ライフサイエンスコーパス: ligand

1 lined by 50-60% in the presence of unlabeled ligand.

2 y complementary 2,6-diacetylamino-4-pyridine ligand.

3 spot containing its corresponding chemokine ligand.

4 4,5-diazafluoren-9-one (DAF) as an ancillary ligand.

5 led a novel active site with a bound unknown ligand.

6 ding with a macrocyclic "pincer-crown ether" ligand.

7 aprotein interactions that is induced by the ligand.

8 methyl TROSY NMR measurements with opposing ligands.

9 e the mechanism of action of ER-beta and its ligands.

10 and dissociation kinetics of this family of ligands.

11 ines its capacity to interact with potential ligands.

12 inking of exogenously supplemented synthetic ligands.

13 0(3)-fold binding enhancements with only two ligands.

14 ess analogous to that used by bona fide TBDT ligands.

15 ces and, thus, that they could inhibit their ligands.

16 between the f-block element and coordinated ligands.

17 heir capture onto the surface using specific ligands.

18 th the metal ion's ability to bind exogenous ligands.

19 significantly up-regulated by TLR3 and TLR4 ligands.

20 oops and their derivatives as a new class of ligands.

21 d each of four different adenosine phosphate ligands.

22 king with dynamic proteins or weakly binding ligands.

23 nal interaction interface with high-affinity ligands.

24 a distinct class of the TGF-beta superfamily ligands.

25 ch are generally considered robust ancillary ligands.

26 g salicylates and diclofenac, as MR1-binding ligands.

27 olizumab is a humanised antiprogrammed death-ligand 1 (PD-L1) monoclonal antibody that inhibits PD-L1

28 Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1

29 we demonstrate that programmed cell death 1 ligand 2 (PD-L2) regulates the production of natural Abs

30 Recent studies have shown that Delta-like ligand 4 (Dll4) was upregulated on APC after respiratory

31 After 1 h of stimulation with ligands, 87, 138, 1013, and 22 genes were upregulated fo

32 Additionally, binding of the ligand-activated AHR to the putative dioxin response ele

33 lar dynamics simulations revealed that these ligands adopt distinct binding poses and engage differen

34 The innovative use of a nonspecific ligand allows a widespread "net" for cancer cells, witho

35 esence of a P-H...pi interaction between the ligand and a conserved aromatic residue in the ligand-bi

36 e and cooperative binding of both an acetato ligand and an amino ligand to zinc occurs in distinct co

37 flies, we find upregulated extracellular Wg ligand and nuclear trans-synaptic signal transduction, a

38 vels while male mice show reductions in both ligand and receptor expression.

39 e products are immobilized by a fixed biotin-ligand and visualized with anti-FAM antibody-coated gold

40 s) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriatel

41 pyridyl complexes (Os, Ru, and Fe) and their ligands and by mixing these complexes, coatings with a w

42 We have developed selective 5-HT2C ligands and herein describe their preclinical effectiven

43 putative binding site in GPR39 for synthetic ligands and knowledge of ligand binding to other recepto

44 producible molecular dynamics simulations of ligands and protein-ligand complexes.

45 The B7-CD28 family of ligands and receptors play important roles in T-cell co-

46 uctural properties of the beta2-adrenoceptor ligands and their interactions with membranes, we have i

47 ions, suggesting activation by autocrine Wnt ligands and/or paracrine Wnts emanating from the bone ma

48 pharmacokinetics, functionally selective D1 ligands, and D1R positive allosteric modulators.

49 folding and unfolding, its interactions with ligands, and its functions.

50 n octet of electrons to bind electronegative ligands, and no low-lying acceptor orbitals on the centr

51 th ligands on the chain ends, small molecule ligands, and palladium ions; polyMOCs are formed via met

52 Indeed, agonist ligands are required for a plethora of GPCRs for therape

53 ganocatalysts or metal complexes with chiral ligands are used, has become the most valuable methodolo

54 e process when different dearomatized pincer ligands are used.

55 ere shown to be upregulated by TLR3 and TLR4 ligands as previous reported, we identified a novel grou

56 ups appear to be out-competing the carbonate ligands associated with the aqueous U species.

57 gs highlight a possible asymmetry in protein-ligand association by suggesting that, within the confin

58 cket can alter the thermodynamics of protein-ligand association.

59 redox potentials are tuned by the choice of ligand at Mn.

60 indicating that Cripto-1 and Cryptic contact ligands at their receptor interaction surfaces and, thus

61 tin receptor langerin for simple and complex ligands augmented by structural insight into murine lang

62 transfer (PT) from the phenol to the peroxo ligand before the barrier; the other involves O-O homoly

63 trapped high-energy state displayed improved ligand binding affinity, compared with the wild-type enz

64 ith an engineered sequence is used to detect ligand binding as blocking events during DNA unzipping,

65 ter cytokine priming, Siglec-8 mAb or glycan ligand binding causes eosinophil apoptosis associated wi

66 In all conjugates, the ligand binding competence toward alphaVbeta3 (using both

67 depended on the source of the extracellular ligand binding domain of the subunit.

68 The PET images matched ligand binding in post-mortem tissue, and histological m

69 heories for the predictions of metal ion and ligand binding sites and metal ion-dependent RNA stabili

70 GPR39 for synthetic ligands and knowledge of ligand binding to other receptors with similar binding p

71 uman fetal retinal pigment epithelium cells, ligand binding to TLR2 induced robust expression of proi

72 emporal synchronization of RNA synthesis and ligand binding-dependent conformational refolding.

73 unbound, sensing riboswitch refolds into the ligand binding-induced output state.

74 le probes for local structure, dynamics, and ligand binding.

75 en used to investigate general properties of ligand binding: we observe both a direct stabilizing eff

76 The ligand-binding betaI and alphaI domains of integrin are

77 ring (SAXS) experiments using isolated GluA2 ligand-binding domain (GluA2-LBD) are consistent with bi

78 mined the crystal structure of the PPARgamma ligand-binding domain (LBD) in complex with VSP-51, whic

79 h subtype-specific residues in the PPARdelta ligand-binding domain (LBD).

80 ng products lacking the entire extracellular ligand-binding domain of the receptor while retaining th

81 gand and a conserved aromatic residue in the ligand-binding pocket.

82 ceptors display near-identical extracellular ligand-binding regions but have intracellular sequences

83 Structural studies of the beta1AR define ligand-binding sites in the transmembrane helices and ef

84 a common theme related to (changes in) metal-ligand bonding.

85 Cytoskeleton and ligand-bound integrins orient in the same direction as r

86 This broad set of ligand-bound poses is then used to investigate general p

87 re-organized conformation that resembles the ligand-bound state.

88 standing of how an interface can select some ligands, but not others.

89 TLR ligands, but not proteases, induced TNF during allergic

90 Exchange of the 1,3-COD ligand by PMe3 led to [Si(II)(Xant)Si(II)]Ni(PMe3)2, whi

91 Systemic evolution of ligands by exponential enrichment of this class of prote

92 n approach involving systematic evolution of ligands by exponential enrichment with a single AMPA rec

93 Different ligands can activate these receptor pairs but lead to di

94 Aqua ligands can undergo rapid internal rotation about the M-

95 d by redox-active pyridine dialdimine (PDAI) ligands catalyze the cycloaddition of two terminal alkyn

96 A specific beta-cell expression of the CCR2-ligand (CCL2) was observed in the pancreata of cadaveric

97 The ligand-centered radical couples antiferromagnetically wi

98 unique, neutral Cu2 I2 (L(.) ) complex of a ligand-centered radical, whereas reaction with the stron

99 e adjacent strands to form an infinite metal-ligand chain along the fibril axis.

100 t Rh2/form-to-naphthyridine, metal/ligand-to-ligand charge-transfer (ML-LCT) excited states were obse

101 In contrast, the TLR9 ligand class C, ODN2395, increased angiogenesis.

102 lic carbenes (NHCs), a promising alternative ligand class regarding stability and variable design str

103 The GPVI ligand collagen and the CLEC2 ligand podoplanin were con

104 dynamics simulations of ligands and protein-ligand complexes.

105 Ligand-conjugated microparticles of iron oxide (MPIO) ha

106 While several chemokine receptors and ligands control multiple stages of this process, their i

107 es to the thermodynamic balance of the metal ligand cooperative reactions, changing the energetics of

108 alladium ions; polyMOCs are formed via metal-ligand coordination and thermal annealing.

109 itate our search, we used a simple adamantyl ligand core that by avoiding stereochemical issues enabl

110 The ligand could be used in a substoichiometric amount (0.25

111 e interparticle interactions dictated by the ligand coverage on nanocrystal surfaces and nanocrystal

112 Finally, blocking of CXCR6 with its ligand CXCL16 significantly inhibited SIVagmSab replicat

113 er treatment with DMXAA or the natural STING ligand cyclic GMP-AMP (cGAMP).

114 gnals responsible for induction of the Notch ligand delta-like 4 (DLL4) in endothelial cells, we find

115 ructure (EXAFS) data using reference organic ligands demonstrated that Fe(II) was complexed primarily

116 teractions with perilipin proteins and ABHD5 ligands, demonstrating that ABHD5 lipase activation coul

117 nsactivation of the AR/AR-V7 target genes in ligand dependent and independent manners respectively.

118 zamides, providing a new structural lead for ligand design.

119 exes for applications that require efficient ligand dissociation, as well as for those that require m

120 A new electronic parameter for ligand donation, derived from experiments on a high-vale

121 pectively, to final states with all bridging ligands doubly reduced and all bpy ligands singly reduce

122 particular, it is shown that the diphosphine ligand, dppm, used in the reaction promotes the formatio

123 receptor-associated protein (RAP) as a model ligand due to its tight binding interaction.

124 The tumor necrosis factor (TNF) family ligand ectodysplasin A (EDA) is produced as 2 full-lengt

125 review describes the role of endogenous RAGE ligands/effectors in normo- and pathophysiological proce

126 nalytical approach, which combines the proxy ligand electrospray ionization mass spectrometry (ESI-MS

127 through proteolytic cleavage in response to ligand engagement.

128 iated antigen (CLA), a functional E-selectin ligand (ESL), is selectively expressed on circulating HS

129 promoter whose activity is repressed by the liganded estrogen and androgen receptors, and by the hyp

130 thout the need for precious metal catalysts, ligands, excess reagents, protecting and/or directing gr

131 es substrate coordination via proton-coupled ligand exchange.

132 Inhibition of signaling after ligand exposure selectively delayed proliferation in cel

133 -33 on alloreactivity, and the role of Notch ligands expressed by fibroblastic stromal cells in alloi

134 regulated mRNA expression of Fgfrs and their ligands Fgfs Deleting Fgfr1/2/3 not only impaired bSC de

135 tively present in the lung, whereas the GPVI ligands fibrin and histone were induced during pneumonia

136 e), taking into account the effect of subtle ligand flexibility on the electronic structure.

137 anic molecule to function as a physiological ligand for a nuclear receptor and direct environmental s

138 Interestingly, hybrubin A was found to be a ligand for a variety of GPCRs with a propensity for pote

139 ient mice implicated IgG as the pathogenetic ligand for endothelial FcgammaRIIB in obesity-induced in

140 e metabolite of dietary vitamin A, acts as a ligand for nuclear receptor transcription factors with m

141 f a cinchona alkaloid-derived aminophosphine ligand for the silver(I) salt and the 2-bis(aryl)methylp

142 ns yielded vibrational modes of the diatomic ligands for conceivable H-cluster structures.

143 his dataset contains 70,219 and 9,511 unique ligands for the allosteric and competitive sets, respect

144 tins are a family of growth factors that are ligands for the tyrosine kinase receptor, Tie2.

145 nal multiple bond between a Ce(IV) ion and a ligand fragment was also isolated by encapsulation of a

146 actic acid by varying the ratio of Zn(2+) to ligand from 0.5 to 0.85 mmol.

147 approach to systematically characterize MHC ligands from 17 patients.

148 Strong TR peptide ligands from platelet GP1balpha and G-protein-coupled re

149 Optimized ligands from the database were virtually screened to obt

150 an autoimmune risk variant and triggered by ligand functions to protect against viral challenge, whi

151 ransmission via the allosteric modulation of ligand-gated chloride channels, such as hetero-oligomeri

152 Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements

153 amyloid structure, which in turn shapes the ligand geometry and catalytic reactivity of Zn(2).

154 The AXL receptor and its activating ligand, growth arrest-specific 6 (GAS6), are important d

155 eptionally hindered class of enantiopure NHC ligands has been developed.

156 A number of mono- and bidentate ligands have also proven to be effective for acceleratin

157 Soluble ligands have commonly been targeted by antibody therapeu

158 However, it remains unclear whether these ligands have effects on AHN.

159 TSPO ligands have shown anti-inflammatory and neuroprotective

160 CB2R ligands have therefore received great attention, and dif

161 affinities >500 M(-1) and >/=93% of all HMO ligands (hGal-1-31 of 31 ligands; hGal-3C-25 of 25; hGal

162 d >/=93% of all HMO ligands (hGal-1-31 of 31 ligands; hGal-3C-25 of 25; hGal-7-28 of 30); no false po

163 eactive BCR knock-in mice lacking self-Thy-1 ligand, immunoglobulin light chain editing occurred, gen

164 ished for the 6,6'-dimesityl-2,2'-bipyridine ligand in [fac-Mn(I)(mes2bpy)(CO)3(CH3CN)](OTf), which p

165 studies also showed that abundance of CXCR2 ligand in blister fluids also creates a favorable milieu

166 cancer cells, involving release of the I(-) ligand in the presence of glutathione (GSH).

167 "clefts" between coordinating diglycolamide ligands in positions that satisfy both repulsive and att

168 Possible alternative ligands include proteoglycans, polysaccharides, and fibe

169 An ER-beta-selective ligand increased markers of tricarboxylic acid-dependent

170 hways and in beta-arrestin 2 recruitment, no ligand-independent activity could be measured.

171 T-ALL NOTCH1 mutations result in ligand-independent and sustained NOTCH1-receptor signali

172 ing FKBP12 increase hepcidin expression in a ligand-independent manner, through BMP-SMAD signaling.

173 r necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

174 e, we gained insight on how the probe senses ligand-induced conformational change in RNA.

175 Butyrate synergistically enhanced AhR ligand-induced Cyp1a1/CYP1A1 in these cells with compara

176 Using this method, we observe ligand-induced dimerization of a receptor tyrosine kinas

177 that this signal does not require canonical ligand induction.

178 of the response and consequence of rotating ligands integrated into porous materials to harness them

179 hods for predicting the magnitude of protein-ligand interactions have the potential to improve the ef

180 tudying structural and functional aspects of ligand interactions with purified P-gp and other ATP-bin

181 the biochemical characterization of receptor-ligand interactions.

182 Mn(0)-Mn(0) dimerization, the [(MeO)2Ph]2bpy ligand introduces an additional electronic influence com

183 velopment and stem cell maintenance, but the ligands involved are ill-defined.

184 which revealed that the 2-methylimidazolate ligand is responsible for multiple redox transformations

185 l, computationally tractable approach to RNA-ligand kinetics, we overcome the two main difficulties b

186 deltaNA values for a family of 16 literature ligands, known as bpp(X,Y) [X,Y-substituted 2,6-(pyrazol

187 ted the concentration of monocarboxylic acid ligand l-lactic acid by varying the ratio of Zn(2+) to l

188 ed (4-c) square porphyrinic tetracarboxylate ligand led to the formation of the targeted RE-shp-MOF.

189 lls stably adorned with Toll-like receptor-9 ligand-loaded particles using streptavidin-biotin cross-

190 oparticles using peptides and other affinity ligands may represent a general strategy to increase the

191 receptor activator of nuclear factor-kappaB ligand-mediated osteoclastogenesis.

192 Oral biotherapy with TLR4 ligands might be useful to potentiate oral tolerance to

193 Surprisingly, these synthetic ligands modulated signaling of a GPR56 mutant defective

194 ceptor complex (FZD4, LRP5, and TSPAN12) and ligand (NDP) of a molecular pathway that controls angiog

195 Utilizing a rigid ferrocene diamide ligand (NN(TBS)), a Dy(III) SIM, (NN(TBS))DyI(THF)2, 1-D

196 r GPCRs, however, neither bind covalently to ligands nor are light sensitive.

197 ymphoma because of a deficiency in CD70, the ligand of CD27.

198 ng electron-donation from the axial thiolate ligand of cytochrome P450 has been proposed to increase

199 Lipid ligands of G2A were found in increased concentrations in

200 evidence to suggest that glucuronides can be ligands of human CYP2C8, making CYP2C8 distinct from the

201 2 metabolites predicted 146 competitive OCT1 ligands, of which an endogenous neurotoxin, 1-benzyl-1,2

202 Ps and the structure of the thiolate capping ligand; of the eight different ligands screened, those w

203 ions of the 2-(pyridin-2-yl)benzo[d]thiazole ligand on the photoluminescence and LEC performance have

204 The effect of the G4-ligands on Panc-1 cancer cells has also been examined.

205 tetra-arm star polymers functionalized with ligands on the chain ends, small molecule ligands, and p

206 volving both cyclopentadienyl and carboranyl ligands on the metal carbonyl, explain the ease of the c

207 identified the on-conformation; without the ligand, only off-conformations were visualized.

208 ression and proliferation, in the absence of ligand or presence of 4OH-tamoxifen (TOT).

209 es, in some cases enhanced with more protein ligands or one or two water molecules, to determine whic

210 Ox40 ligand (Ox40L) locus genetic variants are associated wit

211 tute segregation of CD45 from bound receptor-ligand pairs using purified proteins on model membranes.

212 Expression of PD-1 and its ligands PD-L1 and PD-L2 in chronic rhinosinusitis with n

213 h factor receptor alpha (PDGFRalpha) and its ligand platelet-derived growth factor A (PDGF-A) are co-

214 roup in the designed chiral binaphthyl-based ligand plays the essential role of a general base cataly

215 The GPVI ligand collagen and the CLEC2 ligand podoplanin were constitutively present in the lun

216 re indicated by its only known physiological ligand, podoplanin, being an integral membrane protein.

217 nship between gene transcript levels and HLA ligand presentation.

218 A designer Josiphos ligand promotes the generation of chiral benzylic isomer

219 observe both a direct stabilizing effect of ligand-protein interactions and an indirect destabilizin

220 tation eliminated signal transduction by all ligands, providing a comprehensive assessment of how thi

221 t of fractionation was independent of the Zn:ligand ratio used, indicating isotopic equilibrium and t

222 This is supported by biochemical ligand-receptor interaction assay data.

223 s provide new insights into the mechanism of ligand recognition by this enigmatic family of membrane-

224 e dopamine receptor structure, function, and ligand recognition, we determined crystal structures of

225 a multimeric synthetic sulfated sialoglycan ligand recognizing Siglec-8 in combination with integrin

226 in coupled receptor for which the endogenous ligand remains unknown.

227 analyze the concentration dependence of the ligand response of the rationally designed, artificial t

228 tify cell-to-cell variability of adaptation, ligand response, as well as steady-state output level, a

229 tion between the nonactivated integrin and a ligand resulted in the activation of focal adhesion kina

230 Mechanistically, stimulation with FPR2 ligands resulted in down-regulation of E-cadherin and up

231 Selective inhibition of individual ligands revealed that this signal does not require canon

232 apo PllA and complexes with three different ligands revealed the molecular basis for the strict spec

233 l face-on halogen-pi interaction between the ligand's alkyl chloride and a guanine residue.

234 olate capping ligand; of the eight different ligands screened, those with the shortest alkyl chain, -

235 ing DNA unzipping, allowing determination of ligand selectivity both for small drugs and large protei

236 TNF-alpha-TNFR1 signaling rather than direct ligand sensing, suggesting a form of quorum sensing amon

237 Eos treated with the EBI2 ligands showed significantly increased transwell migrati

238 Labeling with a fluorescent beta2AR ligand shows the receptors are highly expressed in airwa

239 bridging ligands doubly reduced and all bpy ligands singly reduced.

240 y membrane, boosting cell sensitivity to the ligand Sonic Hedgehog (SHH) and consequently altering SH

241 rried out for a wide range of CB2R reference ligands, spanning the range of full, partial, and invers

242 eno-associated viral vectors (AAVs) encoding ligand-specific antagonists into the tibialis anterior (

243 erative signaling, is here shown to regulate ligand-specific Notch signaling.

244 , the relative contribution of various Notch ligands, specifically jagged-2, to the homeostasis of HS

245 Here, we investigate the ligand specificities of the human and murine forms of th

246 ified 13 TAS2R16 residues that contribute to ligand specificity and 38 residues whose mutation elimin

247 nuclear Smad3 was a more precise outcome of ligand stimulation.

248 discovered chemokine receptor CXCR7 and its ligand stromal cell-derived factor (SDF)-1 are known to

249 POL5551 inhibited CXCR4 binding to its ligand, stromal cell-derived factor-1alpha, and reduced

250 imination between VSP-51 from TZDs and other ligands such as telmisartan, SR1663 and SR1664.

251 Ultrastructural localization of endogenous ligands support these functional findings.

252 ying a gradient-based coarse graining to RNA-ligand systems and solving the process in a pseudo-first

253 Here we report a 2-pyridone ligand that binds to palladium and accelerates non-direc

254 noline has now been identified as a feasible ligand that can coordinate to the metal center of Cp*RhC

255 protein homologue 2b (PfRh2b) is an invasion ligand that is a potential blood-stage vaccine candidate

256 ts that are highly sensitive, biorecognition ligands that are capable of exquisite selective binding,

257 We engineered synthekine ligands that assembled IL-2Rbeta/IL-4Ralpha or IL-4Ralph

258 ain enzymes, HTS assays designed to identify ligands that block protein binding are much more challen

259 by chemical functionalization of the organic ligands that connect their metal clusters into multidime

260 In both mouse and human B cells, BCR ligands that deliver a TLR9 agonist induce an initial pr

261 ted from [Ir(COD)OMe]2 and chiral dinitrogen ligands that we recently disclosed.

262 ey also efficiently scavenge their chemokine ligands, thereby contributing to gradient maintenance an

263 o Cho because a different H-bond tethers the ligand to misalign the QA and form weaker interactions w

264 nding of both an acetato ligand and an amino ligand to zinc occurs in distinct confined environments,

265 min, but surprisingly, the capacity of these ligands to bind the P2204L mutant was much reduced despi

266 ar pharmacology of the most widely used CB2R ligands to date.

267 nd relative contributions of Wnt versus RSPO ligands to in vivo canonical Wnt signalling and ISC biol

268 tential to probe the binding of a variety of ligands to metal nanoparticles.

269 and Cryptic blocked binding of their cognate ligands to type I and type II TGF-beta receptors, indica

270 the free energy of binding the hypothesized ligands to YKL-40, addressing thermodynamic preference r

271 and triplet Rh2/form-to-naphthyridine, metal/ligand-to-ligand charge-transfer (ML-LCT) excited states

272 nd emission occurs from a long-lived doublet ligand-to-metal charge-transfer ((2)LMCT) state that is

273 ROSPOROCYTES1) LRR-RLK and its small protein ligand TPD1 (TAPETUM DETERMINANT1) play a fundamental ro

274 TNF-alpha related apoptosis-inducing ligand (TRAIL) selectively kills tumor cells, without da

275 ioxin (TCDD) and also microbiota-derived AhR ligands tryptamine, indole and 1,4-dihydroxy-2-naphthoic

276 with the fetus, as most of the receptors and ligands up-regulated during decidualization have their c

277 isothermal titration calorimetry, and radio-ligand uptake and fluorescent transport assays on ZntB r

278 tease thermolysin with purposefully designed ligands using high-resolution crystallography and isothe

279 e vitamin D receptor (VDR), whose activating ligand vitamin D has been proposed as a modifiable facto

280 O-silylene 7 exhibiting a fascinating siloxy ligand was observed.

281 to innate stimuli such as Toll-like receptor ligands was not sufficient.

282 With all the ligands we found preferential partitioning of isotopical

283 ng from the state-of-the-art of organosulfur ligands, we describe the gold-sulfur bond formation and

284 antigenic liposomes formulated with an hCD22 ligand were shown to prevent B cell activation, increase

285 with the loss of iron-complexing carboxylate ligands were observed, including decreases in UV absorba

286 Ligands were predicted by docking against a comparative

287 es of antimony porphyrins with varying axial ligands were synthesized for electrocatalysis applicatio

288 ial challenges with LPS and Poly I:C, a TLR3 ligand, which was physiologically associated with amplif

289 ach Zn(2+) has two bis-coordinated histidine ligands, which bridge adjacent strands to form an infini

290 p medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynam

291 caused by dysregulation of so-called eat me ligands, which govern the edibility of cells undergoing

292 orbetapir (Amyvid) is an amyloid-binding PET ligand with a half-life suitable for clinical use outsid

293 5-diaza-3,7-diphosphacyclooctane diphosphine ligand with alkyl/aryl groups on N and P), have been dev

294 Using organic ligands with 1, 2, and 3 phenylene rings, we construct m

295 ary, the CaR-ESI-MS assay identified 100% of ligands with affinities >500 M(-1) and >/=93% of all HMO

296 eptor (beta2AR) upon exposure to orthosteric ligands with different efficacies, in the absence and pr

297 amine D1 receptor and adenosine A2A receptor ligands with functionally selective properties between G

298 Despite the presence of TLR ligands within the microenvironment, tumors progress, an

299 nt spin states and bearing different anionic ligands X revealed that the nature of anion influences t

300 Here we demonstrate that a synthetic G4 ligand, Y2H2-6M(4)-oxazole telomestatin derivative (6OTD