ライフサイエンスコーパス: life stress

1 he pathological programming induced by early-life stress.

2 athological modifications triggered by early-life stress.

3 rect the "anxious phenotype" caused by early life stress.

4 embles that seen in animals exposed to early life stress.

5 be heightened in the context of more recent life stress.

6 ognitive deficits that can result from early life stress.

7 deficits in subjects with a history of early life stress.

8 cognitive impairments associated with early-life stress.

9 stress exposure and not by current levels of life stress.

10 ed corticolimbic dysfunction caused by early life stress.

11 at which macaque infants experience an early-life stress.

12 behaviour associated with exposure to early-life stress.

13 ated with depression severity, but not early life stress.

14 ts with major depression and increased early life stress.

15 overexpression reverses the effects of early life stress.

16 individuals also reporting higher levels of life stress.

17 ychopathological conditions related to early-life stress.

18 raits, (4) social isolation, and (5) chronic life stress.

19 may buffer against depressogenic effects of life stress.

20 articularly in cases linked to chronic early-life stress.

21 , or resembled patterns seen following early-life stress.

22 behavioral and neural consequences of early-life stress.

23 r guardians to collect data about cumulative life stress.

24 amily history who reported relatively severe life stress.

25 compared with subjects with moderate or low life stress.

26 ctivation in the hippocampus following early-life stress.

27 biological systems and increased exposure to life stress.

28 oupled with heightened experience of chronic life stress.

29 gdala circuitry and function following early-life stress.

30 haps dose-dependent, relationship with early-life stress.

31 in the hippocampus of pups exposed to early life stress.

32 f the altered programming triggered by early life stress.

33 n mice (1) during development to model early-life stress, (2) in adulthood to model adult-onset stres

34 ient had major psychosocial impairment, high life stress, a low visceral pain threshold, and activati

35 ffect was abolished in mice exposed to early life stress, a prominent risk factor for developing adul

36 sure in humans to examine whether cumulative life stress affected brain morphometry and one type of e

37 atment of adult BALB/c mice exposed to early life stress affected neither their behavioral responses

38 Life stress also differentially affected, as a function

39 and nonenriched BALB/c mice exposed to early life stress also exhibited significantly increased expre

40 s, and in female macaques, exposure to early-life stress alters LHPA-axis activation in response to a

41 on of a link between major depression, early life stress and adverse health outcomes in diseases asso

42 ered within the Htr2a gene promoter by early life stress and biological sex, and increased 6 mA is as

43 tor isoform are more resilient to both early-life stress and chronic psychosocial stress in adulthood

44 ossible to model this relation between early life stress and depression in the rat through maternal d

45 Early-life stress and exposure to stressful stimuli play a maj

46 disrupted in individuals with PTSD and early-life stress and hence may mediate the effects of early-l

47 jor depression patients with increased early life stress and independently correlated with depression

48 , this longitudinal study investigated early life stress and inherited variation in monkey hippocampa

49 ween the neurobiological correlates of early-life stress and of inflammation.

50 ductions in PA that may occur in the wake of life stress and possibly vulnerability to depression pre

51 Finally, we show that early life stress and psychopathology are each associated with

52 f the pathological phenotype caused by early life stress and represents an attractive pharmacological

53 d structural), genotyping, and self-reported life stress and rumination.

54 in brain structure revealed that cumulative life stress and spatial working memory were related to s

55 unted for the association between cumulative life stress and spatial working memory.

56 ation of mitochondrial biogenesis with early life stress and with anxiety and substance use disorders

57 ce abuse conditions, health behavior change, life stresses and crises, and stress-related physical sy

58 measure generic and food specific quality of life, stress and anxiety prior to challenge, on the day

59 present clinical disorder, early and recent life stress, and anxiety symptoms, as well as the intera

60 ditional measures of disease activity, pain, life stress, and coping were collected for use in multip

61 oid vulnerability hypothesis linked to early life stress, and epigenetic and genetic susceptibility m

62 ast some of the behavioral sequelae of early life stress are mediated by reduced expression of LBP du

63 ions between VS activity and early or recent life stress as covariates.

64 ed if 6 mA is present and regulated by early life stress associated with predator odor exposure (POE)

65 Genetic inheritance and developmental life stress both contribute to major depressive disorder

66 adult-knockdown of Otx2 in VTA mimics early life stress by increasing stress susceptibility, whereas

67 Early life stress can disrupt development and negatively impac

68 These findings indicate that chronic early life stress can disrupt maturation of the gamma oscillat

69 These findings illustrate that early life stress can indeed affect specific cognitive functio

70 Together, these findings highlight how early-life stress can lead to altered brain circuitry and emot

71 pose that the psychoneuroimmunology of early-life stress can offer an innovative framework to underst

72 Accumulation of daily life stress (chronic stress) often causes functional gas

73 tic brain injury, general and mental health, life stress, concussion symptoms, cognitive function, di

74 Thus, early-life stress could constitute a 'double-edged sword': mil

75 Recent life stress, current depressive symptoms, and PA were as

76 We discovered that early-life stress decreases the activity of a specific class o

77 e disorder and depressed women without early life stress demonstrated blunted ACTH responses.

78 t also CORT, and we questioned whether early-life stress disrupted attachment learning and its neural

79 We asked whether chronic early life stress disrupts maturation of gamma oscillations, o

80 These results suggest that early-life stress disturbs attachment behavior via a unique ca

81 Here, we test for the first time how early-life stress drives developmental programming and transge

82 Our data suggest that early-life stress during a critical period of neuro developmen

83 Here, we explored how early-life stress (ELS) affects excitatory and inhibitory tran

84 Early life stress (ELS) and function of the hypothalamic-pitui

85 Amygdala circuitry and early life stress (ELS) are both strongly and independently im

86 Animal models of early life stress (ELS) are characterized by augmented amygdal

87 Early life stress (ELS) can compromise development, with highe

88 Early life stress (ELS) experience is associated with persisti

89 act with retrospectively self-reported early life stress (ELS) in patients with psychiatric disorders

90 Early life stress (ELS) in the form of child abuse/neglect is

91 Early life stress (ELS) is highly related to the development o

92 nderstand how the brain is affected by early life stress (ELS), which produces excessive activation o

93 nd environmental risk factors, such as early life stress (ELS).

94 work establishes a mechanism by which early life stress encodes lifelong susceptibility to stress vi

95 e previously found that the effects of early-life stress endure and worsen during adulthood, yet the

96 -documented in adult rats, but whether early life stress endures into adulthood to affect responsivit

97 g mechanism through which greater cumulative life stress engenders decrements in cognitive functionin

98 While early life stress evokes persistent changes in anxiety, it is

99 jor depression patients with increased early life stress exhibit enhanced inflammatory responsiveness

100 on of brain activity and discuss the role of life stress experience in modifying 5-HTT function in th

101 d timing of a stressor to parallel the early-life stress experience of orphanage rearing, controlling

102 which demonstrated that the more severe the life stress experienced, the greater the risk of early H

103 lescent fluoxetine treatment following early life stress exposure increased the proliferation and ear

104 s), while certain cytokine network analyses, life stress factors, and autonomic symptoms could.

105 In rodent models of early-life stress, fragmentation and unpredictability of mater

106 Life stress frequently occurs within the context of home

107 Here we investigated whether a severe early-life stress (i.e., maternal deprivation, MD) promotes DA

108 of this and other studies suggest that early life stress impairs fear conditioning in adult rats wher

109 ant maternal separation, a paradigm of early life stress in rodents, elicits long-lasting changes in

110 Early life stress in the form of infant abuse or neglect const

111 Specifically, early-life stress in the form of maternal separation (MS) in r

112 viability of the hippocampus following early life stress in VFD-reared versus normally-reared subject

113 ong adolescents as a mechanism through which life stress, including neighborhood conditions, may affe

114 egression analyses showed that higher severe life stress increased the odds of developing HIV disease

115 Chronic early life stress increases adult risk for depression, bipolar

116 osing rodents or non-human primates to early life stress increases anxiety-like behaviors and impairs

117 Early-life stress increases NE but also CORT, and we questione

118 Early life stress increases risk for depression.

119 Chronic early-life stress increases vulnerability to alcoholism and an

120 Exposure to early-life stress increases vulnerability to psychiatric disor

121 Early-life stress induces a persistent elevation of IL-6, hype

122 Recent life stress interacted with VS reactivity to predict sel

123 data, we found support for a model by which life stress interacts with the effect of serotonin trans

124 Early life stress is a prominent risk factor for the developme

125 Although early-life stress is a significant risk factor for developing

126 Early life stress is associated with the development of psychi

127 Relatedly, life stress is cited as one of the major risk factors fo

128 Although early-life stress is known to alter health, its long-term cons

129 raise the interesting possibility that early-life stress is protective against extrapyramidal motor e

130 This study provides evidence that early life stress leads to long-term changes in the density of

131 Numerous studies have shown that early life stress leads to persistent changes in behavioral an

132 : Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses,

133 port clinical evidence suggesting that early-life stress may predispose individuals to increased anxi

134 Our results indicate that early life stress may tip the neural balance toward acute thre

135 -life-dependent manner, independent of early life stress mechanisms, underscoring the importance of t

136 nd temporal differences in response to early-life stress might provide unique insight into the cause

137 Here, we used a rodent early-life stress model that leads to robust and longlasting i

138 and women with major depression but no early life stress (N=11).

139 current major depression and increased early life stress (N=14) versus nondepressed male comparison s

140 were measured in healthy women without early life stress (N=20), women with childhood abuse without m

141 ivity predict psychological vulnerability to life stress occurring as much as 1 to 4 years later.

142 The effect of life stress on depression is moderated by a repeat lengt

143 distinction is also made between effects of life stress on first onset of depression and on the subs

144 To determine effects of chronic early life stress on gamma oscillations, we separated pups fro

145 We examined the impact of early-life stress on haloperidol-induced catalepsy using the r

146 ms underlying the long-term effects of early-life stress on hippocampal integrity and function.

147 ediated the effects of genetic variation and life stress on limbic brain volumes, particularly on lef

148 s and hence may mediate the effects of early-life stress on PTSD risk.

149 tional effects of maternal exposure to early-life stress on several phenotypic traits in their offspr

150 Notably, the impact of early-life stress on the mechanisms that govern BLA excitabili

151 ned more variance (1.7%, P = 0.005) than the life stress-only model.

152 n adult neurogenesis after exposure to early life stress or adult chronic fluoxetine treatment.

153 Early life stress, personality traits, and levels of negative

154 eraction of genetic profile scores and early life stress predicted left hippocampal and left amygdala

155 Early-life stress predicts later inflammation, and there are s

156 The highest level of perceived everyday life stress raised the risk of either receiving triple t

157 ularly parenting behaviors, influences later-life stress reactivity.

158 re rats reproduced the consequences of early-life stress, reducing memory functions throughout life.

159 family history regardless of the severity of life stress reported, and it increased in adolescents wi

160 n, potential mediating factors such as early life stress, sex, personality traits, and negative memor

161 viduals who experienced high levels of early life stress showed lower levels of brain activation when

162 concept regarding the origin of toxic early-life stress, stating that it may derive from specific pa

163 During development, early-life stress, such as abuse or trauma, induces long-lasti

164 tic stress disorder and reported more recent life stress than abused women without major depressive d

165 dge, we used a rodent model of chronic early-life stress that engenders robust and enduring increases

166 hronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and

167 rocesses are set into motion that link early life stress to health disorders in the later years?

168 In our model of early-life stress (variable foraging demand [VFD]), food insec

169 udy examined whether high perceived everyday life stress was associated with an increased risk of eit

170 gical momentary assessment showed that daily-life stress was partly decoupled from opioid craving in

171 eported state PA, such that higher levels of life stress were associated with lower PA for participan

172 Moreover, when BALB/c mice exposed to early life stress were raised in an enriched postweaning envir

173 ase progression was also predicted by severe life stress when a proportional odds logistic regression

174 f the altered programming triggered by early life stress, which enhances the vulnerability to stress-

175 frontal cortex (PFC) in the effects of early-life stress, which often emerge in adolescence or young

176 show low PA levels in the context of recent life stress, while those with relatively high VS reactiv

177 nsporter protein gene on the likelihood that life stress will precipitate depression may help to unde

178 port for the notion that the interactions of life stress with biopsychosocial variables have an impac

179 We tested the hypothesis that early life stress would persistently compromise neuronal viabi

180 s (CRHR1, NR3C2, NR3C1, and FKBP5) and early life stress would predict increases in cortisol levels d