ライフサイエンスコーパス: life course

1 havior (e.g. genetics of taste, stage in the life course).

2 a risk factor for poor health throughout the life course.

3 reported higher cognitive activity over the life course.

4 itable and genetically stable throughout the life course.

5 tage of life, and as a setting point for the life course.

6 ant to minimizing caries risk throughout the life course.

7 -reaching implications for health across the life course.

8 regnancy events and chronic disease over the life course.

9 t of human development in the balance of the life course.

10 lack of sophisticated phenotyping across the life course.

11 ntellectual decline in the first half of the life course.

12 lties in relationships shaped the subsequent life course.

13 clerosis early in life and tracks across the life course.

14 ealth and wellbeing is needed throughout the life course.

15 tructural and functional plasticity over the life course.

16 =0.07 and 0.06, respectively) throughout the life course.

17 alth-related events, and patterns across the life course.

18 ded to understand sexual function across the life course.

19 .001 and 0.001, respectively) throughout the life course.

20 farming exposures on atopy endure across the life course.

21 d infant growth and disease risk through the life course.

22 a long-term impact on health throughout the life course.

23 , well-being, learning, or behavior over the life course.

24 inable functional alterations throughout the life course.

25 tes of aortic root remodeling over the adult life course.

26 ssessment of economic effects over a woman's life course.

27 rsistent obesity and overweight early in the life course.

28 gely primary mental disorders throughout the life course.

29 alth challenges with implications across the life course.

30 s likely to improve children's wellbeing and life course.

31 mortality or other health outcomes over the life course.

32 erminants of LV mass tracking over the adult life course.

33 comitant biological responses throughout the life course.

34 of oxidative stress and inflammation over a life course.

35 two measures taken at two time points in the life course.

36 ifferent factors at different periods in the life course.

37 lth of offspring throughout their subsequent life course.

38 r understanding of its determinants over the life course.

39 s, can influence health and disease over the life course.

40 ons and households at specific stages of the life course.

41 data, usually measured at one point over the life course.

42 economic position at different stages of the life course.

43 nesses in suicide victims differs across the life course.

44 rain development and function throughout the life course.

45 pre-conception to maximise health across the life course.

46 lth, human capital, and wellbeing across the life course.

47 nts shape inflammatory phenotypes across the life course.

48 prehypertension, and hypertension across the life course.

49 of social psychological processes across the life course.

50 acts during specific critical periods of the life course.

51 men and Mexican Americans increased over the life course.

52 sity and cardiometabolic outcomes across the life course.

53 promote cardiovascular health throughout the life course.

54 tion predicts psychiatric illness across the life course.

55 nmental exposures experienced throughout the life course.

56 effect of an upward social mobility over the life course.

57 rs impact brain and cognition for the entire life course.

58 multiple adverse health outcomes across the life course.

59 and psychiatric disorders changed across the life course.

60 aging modalities and other stages across the life course.

61 blings has a lasting impact on that person's life course.

62 istic, and interventional research along the life course.

63 orbidities and their consequences across the life course.

64 ors influence health and well-being over the life course.

65 focus on prevention at earlier stages of the life course.

66 nts with diabetes, particularly early in the life course.

67 ldwide that SDH affect health throughout the life-course.

68 higher levels of sexual involvement over the life-course.

69 scular health and healthcare over the entire life-course.

70 ic and environmental factors acting over the life-course.

71 ic and environmental factors acting over the life-course.

72 ical coronary atherosclerosis throughout the life-course.

73 tanding the migration patterns of individual life-courses.

74 s in health and human development across the life course?

75 behaviour) at different times throughout the life course affects the risk of many diseases and, ultim

76 re scarce data on how body weight during the life course affects this relationship.

77 ned statistically significant throughout the life course, although the substantive size of associatio

78 Thus, life-course analysis illustrates that BPA is associated

79 We simulated growth trajectories across the life course and adjusted for secular trends.

80 ychiatric disorders, consistently across the life course and coincident with the experience of the lo

81 posure related to SEP accumulates across the life course and contributes to raised levels of fibrinog

82 le et al, "Mental Disorders Across the Adult Life Course and Future Coronary Heart Disease: Evidence

83 redisposition is more prominent early in the life course and in the early years of AUD.

84 ognitive performance achieved earlier in the life course and less from declines in later life.

85 is a robust predictor of obesity across the life course and may interact with genes affecting metabo

86 stances, and behaviors that cascade over the life course and may ultimately contribute to socioeconom

87 in resistant than white Europeans across the life course and potentially experience beta-cell exhaust

88 on methylation are highly stable across the life course and that developmental change in the genetic

89 of left ventricular (LV) mass over the adult life course and the determinants of such change.

90 Extensive exposure data over the life-course and baseline specimens provide important opp

91 he social determinants of health, across the life course, and in wider social and economic spheres--t

92 and the normalisation of violence across the life course, and transform men's power over women and ch

93 arly life that could be followed through the life course; and the establishment of human epigenetic m

94 Adopting a life course approach, these associations remained statis

95 This highlights the importance of a life-course approach for frailty prevention.

96 The life-course approach to age-related diseases, when syste

97 ct of the developmental origins concept in a life-course approach to the prevention of cardiovascular

98 Specifically, by adopting a life-course approach, they use a multilevel regression w

99 There has been a shift towards a life-course approach, with large cohort longitudinal stu

100 es influence cognitive impairment across the life course are warranted.

101 Most important, the gradient begins the life course as a gradient in developmental health, sugge

102 ealth promotion activities across the entire life course, as well as in access to treatment for ACS a

103 We demonstrate that life-course associations between early growth phenotypes

104 These life-course associations have often been attributed to t

105 revention, with a greater focus early in the life course before disease processes are established.

106 0.03, p = 0.007), and persistent across the life course (beta = 0.26, SE = 0.04, p < 0.0001).

107 risk factors for refractive error across the life course, but ophthalmic examination in such cases to

108 ease and to place these studies in a broader life-course context.

109 84 with reduced alcohol consumption over the life-course, contributing new evidence of an effect befo

110 olescence could yield understanding into the life course development of cardiovascular risk.

111 e a global platform to reduce ACEs and their life-course effect on health.

112 Without all such time points, life course effects will remain only partially understoo

113 Life-course epidemiologic studies frequently obtain data

114 "distal") disease outcomes is referred to as life course epidemiology.

115 likelihood of staying after controlling for life-course events.

116 etween grandparents' (first generation (G1)) life-course exposure to chronic poverty and grandchildre

117 s in a cohort that has experienced different life-course exposures and has different confounding stru

118 e associations under 2 causal structures for life-course exposures and timing of methylation measurem

119 and they support the importance of equity in life-course exposures for reducing racial disparities in

120 oeconomic variation, and we determined which life-course exposures were associated with these inequal

121 ult because of time-dependent confounding by life-course exposures.

122 lity and may reduce risk for dementia due to life-course factors.

123 mother's birth on GBW, adjusted for maternal life-course factors: maltreatment as a child, education

124 orrelation of .711 (p = 2.26e-12) across the life course for general cognitive function.

125 as observed at nearly every point across the life course for major depressive episode, panic disorder

126 ng of risk and protective factors across the life course for many of these problem behaviours.

127 ars are known to be a critical period in the life course for shaping attitudes and behaviors.

128 early childhood is the optimum period in the life course for the primary prevention of adult adiposit

129 mental and physical health problems over the life course; for example, meta-analyses indicate that ex

130 These findings imply that the life-course framework is crucial for understanding the c

131 is substantially heritable across the human life course from adolescence to old age.

132 As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme,

133 As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women from seve

134 rticipating in the Healthy Ageing across the Life Course (HALCyon) research programme, ranging in age

135 d whether these associations vary across the life course has important clinical implications.

136 The obesity-hypertension link over the life course has not been well characterized, although th

137 d the trajectory of body-mass index over the life course have been associated with brain atrophy, whi

138 se in cumulative SEP disadvantage across the life course (hazard ratio = 1.16, 95% confidence interva

139 We administered an HIV test and a life-course history interview to participants.

140 ls differentiate and mature during the human life course; human cytomegalovirus (HCMV) infection is a

141 rajectory of lipids and lipoproteins for the life course in adults and to determine whether CRF modif

142 ransitions between categories of BP over the life course in contemporary, multiracial/multiethnic pop

143 n measures were not different throughout the life course in exposed females or males (all P>0.44), al

144 ion that mtDNA deletions accumulate over the life course in post-mitotic cells of many species.

145 d by social and economic conditions over the life course in producing adverse birth outcome dispariti

146 related role of lead burden and SES over the life course in relation to psychological functioning in

147 line BMI, the rate of change in BMI over the life course increased the risk of incident hypertension

148 of the cohort trends raises questions about life-course inequalities in the social and health enviro

149 Data from the Life-course Influences on Fetal Environments (LIFE) Stud

150 ealth and multiple health domains across the life course, interventions that ameliorate these initial

151 iated with cardiometabolic outcomes over the life course into adulthood.

152 Psychological distress at any point in the life course is associated with higher cardiometabolic ri

153 Cardiac remodeling over the adult life course is characterized by a distinct pattern of in

154 SEP over the life course is related to the risk of incident heart fai

155 rdiovascular health promotion throughout the life course is required.

156 ulation of psychobiological risks across the life course is summarized and represents an important di

157 of overweight and/or obesity over the adult life course is unknown.

158 t with individual vulnerabilities across the life-course is required.

159 wealth) and neighborhood factors across the life course may be necessary.

160 development of personality across the human life course may be observed from three different standpo

161 EP indicators at different points across the life course may be related to a combination of 28 inflam

162 elomere length and physical fitness over the life course may contribute to increased risk of several

163 tal timing, further investigation across the life course may help quantify the full effects and the c

164 mal levels of these risk factors through the life course may prevent atrial remodeling and AF.

165 r weight or body mass index (BMI) across the life course may provide insights into the aetiology of o

166 ychiatric disorders in the first half of the life course may reduce the population burden of age-rela

167 close relationships and its effect in their life-course migration.

168 hts into the developmental components of the life course model of ageing may lead to the design of bi

169 de a common mechanistic process underlying a life course model of ageing.

170 A life course model places ageing in the context of the at

171 Psychological distress profiles over the life course (no distress, childhood only, adulthood only

172 nt with which humans interact throughout the life course, nor does it allow for interrelationships be

173 elevated risk of developing obesity over the life-course (odds ratio=1.36; 95% confidence interval=1.

174 The initiation of foraging during the life course of honeybee workers is of central interest t

175 derstanding the epidemiologic profile of the life course of mental disorders is fundamental for resea

176 d microsimulation model, which simulated the life course of patients on the transplant waiting list a

177 d psychiatric history of the syndrome in the life course of the sufferer.

178 ic information were collected throughout the life-course of individuals.

179 impact of overweight and obesity during the life course on cancer risk remain scarce.

180 e has profound adverse consequences over the life course on human, social, and economic capital.

181 ld development, with implications for future life course outcomes.

182 eschool has demonstrated positive effects on life-course outcomes, limitations in knowledge on progra

183 lomere length (LTL) decreases over the adult life course owing to the cumulative burden of oxidative

184 ed biological aging in the first half of the life course, particularly in men.

185 This study sought to assess whether life course patterns of psychological distress assessed

186 urther, the relative importance of different life-course periods for rate of late-life memory decline

187 Life-course persistent asthma and tobacco smoking are ri

188 Our findings suggest that life-course persistent offending may represent a viable

189 Study members with life-course-persistent asthma had elevated blood eosinop

190 Study members with life-course-persistent asthma had shorter leukocyte telo

191 Life-course-persistent asthma is related to a proposed b

192 her genetic risk were more likely to develop life-course-persistent asthma than were those with a low

193 Blood eosinophil count mediated 29% of the life-course-persistent asthma-leukocyte telomere length

194 Asthma was classified as life-course-persistent, childhood-onset not meeting crit

195 od-onset asthma cases remit and which become life-course-persistent, who might develop impaired lung

196 al studies to pinpoint where and when in the life course personality change is most likely to occur;

197 e findings are reviewed and discussed with a life course perspective, examining the contribution of i

198 Adopting a life course perspective, we examined the effects of earl

199 d myocardial infarction were assessed from a life-course perspective and a current view separately.

200 disparities, it is critical to incorporate a life-course perspective and integrate social theory.

201 es, positive and negative, arise from both a life-course perspective and within a socioecological fra

202 al to quantify the effects of smoking from a life-course perspective in future research and to sugges

203 Applying a life-course perspective would entail modeling transition

204 ertension and myocardial infarction from the life-course perspective, and the risk increased with age

205 l infarction, with a particular focus from a life-course perspective.

206 A life-course plot was used to identify critical periods o

207 Further studies are needed to determine the life course progression of these changes.

208 he authors examined the impact of changes in life-course SEP on incidence of dementia and cognitive i

209 s study, the authors examined the effects of life-course SEP on inflammatory and hemostatic markers:

210 We examined associations between life-course SES and late-life memory function and declin

211 Individuals who experienced life-course SES improvement had intermediate AA compared

212 l geocoding to guide vendor selection in the Life Course Socioeconomic Status, Social Context and Car

213 nvestigations of the link between changes in life-course socioeconomic position (SEP) and cognitive d

214 When more specific information about women's life-course socioeconomic status is taken into account,

215 Associations declined in magnitude with life course stage and number of previous lifetime disord

216 size has its roots earlier in life, yet few life-course studies have data on siblings with which to

217 ing five topics in more detail: the need for life-course studies of pediatric cardiac disease and epi

218 ng, biomarkers, cardioprotective strategies, life-course studies, long-term monitoring technologies,

219 ects of distal causes experienced across the life course, such as segregation, that operate through m

220 developmentally appropriate times during the life course, target multiple risks, and build on existin

221 ly stable intercohort differences across the life course that vary in substantively plausible ways am

222 designs addressing energy balance across the life course, the development and application of highly r

223 anges in physical activity behavior over the life course, the domains of physical activity in which t

224 The higher the sugar consumption along the life course, the higher the dental caries increment.

225 energy allocation strategies throughout the life course, thereby affecting diverse health outcomes.

226 ence offspring adiposity and when across the life course these effects may manifest themselves.

227 Throughout the life course, these pathways can lead to insulin resistan

228 ding how multiple stressors combine over the life course to affect the risk of morbidity and mortalit

229 activity level and low bodyweight across the life course to prevent diabetes.

230 The life course trajectory differs in high and low resource

231 for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI

232 Covariates included sex and life course variables, such as family income, breast-fee

233 etween "stable Non-manual" profiles over the life course versus "Manual to Non-manual" profiles (beta

234 5-15 years of life lost, estimated along the life course via the generalized gamma model.

235 omes experienced by individuals during their life course) were examined using multivariable regressio

236 overall physiological wear-and-tear over the life course, which could partially be the consequence of

237 lth and development, and mothers' health and life-course with home visits beginning during pregnancy

238 ct serotonin receptor populations across the life course, with an emphasis on the contribution of dif

239 terminants of behavior change throughout the life course would contribute greatly to understanding wh

240 s influenced by factors occurring across the life course, yet exposures to area conditions have only

241 The heart progressively remodels over the life course, yet longitudinal data characterizing such r