ライフサイエンスコーパス: lifelong

1 perinatally to ensure adaptive thermogenesis lifelong.

2 that result from blasts are significant and lifelong.

3 birth and the surviving animals exhibiting a lifelong 20% growth retardation.

4 en with antisocial personality disorder show lifelong abnormalities in adaptive decision making guide

5 tiviral treatment is successful but requires lifelong adherence and mostly targets viral factors.

6 Small size at birth is linked with lifelong adverse health implications.

7 Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing.

8 the disease is complex, multifactorial, and lifelong, and affects nutrition and psychological wellbe

9 d human herpesvirus (HHV) infections persist lifelong, and almost all individuals infected with HIV a

10 and how they modulate host immunity, persist lifelong, and contribute to tumorigenesis.

11 ith many disorders being neurodevelopmental, lifelong, and debilitating.

12 nt of gluten-related disorders is based on a lifelong, and strict, gluten-free diet.

13 the roles B cell subsets play in maintaining lifelong anti-peanut IgE levels are unknown.

14 Lifelong antiplatelet treatment is recommended after isc

15 Lifelong antiretroviral therapy (ART) for HIV-1 does not

16 iduals with a similar HIV burden may achieve lifelong ART-free remission.

17 of cartilage injury may prevent serious and lifelong arthritic complications, early detection and tr

18 mold conidia daily and typically experience lifelong asymptomatic clearance.

19 th but diverge during life, and we track the lifelong behavior of CMV- and EBV-specific T cell clonot

20 al behavior and that early Rest activity has lifelong behavioral impacts.

21 Furthermore, the degree of lifelong bilingualism (i.e., high, moderate, or low use)

22 These findings indicate that lifelong bilingualism acts as a powerful CR proxy in dem

23 ecent epidemiological evidence suggests that lifelong bilingualism may act as CR delaying the onset o

24 Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenes

25 Olfactory epithelium (OE) has a lifelong capacity for neurogenesis due to the presence o

26 target mobile populations and retain them in lifelong care.

27 ctional properties of stem cells to maintain lifelong cellular immunity have been hypothesized for ma

28 drugs in predisposed individuals, leading to lifelong changes.

29 patitis C virus is capable of establishing a lifelong chronic infection in the liver, which could dev

30 n take advantage of this niche and establish lifelong chronic infections causing hepatic fibrosis and

31 adrenal (HPA) stress axis, both required for lifelong cognitive and emotional processing.

32 Although lifelong combination antiretroviral therapy (ART) is rec

33 brillators (ICDs) are frequently viewed as a lifelong commitment in that patients are routinely sched

34 L) has become another chronic disease, where lifelong commitment to pharmacologic control is the para

35 nfection of a developing fetus may result in lifelong complications such as deafness and learning dis

36 t of smouldering systemic mastocytosis, is a lifelong condition associated with reduced quality of li

37 autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism rema

38 ost commonly considered in childhood, can be lifelong conditions.

39 ation of energy balance are programmed, with lifelong consequences for obesity risk.

40 Despite growing awareness of the lifelong consequences of TBI, substantial gaps in resear

41 rnal genetics and environmental factors have lifelong consequences on diverse processes ranging from

42 of maternal smoking during pregnancy and the lifelong consequences this has on offspring lung functio

43 health in a myriad of ways and has potential lifelong consequences.

44 estone, and achieving reading competency has lifelong consequences.

45 ect of AMPKgamma2(RG) in the kidney, linking lifelong constitutive activation of AMPK to a potential

46 y to the major challenge of transplantation: lifelong control of alloreactivity while maintaining an

47 tion, and their persistence is important for lifelong control of EBV-related disease.

48 Hair follicles (HFs) undergo lifelong cyclical transformations, progressing through s

49 rent HIV-1 drugs, and patient compliance for lifelong, daily treatment regimens.

50 interventions from infancy, can suffer from lifelong debilitation caused by underdeveloped maxillae.

51 mothers smoked during pregnancy demonstrate lifelong decreases in pulmonary function.

52 Congenital amusia is a lifelong deficit in music perception thought to reflect

53 Current clinical management of betaT is a lifelong dependence on regular blood transfusions, a con

54 Mir122 knockout mice and observed profound, lifelong depletion of polyploid hepatocytes, proving tha

55 Autonomous lifelong development and learning are fundamental capabi

56 s monosaccharide intakes and the progressive lifelong development of caries.

57 y suppresses insulin secretion, resulting in lifelong diabetes.

58 surviving infants are at increased risk for lifelong disabilities.

59 t relieving the suffering and preventing the lifelong disability associated with pediatric ADs.

60 Perinatal stroke causes cerebral palsy and lifelong disability.

61 m newborns often results in major injury and lifelong disability.

62 ing of more powerful approaches for reducing lifelong disease by mitigating the effects of early adve

63 This is particularly important for lifelong disease prevention in unaffected LHON mutation

64 dy investigated whether congenital amusia, a lifelong disorder of musical processing, impacts sensiti

65 that familial relationships and burden of a lifelong disorder with an onset early in personality dev

66 ocalized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2

67 Hallmarks of lifelong DR are reductions in body size, fecundity, and

68 reated in childhood, can lead to significant lifelong educational and socioeconomic consequences in a

69 iven the early onset and therefore potential lifelong effect of many NCDs, there should be more studi

70 eption to a child's second birthday-can have lifelong effects on health, because this is a crucial ph

71 Symptomatic asthma in childhood has lifelong effects on lung function and disease severity,

72 Lifelong elevation of neuronal VAPB slowed the decline o

73 egrates early life dietary cues that lead to lifelong epigenetic adaptations to a perceived nutrition

74 The only option is the strict lifelong exclusion of dietary gluten, which is difficult

75 was later and, particularly in rural areas, lifelong exclusive cigarette use was less common than in

76 Participants reported lifelong exercise history patterns.

77 Athletes with a lifelong exercise volume >2000 MET-min/wk (n=75) had a s

78 aimed to determine the relationship between lifelong exercise volumes and coronary atherosclerosis.

79 ns, characterized by hyperglycemia requiring lifelong exogenous insulin therapy.

80 These results suggest that lifelong exposure to low PCSK9 levels and cumulative exp

81 ss-of-function (LOF) variants that result in lifelong exposure to lower levels of low-density lipopro

82 e advantageous in children as a way to avoid lifelong exposure to TKIs and their associated adverse e

83 als with developmental prosopagnosia (DP), a lifelong face recognition impairment, have been shown to

84 , people with developmental prosopagnosia, a lifelong face recognition impairment, have reduced face

85 ines, indicating that individuals maintained lifelong fidelity to the grooming style of their mothers

86 risk stratification assessment of ES during lifelong follow-up.

87 These findings can explain lifelong food allergies observed in human subjects as th

88 f severed axons to regenerate and results in lifelong functional deficits.

89 ive effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence

90 Transgender women experience lifelong gender dysphoria due to a gender assignment at

91 of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligoden

92 Whether the risk of CAD associated with lifelong genetic exposure to increased serum calcium lev

93 only treatment for celiac disease (CeD) is a lifelong gluten-free diet (GFD).

94 s, with potential important implications for lifelong gut health, and that the gut microbiome guides

95 enetic programming, which in turn may impact lifelong health and disease risk.

96 veloping organ systems that are critical for lifelong health and well-being.

97 and shed light on the mechanisms behind the lifelong health consequences of delivery and infant feed

98 t of spermatogenesis and the development and lifelong health of Leydig cells.

99 genetic data were linked to the individuals' lifelong health records, we observed no significant rela

100 y and practice: (1) early experiences affect lifelong health, not just learning; (2) healthy brain de

101 hey critically influence both physiology and lifelong health.

102 ensory hair cell stereocilia is critical for lifelong hearing; however, mechanisms of structural home

103 opoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers.

104 ors of human HSPC function and important for lifelong hematopoiesis.

105 ich are the self-renewing units that sustain lifelong hematopoiesis.

106 visions and preserves the HSC pool to ensure lifelong hematopoiesis.

107 poietic stem cells (LT-HSCs) is critical for lifelong hematopoietic regeneration.

108 mage in elite endurance master athletes with lifelong high training volumes seems to be unlikely.

109 e of 2 brothers, sons of first cousins, with lifelong history of abnormal bleeding, associated with d

110 A lifelong history of consistent physical activity, regard

111 sually leads to acute illness and results in lifelong homotypic immunity, but individuals remain susc

112 es iatrogenic hypopituitarism which requires lifelong hormonal supplementation.

113 pects of this view, including the ability of lifelong HSCs to contribute to tissue-resident immune ce

114 igms, our data show that clinically relevant lifelong IgE titers are not sustained by long-lived IgE(

115 serotypes (DENV-1-4) is thought to result in lifelong immunity to homotypic reinfection (ie, reinfect

116 h mutants, are highly effective in eliciting lifelong immunity to virulent acute infection by Toxopla

117 are thought to be responsible for sustaining lifelong immunity, but its underlying basis is controver

118 to dengue virus (DENV) is thought to elicit lifelong immunity, mediated by DENV-neutralizing antibod

119 lls to expand upon demand, thereby providing lifelong immunity.

120 e first influenza virus variant encounter on lifelong immunity.

121 To ensure lifelong immunocompetency, naive and memory T cells must

122 ts with end-stage organ failure but requires lifelong immunosuppression with resultant morbidity.

123 controversies and scepticism because of the lifelong immunosuppression, the unclear risk-benefit rat

124 ce and (ideally) circumvent the necessity of lifelong immunosuppression.

125 educe the risk of rejection and the need for lifelong immunosuppression.

126 er, offer to patients remains limited due to lifelong immunosuppression.

127 o long-term graft survival that necessitates lifelong immunosuppressive therapy after renal transplan

128 antly to infant mortality and morbidity with lifelong impact.

129 rget genes during larval development and has lifelong impacts on behavior.

130 rget genes during larval development and has lifelong impacts on behavior.

131 Lifelong impairment of the stress response results from

132 th results in developmental disabilities and lifelong impairments.

133 Establishment of the infant microbiome has lifelong implications on health and immunity.

134 The gammaherpesviruses (GHVs) cause lifelong infection and can cause chronic inflammatory di

135 reservoir size in the body, which guarantees lifelong infection and resumption of virus replication a

136 nodeficiency virus (HIV) infection remains a lifelong infection because of latent viral reservoirs in

137 uses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are a

138 Epstein-Barr virus (EBV) establishes lifelong infection in B lymphocytes of most human hosts

139 Herpes simplex viruses (HSVs) establish lifelong infection in more than 80% of the human populat

140 irus (EBV) is a tumor virus that establishes lifelong infection in most of humanity, despite elicitin

141 ytes, which may contribute to establishing a lifelong infection in the host.

142 Herpes simplex virus 1 (HSV-1) establishes lifelong infection in the neurons of trigeminal ganglia

143 to the ability of HSV to cause a persistent, lifelong infection in the peripheral nervous system, the

144 of latency in myeloid cells that results in lifelong infection.

145 se, which ensures establishment of a chronic lifelong infection.

146 Gammaherpesviruses establish lifelong infections that are associated with the develop

147 adversely impacted by viruses that establish lifelong infections that are often accompanied with incr

148 These viruses establish lifelong infections that place their respective human an

149 Herpesviruses establish chronic lifelong infections using a strategy of replicative expa

150 KSHV establishes lifelong infections using its latency-associated nuclear

151 re the onset of critical periods resulted in lifelong juvenile ocular dominance plasticity.

152 nation antiretroviral therapy (cART) remains lifelong largely because the virus persists in latent re

153 Neurons are the site of lifelong latency and are a crucial target for long-term

154 Lifelong latency and the ability to reactivate from late

155 pathogenic betaherpesviruses persisting in a lifelong latency from which reactivation can occur under

156 f alphaherpesviruses is the establishment of lifelong latency in host sensory ganglia with occasional

157 ollowing acute infection, BoHV-1 establishes lifelong latency in sensory neurons.

158 ), an important bovine pathogen, establishes lifelong latency in sensory neurons.

159 HV) is a gammaherpesvirus known to establish lifelong latency in the human host.

160 KSHV establishes a lifelong latency in the infected host, during which only

161 he latency-reactivation cycle.IMPORTANCE The lifelong latency of bovine herpesvirus 1 (BoHV-1) requir

162 y differentiated neurons is also crucial for lifelong latency.

163 Human herpesviruses (HHV) establish lifelong latent infection and are transmitted primarily

164 It establishes a lifelong latent infection and persists in infected cells

165 s varicella-zoster virus (VZV) establishes a lifelong latent infection in humans following primary in

166 Epstein-Barr virus (EBV) maintains a lifelong latent infection within a subset of its host's

167 transport to sensory ganglia and establish a lifelong latent infection within neurons.

168 causes a variety of diseases, can establish lifelong latent infections from which virus can reactiva

169 1 is largely due to its ability to establish lifelong latent infections in neurons and to occasionall

170 , keratinocytes, and monocytes) to establish lifelong latent infections.

171 stress is characteristic of reactivation of lifelong latent infections.

172 viruses harboring the capacity to establish lifelong latent-recurrent infections.

173 assess faculty competence and commitment to lifelong learning across missions.

174 e survey identified the strategies to assess lifelong learning and faculty competence and compliance

175 ediatric department chairs on principles for lifelong learning and strategies and approaches used to

176 ovascular Training Statement, curricular and lifelong learning competencies, and the Accreditation Co

177 survey in July 2015 to define principles of lifelong learning in pediatric medicine and determine th

178 hairs endorsed a requirement for evidence of lifelong learning, competence, and compliance by all fac

179 ard of Pediatrics in assessing and verifying lifelong learning, knowledge, and competence in general

180 ion of training with public health research; lifelong learning, mentorship, and teamwork; and efficie

181 t it is necessary to go further and consider lifelong learning, which includes developmental learning

182 ith a view to obtain comparative metrics for lifelong LTL attrition and learn about the temporal asso

183 al years results in disease which impacts on lifelong lung health.

184 highlight the progress made toward achieving lifelong LVAD support and the challenges that remain.

185 Specialized niches support the lifelong maintenance and function of tissue-specific ste

186 gnitive impairment, phenylketonuria requires lifelong management of blood phenylalanine (Phe) concent

187 aps in knowledge needed to improve early and lifelong management of these patients.

188 Most lifelong masters endurance athletes with a low atheroscl

189 thyroid disorders will require long-term to lifelong medical therapy and/or surveillance.

190 ghrelin during neonatal life is pivotal for lifelong metabolic regulation.

191 deficits in adulthood, and whether continued lifelong Mn exposure exacerbates these effects, using a

192 Our study highlights the importance of lifelong monitoring of cardiovascular risk factors in wo

193 obesity contributes to an increased risk of lifelong morbidity and mortality for both the mother and

194 ncreases risk of HIV infection and can cause lifelong morbidity in children born to infected mothers.

195 en associated with significant lethality and lifelong morbidity.

196 solid organ transplants are to eliminate the lifelong need for immunosuppressive (IS) drugs and to pr

197 tion of extremely preterm birth and leads to lifelong neurodevelopmental disabilities.

198 ants are at significantly increased risk for lifelong neurodevelopmental disability with male offspri

199 apacity of the olfactory epithelium (OE) for lifelong neurogenesis and regeneration depends on the pe

200 tivation (MIA) alone is sufficient to impart lifelong neuropathology and altered behaviors in offspri

201 e, waterpipe-only smokers in comparison with lifelong nonsmokers using clinical parameters of cough a

202 gration of adult-born OSNs may contribute to lifelong OB plasticity is unclear.

203 ulmonary dysplasia (BPD) is characterized by lifelong obstructive lung disease and profound, refracto

204 Lifelong oral anticoagulation, either with warfarin or a

205 tal disease to a disorder amenable simply to lifelong oral medication and compatible with a normal li

206 ed disorder characterized by the presence of lifelong peripheral eosinophilia (>1500/muL).

207 Varicella zoster virus (VZV) establishes lifelong persistence and may reactivate in individuals w

208 establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi's sarcom

209 cts multiple cell types in vivo, establishes lifelong persistence in the host, and can cause serious

210 symptomatic infection, the virus establishes lifelong persistence in the kidney and possibly other ex

211 is important for viral transmission and the lifelong persistence of herpesviruses in the human popul

212 Lifelong persistence of the virus may also contribute to

213 (+) HPCs by HCMV.IMPORTANCE HCMV establishes lifelong persistence within the majority of the human po

214 ruses (gammaHVs) have a dynamic strategy for lifelong persistence, involving productive infection, la

215 strategy by which herpesviruses ensure their lifelong persistence.

216 sarcoma-associated herpesvirus (KSHV) cause lifelong persistent infection and play causative roles i

217 Lifelong persistent infection has also been linked with

218 a wide range of clinical presentations and a lifelong persistent infection.

219 arge, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods

220 necessary feature of viruses that establish lifelong persistent infections in the face of strong imm

221 ghlight the importance of ensuring access to lifelong personalized screening, surveillance, and chron

222 on or stress during pregnancy, can influence lifelong phenotypes in the progeny.

223 -response association of different levels of lifelong physical activity on myocardial fibrosis has no

224 Lifelong physical activity, which promotes mitochondrial

225 volumes, and masses with increasing doses of lifelong physical activity.

226 pH/impedance monitoring before committing to lifelong PPIs to help distinguish GERD from a functional

227 uals less likely to receive net benefit from lifelong preventive pharmacotherapy.

228 cells (HSPCs) are capable of supporting the lifelong production of blood cells exerting a wide spect

229 ic stem cells (HSCs) are responsible for the lifelong production of blood cells.

230 oietic stem cells (HSCs) are responsible for lifelong production of blood cells.

231 ity during pregnancy affects the offspring's lifelong propensity for physical activity and may have i

232 an individual's first IAV infection confers lifelong protection against severe disease from novel he

233 Under base-case assumptions (lifelong protection, full efficacy at two doses), HPV4 w

234 at infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of p

235 tion of cysts in the host or the presence of lifelong protective immunity, which led us to question t

236 are highly debilitating, conferring risk for lifelong psychopathology.

237 Instead, lifelong reactivity is conferred by allergen-specific lo

238 MDD patients often suffer from lifelong recurring episodes of increasing severity, redu

239 with beta-thalassemia major require regular lifelong Red Blood Cell transfusions to survive.

240 These results suggest that lifelong reduction of satellite cells neither accelerate

241 tic regulation as a key mechanism underlying lifelong regulation of gene expression that mediates str

242 sels are crucial for the normal development, lifelong repair and homeostasis of tissues.

243 Microglia, the only lifelong resident immune cells of the central nervous sy

244 ll serotypes (cross-protection), followed by lifelong resistance to the infecting serotype, but not t

245 therapy, many of these survivors will face a lifelong risk of endocrine late effects.

246 maternal adiposity during pregnancy affects lifelong risk of offspring fatness via intrauterine mech

247 etal or neonatal death, neurodisability, and lifelong risks to the health of the affected child.

248 recent 30 year prospective study showed that lifelong sauna use reduces cardiovascular-related and al

249 he hierarchy are long-term HSCs endowed with lifelong self-renewal and differentiation properties.

250 Importance: Ocular trauma can lead to lifelong sequelae, and sports-related ocular injuries ha

251 Compared with those who are married, lifelong single (relative risk=1.42 (95% CI 1.07 to 1.90

252 th reduced risk of dementia than widowed and lifelong single people, who are also underdiagnosed in r

253 d worse physical health the elevated risk in lifelong single people.

254 relative risks of being widowed, divorced or lifelong single, compared with being married.

255 ritical to establish sufficient strength for lifelong skeletal health.

256 cells are critical to humoral immunity as a lifelong source of protective antibodies.

257 tral visual disturbance in childhood and had lifelong sparse scalp hair with normal facial hair.

258 ith the transcription factor FOXC2 to ensure lifelong stability of the lymphatic vasculature.

259 When we adjusted the effect of CXL to a lifelong stabilizing effect, the ICER decreased to euro1

260 dysregulation and 5-HT neuron activity in a lifelong stress paradigm, suggesting these channels as t

261 ntially over time, underscoring the need for lifelong subspecialty follow-up of those at risk.

262 children may minimize sun damage and foster lifelong sun protection behaviors that will reduce the l

263 ion within Leydig cells is essential for the lifelong support of spermatogenesis and the development

264 should trigger germline testing, followed by lifelong surveillance for both colorectal and extracolor

265 Lifelong surveillance for monitoring of recurrent or res

266 open repair, which needs to be addressed by lifelong surveillance of EVAR and re-intervention if nec

267 rophylactic bilateral ureteronephrectomy and lifelong surveillance of the bladder are performed.

268 mechanism by which early life stress encodes lifelong susceptibility to stress via long-lasting trans

269 Self-management may be a lifelong task for patients with chronic back pain.

270 We further characterize the extremes of lifelong TCR repertoire evolution, analyzing samples ran

271 Here, we study spatio-temporal variation in lifelong telomere dynamics in the Seychelles warbler, Ac

272 ctiveness of minimally invasive, potentially lifelong TES treatment of epilepsy either alone or as a

273 HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal.

274 n prolonging life, infected individuals face lifelong therapy because of a reservoir of latently-infe

275 Consequently, lifelong therapy is required to maintain viral suppressi

276 Given the challenges in providing lifelong therapy to a global population of more than 35

277 virus-1 (HIV-1) infection currently requires lifelong therapy with drugs that are used in combination

278 for chronic hepatitis B require long-term or lifelong therapy.

279 not eliminate latent HIV, thus necessitating lifelong therapy.

280 Lifelong tracking studies will allow researchers to iden

281 We conjectured, therefore, that the lifelong transcriptional stability of an organism may be

282 y is increasingly being viewed as subject to lifelong transformations that are reflected in the neura

283 Most patients in the registry require lifelong transfusion and often have associated congenita

284 emia is also still far from ideal, requiring lifelong transfusion or allogeneic bone marrow transplan

285 ansplant tolerance: a state which guarantees lifelong transplant acceptance without ongoing immunosup

286 s manage to control the disease progression, lifelong treatment and surveillance are required because

287 is between 360 mumol/L and 600 mumol/L, and lifelong treatment is recommended if the concentration i

288 nd limit seeding of the viral reservoir, but lifelong treatment is required for the majority of patie

289 on with little or no impact on cccDNA, hence lifelong treatment is required in the vast majority of p

290 V) infection but does not eliminate HIV, and lifelong treatment is therefore required.

291 n and wild-type littermates received an oral lifelong treatment with ranolazine and were compared wit

292 diabetes is a chronic disorder that requires lifelong treatment.

293 ned in care for 10 years (false-positive) or lifelong (true-positive).

294 ed against the complications associated with lifelong use of TKIs.

295 MV), a highly prevalent herpes virus causing lifelong, usually latent, infections, drives the expansi

296 versus quadrivalent vaccine (HPV4), assuming lifelong vaccine protection, two vaccine doses, and that

297 cular disorder and the most leading cause of lifelong visual loss.

298 pproach in treating human obesity and aiding lifelong weight management.

299 One third of humans are infected lifelong with the brain-dwelling, protozoan parasite, To

300 llergies (eg, fish, shellfish, and nuts) are lifelong, without any disease-transforming therapies, an