ライフサイエンスコーパス: life

1 oplasm is the defining feature of eukaryotic life.

2 dually increased during the first 4 years of life.

3 e increased intestinal permeability in early life.

4 of the impact this disease has on a person's life.

5 up members a fundamental challenge of social life.

6 dases that are found in all three domains of life.

7 al ( approximately 0.025 V) for a long cycle life.

8 health effects evident at birth and later in life.

9 fewer toxic effects, or improved quality of life.

10 hat is imparted by high iron status in early life.

11 with no significant variations during shelf-life.

12 n regarding items associated with quality of life.

13 od cells produced throughout an individual's life.

14 ate and remodel myelin via mTORC1 throughout life.

15 e a key unanswered question in the origin of life.

16 poorer sleep quality and reduced quality of life.

17 These ideas still frame how we understand life.

18 enia symptoms, including psychosis, later in life.

19 egenerate, but only during the first week of life.

20 ring evolution and present in all domains of life.

21 o regulate intestinal homeostasis throughout life.

22 iochip was found to have a much longer shelf life.

23 n of strategy diversity compared to solitary life.

24 to severe scores for symptoms and quality of life.

25 lping this susceptible group adjust to adult life.

26 ential for the development of complex animal life.

27 to increased anxiety and depression later in life.

28 ell size in organisms throughout the tree of life.

29 normalization of weight in the first year of life.

30 en discovered in all evolutionary domains of life.

31 servoirs in sensory neurons and persists for life.

32 nized aortic aneurysms as an acute threat to life.

33 nce, morbidity, and impact on the quality of life.

34 pediatric population, and to CFRD, later in life.

35 tal death, functional status, and quality of life (12-Item Short Form Health Survey, ranging from 0 t

36 in the blood and has a long circulation half-life (19 days).

37 and other pathological outcomes, quality of life (36-Item Short Form Survey and 20-item Multidimensi

38 phenotypes were much better maintained (half-life, 4-10 years).

39 lities determined by the European Quality of Life-5 Dimensions health survey at baseline and over fol

40 ith differences in body composition in early life, a known contributor to obesity risk.

41 re lethal or associated with poor quality of life, a view that is now being challenged.

42 eczema/skin allergy in the first 6 years of life, adjusting for confounders.

43 e in mitigating their catastrophic impact on life, agriculture and property.Against the backdrop of a

44 g, thereby improving survival and quality of life among patients with MI.

45 chow-fed dams throughout their first year of life, an effect not present in the offspring from high f

46 chieving a high energy density, a long cycle life and an excellent power density, has the potential t

47 between body size and MM originate early in life and are driven largely by height and birth weight,

48 ies that document contemporary inmate social life and call for increased researcher-practitioner part

49 Proteins are fundamental to life and exhibit a wide diversity of activities, some of

50 ory of psychopathy seemingly begins early in life and includes the presence of callous-unemotional (C

51 s of depression and mania, disrupting normal life and increasing the risk of suicide greatly.

52 Using data collected prospectively across life and multilevel modeling, we investigated how the re

53 was found for antibiotics exposure early in life and objective atopy measurements including positive

54 l therapy for MPS-I at a very early stage in life and represents a novel model to test UCB-based tran

55 Communication, health-related quality-of-life and satisfaction measures and a manualised consulta

56 is considered to represent the dry limit for life and to be an analogue for Martian soils.

57 ures: HIV transmissions and deaths, years of life, and budgetary outlays (2015 U.S. dollars).

58 selective pressure are inherent phenomena in life, and but few artificial systems exhibit these pheno

59 To assess disability, quality of life, and complications in patients with displaced tibia

60 iderable morbidity, decrements in quality of life, and costs to the health care system.

61 Rate of adverse events, quality of life, and patient satisfaction were not significantly di

62 on precision, improving patients' quality of life, and relieve the economic and societal burden due t

63 e development of cytokine responses in early life, and that cytokine responses to specific microbial

64 ple pathways of type 2 inflammation in early life are at greatest risk for asthma development.

65 (K2P) subunits, largely dispensable early in life, are necessary for terminating contraction (systole

66 ing disaster, however, can impair quality of life, as in anxiety and paranoia.

67 Nutrients are necessary for life, as they are a crucial requirement for biological p

68 th respect to itching (P < .001), quality of life assessed by using the Skindex-29 questionnaire (P <

69 t not in patients with acceptable quality of life at the time of LVAD implantation.

70 syndrome (22q11DS) is associated with early-life behavioral abnormalities, affected individuals are

71 um thermodynamics underpins the emergence of life, but how has been a long-outstanding puzzle.

72 services, and an increasing need for end-of-life care.

73 e results suggest that by the second year of life, children make sophisticated and subtle distinction

74 antiviral (DAA) treatment policies in a real-life cohort of hepatitis C virus-infected policy 1, "uni

75 l of patients with ACOS identified in a real-life cohort of patients with COPD.

76 ted for five months, under accelerated shelf-life, compared to the synthetic antioxidant, butylated h

77 fluids >/=48 hours, admission >/=14 days of life, congenital heart disease requiring surgical repair

78 n movement signatures during the 1st year of life constrain early development in 71 healthy typically

79 red as a consequence of brain aging in later life, contributing to cognitive and memory decline, is u

80 body composition over the first 5 months of life correspond with differences in cellular metabolism

81 Further studies are needed to determine the life course progression of these changes.

82 developmentally appropriate times during the life course, target multiple risks, and build on existin

83 nts shape inflammatory phenotypes across the life course.

84 arly life that could be followed through the life course; and the establishment of human epigenetic m

85 lity and may reduce risk for dementia due to life-course factors.

86 size has its roots earlier in life, yet few life-course studies have data on siblings with which to

87 Life-critical perceptual decisions often involve searchi

88 ts a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing effo

89 In this overview, we review the EBV life cycle and discuss our current understanding of the

90 ation interventions as part of an integrated life cycle approach to development.

91 Unlike animals, plants can pause their life cycle as dormant seeds.

92 circumvent the limitations of scenario-based life cycle assessment (LCA), we develop a multiobjective

93 We present a Life Cycle Assessment of coal-fired electricity generati

94 In this regard, the evolution of life cycle complexity promotes phenotypic diversity.

95 tion in acutely infected mice, extending the life cycle from 24 h to 40 h.

96 A fuller understanding of the virus life cycle is important to aid control strategies.

97 ssociation between E2 and ChlR1 in the HPV16 life cycle is unresolved.

98 nt information for further understanding the life cycle of HCV and its interaction with the host cell

99 hat is involved in both circadian timing and life cycle progression.

100 This study reviewed 147 life cycle studies, with 28 found suitable for harmonizi

101 formation, essential steps in the Plasmodium life cycle, are targets of existing antimalarials.

102 e expression in late events during the viral life cycle, RNA-Seq was carried out on triplicate differ

103 e only four proteins to accomplish the viral life cycle, so each arenavirus protein likely plays unap

104 ferent life-history stages across the annual life cycle.

105 y, cell entry, and other stages of the viral life cycle.

106 formation are changed during an entire algal life cycle.

107 l C. jejuni factors essential throughout its life cycle.

108 nabling coal-based electricity with net-zero life-cycle GHG.

109 that may have a substantial influence on the life-cycle impacts.

110 eal-time qPCR has confirmed the differential life-cycle stage expression of a set of selected lincRNA

111 These genes, termed late-life cyclers, were also rhythmically induced in young fl

112 little about the ecology of chytrids, their life cycles, phylogeny, host specificity and range.

113 ects of methyl-6-adenosine in distinct viral life cycles, the role of 2' O-methyl modifications in RN

114 f DNA bacteriophages play essential roles in life cycles.

115 osine to inosine modifications in retroviral life cycles.

116 es across ontogeny in organisms with complex life cycles.

117 ism, inter-organelle communication, and cell life/death decisions.

118 End-of-life decisions are not only common in the ICU but also f

119 The etiologic factors of late-life depression are still poorly understood.

120 p data that capture financial and quality-of-life end points.

121 rated what self-management support at end of life entails and how it is enacted in practice.

122 variants may moderate the effect of adverse life events on the risk of GAD.

123 en living with HIV, had much shorter overall life expectancies than did their HIV-negative counterpar

124 escribe population-level trends in the adult life expectancy and trends in the residual burden of HIV

125 the numbers of deaths and in life years and life expectancy at birth, attributable to changes in PM2

126 Life expectancy has risen among middle-income and high-i

127 Life expectancy in King County, WA, USA, is in the 95th

128 nsionally measurable disease (by CT or MRI); life expectancy of 6 months or more; adequate haematolog

129 In 2014, life expectancy ranged from 68.4 years (95% UI 66.9-70.1

130 0% probability that by 2030, national female life expectancy will break the 90 year barrier, a level

131 Telomere length at birth has been related to life expectancy.

132 e transcription and may be modified by early-life experience.

133 idemiological data suggest that sex-specific life experiences such as pregnancy increase stroke risk.

134 stigated how the relationships between early-life exposures (infant lower respiratory infection, manu

135 dies, mostly from Europe, suggest that early-life farming exposures protect against childhood asthma

136 tal protocol did not perfectly simulate real-life field scenarios.

137 tance of maintaining or improving quality of life for patients with recurrent or metastatic squamous

138 ic analyses demonstrated: 1) poor quality of life for patients; 2) surrogate stress and anxiety; 3) o

139 Viruses represent the most abundant life forms on the planet.

140 that sought explanations for the origins of life from chemical and physical first principles.

141 eferences 536 There is growing evidence that life has been on land for billions of years.

142 posures during the first months and years of life have been linked with risk of allergic sensitizatio

143 e more signs of congestion, worse quality of life, higher N-terminal pro-B-type natriuretic peptide l

144 empirical baseline for tagging experiments, life histories extrapolated from otolith microchemistry

145 especially useful to improve cross-cultural life history datasets for small-scale societies for whic

146 hapes the passage of each individual through life history decision nodes (eg, how fast to grow, when

147 erstood when integrated into an evolutionary life history framework.

148 d provides an unprecedented insight into the life history of this iconic bird.

149 for individuals and groups to adopt a slower life history strategy, a greater focus on the future (vs

150 threats, and these differences can influence life-history parameters such as growth, survival and fut

151 of phenotypic evolution of tadpole and adult life-history phases, and for the underlying expression o

152 the direct impacts of cyclones on different life-history stages across the annual life cycle.

153 r & Nettle cannot be adequately explained by life-history theory.

154 nvironments (recruitment) represents a major life-history transition.

155 ited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH).

156 Health-related quality of life (HRQoL) measurement has become a valuable metric to

157 on, education, and health-related quality of life (HRQOL) were measured.

158 health status and health-related quality of life (HRQoL).

159 ability of maternal sensory signals early in life impacts cognitive function in both rats and humans.

160 eeded to assess the durability of quality-of-life improvement with TAVR vs SAVR in this population.

161 tive assessment of health-related quality of life in a patient population confined to people with ade

162 provide important structural components for life in coastal waters.

163 ypical symptoms, and report worse quality of life in comparison with men.

164 hirality is explained by origin of prebiotic life in one hemisphere of earth and its evolution to EE

165 line was observed starting a decade later in life in the 30- to 39-year age range.

166 able for 56-177 days, depending on bNAb half-life in vivo.

167 amily financial resources available in early life influences child health and development.

168 Extension of the serum half-life is an important issue in developing new therapeutic

169 ibrotic diseases, but its short in vivo half-life is an obstacle to long-term administration.

170 Rhinoconjunctivitis-specific quality of life is often reduced during seasonal allergies.

171 All of life is social, from genes cooperating to form organisms

172 distress and lower health-related quality of life is unknown.

173 nction between unicellular and multicellular life is visible in the intrinsically encoded nucleosome

174 ncluding additional dimensions of quality of life, is indicated.

175 ease requiring surgical repair at <7 days of life, lethal chromosomal anomaly, death within 48 hours,

176 treatment have led to more young adults with life-limiting conditions living beyond childhood, which

177 he skin that leads to fibrosis, which can be life-limiting.

178 Installation of a water softener in early life may be able to prevent AD development.

179 ary intake of vegetables were observed.Early life may be an optimum time for both infants and their m

180 ard monitoring group vs. $86,829 in the real-life monitoring group) in France and $11,965 ($93,795 vs

181 ned to assess people's conceptions of mental life more directly.

182 dities, and lower vision-specific quality-of-life (NEI VFQ-25) scores were associated with higher odd

183 portional pharmacokinetic profile and a half-life of 12 days.

184 netic properties, including a predicted half-life of 16-19 h.

185 rate of return to clinic decayed with a half-life of 7.0 days after tracing (95% CI, 2.6 %-12.9%).

186 es an understanding of when and where in the life of a pre-mRNA transcript the modifications are made

187 ted, order of magnitude improvement in creep life of alloys upon adding small amounts of elements lik

188 Without post-manufacture HIPing the fatigue life of electron beam melting (EBM) additively manufactu

189 on of the existing literature about the half-life of IgE in both the circulation and skin.

190 without compromising the standard commercial life of industrial bread and allowing to save packaging

191 creases the transplacental transfer and half-life of malaria-specific IgG3 in young infants and is as

192 tion of pretreatment with packaging on shelf life of minimally processed cilantro leaves (MPCL) was a

193 germination is a major decision point in the life of plants determining future growth and development

194 However, MB and HIFU are limited by the half-life of the contrast agent and challenges in accurate co

195 eature enhances biodistribution and the half-life of the peptides, while integration into the target

196 pathway T cells, arguably persisting for the life of the transplant.

197 nts most commonly in the first five years of life, often after the first known ingestion with typical

198 Early-life OM episodes historically associated with vaccine-se

199 t impact patients' health-related quality-of-life or the likelihood that their health information or

200 , especially for patients given shorter half-life pharmacotherapies and who boarded in the emergency

201 aining peptides (DAACPs) are crucial to many life processes.

202 atabolism, and negatively impacts quality of life (QL).

203 l-known significant impairment of quality of life (QoL) in allergic rhinitis (AR), the degree of impa

204 onstitution, donor chimerism, and quality of life (QoL) of IL2RG/JAK3 SCID patients >2 years post-HSC

205 nger and satiety assessments, and quality of life (QOL) surveys, reported up to 3 months.

206 Overall survival (OS), quality of life (QoL), and safety.

207 Thus, the aOX assumption to improve life-quality is misleading as oxidative stress and exace

208 CPAP indication), health-related quality-of-life questionnaires, 24-hour blood pressure monitoring,

209 The number of early life risk factors, including high levels (extreme 75th p

210 METHODS AND We measured the Life's Simple 7 ideal cardiovascular health metrics in 4

211 Finally, GMO mixtures and a real-life sample were analyzed to illustrate the applicabilit

212 ights into activity patterns associated with life satisfaction and self-reported disease.

213 e BL group had a mean increase in quality of life score compared with the placebo group.

214 uous non-invasive alcohol monitoring in real-life situations.

215 tion of imaging correlates elicited by early-life social stress is lacking.

216 eviewed the literature related to quality of life, social, economic, academic, and occupational impac

217 accurate and specific reconstruction of real-life sounds from high-resolution functional magnetic res

218 s, the longest living rodent, with a maximum life span exceeding 30 years, and found that injury resp

219 ntity causes a severe decline of replicative life span of daughter cells.

220 that dC+dT delayed disease onset, prolonged life span of Tk2-deficient mice and restored mtDNA copy

221 to mutant knockin LRRK2 mice over half their life span, with observable and measurable phenotype, is

222 Notably, mature taste cells have life spans of only 5-20 days and, consequently, are cons

223 ivors, better annual physical and quality of life status, but not psychiatric status, were associated

224 Better annual physical and quality of life status, but not psychiatric status, were associated

225 ing the molecular pathways through which our life stories sculpt genomic function to contribute to co

226 Here, we test for the first time how early-life stress drives developmental programming and transge

227 port clinical evidence suggesting that early-life stress may predispose individuals to increased anxi

228 tional effects of maternal exposure to early-life stress on several phenotypic traits in their offspr

229 may buffer against depressogenic effects of life stress.

230 Our results suggest that life successfully moved into arsenic-rich environments i

231 uclides with a relatively long physical half-life, such as (89)Zr.

232 unctional ATM is still compatible with early life, suggesting that adaptation mechanisms contributing

233 is an amyloid-binding PET ligand with a half-life suitable for clinical use outside of the research s

234 d surrogates involved in a decision to limit life support in the ICU.

235 nd euthanasia and withholding or withdrawing life support, 3) the morality of a physician deliberatel

236 aneous circulation and 22% by extracorporeal life support.

237 rall health on the Kidney Disease Quality of Life Survey (median score, 0 in the sertraline group vs

238 e of Cardiology third decennial Professional Life Survey was completed by 2,313 cardiologists: 964 wo

239 nce of understanding patient preferences for life-sustaining treatment is well described for individu

240 d acetone at 295 K, the radical 2 has a half-life, tau1/2 = 49 h (DeltaH(double dagger) = 17.9 +/- 0.

241 patients had lower health-related quality of life than an age- and sex-matched control group in the d

242 ores with respect to behavior and quality of life than did those who continued medical therapy alone

243 n development and metabolic changes in early life that could be followed through the life course; and

244 years and then repeatedly infects throughout life; this it does despite relatively slight variations

245 Hymenoptera venom allergy is a potentially life-threatening allergic reaction following a honeybee,

246 are characterized by severe bradycardia and life-threatening apneas.

247 Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of

248 disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infections and abe

249 d toward lower rates of GUSTO-defined severe/life-threatening bleeding with cangrelor alone compared

250 Coronary artery anomalies may cause life-threatening cardiac complications; however, develop

251 d was associated with higher rates of severe life-threatening complications.

252 ses mild dengue fever, but, in severe cases, life-threatening dengue hemorrhagic fever (DHF) and deng

253 se, dengue fever (DF), while few develop the life-threatening diseases dengue hemorrhagic fever (DHF)

254 er-refractory status epilepticus (SRSE) is a life-threatening form of status epilepticus that continu

255 iency, a rare metabolic disorder that can be life-threatening if left untreated.

256 as a dangerous pathogen that causes rare but life-threatening infections.

257 Life-threatening manifestations can develop in a small p

258 mptoms may range from mild abdominal pain to life-threatening obstruction and strangulation.

259 Angioedema is a potentially life-threatening occurrence that is encountered by criti

260 ve fungal infections and 5 patients (4%) had life-threatening or fatal infections.

261 n of a C. sativa allergy varies from mild to life-threatening reactions and often seems to depend on

262 palpation determines if a patient's pain is life-threatening requiring emergency intervention/surger

263 individuals, C. albicans may spread to cause life-threatening systemic infections.

264 nce of shear stress in platelet function and life-threatening thrombus formation.

265 Peanut allergy is common, life-threatening, and without therapeutic options.

266 he environment is important since it enabled life to emerge, and shapes evolution today.

267 eted as evidence that people consider mental life to have two core components-experience (e.g., hunge

268 irst reported Cas9 in the archaeal domain of life, to our knowledge.

269 adverse events, changes in sexual quality of life using the Cancer Rehabilitation Evaluation System s

270 it is not feasible to build a viral tree of life using traditional phylogenetic methods based on con

271 novel approach for rational design of early-life vaccines.

272 trategies for future CM quantities in end-of-life vehicles (ELVs) are poorly understood, mainly due t

273 ation about the prospective recipient (whose life was saved by the donation) increased the participan

274 In our daily life, we rapidly and flexibly retrieve a host of biograp

275 might contribute to the development of early life wheezing disorders and asthma, and discuss the exte

276 d throughout much of the bacterial domain of life, where it commonly controls the expression of prote

277 oss-of-function cases were incompatible with life, whereas those individuals with milder missense var

278 .1% versus 26.6%) during the last 30 days of life, while diagnoses of opioid use disorder during this

279 speak of the desire to control when and how life will end.

280 n of air pollution in utero and during early life with pubertal development in Hong Kong, China, an a

281 CrI: US$51, US$166) per Disability Adjusted Life Year (DALY) averted, PMI-funded interventions are h

282 s) in 2015 U.S. dollars per quality-adjusted life year (QALY) gained and number of fragility fracture

283 ectiveness ratios (cost per quality-adjusted life year gained) from the societal perspective across a

284 nterval 12 662-132 452) per quality-adjusted life-year (QALY) gained, pound372 207 (268 162-1 903 385

285 justed life-year to $150000/quality-adjusted life-year range frequently cited as cost-effective in th

286 trial is within the $50000/quality-adjusted life-year to $150000/quality-adjusted life-year range fr

287 ding increases in survival, quality-adjusted life years (QALYs), costs, and resulting budget impact b

288 mate changes in the numbers of deaths and in life years and life expectancy at birth, attributable to

289 million (95% CI: 7.90 million-9.59 million) life years that might have been achieved if South Africa

290 easures: Incremental costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness r

291 time costs, life-years, and quality-adjusted life-years (QALYs).

292 robably lose 2.3 million disability-adjusted life-years and US$3.5 billion of economic productivity e

293 nd stroke) deaths prevented or postponed and life-years gained (LYGs) over the study period, stratifi

294 information on the long-term benefits (e.g., life-years gained and mortality reduction) and harms (e.

295 Benefits were measured in quality-adjusted life-years gained.

296 rimary outcomes of the model were changes in life-years per 100 000 total population over 40 years (t

297 IR prolonged survival; the mean number of life-years per patient was 19.4 in the scenario with IR

298 Changes in quality-adjusted life-years were assessed with utilities determined by th

299 nd impact on health status (quality-adjusted life-years).

300 Outcome Measures: Average lifetime costs, life-years, and quality-adjusted life-years (QALYs).

301 hat adult body size has its roots earlier in life, yet few life-course studies have data on siblings