ライフサイエンスコーパス: life span

1 ion, reduced striatal atrophy, and prolonged life span.

2 uit flies, impairing eclosion and decreasing life span.

3 a genetic continuum that acts throughout the life span.

4 es that may manifest at any point across the life span.

5 phages, which had dual origins and a shorter life span.

6 tly increases ins-6 expression and decreases life span.

7 ations (3 and 10 ppm) throughout their whole life span.

8 aused by TE activation and extending healthy life span.

9 vels from single cells to mouse behavior and life span.

10 changes in trait expression throughout their life span.

11 iduals who are treated early a nearly normal life span.

12 ic cells, defective locomotion and a shorter life span.

13 nucleosome assembly and advanced replicative life span.

14 ukocytosis, dry eye, hair loss, or a reduced life span.

15 , leukocytosis, xanthomatosis, and a reduced life span.

16 ecline to maintain decision quality over the life span.

17 nd increased oxidative stress resistance and life span.

18 dermal adherence, and increased the animals' life span.

19 s and heart dysfunction, markedly shortening life span.

20 ents and between tissues to ensure a healthy life span.

21 ophagy in Maf1(-/-) mice with their extended life span.

22 natal growth, muscle weakness, and a shorter life span.

23 ion graph technique and leads to a shortened life span.

24 production can prolong both health span and life span.

25 was calculated and compared by body size and life span.

26 impaired fear memory, and a slightly reduced life span.

27 f temporally controlled strategies to extend life span.

28 ism-level phenotypes, including behavior and life span.

29 ubset of genes in old cells and with shorter life span.

30 h1Delta mutant had a shortened chronological life span.

31 m holds for cognition and the brain over the life span.

32 ) that proliferates throughout the mammalian life span.

33 ransition (EMT) state and extends hepatocyte life span.

34 s cryptic transcript initiation, and extends life span.

35 generative processes over their decades-long life span.

36 SCA1 mice and to a modest increase in their life span.

37 BP trajectory with aging over the male adult life span.

38 n of sperm over long periods of reproductive life span.

39 intracellular lysosomal storage, and reduced life span.

40 reduces resistance to starvation, and limits life span.

41 e actin cytoskeleton, stress resistance, and life span.

42 rain itself, qualitatively changing over the life span.

43 cessfully, but experience a relatively short life span.

44 ll as positive effects on motor activity and life span.

45 tin-induced neurodegeneration, and prolonged life span.

46 tive test performance across the adult human life span.

47 ng kidney disease progression, and extending life span.

48 substantial increases in muscle strength and life span.

49 ments in a variety of populations across the life span.

50 eovessels and subsequently reduces neovessel life span.

51 ity of recruitment and extended reproductive life span.

52 udying these metrics across the entire adult life span.

53 iverse neuropsychiatric disorders across the life span.

54 to form new axes of growth throughout their life span.

55 ning is correlated with reduced survival and life span.

56 o lower chronic disease incidence and longer life span.

57 r function with an unprecedented increase in life span.

58 ta plays a key role in modulating vertebrate life span.

59 to 30% in women and 15% in men during their life span.

60 rochromatin silencing loss regulate cellular life span.

61 ress responsivity and anxiety throughout the life span.

62 cing or sustained loss of silencing shortens life span.

63 gut motility, feeding defects, and decreased life span.

64 hip among oxidative stress, health span, and life span.

65 ar)3-9 or Dicer-2 also led to an increase in life span.

66 o optic and peripheral neuropathy across the life span.

67 ession led to increased cellular replicative life span.

68 ease prevention and the extension of healthy life span.

69 h leads to reduced body weight and shortened life span.

70 undergo senescence independent of organismal life span.

71 rt rate is a heritable trait correlated with life span.

72 t likely source of recent increases in adult life span.

73 n the brain and intestine extends health and life span.

74 expectation for an extended (if not normal) life span.

75 dependent SAH accumulation lead to increased life span.

76 ulmonary complications, resulting in shorter life-span.

77 we consider developmental change across the life-span.

78 ction, loss of synaptic protein, and reduced life-span.

79 cult to investigate using animals with short life spans.

80 roteins, accounting for differences in their life spans.

81 lose to the expected levels and lived normal life spans.

82 ated hearts and showed significantly shorter life spans.

83 ng processes and extends average and maximal life spans.

84 ing phase that largely determine their final life spans.

85 ticipants (humans), sampled across the adult life span (20-89 years), to reveal that RSFC-based netwo

86 roup of individuals sampled across the adult life span (20-89 years), we measured correlations at res

87 impairment is not progressive throughout the life span; 3) is present in bipolar disorder, albeit to

88 mmodates the persistent virus throughout the life span, a phenomenon herein referred to as non-recove

89 e (maintained over time) in forbs with short life spans; a 2-3-year delayed surge in long-lived forbs

90 ke, improves health during aging and extends life span across multiple species.

91 l purposes have been hampered by their short life span after isolation.

92 Extending neutrophil life span allowed efficient transfection of plasmids (40

93 on key indicators of arthropathy across the life-span among participants with severe hemophilia A.

94 titial macrophage populations exhibit a long life span and a low turnover in the steady state.

95 ced fat oxidation, were allowed to age while life span and a number of physiological parameters (gluc

96 on aneuploidy, these adult mice with reduced life span and accelerated progeroid features are indisti

97 were further developed to enhance the column life span and achieve the separation of dapagliflozin fr

98 s tetrix - we quantified the effects of age, life span and age of first lek attendance (AFL) on male

99 activities, p53-deficient fish have a normal life span and few morphological changes.

100 might be involved in the fine-tuning of the life span and function of activated DCs.

101 schizophrenia from mood disorders across the life span and generalize to new patients as well as to e

102 hypoxia-inducible factor 1 (HIF-1) increases life span and health span in nematodes through an unknow

103 e precise molecular mechanisms regulating DC life span and homeostasis are unclear.

104 ological ablation of senescent cells extends life span and improves health span.

105 of sirtuin inhibition in delimiting platelet life span and management of thrombosis.

106 um pantetheinase level regulates erythrocyte life span and modulates the risk of developing complicat

107 ogy and produced significant improvements in life span and motor function in Ppt1(-/-) mice.

108 trinsic and environmental stimuli control DC life span and numbers.

109 he connection between AD risk factors across life span and provide mechanistic insight to the process

110 t bacteria, and hence, have severely reduced life span and resistance to infections.

111 ocation changes over a mother's reproductive life span and that age-specific differences differ in no

112 age systems remain largely stable across the life span and that both younger and older adults depend

113 larly challenging to model, due to its short life span and the dispersive effects of constant water m

114 and unequal recombination affect replicative life span and the role of Ubp3 in these processes.

115 gamete lineage is nearly independent of both life span and vegetative growth.

116 ingly, mice heterozygous in Fdxr had a short life span and were prone to spontaneous tumors and liver

117 on and lectin deficiencies increased protein life spans and abundance, and the basal rate of N-glycan

118 f how telomere dynamics vary over individual life spans and cohorts, and with spatio-temporal variati

119 Our previous studies have shown that life-span and antitumor function of T cells can be enhan

120 lecular basis of NAD(+) metabolism, cellular life span, and diseases associated with NAD(+) deficienc

121 one, leading to simple battery design, long life span, and excellent safety.

122 e Mfn1 completely rescued heart dysfunction, life span, and respiratory chain function.

123 al trade-off between reproductive effort and life span, and whether such trade-off can be overcome th

124 scriptional precision that is detrimental to life span, and, importantly, this acceleration in aging

125 ics vary in a complex manner over individual life spans, and across space and time.

126 Moreover, these pTreg cells have a limited life span, are distinguishable from microbiota-induced p

127 phrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar cha

128 omotor performance and ameliorates shortened life span, as well as reducing neurodegeneration in Alzh

129 ost of developmental disabilities across the life span, better methods are needed to detect the risk

130 nt stomatal conductance, leaf sizes and stem life span between dominant clades would have shifted the

131 Significant differences were observed in life span between genders, where females survived longer

132 scale is an emerging phenomenon of shortened life span, but the specific mechanisms linking these obs

133 damage, and the extension of health span and life span by augmenting antioxidant activity has been in

134 ory neurons shortens Caenorhabditis elegans' life span by differentially regulating the expression of

135 bulk telomere shortening but extend cellular life span by healing the shortest telomeres.

136 In fact, ACT prolongs the neutrophil life span by inhibiting constitutive apoptosis and preve

137 mouse models of late-onset HPP with extended life spans by engineering a floxed Alpl allele, allowing

138 after exposure further reduced their overall life spans by nearly one-half.

139 aning (1.2 x 1012GC), exhibited an increased life span, characterized by delayed weight loss and dimi

140 in mediating the extension of chronological life span (CLS) by caloric restriction (CR).

141 With this increased life span comes increased age-associated disease and the

142 cued from autoinflammation and have improved life span compared with Stat1(+/-)Pdgfrb(+/D849V) mice.

143 essential to cellular stress resistance and life-span determination.

144 those: increasing organism body size and/or life span, disrupting processes within the organism, and

145 ange in sexual function during an individual life span driven by environmental cues - is an exceeding

146 d not increase with body size and/or maximum life span (eg, for rock hyrax, 1% [95% CI, 0%-5%]; Afric

147 Despite their large body size and long life span, elephants remain cancer resistant, with an es

148 s, the longest living rodent, with a maximum life span exceeding 30 years, and found that injury resp

149 served in eukaryotes and induced by multiple life span-extending interventions in mice, which suggest

150 with bacteria from young donors resulted in life span extension and delayed behavioral decline.

151 Reduced mTORC1 signaling is associated with life span extension and improved metabolic homeostasis,

152 ing beneficial systemic effects that lead to life span extension in a vertebrate model.

153 nine pathway components revealed significant life span extension in response to down-regulation of tw

154 +) homeostasis factor and ssy5Delta-mediated life span extension is likely due to concomitantly incre

155 n clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent m

156 upregulation of anti-aging pathways mediate life span extension via the induction of autophagy.

157 ) homeostasis factors play key roles in this life span extension.

158 iction (DR) and is necessary for DR-mediated life-span extension, which suggests that this enzyme rep

159 defect and, in adults, reversed a shortened life span (followed for 2 y).

160 ructural integrity of IgG1 during its normal life span; for IgG2 and IgG3 the inter-heavy chain disul

161 er to address these questions and to isolate life span from phylogenetic and environmental factors, w

162 microbiota composition during an organism's life span has remained unclear.

163 under which traits associated with long leaf life span, high hydraulic and thermal capacitances, and

164 hey have to persist throughout an organism's life span, HSCs tightly regulate the balance between pro

165 ad yet) tricarboxylate carrier increased the life span in different species by mechanisms akin to cal

166 d with age-related WM differences across the life span in healthy individuals 9-86 years of age (n =

167 Here we show that RAGE exhibits an extended life span in lung epithelia (t(1/2) 6 h), is monoubiquit

168 tic inhibition of mTORC1 was shown to extend life span in mammals, reduce pathological hypertrophy an

169 ystem involves sensory neurons, which affect life span in many species.

170 ealthy neuromuscular age and a major axis of life span in model systems.

171 reased TE transposition as well as increased life span in TE-sensitized Dicer-2 mutants.

172 ofibers and modest increases of strength and life span in the severely myopathic Mtm1delta4 mouse mod

173 Attenuated nutrient signaling extends the life span in yeast and higher eukaryotes; however, the m

174 ein kinase regulates metabolism, growth, and life span in yeast, animals, and plants in coordination

175 n vertebrates, and usually result in shorter life spans in the larger sex, although the underlying me

176 sing resting-state fMRI methods across their life-span in a cross-sectional design to analyze changes

177 uctive rates, lifetime reproductive success, life span) in red and green colour morphs of clonal pea

178 ular development in utero and throughout the life span, in vision performance in young and later adul

179 Modulation of these pathways to extend life span, including insulin-like signaling and the resp

180 is compatible with normal heart function and life span indicating a more moderate impact of Plin5 ove

181 , 3-24.8) across a median 10.0-year iterated life span (IQR, 4.1-16.7).

182 The number of rolls during the eddy life span is a constant independent of eddy size.

183 (Callithrix jacchus) with a relatively short life span is an ideal model for aging research.

184 ysiological conditions, however, erythrocyte life span is compromised severely, which threatens the o

185 In summary, arbuscule life span is influenced by PT4 and ATM2;3, and their rel

186 Over a human's life span, keratinized skin cells, immune cells, and mic

187 sceptible to HPV-related EGLs throughout the life span, making it necessary to ensure the longevity o

188 unmet needs, which include normalization of life span (myelofibrosis and some patients with PV), red

189 e some unsolved problems which include short life-span, narrowed antibacterial spectrum, ineffectiven

190 at least 2 months, thus exceeding the short life-span normally associated with cell-based sensors.

191 mature deaths and an estimated extended mean life span of 19 to 20 years.

192 -lived vertebrate in captivity with a median life span of 4-6 months.

193 d visual function in healthy eyes across the life span of a German population aged 20 to 69 years (n

194 llular IAP leader dramatically shortened the life span of a long-lived viral IAP (Op-IAP3) when fused

195 ired MHC-class I on recipient DCs during the life span of a skin graft.

196 At low dose exposure, the life span of affected organisms is barely shortened, ena

197 ystem for studying axonal transport over the life span of an animal and thus for characterization of

198 ks (81 to 502 cm in total length) revealed a life span of at least 272 years.

199 d Rrm2 gene dosage significantly extends the life span of ATR mutant mice.

200 tion in alginate significantly increased the life span of BACs.

201 mpare viral alleles or to expand the ex vivo life span of cells from HIV-1-infected individuals for e

202 platelet activation and markedly reduced the life span of circulating platelets.

203 ntity causes a severe decline of replicative life span of daughter cells.

204 hood of malaria transmission by reducing the life span of feeding mosquitoes.

205 Antiretroviral therapy has increased the life span of HIV+ individuals; however, HIV-associated n

206 m, selenoprotein expression, and replicative life span of human embryonic lung fibroblast WI-38 cells

207 eir critical role in long-term immunity, the life span of individual memory B cells remains poorly de

208 rve between cardenolide non-polarity and the life span of infected butterflies.

209 and vascular calcification and increased the life span of kl/kl mice >12-fold in males and >4-fold in

210 predation reduced the abundance and average life span of latently infected snails.

211 gh risk of serious infection and a predicted life span of less than 1 year in the absence of a matche

212 proved the quality of life and increased the life span of many HIV-infected individuals, this therape

213 Wnt/betacatenin signaling in controlling the life span of mature osteoclasts.

214 metastasis of MDA-MB-231 cells and prolongs life span of mice injected with these cells.

215 ays the onset of ESKD, thereby expanding the life span of mice lacking the adapter protein CD2AP.

216 me biological obstacles, including the short life span of monocytes and their antiviral proapoptotic

217 dissemination, HCMV subverts the short 48-h life span of monocytes by inducing the expression of cel

218 eviously shown HCMV to extend the short 48-h life span of monocytes.

219 invasive predators on size structure but not life span of natives).

220 Although BMT increases the life span of patients with MPS IH, musculoskeletal manif

221 inergic interneurons is reduced early in the life span of Q140 mice, raising the possibility that thi

222 iferation induces dysplasia and shortens the life span of the host, the phenotypic consequences of de

223 pensated the Tk2 deficiency, during a normal life span of the mice.

224 These compounds also extended the life span of the mice.

225 ols exhibited t1/2 that appear to exceed the life span of the mouse, contrasting dramatically with ma

226 the NAD(+) deficiency and rescuing the short life span of the npt1Delta mutant.

227 The shortened chronological life span of the pah1Delta mutant along with its growth

228 hereas others appear not to do so during the life span of the patient.

229 the forebrain than the hindbrain across the life span of the Tg mice, suggesting that sortilin, at l

230 In contrast, dCMP+dTMP+THU therapy decreased life span of Tk2(-/-) animals compared to dCMP+dTMP.

231 thymidine monophosphate (dTMP), prolongs the life span of Tk2-deficient (Tk2(-/-) ) mice by 2- to 3-f

232 that dC+dT delayed disease onset, prolonged life span of Tk2-deficient mice and restored mtDNA copy

233 nged global immunosuppression and limits the life span of transplanted allografts.

234 ne ameliorated RTT symptoms and extended the life span of treated Mecp2-null mice without adverse sid

235 infected butterflies, they also reduced the life span of uninfected butterflies, resulting in a hump

236 terized multiple Abetao forms throughout the life span of various AD mice and in post-mortem human br

237 The 30% CR diet increased the life span of wild-type (WT) mice by 20% compared to mice

238 The life span of Wolbachia-depleted worms is reduced by 70%-

239 the secreted proteome are controlled by the life spans of different proteins.

240 c mutations, and it scales to very divergent life spans of mammalian species.

241 Notably, mature taste cells have life spans of only 5-20 days and, consequently, are cons

242 anad libitum(AL) diet but failed to increase life span ofBmal1(-/-)mice.

243 Viral contamination did not reduce the life span or fecundity of female M. similis.

244 out their lifetime despite no differences in life span or in the number of reproductive bouts compare

245 ts, on subjects at different ages across the life span, or on temporal trajectories of phenotypes aft

246 birth are associated with a longer maternal life span (P 1.4 x 10-3).

247 timing are associated with a longer parental life span (P 6.2 x 10-6 for fathers and P 2.0 x 10-3 for

248 d assumption that the brevity of wild insect life spans precludes senescence.

249 aluation of the PA-cognition link across the life span provides modest support for the effect of PA o

250 Life spans ranged from 3.0 to 6.2 days, with females bei

251 luding runting, hydrocephalus, and shortened life span, recapitulating the abnormalities observed in

252 erexpression is neuroprotective by extending life span, reducing TDP-43 aggregation, and suppressing

253 zation in diabetes with dysregulation of the life-span regulators p66Shc and Sirt1.

254 dietary restriction regimen, known to extend life span, repressed the age-related increased expressio

255 'pace of life', that encompasses patterns in life span, reproduction, and rates of development among

256 on of SSY5 (ssy5Delta) increases replicative life span (RLS) by approximately 50%.

257 Using the replicative life span (RLS) of Saccharomyces cerevisiae as a model,

258 ansactions, including control of replicative life span (RLS), prevention of collision between replica

259 achromatid recombination and the replicative life span (RLS).

260 recombination and controlled the replicative life span (RLS).

261 Here, we describe a life span screen in Saccharomyces cerevisiae that is des

262 ence and that both relatively long and short life spans select against choosy behavior in the host.

263 8 deficiency produces locomotive defects and life span shortening in TDP-43 with and without animals.

264 of health and economic advantages across the life-span should be dynamically integrated to better und

265 ing hypothesis proposes that increased human life span since 1850 has resulted from decreased exposur

266 eritis-nodosa (PAN)-like vasculitis in their life span, some as early as 4 months of age.

267 ing in Neighborhoods of Diversity across the Life Span study (HANDLS).

268 For this reason, the Life Span Study has become fundamental to risk assessmen

269 omic bombings of Hiroshima and Nagasaki (the Life Span Study) is thought to be the most reliable sour

270 expression change with age, and a shortened life span, suggesting a causative role of the H3K36me3 m

271 e with an SHP2 inhibitor and found increased life span, suppressed crescentic glomerulonephritis, red

272 For rolling bodies, the life span (t) and the life travel (L) should increase wi

273 er trade-offs between early reproduction and life span than green morphs; and red consistent (non)dro

274 tion may be enhanced more by extending adult life spans than by increasing daily fertility.

275 el movements had longer average reproductive life spans than those who made only one directed movemen

276 udding yeast cells have a finite replicative life span; that is, a mother cell produces only a limite

277 With longer life spans, there has also been an increase in years liv

278 e is no clear indication of how early in the life span this association manifests.

279 High milk consumption might shorten life span through increased oxidative stress.

280 Median iterated life span (timespan across which modifications occurred

281 development of surveillance data across the life span to provide empirical estimates of the prevalen

282 on errors in Arabidopsis with short and long life spans to determine the number of replications in li

283 To map precisely the life-span trajectory of this key visual computation, in

284 How early during the normal life span underlying AD pathologies begin to develop, th

285 y and cognitive performance across the adult life span using fMRI.

286 a robust induction of SMN protein, and mean life span was extended from an average survival of 13 to

287 Although platelet life span was only mildly affected, ck2beta(-/-) MK disp

288 Life span was unrelated to AMS, but early AFL tended to

289 ntimeters (cm) in total length, suggesting a life span well beyond those of other vertebrates.

290 development, reduced brood size, and reduced life span were observed in the mutants, indicating compr

291 antly accelerated phenotypes and a shortened life span when compared with N463-Q148, N536-Q148, and N

292 n mimic or FBXO24 silencing increases NDPK-A life span which, in turn, impairs cell migration and wou

293 illations are altered over the course of the life span, which could contribute to hippocampus-depende

294 t was sequestered in RBCs during their 120-d life span, which resulted in a slower whole blood cleara

295 hat reduction of DNM2 in XLCNM mice restored life span, whole-body strength, and diaphragm function a

296 Further studies across the life span will determine progression of cardiac dysfunct

297 ets resulted in an unprecedented increase in life span with improved motor function, persistent GALC

298 to mutant knockin LRRK2 mice over half their life span, with observable and measurable phenotype, is

299 duced oxidative damage, and increased median life spans, without an effect on animal reproduction.

300 interactions of space and number through the life span, yet propose a theory with several weaknesses.