ライフサイエンスコーパス: ligand-binding domain

1 ed folding of full-length transcripts of the ligand binding domain.

2 with binding hot spots within the PPARgamma ligand binding domain.

3 nd UT-155) also binding the carboxy-terminal ligand binding domain.

4 ine-rich nuclear export signals (NES) in its ligand binding domain.

5 nt missense mutations in the Dalpha7 nAChR's ligand binding domain.

6 ed recruitment of cofactor motifs to the FXR-ligand binding domain.

7 a functional dimer to interact with the LasR ligand binding domain.

8 es of agonist interactions with the receptor ligand binding domain.

9 nel and kinetics of glycine binding with its ligand binding domain.

10 R (hPXR) by interacting with its promiscuous ligand binding domain.

11 mprove key interactions with the human GluA2 ligand-binding domain.

12 ovo amino acid substitutions, all within the ligand-binding domain.

13 ller structure resembling the alpha-integrin ligand-binding domain.

14 en receptor (AR) splice variants lacking the ligand-binding domain.

15 activated by targeting a site outside of its ligand-binding domain.

16 binding of glutamate to a solvent-accessible ligand-binding domain.

17 EID1 mimics helix H1 of the nuclear receptor ligand-binding domain.

18 receptor assembly, driven by closure of the ligand-binding domain.

19 AFs), AF-1 in the N-terminal and AF-2 in the ligand-binding domain.

20 hrough a pathway that bypasses its canonical ligand-binding domain.

21 truncated AR variant proteins lacking the AR ligand-binding domain.

22 d AR splice variants (AR-V) that lack the AR ligand-binding domain.

23 y is dependent on helix 12 of the C-terminal ligand-binding domain.

24 by insertion of the estrogen receptor-alpha ligand-binding domain.

25 fferences in the quaternary structure of the ligand-binding domain.

26 nd the beta8-beta9 loop in the extracellular ligand-binding domain.

27 dues facing the heterodimer interface of the ligand-binding domain.

28 (GR) GRalpha, as the GRbeta isoform lacks a ligand-binding domain.

29 ardants and dust extracts to human PPARgamma ligand-binding domain.

30 ee clinically relevant GR modulators from GR ligand binding domains.

31 are often oligomeric receptors with multiple ligand binding domains.

32 are located in the highly structured DNA and ligand binding domains.

33 RNA splicing to produce isoforms with 1 or 2 ligand-binding domains.

34 interactions between the amino-terminal and ligand-binding domains.

35 nal rearrangements of the amino-terminal and ligand-binding domains.

36 which have conserved DNA-binding domains and ligand-binding domains.

37 ring specific structural elements within the ligand-binding domains.

38 ion channel and linkers connecting it to the ligand-binding domains.

39 sion system was used to express SdrF and its ligand-binding domains.

40 M) and greater than AHR containing the mouse ligand-binding domain (0.08 nM).

41 h a newly identified region of the PPARgamma-ligand binding domain (1).

42 lical proteins that consist of a periplasmic ligand-binding domain; a transmembrane region; a cytopla

43 rom the combination of three residues in the ligand-binding domain: A354 and A370, and N325.

44 promotes conformational changes in the EphA4 ligand-binding domain allowing the formation of signalin

45 onocytes also express Siglec-14, which has a ligand-binding domain almost identical to Siglec-5 but s

46 Rbeta antibodies, we showed that an in-frame ligand binding domain and C terminus were present in the

47 a structural model of the androgen receptor-ligand binding domain and to investigate the structural

48 t formed by the interface of two neighboring ligand binding domains and act by stabilizing the agonis

49 Ncoa3 interacts with Esrrb via its ligand-binding domain and bridges Esrrb to RNA polymeras

50 beta isoform, however, lacks helix 12 of the ligand-binding domain and cannot bind GCs.

51 that some MODY1 mutations, positioned on the ligand-binding domain and hinge regions of the receptor,

52 of an electrostatic interaction between the ligand-binding domain and linker region to the pore that

53 explanation for this discrepancy is that the ligand-binding domain and NCoR1 peptides used for in vit

54 on of diverse AR variant species lacking the ligand-binding domain and possessing ligand-independent

55 On the AMPAR extracellular domains, the ligand-binding domain and possibly a stretch of linker,

56 elding N-terminal fragments encompassing the ligand-binding domain and the majority of the central mo

57 r composed of the alpha7 nAChR extracellular ligand-binding domain and the transmembrane domain of al

58 alternatively spliced isoform that lacks the ligand-binding domain and thus no longer localizes at th

59 eft closure conformational change toward the ligand-binding domain and transmembrane segments, ultima

60 forms an interface between the cytoplasmic (ligand-binding) domain and the transmembrane pore, and m

61 he formation of an active catalytic, but not ligand-binding domain, and that mutations that inhibit t

62 ptor subtypes was mapped structurally to the ligand-binding domain, and was proposed to be mediated b

63 nzalutamide-resistant prostate cancers where ligand-binding domain antagonists are ineffective.

64 variants (AR-Vs) lack the androgen receptor ligand-binding domain (AR-LBD), the intended target of a

65 es of these compounds in the zebra fish zVDR ligand binding domain as complexes with NCoA-2 coactivat

66 ex with the liver receptor homolog-1 (LRH-1) ligand binding domain at 2.8 A resolution as the first s

67 fied, full-length LRH-1, as well as isolated ligand binding domain, bound to PGC1alpha with higher af

68 n monocytes and neutrophils, share identical ligand-binding domains but have opposing signaling funct

69 l transactivation domain, and the C-terminal ligand binding domain, but not the DNA-binding domain of

70 ess-type MMTV integration site family member-ligand-binding domain, but lacks the transmembrane domai

71 racterized AF2 interaction surface in the GR ligand-binding domain, but Lin11, Isl-1, Mec-3 (LIM) dom

72 tudies revealed an essential role for the GR ligand-binding domain, but no clear requirement for liga

73 lly for F-actin binding proteins, the DNGR-1 ligand binding domain contacts three actin subunits heli

74 ctivator peptide binds to the human RXRalpha ligand binding domain containing two clinically relevant

75 easurements reveal that interactions between ligand-binding domains control the conformational rearra

76 ged as a triangle, with an interface between ligand-binding domains D1 and D5.

77 iption factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively).

78 c-finger DNA-binding domain and the putative ligand-binding domain decrease NR2F1 transcriptional act

79 ects 9cRA-induced coactivator binding to the ligand binding domain demonstrated that UVI3003 signific

80 its high constitutive activity, both direct (ligand-binding domain-dependent) and indirect activation

81 ents in the AMPAR extracellular domain, with ligand-binding domain dimers losing their local 2-fold r

82 and antiestrogen resistance and suggest that ligand-binding domain dysfunction leads to endocrine the

83 conformational changes of the extracellular ligand-binding domains (ECDs) associated with receptor a

84 ansfected partial receptor consisting of the ligand binding domain (ER-bla; ERalpha beta-lactamase ce

85 larity, recombinant forms of the Ace and Cna ligand-binding domains exhibit significantly different a

86 activated fusion protein, which contains the ligand binding domain from a target NHR (human thyroid r

87 stitutive activity reveals uncoupling of the ligand-binding domain from conserved connector residues,

88 interactions of RID1 and RID2 with 20 other ligand-binding domains from different NR subtypes were o

89 ring in the portion of the gene encoding the ligand-binding domain, functionally suppressed RARA-medi

90 We show how TARPs sculpt the ligand-binding domain gating ring, enhancing kainate pot

91 n fluorescent protein (GFP) insertion into a ligand-binding domain, generating the requisite alloster

92 ring (SAXS) experiments using isolated GluA2 ligand-binding domain (GluA2-LBD) are consistent with bi

93 data for 7-CKA binding to the isolated GluD2 ligand binding domain (GluD2-LBD), we find that binding

94 antagonism, the crystal structure of the GR ligand-binding domain (GR LBD) complex with a nonsteroid

95 ective larval stage, and as such, the DAF-12 ligand binding domain has been identified as an importan

96 Thus, the CD22 ligand-binding domain has a crucial function in regulati

97 minally truncated AR variants lacking the AR ligand-binding domain has emerged as an important mechan

98 compounds, including (+)-11b, within the AR ligand-binding domain have been studied by cocrystalliza

99 Structures of a soluble ligand-binding domain have provided atomic-scale insight

100 TRalpha*T3:RXRalpha*9-cis retinoic acid (9c) ligand binding domain heterodimer complex at 2.95 A alon

101 vivo whereas adding another mutation in the ligand-binding domain (I634A) severely compromises homod

102 seudo-four-fold symmetric arrangement of the ligand-binding domains, illustrating subtle changes in s

103 f the hookworm Ancylostoma ceylanicum DAF-12 ligand binding domain in complex with DA and cholestenoi

104 The crystal structure of the zebrafish VDR ligand binding domain in complex with LCA and the SRC-2

105 ic study of vitamin D nuclear receptor (VDR) ligand binding domain in complexes with six nonsecostero

106 etermine the location and composition of the ligand binding domain in EBI2, we used a site-directed m

107 odulators were cocrystallized with the GluA2 ligand binding domain in order to decipher the impact of

108 bimagrumab binds to both ActRIIA and ActRIIB ligand binding domains in a competitive manner at the cr

109 ystal structures of the human and insect TLX ligand-binding domain in complex with Atro box peptides.

110 ve solved the crystal structure of the GluN1 ligand-binding domain in complex with TK40 and show that

111 reduces coactivator interaction with the CAR ligand-binding domain in mammalian two-hybrid assays; an

112 conserved in all x-ray structures of the RXR ligand-binding domain in the presence of agonist and coa

113 hydrogen bonds in the GluA2 (AMPA receptor) ligand-binding domain in the presence of several full an

114 fold to four-fold symmetry transition in the ligand-binding domains in both subtypes.

115 oth the density of ligands and the number of ligand-binding domains in the oligomers.

116 The ligand-binding domain influences assembly through a proc

117 on Model", which demonstrates how two tandem ligand-binding domains interact to regulate protein func

118 ts triggers a concerted rearrangement in the ligand-binding domain, involving an ~1-A outward displac

119 apping at two sites in the lower lobe of the ligand binding domain is consistent with deformation of

120 assays revealed that His323 of the PPARgamma ligand binding domain is important for binding to S1P.

121 eterotetramer complex than they do when each ligand-binding domain is examined alone.

122 stablishment of a ring-like structure in the ligand-binding domain layer of the receptor.

123 st binding modulates the conformation of the ligand-binding domain "layer" of the intact receptors an

124 pressed in prostate cancer (PCa) lack the AR ligand binding domain (LBD) and function as constitutive

125 f human NR5A1 (steroidogenic factor-1, SF-1) ligand binding domain (LBD) bound to PIP2 and PIP3 show

126 mino terminal domain and a twofold symmetric ligand binding domain (LBD) dimer of dimers assembly.

127 stic fashion, i.e., helix 12 not sealing the ligand binding domain (LBD) effectively, and therefore r

128 show how competitive antagonists rupture the ligand binding domain (LBD) gating "ring," how agonists

129 orylation of two additional tyrosines in the ligand binding domain (LBD) in P1-HNF4alpha.

130 racted with four proteins of 37-172 kDa, and ligand binding domain (LBD) interacted with six proteins

131 pe III domain ((10)Fn3), that target the PXR ligand binding domain (LBD) interactions with the steroi

132 We also show that the GR ligand binding domain (LBD) is not required for SMRT-med

133 both wild-type AR and the two most common AR ligand binding domain (LBD) mutants.

134 model examining the interaction between the ligand binding domain (LBD) of RORalpha or RORgamma with

135 Co-crystallization of the ligand binding domain (LBD) of RORgammat with a series o

136 ructure, starting with the first view of the ligand binding domain (LBD) published in 1998, and in ma

137 ystal structure of compound 10 within the GR ligand binding domain (LBD) unveils a novel binding conf

138 this process is initiated in their bilobate ligand binding domain (LBD) where agonist binding to lob

139 igands bind directly to recombinant RORgamma ligand binding domain (LBD), promote recruitment of a co

140 ased on identities of key amino acids in the ligand binding domain (LBD).

141 roline at position 227 in helix 3 in the VDR ligand binding domain (LBD).

142 tified on AR, both located in its C-terminal ligand binding domain (LBD).

143 o acid residues, Tyr-454 and Arg-461, in its ligand binding domain (LBD).

144 controlled by conformational changes in the ligand binding domain (LBD); however, glutamate receptor

145 the toxin acts like a straightjacket on the ligand-binding domain (LBD) "gating ring," restraining t

146 The RARbeta ligand-binding domain (LBD) and DNA-binding domain (DBD)

147 ators bind within the dimer interface of the ligand-binding domain (LBD) and stabilize the agonist-bo

148 es binding of neurotransmitter agonists to a ligand-binding domain (LBD) and structural rearrangement

149 ARs, we manipulated the coupling between the ligand-binding domain (LBD) and the ion channel by inser

150 eptor splicing variants (ARVs) that lack the ligand-binding domain (LBD) are associated with the deve

151 hus, endocrine therapies that inhibit the AR ligand-binding domain (LBD) are effective in treating PC

152 A crystal structure of the ERalpha ligand-binding domain (LBD) as a complex with resveratro

153 Here, we produce biosensors based on a ligand-binding domain (LBD) by using a method that, in p

154 of the GluA2 AMPA subtype glutamate receptor ligand-binding domain (LBD) dimers to characterize a nat

155 The presence of intact ligand-binding domain (LBD) ensures the strict androgen-

156 tal structures of GluN1/GluN2A NMDA receptor ligand-binding domain (LBD) heterodimers in complex with

157 d identified mutations in ESR1 affecting the ligand-binding domain (LBD) in 14 of 80 cases.

158 mined the crystal structure of the PPARgamma ligand-binding domain (LBD) in complex with VSP-51, whic

159 t stability of the D1 dimer interface in the ligand-binding domain (LBD) is an important determinant

160 static interactions at the apex of the AMPAR ligand-binding domain (LBD) is essential for gating by p

161 Using ligand-binding domain (LBD) mutants for electrophysiolog

162 , for the ligand-binding pocket (LBP) in the ligand-binding domain (LBD) of AR.

163 tal structures of the key analogue 2i in the ligand-binding domain (LBD) of GluA2 and GluK3 were dete

164 tallography reveals that SJB7 resides in the ligand-binding domain (LBD) of hPXR, interacting with th

165 n, and AF-2 is distributed in the C-terminal ligand-binding domain (LBD) of the ERalpha protein.

166 ined the effects of mutations within the AhR ligand-binding domain (LBD) on the activity of diverse A

167 The crystal structure of the PPARgamma ligand-binding domain (LBD) reveals that luteolin occupi

168 forms the ion channel, the membrane-proximal ligand-binding domain (LBD) that binds agonists such as

169 prototypical iGluR, reveals a clamshell-like ligand-binding domain (LBD) that closes in the presence

170 nnects the DNA-binding domain (DBD) with the ligand-binding domain (LBD) via a mix of positively char

171 Agonists bind to the ligand-binding domain (LBD) which is arranged as a dimer

172 l domains: an amino-terminal domain (ATD), a ligand-binding domain (LBD), a channel-forming transmemb

173 ses harbored mutations of ESR1 affecting its ligand-binding domain (LBD), all of whom had been treate

174 omposed of an amino terminal domain (ATD), a ligand-binding domain (LBD), and a transmembrane domain

175 ate cancer target the androgen receptor (AR) ligand-binding domain (LBD), but these ultimately fail a

176 R is activated by androgens that bind to its ligand-binding domain (LBD), causing the transcription f

177 amolecular interaction between CAR's DBD and ligand-binding domain (LBD), enabling the homodimer-hete

178 hrough their modulation of the extracellular ligand-binding domain (LBD), less is known about their r

179 It is activated by androgens through its ligand-binding domain (LBD), which consists predominantl

180 A 'clamshell' ligand-binding domain (LBD), which contains the ligand-b

181 membrane-distal N-terminal domain (NTD) and ligand-binding domain (LBD), which is fused to the ion c

182 rs by stabilizing the apo state of the GluN1 ligand-binding domain (LBD), which is incapable of trigg

183 h subtype-specific residues in the PPARdelta ligand-binding domain (LBD).

184 formational dynamics of the nuclear receptor ligand-binding domain (LBD).

185 N-terminal domain and AF2 in the C-terminal ligand-binding domain (LBD).

186 osed clamshell-like structure of the bilobed ligand-binding domain (LBD).

187 ated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a str

188 lar dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate t

189 Glutamate binding to clamshell-shaped ligand binding domains (LBDs) triggers opening of the in

190 However, steroid receptor ligand-binding domains (LBDs) are inherently unstable, a

191 those produced by NMDAR mutants in which the ligand-binding domains (LBDs) are locked in the closed c

192 The ligand-binding domains (LBDs) of the four subunits are e

193 tal structures of the ML032222a and PbiGluR3 ligand-binding domains (LBDs) reveal endogenous glycine

194 terminal Helix (H12) is more flexible in the ligand-binding domains (LBDs) without ligand, this incre

195 he association of glutamate molecules to the ligand-binding domains (LBDs).

196 reaches the recessed binding pocket in iGluR ligand-binding domains (LBDs).

197 -GluN2A dimer interface of the extracellular ligand-binding domains (LBDs).

198 A1 non-covalently and independently of known ligand binding domains located in the N-terminus and 5(t

199 tor (MR) on Ser-843, a residue placed on the ligand binding domain, lowers affinity for agonists, pro

200 e developed a ligand switch strategy using a ligand-binding domain mutation (W741C) that renders AR r

201 ed or enriched post treatment, including two ligand-binding domain mutations in ESR1.

202 s of the amino acids at two sites within the ligand binding domain of AHR1 (chicken--highly sensitive

203 nd-dependent transactivation function in the ligand binding domain of ERalpha C terminus (AF-2) and a

204 The relative positioning in the ligand binding domain of FXR, explored through docking c

205 ructure was obtained of 1b when bound in the ligand binding domain of GluK1.

206 cine ligand by anisotropy measurement at the ligand binding domain of GluN1 subunit.

207 al structures of each homologue bound to the ligand binding domain of hRXRalpha.

208 Cys(79) in the ligand binding domain of LasR appears to be important fo

209 cture of QslA in complex with the N-terminal ligand binding domain of LasR.

210 The amino-terminal ligand binding domain of SIRPalpha is highly polymorphic

211 The structure of kaitocephalin bound to the ligand binding domain of the AMPA receptor subtype, GluA

212 s a destabilizing domain system based on the ligand binding domain of the estrogen receptor that can

213 fusion of the Zif268 DNA binding domain, the ligand binding domain of the human estrogen receptor and

214 Mutational analysis of the ligand binding domain of the mGlu1a receptor revealed th

215 crystal structure of an agonist bound to the ligand binding domain of the PPARalpha receptor have bee

216 We have purified the ligand binding domain of the receptor PqsRLBD for PQS an

217 X-ray studies of four rexinoids bound to the ligand binding domain of the retinoid X receptor reveal

218 depended on the source of the extracellular ligand binding domain of the subunit.

219 Crystal structures of the ligand binding domains of most of the phylogenetically w

220 iquitin ligase, interacts with the hinge and ligand binding domains of PPARgamma and is a bona fide E

221 lecule positive allosteric modulators of the ligand-binding domain of (S)-2-amino-3-(3-hydroxy-5-meth

222 Antiandrogens target ligand-binding domain of androgen receptor (AR) and are

223 teract with a binding site distinct from the ligand-binding domain of apoER2 for selenium delivery.

224 Mice with a mutated CD22 ligand-binding domain of CD22 showed strongly reduced Ca

225 ds to the cleft between the two lobes of the ligand-binding domain of each subunit.

226 allosteric binding site in the extracellular ligand-binding domain of ELIC.

227 te the potential of Nanobodies to target the ligand-binding domain of EphA4.

228 romoted the direct binding of LXRbeta to the ligand-binding domain of ERalpha and initiated an extran

229 loop connecting Helix 11 and Helix 12 in the ligand-binding domain of ERalpha, which leads to a stabi

230 ly occurring four-amino-acid deletion in the ligand-binding domain of GLC-1, the alpha-subunit of a g

231 design using X-ray crystal structures of the ligand-binding domain of human GluA2 led to the discover

232 rimetry (ITC) analyses demonstrated that the ligand-binding domain of MCP2901 (MCP2901LBD) bound to c

233 ith the acetylcholine-binding protein or the ligand-binding domain of nicotinic receptors.

234 ded mostly by the three-layer, alpha-helical ligand-binding domain of nuclear receptors.

235 We found that AA binds to and stabilizes the ligand-binding domain of peroxisome proliferator-activat

236 hown that heme decreases the affinity of the ligand-binding domain of Rev-erb NRs for NCoR1 peptides.

237 re, we report the crystal structures for the ligand-binding domain of RORgammat in both apo and ligan

238 stituted selected amino acid residues in the ligand-binding domain of the alpha4 subunit by the corre

239 subunit chimera that contains the N-terminal ligand-binding domain of the alpha6 subunit).

240 ifornica AChBP that was made to resemble the ligand-binding domain of the alpha7 nAChR.

241 resent the crystal structure of the isolated ligand-binding domain of the GluN1-GluN2A NMDA receptor

242 % sequence similarity with the extracellular ligand-binding domain of the human alpha7 nAChR, to inve

243 potent and selective Nanobodies against the ligand-binding domain of the human EphA4 receptor.

244 of non-steroidal ligands able to bind to the ligand-binding domain of the MR and recruit different co

245 X-ray diffraction studies of the ligand-binding domain of the receptor are elucidating th

246 ng products lacking the entire extracellular ligand-binding domain of the receptor while retaining th

247 that independently binds the DNA-binding and ligand-binding domains of AR, and the interaction preven

248 iA through fusion of the Spinach2 aptamer to ligand-binding domains of cdiA riboswitches.

249 tructures for the soluble amino-terminal and ligand-binding domains of glutamate receptor ion channel

250 the heterodimeric complex formed between the ligand-binding domains of human PXR and RXRalpha.

251 designed corresponding to the extracellular ligand-binding domains of LRP1.

252 (AChBPs) are unique spatial homologs of the ligand-binding domains of nicotinic acetylcholine recept

253 Here we show that fusing ligand-binding domains of nuclear receptors to split Cas

254 By comparing ligand-binding domains of regulators with structurally c

255 and novel CAR designs that have alternative ligand binding domains or confer regulated function and/

256 viral DGR system targets putative tail fibre ligand-binding domains, potentially generating >10(18) p

257 Upon agonist binding, lobe closure of the ligand-binding domain produced outward pulling of the M3

258 s further modulated by ligand binding in the ligand-binding domain, providing evidence for Pin1-depen

259 etion of a conserved, unique sequence in the ligand binding domain (PXR174-210) did not interact with

260 domains are primed for activation while the ligand-binding domain remains unchanged.

261 sites at lysine 122 and 275 in the AF-1 and ligand binding domains, respectively, of FXR were subjec

262 A point mutation (E102Q) in the ligand-binding domain results in the juvenile form of am

263 Crystallization of the DGluR1A ligand-binding domain reveals amino acid exchanges that

264 ntagonist AP5; crystallization of the KaiR1D ligand-binding domain reveals that these ligands stabili

265 isoform of ERbeta (mERbeta2) with a modified ligand-binding domain sequence.

266 The alphaI domain (AID), a ligand binding domain shared by seven integrin alpha-sub

267 Recombinant soluble molecules displaying ligand-binding domains show marked quantitative and qual

268 h brace the heterodimer interface within the ligand binding domain, stabilize actively gating recepto

269 ulated ectodomain cleavage that releases the ligand-binding domain (sTie2) into the circulation.

270 The GR ligand-binding domain suffices for these biological resp

271 have additional intersubunit contacts in the ligand binding domain that occur at both conserved and n

272 e domain is oftentimes flanked by additional ligand binding domains that up- or down-regulate catalyt

273 C-terminal angiopoietin domains to the Tie2 ligand-binding domain, the mechanisms for Tie2 activatio

274 Both agents covalently bind to the PPARgamma ligand binding domain through a Michael addition reactio

275 ZNF764 physically interacted with GR at ligand-binding domain through its KRAB domain, and both

276 nd JH, which has been mapped to a particular ligand-binding domain, thus establishing this bHLH-PAS p

277 together with in silico modeling of the AHR ligand binding domain to identify indole, a microbial tr

278 w approaches that use genotyping of the AHR1 ligand binding domain to screen for DLC sensitivity amon

279 ciable pre-complex, enabling its neighboring ligand binding domain to tightly clamp the two polypepti

280 ors can bind within a pocket adjacent to the ligand-binding domain to stabilize specific conformation

281 possibly a stretch of linker, connecting the ligand-binding domain to the fourth membrane-spanning se

282 e opportunities through the use of different ligand-binding domains to enable multiplexed genome regu

283 A of the C-terminal part of the periplasmic ligand-binding domain upon ligand occupancy in the citra

284 erved tertiary architectural elements of the ligand binding domain using an in vitro single-turnover

285 he linkers that connect these helices to the ligand-binding domain using engineered cross-links, eith

286 n rat brain membranes and the purified GluN1 ligand-binding domain using glycine site GluN1 radioliga

287 h a crystallographic analysis of the GluRIIB ligand binding domain, we use this system to characteriz

288 raction of these agents within the PPARgamma ligand binding domain were obtained by docking analysis.

289 s of both eutomers in complex with the GluA2 ligand binding domain were solved.

290 Two X-ray structures of ligand binding domains were obtained: 2e in GluA2-LBD an

291 uctures of the three modulators in the GluK1 ligand-binding domain were determined, locating two modu

292 y BMP7 and were sensitive to deletion of the ligand binding domain, whereas the engineered ACVR1(Q207

293 peared solely dependent on the nature of the ligand-binding domain, whereas efficacy of cytisine was

294 domains; domains 2 and 3 (D23) represent the ligand-binding domain, whereas the function of D4-7 is u

295 soform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutami

296 tion leads to a conformational change in the ligand-binding domain, which mimics the conformation of

297 es, the ion channels are closed, whereas the ligand-binding domains, which are physically coupled to

298 rthermore, two NES were characterized in the ligand binding domain, whose deletion caused Nurr1 to ac

299 ized state, when ligands remain bound at the ligand binding domain with the conformation similar to t

300 domain arrangement consisting of individual ligand binding domains, with a defined higher order arch