, are likely to lie within the scientific disciplines of environmental d
190 dentified a suppressor mutation predicted to lie within the second periplasmic loop of TatC, a region
191 tion for post-transcriptional regulation can lie within the sequence or structure of the RNA transcri
192 f this deglacial deep-water warming does not lie within the tropics, nor can its early onset between
194 positively selected sequence is expected to lie within the wealth of functional 'dark matter' presen
195 T-Box transcription factor gene, Tbx1, which lies within the 22q11.2 region and is responsible for mo
197 rmation of Michael adducts on His 173, which lies within the active site catalytic triad of hDDAH-1.
200 he right superior temporal sulcus (STS) that lies within the auditory cortex, and is activated by aud
204 on 55 of the rat alpha7 nAChR subunit, which lies within the beta2 strand, was studied by mutating it
205 fficient for cellular adherence and invasion lies within the C-terminal 12 to 24 amino acids and is c
206 show that specificity toward UBA6 and UBE2Z lies within the C-terminal CYCI tetrapeptide in FAT10.
207 (HP) determined the polar localization motif lies within the central domain of the protein and that t
209 glial over neuronal fate, a difference that lies within the combined properties of amino terminal an
210 pB (residues 51-59), which reveals that PopB lies within the concave face of PcrH, employing mostly b
211 istent with the hypothesis that this residue lies within the conduction path, but the observed reacti
212 up to a plateau at approximately 1100, which lies within the consensus equilibrium range, 1000 +/- 10
213 onine (Thr-38) on the substrate Ets-1, which lies within the consensus sequence 36phi-chi-Thr-Pro39 (
217 ly, because the locus encoding human SHROOM2 lies within the critical region for two distinct forms o
218 tralia's Flat Rocks locality (121-112.5 Ma), lies within the crown clade Monotremata, as a basal plat
219 in G:A at position 10 of the serT gene that lies within the D-stem of the essential tRNA((cmo)5)UGA(
224 lopment, the bulk of the dendritic structure lies within the electrode, underneath the polymer/electr
225 ted with a distinct root of the Archaea that lies within the Euryarchaeota, challenging the tradition
231 ne H3 lysine 56 (H3K56) is unique in that it lies within the globular core domain near the entry-exit
232 We also find that the G134R mutation, which lies within the glycine zipper packing interface and cau
234 2 has similarity to ylmF which, like divIVA, lies within the Gram-positive bacterial ylm gene cluster
235 how here that a second binding site for HapR lies within the hapR promoter from which it functions to
236 Furthermore, we show that this rearrangement lies within the homogeneous staining regions (HSR) in IM
238 encoding 12/15-LO (gene designation Alox15) lies within the Idd4 diabetes susceptibility interval in
239 ding domain for BoNT was selected because it lies within the immunodominant H chain as a beta-trefoil
240 Our results now reveal that the CHD6 protein lies within the infrastructure of multiple transcription
241 s during motivational and affective behavior lies within the interactions of anterior cingulate, insu
244 ng RNA SPRIGHTLY (formerly SPRY4-IT1), which lies within the intronic region of the SPRY4 gene, is up
245 ditary erythromelalgia mutation (N395K) that lies within the local anaesthetic binding site of the ch
246 domain within the N-terminal of the protein lies within the lumen and is thought to represent the se
249 c risk for developing adult and juvenile IIM lies within the major histocompatibility complex, recent
250 in Ae. tauschii that also produces miRW1 and lies within the marker-based location of Iw2 We propose
251 egion with the strongest evidence of linkage lies within the minimum critical region for FTLD-U.
253 stin domain required for binding to atlastin lies within the N-terminal 80 residues of the protein, a
254 es within the activation loop, and the other lies within the N-terminal acidic region (N region).
255 n, indicating that the binding site for SsrA lies within the N-terminal nucleotide-binding domain.
262 g domain on amino acids 40-49 of YpkA, which lies within the previously identified membrane localizat
263 ase I footprinting showed that this sequence lies within the protected regions of the pfr and hydA pr
266 out one degree of latitude per decade, which lies within the range of estimates of the observed expan
267 of 5-7 years, the distribution parameter rho lies within the range that indicates infinite variance.
269 leotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT
275 evealed that the central binding determinant lies within the segment of residues 293-380, also known
278 he lytic cycle of the virus and its promoter lies within the terminal repeat which contains the bindi
282 We explored whether the zinc-binding site lies within the vestibules running down the central axis
284 vated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-
285 pattern showing clear 2/3 PL preference and lying within the alpha band was observed exclusively abo
286 fine a single AzBCQ covalent attachment site lying within the digestive vacuolar-disposed loop betwee
287 ified a primary disease susceptibility locus lying within the major histocompatibility complex (MHC),
288 se data also suggest that a boundary element lying within the PWS critical region prevents UBE3A-ATS
292 Hsp72 with regard to tau clearance kinetics lies within their C-terminal domains, which are essentia
297 The packaging signals in each of these RNAs lie within two separate regions at the 3' and 5' termini
299 ividuals against background sets of variants lying within VDR-binding regions that had been matched i
300 n event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing
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